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The increasing number of Open Access articles widens the reading offer
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While most of the selected texts belong to original articles,
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The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study.
The causal effects of lifestyle, circulating, pigment, and metabolic factors on early age-related macular degeneration: a comprehensive Mendelian randomization study.
Fuente:Journal of Translational Medicine
Extracto:
Our comprehensive MR
analysis demonstrated that elevated circulating HDL-C levels increase the risk of
early AMD, while TG and fatty acid levels are associated with a decreased risk.
These findings provide robust evidence for improved diagnosis and personalized
prevention and treatment of early AMD.
Claves:Early age-related macular degeneration, Lifestyle factors, Mendelian randomization, Metabolic factors, Serum lipids, Skin and hair color
Cita:J Transl Med 2024 Nov 1; 22 (1) : 988.
Autor/es:Shen, Gang (a) Chen, Yaqiong (b)
institución:(a) Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600#, Guangzhou, 510630, China. (b) Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600#, Guangzhou, 510630, China.
Conflicto:There is no competing interest to disclose.
A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies.
A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies.
Fuente:Bmc Medicine
Extracto:
The DemNCD
is the first tool to predict both dementia and multiple cardio-metabolic diseases
using comprehensive risk factors and provided similar predictive accuracy to
existing risk tools. It has similar predictive accuracy as tools designed for
single outcomes in this age-group. DemNCD has the potential to be used in
community and clinical settings as it includes self-reported and routinely
available clinical measures.
institución:(a) School of Psychology, University of New South Wales, Kensington, NSW, Australia. (b) Neuroscience Research Australia, Randwick, NSW, Australia.
Conflicto:JES has received honoraria for scientific advisory, lectures, and clinical research from Pfizer; Roche; Zuellig Pharma; Astra Zeneca; Sanofi; Novo Nordisk; MSD; Eli Lilly; Abbott; Mylan; Boehringer Ingelheim. CSA has received grants from Takeda.
Extracto:
Our findings suggest that in
typically developing children presenting with fussy eating, oral sensory
hypersensitivity and higher scores in social-emotional responses to sensory
processing may be an underlying determinant. The relationship observed between
'Oral' and 'Social-Emotional' sensory processing segments and 'Desire to Drink'
requires further research to ascertain the type of drinks being consumed and how
this impacts appetite. Further research is also required to explore the influence
of maternal sensory profile on their offsprings response to sensory input.
institución:(a) UCD Perinatal Research Centre, School of Medicine, University College Dublin, The National Maternity Hospital, Dublin 2, Ireland. (b) UCD Perinatal Research Centre, School of Medicine, University College Dublin, The National Maternity Hospital, Dublin 2, Ireland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy.
Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy.
Fuente:Frontiers in Immunology
Extracto:
This study identified GBP2,
P2RY12 and PSAP as NETs-associated biomarkers in the development of PDR, offering
new insights for clinical diagnosis and potential treatment strategies for DR.
institución:(a) Department of Ophthalmology, the Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China. (b) Department of Ophthalmology, the Second Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Occupational stress and body composition of hospital workers: a follow-up study.
Occupational stress and body composition of hospital workers: a follow-up study.
Fuente:Frontiers in Public Health
Extracto:
Therefore, managers
must promote adequate working conditions and understand the need for periodic
body composition assessments.
Claves:anthropometry, cohort study, likelihood functions, linear models, mixed effects models, worker’s health
Cita:Front Public Health 2024; 12 : 1459809.
Autor/es:de Lira, Carlos Rodrigo Nascimento (a) Akutsu, Rita de Cássia Coelho de Almeida (b)
institución:(a) School of Nutrition, Federal University of Bahia, Salvador, Brazil. (b) Department of Nutrition, Campus Darcy Ribeiro, University of Brasilia, Brasília, Brazil.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans.
Trends in hepatocellular carcinoma and viral hepatitis treatment in older Americans.
Fuente:Plos One
Extracto:
A decreased
incidence of HBV-attributable HCC corresponded with an increased uptake in
treatment for that infection. Despite a marked increase in the effectiveness and
frequency of HCV treatment in 2014 and 2015, HCV-attributable HCC had not begun
to fall as of 2017.
Cita:PLoS One 2024; 19 (11) : e0307746.
Autor/es:Jiang, Joy (a) Shiels, Meredith S (b)
institución:(a) Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America. (b) Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between measures of kidney function and preserved ratio impaired spirometry in diabetes: NHANES 2007-2012.
Association between measures of kidney function and preserved ratio impaired spirometry in diabetes: NHANES 2007-2012.
Fuente:Bmj Open
Tipo de trabajo:Estudio de cohortes
Extracto:
An elevated UACR and albuminuria
were linked to a higher risk of PRISm. Our study emphasises that kidney and lung
function are correlated. Further research is necessary to confirm our findings.
Claves:Diabetic nephropathy & vascular disease, Pulmonary Disease, Chronic Obstructive, Respiratory Function Test
institución:(a) Department of Endocrinology, Beijing Tongren Hospital CMU, Beijing, China. (b) Department of Endocrinology, Beijing Tongren Hospital CMU, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Health effects of selected environmental Exposomes Across the Life courSe in Indian populations using longitudinal cohort studies: GEOHealth HEALS Study protocol.
Health effects of selected environmental Exposomes Across the Life courSe in Indian populations using longitudinal cohort studies: GEOHealth HEALS Study protocol.
Fuente:Bmj Open
Tipo de trabajo:Revisión
Extracto:
Training of
Indian scientists will build the capacity to undertake research on selected
adverse environmental exposures on population health in India.
Claves:epidemiologic studies, epidemiology, public health
Cita:BMJ Open 2024 Nov 1; 14 (10) : e087445.
Autor/es:Prabhakaran, Dorairaj (a) Sieber, Nancy Long (b)
institución:(a) Centre for Chronic Disease Control, New Delhi, Delhi, India dprabhakaran@ccdcindia.org. (b) Department of Environmental Health, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Liver Cancer and Risk Factors in the MENA Region: Epidemiology and Temporal Trends Based on the 2019 Global Burden of Disease Data.
Liver Cancer and Risk Factors in the MENA Region: Epidemiology and Temporal Trends Based on the 2019 Global Burden of Disease Data.
Fuente:Cancer Control Journal of The Moffitt Cancer Center
Extracto:
A
comprehensive strategy is vital, encompassing vaccination promotion, health care
enhancements, and lifestyle awareness. Urgent coordinated efforts are needed to
address disparities, implement evidence-based interventions, and alleviate the
escalating LivCa burden in the MENA region.
Cita:Cancer Control 2024 Jan-Dec; 31 : 10732748241297346.
Autor/es:Lakkis, Najla A (a) Mokalled, Nour M (b)
institución:(a) Department of Family Medicine, American University of Beirut Medical Center (AUBMC), Beirut, Lebanon. RINGGOLD: 66984 (b) Department of Internal Medicine, Hematology-Oncology, American University of Beirut (AUB), Beirut, Lebanon. RINGGOLD: 66984
Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Randomized trial of early exercise rehabilitation and its effects on patients with acute coronary syndrome.
Randomized trial of early exercise rehabilitation and its effects on patients with acute coronary syndrome.
Fuente:Scientific Reports
Extracto:
Early exercise rehabilitation has notable
benefits for ACS patients, including reduced depression, improved blood glucose
control, and enhanced myocardial protection, especially in nondiabetic NSTEMI
patients aged 60 and above.
institución:(a) Department of Cardiology/Endocrinolog, Fuzhou University Affiliated Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China. (b) Department of Cardiology, Fuzhou University Affiliated Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, No. 134 East Street, Gulou District, Fuzhou, 350001, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
An enhanced machine learning algorithm for type 2 diabetes prognosis with a detailed examination of Key correlates.
An enhanced machine learning algorithm for type 2 diabetes prognosis with a detailed examination of Key correlates.
Fuente:Scientific Reports
Extracto:
The number
of correlation factors was significantly lower compared to traditional
statistical methods, leading to a more accurate prediction performance than the
latter.
institución:(a) Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China. (b) Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China. yexinsarah@163.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Physical activity and renal outcome in diabetic and non-diabetic patients with chronic kidney disease stage G3b to G5.
Physical activity and renal outcome in diabetic and non-diabetic patients with chronic kidney disease stage G3b to G5.
Fuente:Scientific Reports
Extracto:
Our study suggests that exercise is
associated with better survival in non-diabetic patients with CKD stage G3b-5,
and better renal outcome in diabetic and non-diabetic CKD stage G3b.
institución:(a) Department of Nephrology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. hoshino.junichi@twmu.ac.jp. (b) Department of Nephrology, Faculty of Medicine, Institute of Medicine, University of Tsukuba, 1-1-1, Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. hoshino.junichi@twmu.ac.jp.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Correlation of metabolic markers and OPG gene mutations with bone mass abnormalities in postmenopausal women.
Correlation of metabolic markers and OPG gene mutations with bone mass abnormalities in postmenopausal women.
Fuente:Journal of Orthopaedic Surgery and Research
Extracto:
Elevated blood glucose levels in postmenopausal women
were associated with an increased risk of ABM, and UA played a mediating role in
the relationship FPG levels and BMD (L1-4), accounting for 21% of the variance.
Mutations at the rs4355801 locus of the OPG gene were associated with a reduced
risk of ABM in postmenopausal women. The interaction between T2DM and mutations
at the rs4355801 locus of the OPG gene in postmenopausal women affects BMD
(L1-4), and mutations at this locus attenuate the increased risk of ABM due to
elevated blood glucose levels.
Claves:Abnormal bone mass, Blood glucose, OPG gene, Uric acid
Cita:J Orthop Surg Res 2024 Nov 1; 19 (1) : 706.
Autor/es:Li, Jun (a) Li, Zixin (b)
institución:(a) Department of Endocrinology and Metabolism, The First Affliated Hospital of Shihezi University, Hongshan Sub-District, Shihezi, 832000, Xinjiang, China. xjlijun@163.com. (b) Department of Endocrinology and Metabolism, The First Affliated Hospital of Shihezi University, Hongshan Sub-District, Shihezi, 832000, Xinjiang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy.
Phenotypic insights into genetic risk factors for immune-related adverse events in cancer immunotherapy.
Fuente:Cancer Immunology, Immunotherapy Cii
Tipo de trabajo:Estudio clínico
Extracto:
This study has not only identified new risk factors for irAEs but
also confirmed several well-established ones. Further investigation is crucial to
validate and assess these identified risk factors within clinical trials. A
mechanistic understanding of these causal factors is essential for improving the
management and prevention of irAEs.
Cita:Cancer Immunol Immunother 2024 Nov 2; 74 (1) : 1.
Autor/es:Ma, Haochuan (a) Song, Dili (b)
institución:(a) Department of Oncology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China. (b) Guangdong Provincial Hospital of Chinese Medicine Postdoctoral Research Workstation, Guangzhou, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Telehealth service use and quality of care among US adults with diabetes: A cross-sectional study of the 2022 health information national trends survey.
Telehealth service use and quality of care among US adults with diabetes: A cross-sectional study of the 2022 health information national trends survey.
Fuente:Bmj Open
Tipo de trabajo:Orientaciones y guía
Extracto:
Around half of US adults with diabetes used telehealth services in
the past year. Patient-reported care quality was similar for telehealth and
in-person visits. However, further efforts are needed to address key barriers to
telehealth adoption, including privacy concern, technology difficulties, and care
coordination issues.
institución:(a) Health Services Research Management and Policy, University of Florida, Gainesville, Florida, USA youngrock.h@phhp.ufl.edu afwalker@ufl.edu. (b) University of North Florida Brooks College of Health, Jacksonville, Florida, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Increased FT3/FT4 ratio in a certain range is associated with decreased glycemic variability in patients with type 2 diabetes.
Increased FT3/FT4 ratio in a certain range is associated with decreased glycemic variability in patients with type 2 diabetes.
Fuente:Scientific Reports
Extracto:
The FT3/FT4 ratio may act as a potential
independent protective factor for glycemic fluctuation and glycemic control in
patients with T2DM when it increases within a specific range.
Claves:Continuous glucose monitoring, Free triiodothyronine to free thyroxine (FT3/FT4) ratio, Glycemic variability, Type 2 diabetes
Cita:Sci Rep 2024 Nov 4; 14 (1) : 26556.
Autor/es:Li, Ying (a) Pan, Tianrong (b)
institución:(a) Department of Endocrinology and Metabolism, Second Affiliated Hospital of Anhui Medical University, No.678 Furong Road, Hefei, 230601, Anhui, People's Republic of China. (b) Hefei City First People's Hospital, Hefei, 230001, Anhui, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Design, synthesis, biological evaluation and computational studies of 4-Aminopiperidine-3, 4-dihyroquinazoline-2-uracil derivatives as promising antidiabetic agents.
Design, synthesis, biological evaluation and computational studies of 4-Aminopiperidine-3, 4-dihyroquinazoline-2-uracil derivatives as promising antidiabetic agents.
Fuente:Scientific Reports
Extracto:
Taken together, our results showed the potential of
4-aminopiperidin-3,4-dihyroquinazoline-2-uracil derivatives as promising
candidates for developing some novel DPP4 inhibitors for managing of type 2
diabetes.
institución:(a) Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. (b) Department of Radiology, Hanyang University Medical Center, 222-1 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Preventive Effects of a CVD Polypill on Developing Diabetes Among Patients With Metabolic Syndrome: Results of the PolyIran-Liver Trial.
Preventive Effects of a CVD Polypill on Developing Diabetes Among Patients With Metabolic Syndrome: Results of the PolyIran-Liver Trial.
Fuente:Archives of Iranian Medicine
Extracto:
The polypill used in
this study may have the potential to delay the onset of diabetes in patients with
MetS more effectively than in the general population. However, its beneficial
effects on the blood sugar levels of diabetic individuals require further
investigation.
institución:(a) Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. (b) Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
