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"Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.
"Surviving and Thriving": evidence for cortical GABA stabilization in cognitively-intact oldest-old adults.
Fuente:Translational Psychiatry
Extracto:
This work contributes to
a growing body of evidence suggesting that successful cognitive aging may require
intact GABAergic function, as well as further characterizing successful aging
amongst oldest-old adults and emphasizing GABA as a potential target for
interventions to prolong cognitive health in aging.
Cita:Transl Psychiatry 2025 Mar 13; 15 (1) : 79.
Autor/es:Britton, Mark K (a) Jensen, Greg (b)
institución:(a) Department of Epidemiology, College of Public Health and Health Professions & College of Medicine, University of Florida, Gainesville, FL, USA. mark.britton@ufl.edu. (b) Center for Cognitive Aging and Memory, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA. mark.britton@ufl.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Pharmacy, Jiangxi Provincial People'S Hospital & the First Affiliated Hospital of Nanchang Medical College, Nanchang, China. (b) First School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China. rzcdsg1999@126.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A multi model deep net with an explainable AI based framework for diabetic retinopathy segmentation and classification.
A multi model deep net with an explainable AI based framework for diabetic retinopathy segmentation and classification.
Fuente:Scientific Reports
Extracto:
The suggested model achieved an accuracy of 99.01% on the
DiaRetDB1 dataset, 98.98% on the APTOS 2019 dataset, and 99.12% on the EyePacs
dataset.
Claves:Adaptive Gabor filter, Diabetic Retinopathy, Explainable AI and Grad Cam, Modified U-Net, Multi-folded features, Self-Adaptive Northern Goshawk Optimization
Cita:Sci Rep 2025 Mar 13; 15 (1) : 8777.
Autor/es:Sharma, Neeraj (a) Lalwani, Praveen (b)
institución:(a) School of Computing Sciences and Engineering, VIT Bhopal University, Kothrikalan, Sehore, 466114, Madhya Pradesh, India. neeraj.sharma2019@vitbhopal.ac.in. (b) School of Computing Sciences and Engineering, VIT Bhopal University, Kothrikalan, Sehore, 466114, Madhya Pradesh, India.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of combined left and right handgrip strength with new-onset chronic kidney disease in middle-aged and older adults
Association of combined left and right handgrip strength with new-onset chronic kidney disease in middle-aged and older adults
Fuente:Bmc Public Health
Tipo de trabajo:Estudio de cohortes
Extracto:
This
study demonstrated a longitudinal association between CHS and new-onset CKD in
middle-aged and older Chinese adults. These findings highlight the potential of
early-life multi-site muscle strength interventions for the prevention of CKD.
institución:(a) Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Xinqiao Main Street No.183, Shapingba District, 400037, Chongqing, China. (b) Department of Nephrology, Chongqing Key Laboratory of Prevention and Treatment of Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Xinqiao Main Street No.183, Shapingba District, 400037, Chongqing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Risk factors for non-union in foot and ankle arthrodesis: a population-based case-control study using registry data.
Risk factors for non-union in foot and ankle arthrodesis: a population-based case-control study using registry data.
Fuente:Bmc Musculoskeletal Disorders
Extracto:
Diabetes mellitus increases
the risk of nonunion among patients with and without diabetes mellitus. For those
without diabetes mellitus, arthrodesis in the tarsometatarsal joint is associated
with the highest risk of nonunion.
Cita:BMC Musculoskelet Disord 2025 Mar 13; 26 (1) : 253.
Autor/es:Chiang, Chen-Hao (a) Lin, Chang-Hao (b)
institución:(a) Department of Orthopaedics, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan. (b) Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chia-Yi University, Chia-Yi, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospective study.
Risk factors of immune-related endocrine toxicities in non-small cell lung cancer patients treated with pembrolizumab and its impact on patient outcomes: a multicenter retrospective study.
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
E-irAE are recognized
as prevalent common irAE with various phenotypic manifestations. Low MLR and
positive TGAb at baseline have been identified as risk factors that increase the
likelihood of developing irTD. Sex and the occurrence of irTD were independently
associated with improved PFS.
institución:(a) Department of Infectious Diseases, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China. (b) Department of Respiratory and Critical Care Medicine, International School of Medicine, The Fourth Affiliated Hospital of School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence of chronic diabetic complications and associated risk factors among follow-up diabetic patients: estimates from a referral national diabetes center in Yemen.
Prevalence of chronic diabetic complications and associated risk factors among follow-up diabetic patients: estimates from a referral national diabetes center in Yemen.
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Estudio clínico
Extracto:
Chronic complications related to
diabetes were common among patients in Yemen. Factors such as unemployment,
obesity, non-adherence to diabetes regimens, uncontrolled hypertension, longer
duration of T1DM, and irregular physician check-ups were identified as key
predictors of these complications. Implementation of the WHO non-communicable
disease package is strongly recommended. This package comprises comprehensive
measures aimed at detecting, treating, preventing, and controlling diabetic
complications and ultimately improving the overall management of diabetes in
Yemen. CLINICAL TRIAL NUMBER: Not applicable.
institución:(a) Department of Community Health, College of Nursing, University of Hail, Hail, 2440, Saudi Arabia. alrubaiee73@gmail.com. (b) Department of Community Health and Nutrition, Al-Razi University, Sana'a, Yemen. alrubaiee73@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Nonlinear association between blood urea nitrogen to creatinine ratio and obstructive sleep apnea: a cross-sectional study from NHANES.
Nonlinear association between blood urea nitrogen to creatinine ratio and obstructive sleep apnea: a cross-sectional study from NHANES.
Fuente:Bmc Pulmonary Medicine
Extracto:
This study
reveals a significant correlation between elevated BUCR levels and the incidence
of OSA, particularly in the presence of diabetes. This discovery underscores the
necessity for additional research to investigate the underlying mechanisms and
ramifications of this connection within the diabetic context.
institución:(a) Department of Respiratory Medicine, The First Hospital of Lanzhou University, Lanzhou, China. (b) Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Polymorphic variants and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
Polymorphic variants and risk of diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
Fuente:Bmc Endocrine Disorders
Tipo de trabajo:Revisión sistemática
Extracto:
TRIAL REGISTRATION: This research received no funding and was
registered in PROSPERO (ID CRD42024505256).
Claves:Diabetic neuropathies, Genetic association studies, Genetic polymorphism
Cita:BMC Endocr Disord 2025 Mar 14; 25 (1) : 69.
Autor/es:Vinelli-Arzubiaga, Daniella (a) Suasnabar Campos, Carmen Elizabeth (b)
institución:(a) Instituto de Investigaciones de Ciencias Biomédicas, Universidad Ricardo Palma, Avenida Benavides, Lima, 5440, Perú. (b) Instituto de Investigaciones de Ciencias Biomédicas, Universidad Ricardo Palma, Avenida Benavides, Lima, 5440, Perú.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A comparative study of clinical outcomes and risk factors of tuberculosis in kidney transplant recipients from deceased donors.
A comparative study of clinical outcomes and risk factors of tuberculosis in kidney transplant recipients from deceased donors.
Fuente:European Journal of Medical Research
Extracto:
Over half of the tuberculosis cases
(51.6%) occurred within the first year post-transplant, highlighting the need for
heightened vigilance during this early period. While standard anti-TB therapy
achieved good overall patient survival, it takes a toll on kidney function which
underscores the importance of close kidney function monitoring and delicate
immunosuppressant management during TB treatment. Diabetes mellitus and hepatitis
were identified as independent risk factors for post-transplant TB infection.
Prophylaxis measures should be considered for these high-risk patients during
early time post-transplant.
institución:(a) Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. (b) Clinical Research Center for Organ Transplantation in Hunan Province, Changsha, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Machine learning based model for the early detection of Gestational Diabetes Mellitus.
Machine learning based model for the early detection of Gestational Diabetes Mellitus.
Fuente:Bmc Medical Informatics and Decision Making
Extracto:
We believe our
findings will complement the current clinical practice of GDM diagnosis at an
early stage of pregnancy, leading toward minimizing its burden on the healthcare
system.Source code is available in GitHub at: https://github.com/H-Zaky/GD.git.
Cita:BMC Med Inform Decis Mak 2025 Mar 13; 25 (1) : 130.
Autor/es:Zaky, Hesham (a) Fthenou, Eleni (b)
institución:(a) College of Science and Engineering, Hamad Bin Khalifa University, Doha, Qatar. (b) Qatar Foundation for Education, Science, and Community, Qatar Biobank for Medical, ResearchDoha, Qatar.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between autoimmune disease and neurodevelopmental disorder: a Mendelian randomization analysis.
Association between autoimmune disease and neurodevelopmental disorder: a Mendelian randomization analysis.
Fuente:Italian Journal of Pediatrics
Extracto:
According to our data, we failed to identify an
association between autoimmune diseases and neurodevelopmental disorders.
However, we demonstrated that some pro-inflammatory factors are involved in
neurodevelopmental disorders.
institución:(a) Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, 20 3rd Section, Renmin S.Rd., Chengdu, 610041, Sichuan, China. (b) Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, 20 3rd Section, Renmin S.Rd., Chengdu, 610041, Sichuan, China.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare that they have no conflict of interest.
Unmet needs of Italian centers for pediatric diabetes care: analysis of a survey among pediatric diabetologists facing the national screening program for Type 1 Diabetes.
Unmet needs of Italian centers for pediatric diabetes care: analysis of a survey among pediatric diabetologists facing the national screening program for Type 1 Diabetes.
Fuente:Italian Journal of Pediatrics
Extracto:
The observed decrease in the
overall number of pediatric diabetes Centers, the reduction in specialized and
dedicated HCPs, and the concurrent increase in the number of treated CwD in the
last ten years indicate an alarming situation for pediatric diabetes treatment in
Italy. Furthermore, the projected rise in CwD due to the National T1D screening
program emphasizes the need for increased resources for specialized pediatric
care of CwD at all stages.
Claves:Adolescents, Benchmarking, Care, Children, Screening, Team, Technology, Type 1 diabetes
Cita:Ital J Pediatr 2025 Mar 13; 51 (1) : 77.
Autor/es:Marigliano, Marco (a) Franceschi, Roberto (b)
institución:(a) Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University of Verona, Verona, Italy. marco.marigliano@univr.it. (b) Azienda Ospedaliera Universitaria Integrata of Verona - Piazzale A. Stefani, Verona, 37126, Italy. marco.marigliano@univr.it.
Conflicto:Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors state there is no conflict of interest.
Glycemic Control in Obese Type 2 Diabetic Patients Treated with Laparoscopic Sleeve Gastrectomy and Transit Bipartition.
Glycemic Control in Obese Type 2 Diabetic Patients Treated with Laparoscopic Sleeve Gastrectomy and Transit Bipartition.
Fuente:Medical Science Monitor International Medical Journal of Experimental and Clinical Research
Extracto:
LSG+TB effectively improves glycemic control in obese T2DM
patients. A 6 cm stapler line distance from the pylorus is associated with
superior HbA1c reduction and comparable safety to longer distances.
Cita:Med Sci Monit 2025 Mar 14; 31 : e947047.
Autor/es:Şahin, Samet (a) Güzel, Kerim (b)
institución:(a) Department of General Surgery, Muğla Sıtkı Koçman University, Muğla, Turkey. (b) Department of General Surgery, Biruni University, Istanbul, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China.
Association of serum inflammatory markers in early-pregnancy with the risk for gestational diabetes mellitus: a prospective cohort in Shenzhen, China.
Fuente:Frontiers in Endocrinology
Extracto:
As novel, valuable, and convenient indicators of
inflammation, SII and SIRI could be used to a potential predictor for GDM in
early pregnancy.
institución:(a) Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China. (b) Department of Public Health, Ningxia Medical University, Yinchuan, Ningxia, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Development and validation of a risk prediction model for 30-day readmission in elderly type 2 diabetes patients complicated with heart failure: a multicenter, retrospective study.
Development and validation of a risk prediction model for 30-day readmission in elderly type 2 diabetes patients complicated with heart failure: a multicenter, retrospective study.
Fuente:Frontiers in Endocrinology
Extracto:
A 30-day readmission risk
prediction model was developed and externally validated. This model facilitates
the targeting of interventions for elderly T2DM patients complicated with HF who
are at high risk of an early readmission.
Claves:30-day readmission, electronic medical records, heart failure, prediction model, type 2 diabetes mellitus
institución:(a) Department of Medical Administration, Affiliated Banan Hospital of Chongqing Medical University, Chongqing, China. (b) Medical Recorods Department, Women and Children's Hospital of Chongqing Medical University, Chongqing Health Center for Women and Children, Chongqing, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis.
A study on the genetic comorbidity between autoimmune diseases and pulmonary hypertension: an observational study and POST-GWAS analysis.
Fuente:International Journal of Medical Sciences
Extracto:
Conclusions: Our study indicates a genetic correlation and
shared risk genes between PH and autoimmune diseases, offering insights into the
mechanisms underlying their co-occurrence and potential implications for future
therapeutic strategies.
institución:(a) State Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Guangdong Key Laboratory of Vascular Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, 510120. (b) Guangzhou Medical University, Guangzhou, Guangdong, China, 510260.
Conflicto:Competing Interests: The authors have declared that no competing interest exists.
INCEPT: The Intensive Care Platform Trial-Design and protocol.
INCEPT: The Intensive Care Platform Trial-Design and protocol.
Fuente:Acta Anaesthesiologica Scandinavica
Tipo de trabajo:Estudio abierto
Extracto:
INCEPT
provides an efficient, pragmatic, and flexible platform for comparing the effects
of many interventions used in adult ICU patients. The adaptive design enables the
trial to use accumulating data to improve the treatment of future participants.
INCEPT will provide high-certainty, conclusive evidence for many interventions,
directly inform clinical practice, and thus improve patient-important outcomes.
Claves:adaptive platform trial, intensive care, randomised clinical trial, trial protocol
Autor/es:Granholm, Anders (a) Møller, Morten Hylander (b)
institución:(a) Department of Intensive Care, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. (b) Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Conflicto:Bodil Steen Rasmussen: unrestricted grant from the Novo Nordisk Foundation for long‐term follow‐up in the Handling Oxygenation Targets in the Intensive Care Unit (HOT‐ICU) trial (ended June 2024). Tine Sylvest Meyhoff: coordinating investigator of the CLASSIC trial (NCT03668236) which was supported by a grant (NNF17OC0028608) from the Novo Nordisk Foundation and by the Sofus Friis' Foundation, Rigshospitalet's Research Council, and...
l, and supported by the Danish Society of Anesthesiology and Intensive Care Medicine. Hans‐Christian Thorsen‐Meyer: research grant from the Novo Nordisk Foundation (NNF19OC0054863). Marie Oxenbøll Collet: the Novo Nordisk Foundation, Grant NNF21OC0072048 Postdoc fellowships in Nursing Research 2021. Ole Mathiesen: funding to research group from the Novo Nordisk Foundation and Sygeforsikringen ‘danmark’ for other projects. Mathias Maagaard: holds shares in Novo Nordisk. Peter Rossing: grants for investigator‐initiated studies to Steno Diabetes Center Copenhagen, from Novo Nordisk, Bayer, AstraZeneca, and Lexicon. Honoraria to Steno Diabetes Center Copenhagen for steering group membership, consultancy, and education from AstraZeneca, Abbott, Bayer, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Gilead, and Sanofi. No personal honoraria and no shares/patents. Asger Granfeldt: paid member of data safety monitoring board for Noorik Pharmaceuticals (ended November 2022), work for hire for NMD Pharma, and task force member of the International Liaison Committee on Resuscitation (ILCOR) advanced life support task force. Theis Skovsgaard Itenov: the Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital—Bispebjerg and Frederiksberg Hospital has a collaboration with Radiometer Medical Denmark on the testing and evaluation of equipment. The department receives reimbursements from the company. No individual receives any personal benefits or payments from the collaboration. Johanna Hästbacka: advisory board honorary fee from Paion (2022). Carmen Andrea Pfortmueller: no personal conflict of interests (personal financial interest). The department of Intensive Care at Inselspital, University Hospital of Bern reports grants from Orion Pharma, Abbott Nutrition International, B. Braun Medical AG, CSEM AG, Edwards Lifesciences Services GmbH, Kenta Biotech Ltd., Maquet Critical Care AB, Omnicare Clinical Research AG, Nestle, Pierre Fabre Pharma AG, Pfizer, Bard Medica S.A., Abbott AG, Anandic Medical Systems, Pan Gas AG Healthcare, Bracco, Hamilton Medical AG, Fresenius Kabi, Getinge Group Maquet AG, Dräger AG, Teleflex Medical GmbH, Glaxo Smith Kline, Merck Sharp and Dohme AG, Eli Lilly and Company, Baxter, Astellas, Astra Zeneca, CSL Behring, Novartis, Covidien, and Nycomed outside the submitted work. The money was paid into departmental funds; no personal financial gain applied. Davide Placido: holds stocks in Novo Nordisk. Theis Lange: served on data safety monitoring boards in studies run by Novo Nordisk and Leo Pharma. Anders Perner: research grants from the Novo Nordisk Foundation. All other authors: no relevant conflicts of interest.
Prevalence and socioeconomic factors of diabetes: a population-based cross-sectional analysis from Jordan.
Prevalence and socioeconomic factors of diabetes: a population-based cross-sectional analysis from Jordan.
Fuente:Journal of Global Health
Extracto:
The study findings
emphasise the need for specifically tailored and delivered public health
interventions targeting individuals with challenging socioeconomic factors such
as older age and low educational attainment. Healthcare providers and
policymakers should focus on delivering and sponsoring educational and awareness
programmes to promote self-care and the adoption of health-seeking lifestyle
behaviours and practices among unprivileged and at-risk local communities.
Healthcare authorities could initiate community-based diabetes screening
programmes targeting marginalised and at-risk groups.
Cita:J Glob Health 2025 Mar 14; 15 : 04095.
Autor/es:Al-Taani, Ghaith M (a) El-Osta, Austen (b)
institución:(a) Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan. (b) Self-Care Academic Research Unit (SCARU), Imperial College London Department of Primary Care & Public Health, London, UK.
Conflicto:Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests.
Elevated platelet distribution width and diabetes may serve as preoperative predictors of microvascular invasion in primary hepatocellular carcinoma.
Elevated platelet distribution width and diabetes may serve as preoperative predictors of microvascular invasion in primary hepatocellular carcinoma.
Fuente:Journal of Cancer Research and Clinical Oncology
Extracto:
This study confirmed PDW and
diabetes mellitus as reliable indicators for predicting preoperative MVI in HCC
and established a corresponding predictive model. Future research should further
explore the underlying mechanisms and enhance clinical validation to advance the
field of HCC treatment.
Claves:Diabetes mellitus, Hepatocellular carcinoma, Microvascular invasion, Nomogram, Platelet distribution width
Cita:J Cancer Res Clin Oncol 2025 Mar 14; 151 (3) : 111.
Autor/es:Wang, Ling (a) Jun, Liu (b)
institución:(a) Department of Laboratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China. (b) Department of Laboratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
