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High-dose vitamin D(3) to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan
High-dose vitamin D(3) to improve outcomes in the convalescent phase of complicated severe acute malnutrition in Pakistan
Fuente:Nature Communications
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
The trial was registered at ClinicalTrials.gov with the
identifier NCT04270643.
Cita:Nat Commun 2025 Mar 15; 16 (1) : 2554.
Autor/es:Saleem, Javeria (a) Zakar, Rubeena (b)
institución:(a) Department of Public Health, University of the Punjab, Lahore, Punjab, Pakistan. javeria.hasan@hotmail.com. (b) Department of Public Health, University of the Punjab, Lahore, Punjab, Pakistan.
Conflicto:Competing interests: ARM declares receipt of funding in the last 36 months to support vitamin D research from the following companies who manufacture or sell vitamin D supplements: Pharma Nord Ltd, DSM Nutritional Products Ltd, Thornton & Ross Ltd and Hyphens Pharma Ltd. ARM also declares receipt of vitamin D capsules for clinical trial use from Pharma Nord Ltd, Synergy...
Biologics Ltd and Cytoplan Ltd; support for attending meetings from Pharma Nord Ltd and Abiogen Pharma Ltd; receipt of consultancy fees from DSM Nutritional Products Ltd and Qiagen Ltd; receipt of a speaker fee from the Linus Pauling Institute; participation on Data and Safety Monitoring Boards for the VITALITY trial (Vitamin D for Adolescents with HIV to reduce musculoskeletal morbidity and immunopathology, Pan African Clinical Trials Registry ref PACTR20200989766029) and the Trial of Vitamin D and Zinc Supplementation for Improving Treatment Outcomes Among COVID-19 Patients in India (ClinicalTrials.gov ref NCT04641195); and unpaid work as a Programme Committee member for the Vitamin D Workshop. All other authors declare that they have no competing interests.
Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.
Crohn's Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function.
Fuente:Nature Communications
Extracto:
Therefore, our study provides a mechanism linking these specific LACC1 variants
to colitis by attributing promoter region variants to changes in T cell
metabolism and function.
Cita:Nat Commun 2025 Mar 15; 16 (1) : 2577.
Autor/es:Li, Yingcong (a) Ascui, Gabriel (b)
institución:(a) La Jolla Institute for Immunology, La Jolla, CA, USA. (b) Department of Molecular Biology, University of California San Diego, La Jolla, CA, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical and radiographic peri-implant parameters in type-2 diabetic and non-diabetic individuals with major depressive disorder.
Clinical and radiographic peri-implant parameters in type-2 diabetic and non-diabetic individuals with major depressive disorder.
Fuente:Scientific Reports
Extracto:
Clinical relevance:
Peri-implant soft tissue and osseous statuses are compromised among patients with
type-2 DM, and MDD regardless of whether these conditions occur individually or
in combination.
Autor/es:Aljudaibi, Suha Mohammed (a) Alqhtani, Mohammad Abdullah Zayed (b)
institución:(a) Department of Preventive Dental Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. (b) Prosthetic Dental Science Department Faculty of Dentistry, Najran University, Najran, 66462, Kingdom of Saudi Arabia. mazayed@nu.edu.sa.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Physical activity during pregnancy and pregnancy related complication.
Physical activity during pregnancy and pregnancy related complication.
Fuente:Scientific Reports
Extracto:
The finding of this study showed that pregnancy-related
complications, specifically HDP and GDM, were low in women who had vigorous
physical activities during pregnancy as compared to those who had a sedentary
lifestyle or engaged in light physical activities.
Claves:Gestational, Hypertensive disorder of pregnancy, Intensity of physical activity
Cita:Sci Rep 2025 Mar 15; 15 (1) : 8980.
Autor/es:Hailu, Molla (a) Amare Tesfa, Natnael (b)
institución:(a) Department of Biomedical Science, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia. mol21hi@gmail.com. (b) Department of Biomedical Science, College of Medicine and Health Sciences, Woldia University, Woldia, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Influences of gestational diabetes mellitus on the changes in the vaginal microbiota from antepartum to postpartum.
Influences of gestational diabetes mellitus on the changes in the vaginal microbiota from antepartum to postpartum.
Fuente:Bmc Pregnancy and Childbirth
Tipo de trabajo:Consenso
Extracto:
We found that GDM affected the
succession of vaginal microbiota in the perinatal period. Our findings provided
additional evidence for regulating the vaginal microbiota during pregnancy and
postpartum to reduce adverse pregnancy outcomes and achieve long-term vaginal
health outcomes.
Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin.
Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
IR, independent of hyperglycemia, drives
placental inflammation and trophoblastic injury via pyroptosis. Targeting the
ROS/TXNIP/NLRP3 pathway with metformin or other therapeutic agents offers
potential therapeutic value in managing IR-related complications in GDM.
Cita:BMC Pregnancy Childbirth 2025 Mar 15; 25 (1) : 293.
Autor/es:Du, Runyu (a) Bai, Yu (b)
institución:(a) Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. (b) Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Double balloon catheter induction of labor in pregnant women with COVID-19 infection.
Double balloon catheter induction of labor in pregnant women with COVID-19 infection.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
Double balloon catheter is an effective
and safe method for labor induction in pregnant women with COVID-19 and is not
associated with an increased risk of fetal distress, intrapartum fever and
cesarean section.
Cita:BMC Pregnancy Childbirth 2025 Mar 15; 25 (1) : 287.
Autor/es:Yi, Jiao (a) Chen, Lei (b)
institución:(a) Department of Obstetrics and Gynecology, Maternal and Child Medicine Center affiliated with, Hefei Maternal and Child Health Care Hospital, Anhui Medical University, Hefei, China. yijiao2010@126.com. (b) Department of Obstetrics and Gynecology, Maternal and Child Medicine Center affiliated with, Hefei Maternal and Child Health Care Hospital, Anhui Medical University, Hefei, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Risk prediction and early intervention strategies for persistent SARS-CoV-2 infection in patients with non-Hodgkin lymphoma
Risk prediction and early intervention strategies for persistent SARS-CoV-2 infection in patients with non-Hodgkin lymphoma
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
This study identifies critical risk factors for persistent
SARS-CoV-2 infection in NHL patients and underscores the importance of early
intervention strategies. These findings may guide clinical decision-making to
improve outcomes in this high-risk population.
institución:(a) Department of Pulmonary and Critical Care Medicine, Aerospace Center Hospital, Beijing, 100049, China. (b) Department of Pulmonary and Critical Care Medicine, Aerospace Center Hospital, Beijing, 100049, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Circulating miR-486-3p as a potential biomarker for the diagnosis of gestational diabetes mellitus and the prediction of adverse pregnancy outcomes.
Circulating miR-486-3p as a potential biomarker for the diagnosis of gestational diabetes mellitus and the prediction of adverse pregnancy outcomes.
Fuente:Bmc Pregnancy and Childbirth
Extracto:
miR-486-3p showed a clinical
predictive value for GDM in early pregnancy. miR-486-3p, HbA1c, HOMA-IR, and FBG
indicators can be considered adverse pregnancy outcome risk factors in GDM
patients.
Claves:Biomarker, Diagnosis, GDM, miR-486-3p
Cita:BMC Pregnancy Childbirth 2025 Mar 15; 25 (1) : 291.
Autor/es:Hu, Yaqin (a) Zeng, Yukai (b)
institución:(a) Department of Endocrinology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China. (b) School of Biomedical Engineering, Capital Medical University, Beijing, 100069, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.
Surrogate markers of insulin resistance and coronary artery disease in type 2 diabetes: U-shaped TyG association and insights from machine learning integration.
Fuente:Lipids in Health and Disease
Extracto:
Surrogate IR indices could
be used as valuable tools for evaluating cardiometabolic risk in patients with
T2D, who are at high risk for CAD. Integrating machine learning models further
improved CAD prediction, underscoring their potential for better risk
stratification. The observed association between these indices and CAD in T2D may
help clarify the complex pathophysiology of CAD and offer insights for future
research.
institución:(a) Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran. (b) Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The National Paediatric Applied Research Translation Initiative (N-PARTI): using implementation science to improve primary care for Australian children with asthma, type 1 diabetes, and infections.
The National Paediatric Applied Research Translation Initiative (N-PARTI): using implementation science to improve primary care for Australian children with asthma, type 1 diabetes, and infections.
Fuente:Bmc Health Services Research
Extracto:
This is
the co-designed National Paediatric Applied Research Translation Initiative
(N-PARTI), a bespoke, three-phased research solution by deploying mixed methods,
simulation and scale-up of evidence into practice.
Claves:Antibiotic use, Asthma, Evidence-based paediatric practice, Implementation science, Systems improvement, Type 1 diabetes
Cita:BMC Health Serv Res 2025 Mar 15; 25 (1) : 383.
institución:(a) Australian Institute of Health Innovation, Macquarie University, 75 Talavera Road, North Ryde 2113, Sydney, NSW, 2109, Australia. jeffrey.braithwaite@mq.edu.au. (b) Discipline of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Medicine, UNSW Sydney, Randwick, NSW, Australia. jeffrey.braithwaite@mq.edu.au.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Non-linear relationship between triglyceride glucose index and new-onset diabetes among individuals with non-alcoholic fatty liver disease
Non-linear relationship between triglyceride glucose index and new-onset diabetes among individuals with non-alcoholic fatty liver disease
Fuente:Lipids in Health and Disease
Tipo de trabajo:Estudio de cohortes
Extracto:
The findings validate a
U-shaped association between TyG levels and new-onset diabetes in adults with
NAFLD. Both low and high TyG levels increase diabetes probability in such a
group.
institución:(a) Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, China. (b) Department of Critical Care Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Burden of diabetic macular oedema and its associated factors among adult patients with diabetes attending comprehensive specialised hospitals in Northwest Ethiopia, 2023
Burden of diabetic macular oedema and its associated factors among adult patients with diabetes attending comprehensive specialised hospitals in Northwest Ethiopia, 2023
Fuente:Bmj Open
Tipo de trabajo:Estudio multicéntrico
Extracto:
In Northwest Ethiopia, a
quarter of patients with diabetes were found to have diabetic macular oedema.
Factors such as peripheral neuropathy, hypertension, poor blood glucose levels,
obesity, long duration of diabetes mellitus and poor adherence to diabetic
medications were significantly associated with diabetic macular oedema.
Improvement of glucose control and exercise for optimal body weight maintenance
are recommended to prevent the development of diabetic macular oedema.
Claves:Diabetes Mellitus, Type 2, Diabetic retinopathy, Prevalence
institución:(a) Department of Optometry, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia abebechfikade1@gmail.com. (b) Department of Optometry, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Impact of digital antenatal care intervention on paper-based antenatal care recordkeeping: a before-and-after study in primary healthcare facilities in Nepal.
Impact of digital antenatal care intervention on paper-based antenatal care recordkeeping: a before-and-after study in primary healthcare facilities in Nepal.
Fuente:Bmj Open
Extracto:
We found slight improvements in the
completeness and agreement of paper-based ANC records following EDSS
implementation. The lower percentage of completeness in the EDSS suggests that
any large-scale implementation should consider how to integrate digital and
paper-based records to decrease the data entry burden on ANC providers. However,
the study's small sample size limited the ability to examine variation in
effects.
Claves:Clinical Decision-Making, Health Services, Quality Improvement
Cita:BMJ Open 2025 Mar 15; 15 (3) : e086255.
Autor/es:Das, Seema (a) Radovich, Emma (b)
institución:(a) Research and Development Division, Department of Public Health and Community Programs, Dhulikhel Hospital Kathmandu University Hospital, Dhulikhel, Nepal daseema17@gmail.com. (b) Emory University, Atlanta, Georgia, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Causal impact of elevated body mass index on diabetic kidney disease: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis.
Causal impact of elevated body mass index on diabetic kidney disease: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis.
Fuente:Renal Failure
Extracto:
Elevated BMI is a significant causal risk factor for T2DKD. The integration of MR
and GBD 2021 data underscores the urgent need for targeted public health
interventions to reduce BMI levels, especially in high-risk regions and aging
populations.
Claves:Global Burden of Disease Study 2021, Mendelian Randomization, chronic kidney disease, diabetic kidney disease, elevated body mass index, type 2 diabetes mellitus
Cita:Ren Fail 2025 Dec; 47 (1) : 2472981.
Autor/es:Chen, Ye-Xin (a) Hu, Dong-Sen (b)
institución:(a) Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China. (b) Beijing University of Chinese Medicine, Beijing, China.
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis.
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis.
Fuente:The Journal of Clinical Investigation
Extracto:
nsulin-mediated inhibition of adipose tissue lipolysis via ATGL
is dysregulated among adolescents with IR compared with those with IS, thereby
serving as a vital mechanism linking glucose and insulin dysregulation and
ectopic lipid storage within the liver.FUNDINGThis work was supported by funding
from the NIH (R01-HD028016-25A1, T32- DK-007058, R01-DK124272, RO1-DK119968,
R01MD015974, RO1-DK113984, P3-DK045735, RO1-DK133143, and RC2-DK120534) and the
Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award.
Characterization of the gut microbiota in urinary calculi patients with preoperative urinary tract infection.
Characterization of the gut microbiota in urinary calculi patients with preoperative urinary tract infection.
Fuente:Frontiers in Cellular and Infection Microbiology
Extracto:
Urolithiasis with gut dysbiosis developed
a higher incidence of urinary tract infections, which may be associated with the
increasing of Intestinibacter and affect the expression of IL-17A by
translational, ribosomal structural and biosynthetic function.
Claves:16S rRNA, gut microbiota, serum metabolome, urinary tract infection, urolithiasis
institución:(a) Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China. (b) Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes.
Mitochondrial mt12361A>G increased risk of metabolic dysfunction-associated steatotic liver disease among non-diabetes.
Fuente:World Journal of Gastroenterology
Extracto:
The mt12361A>G variant increased the
severity of MASLD in non-diabetic patients. AI supports the screening and
management of MASLD in primary care settings.
Cita:World J Gastroenterol 2025 Mar 14; 31 (10) : 103716.
Autor/es:Lu, Ming-Ying (a) Wei, Yu-Ju (b)
institución:(a) Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. (b) School of Medicine and Doctoral Program of Clinical and Experimental Medicine, College of Medicine and Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung 80708, Taiwan.
Conflicto:Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Burden, trends, and predictions of low physical activity-related diseases in China: analysis from the Global Burden of Disease Study, 1990-2021, with projections to 2035.
Burden, trends, and predictions of low physical activity-related diseases in China: analysis from the Global Burden of Disease Study, 1990-2021, with projections to 2035.
Fuente:Frontiers in Public Health
Extracto:
From 1990 to 2021, the age-standardized
death and DALY rates associated with low physical activity in China declined, yet
the absolute number of deaths and DALYs increased due to population growth and
aging. Special attention is needed for diabetes and ischemic heart disease, as
their burdens have significantly risen. Although females are more affected by low
physical activity than males, the increase in the burden among males has been
more pronounced in recent years. The impact of low physical activity intensifies
with age, particularly among the older adult. Thus, targeted strategies are
essential to mitigate the burden of low physical activity in China.
Claves:Bayesian Age-Period-Cohort model (BAPC), Global Burden of Disease (GBD) database, disease burden, estimated annual percentage change, low physical activity, trends analysis
Cita:Front Public Health 2025; 13 : 1461554.
Autor/es:Zhang, Chuan (a) Chen, Quanzheng (b)
institución:(a) Department of Physical Education and Health, Guangxi Normal University, Guilin, China. (b) Department of Physical Education and Health, Guangxi Normal University, Guilin, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Extracto:
This systematic review
is the first to evaluate the relationship between ghrelin and thyroid disease.
Determining the role of ghrelin in thyroid disease will significantly contribute
to understand of symptom or pathomechanism. SYSTEMATIC REVIEW REGISTRATION:
https://www.crd.york.ac.uk/prospero/, identifier CRD42024591501.
Claves:ghrelin, hyperthyroidism, hypothyroidism, meta - analysis, thyroid disease
institución:(a) Department of Endocrinology and Metabolism, Fourth People's Hospital of Shenyang, Shenyang, China. (b) Department of Endocrinology and Metabolism, First Affiliated Hospital of Soochow University, Suzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
