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SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes.
SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
Diabetes remission was more common in Veterans with new-onset diabetes after
SARS-CoV-2. In non-hospitalized participants, who were likely to have more
similar laboratory surveillance, the association was diminished. Differences in
surveillance or transient hyperglycemia may explain the observed association.
Cita:PLoS One 2025; 20 (2) : e0317348.
Autor/es:Wander, Pandora L (a) Lowy, Elliott (b)
institución:(a) Veterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington, United States of America. (b) Department of Medicine, University of Washington, Seattle, Washington, United States of America.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Comparison of visfatin levels before and after non-surgical periodontal therapy
Comparison of visfatin levels before and after non-surgical periodontal therapy
Fuente:Plos One
Tipo de trabajo:Revisión sistemática
Extracto:
Therefore, visfatin level may be used as a diagnostic and therapeutic
noninvasive biomarker in patients with periodontitis, which requires further
studies.
Cita:PLoS One 2025; 20 (2) : e0315035.
Autor/es:Tajik, Zahra (a) Mehrafarid, Hamid (b)
institución:(a) Student Research Committee, Arak University of Medical Sciences, Arak, Iran. (b) Student Research Committee, Arak University of Medical Sciences, Arak, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study.
Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study.
Fuente:Bmj Open
Extracto:
This study investigated the relationship among PA, SII
and DM. We provide robust evidence supporting the inverse association between PA
and DM risk while highlighting the mediating role of inflammation, as reflected
by SII. These findings contribute valuable insights to inform public health
strategies and clinical interventions aimed at reducing the global burden of DM.
Claves:DIABETES & ENDOCRINOLOGY, General diabetes, General endocrinology
Cita:BMJ Open 2025 Feb 19; 15 (2) : e082996.
Autor/es:Chen, Yongze (a) Huang, Ruixian (b)
institución:(a) Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong, China. (b) Department of Gastroenterology, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Climate footprint of industry-sponsored in-human clinical trials: life cycle assessments of clinical trials spanning multiple phases and disease areas.
Climate footprint of industry-sponsored in-human clinical trials: life cycle assessments of clinical trials spanning multiple phases and disease areas.
Fuente:Bmj Open
Tipo de trabajo:Estudio clínico
Extracto:
Based on our LCAs of
seven clinical trials spanning all four phases of development and multiple
disease areas, there are five activities that drive no less than 79% of the
average clinical trial's GHG footprint. These are drug product manufacture,
packaging, and distribution; patient travel; on-site monitoring visit travel; the
collection, transport and processing of laboratory samples; and sponsor staff
commuting between their homes and the office. Understanding the activities that
drive GHG emissions in clinical trials can both guide trial designers in avoiding
or minimising reliance on these activities when designing new trials and guide
trial sponsors in taking targeted actions to reduce GHG emissions from these
activities where their use cannot be avoided. TRIAL REGISTRATION NUMBER:
TMC114FD1HTX1002 (ClinicalTrials.gov: NCT04208061), 77242113PSO2001
(ClinicalTrials.gov: NCT05364554), 42756493BLC2002 (ClinicalTrials.gov:
NCT03473743), 54767414MMY3012 (ClinicalTrials.gov: NCT03277105), VAC18193RSV3006
(ClinicalTrials.gov: NCT05070546), R092670PSY3016 (ClinicalTrials.gov:
NCT04072575) and 28431754DIA4032 (ClinicalTrials.gov: NCT04288778).
Autor/es:LaRoche, Jason Keith (a) Lanier, Jason (b)
institución:(a) Innovative Health, Johnson & Johnson Innovative Medicine, Delft, Zuid Holland, The Netherlands jlaroche@its.jnj.com. (b) Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands.
Conflicto:Competing interests: JKL is an employee of Johnson & Johnson Innovative Medicine, LLC, and a member of the faculty at Delft University of Technology. JL is an employee of Johnson & Johnson Innovative Medicine, LLC. RA is an employee of Environmental Resource Management, LLC. MC is an employee of Environmental Resource Management, LLC. TC is an employee of Environmental Resource...
Management, LLC. HW is an employee of Environmental Resource Management, LLC. AC is an employee of ICON, PLC. WDS is an employee of Johnson & Johnson Innovative Medicine, LLC. JF is a faculty member at Delft University of Technology. KR is an employee of Johnson & Johnson Innovative Medicine, LLC.
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hand grip strength in U.S. adults.
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hand grip strength in U.S. adults.
Fuente:Scientific Reports
Extracto:
Considering that a decline in HGS is an important manifestation of sarcopenia, it
may be relevant to the prevention and control of sarcopenia through close
detection and management of NHHR.
Cita:Sci Rep 2025 Feb 19; 15 (1) : 6039.
Autor/es:Wang, Huimin (a) Huang, Qihui (b)
institución:(a) Department of Endocrinology, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230000, China. (b) Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states.
The correlation between the atherogenic index of plasma and the severity of coronary artery disease in acute myocardial infarction patients under different glucose metabolic states.
Fuente:Scientific Reports
Tipo de trabajo:Guía
Extracto:
In Pre-DM patients, AIP is clearly associated
with the severity of CAD, whereas this association is absent in the NGR and DM
groups.
Claves:Atherogenic index of plasma, Coronary artery disease, Glucose metabolic states, Myocardial infarction, The severity of coronary artery disease
Cita:Sci Rep 2025 Feb 19; 15 (1) : 6128.
Autor/es:Jin, Kaiqin (a) Ma, Zijun (b)
institución:(a) Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, 442000, Hubei, China. (b) Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei University of Medicine, Shiyan, 442000, Hubei, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between diabetes of different durations and hip fracture in middle-aged and older people
Association between diabetes of different durations and hip fracture in middle-aged and older people
Fuente:Bmc Public Health
Tipo de trabajo:Estudio de cohortes
Extracto:
Neither newly diagnosed diabetes nor diabetes with a disease duration of < 6
years was associated with hip fracture compared with no diabetes people. When the
duration of diabetes is ≥ 6 years, the risk of hip fracture is significantly
increased, and appropriate preventive measures are recommended.
Claves:CHARLS, Diabetes, Diabetes durations, Hip fracture
Cita:BMC Public Health 2025 Feb 19; 25 (1) : 691.
Autor/es:Chang, Yu (a) Huang, Yunda (b)
institución:(a) Department of Endocrinology, The Third People's Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, 292 Beijing Road, Kunming, Yunnan, 650011, China. (b) Department of Geriatrics, The Third People's Hospital of Yunnan Province, The Second Affiliated Hospital of Dali University, Kunming, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prediction of hypertensive responses associated with interscalene block, a prospective cohort study.
Prediction of hypertensive responses associated with interscalene block, a prospective cohort study.
Fuente:Bmc Anesthesiology
Tipo de trabajo:Estudio de cohortes
Extracto:
Preoperative evaluation of anatomical
and clinical predictors, such as CIMT and anterior scalene muscle thickness, may
improve patient safety, particularly for high-risk individuals during ISB.
However, the moderate predictive ability of these factors suggests that they
should be considered part of a comprehensive preoperative risk assessment. TRIAL
REGISTRATION: NCT06394960, date: January 25, 2024, first patient registration
date: May 2, 2024.
institución:(a) Department of Anesthesiology and Reanimation-Konya, University of Health Sciences, Konya City Hospital, Akabe mahallesi, Adana çevre yolu, Cad. No:135/1, Konya, 42020, Turkey. masatu42@gmail.com. (b) Department of Anesthesiology and Reanimation-Konya, University of Health Sciences, Konya City Hospital, Akabe mahallesi, Adana çevre yolu, Cad. No:135/1, Konya, 42020, Turkey.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac MRI.
Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac MRI.
Fuente:Cardiovascular Diabetology
Extracto:
SO is a potentially high-risk
phenotype with adverse LV remodeling and poor clinical outcomes in diabetic
patients with HFrEF that may require more attention.
Claves:Diabetes mellitus, Heart failure with reduced ejection fraction, Left ventricular remodeling, Outcome, Sarcopenic obesity
Cita:Cardiovasc Diabetol 2025 Feb 17; 24 (1) : 79.
Autor/es:Shi, Ke (a) Zhang, Ge (b)
institución:(a) Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. (b) Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation.
Identification of 17 novel epigenetic biomarkers associated with anxiety disorders using differential methylation analysis followed by machine learning-based validation.
Fuente:Clinical Epigenetics
Extracto:
Our findings support the potential of blood liquid biopsy in
enhancing the clinical utility of anxiety disorder diagnostics. This unique set
of epigenetic biomarkers holds the potential for early diagnosis, prediction of
treatment efficacy, continuous monitoring, health screening, and the delivery of
personalized therapeutic interventions for individuals affected by anxiety
disorders.
institución:(a) Korean Genomics Center (KOGIC), Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea. (b) Department of Biomedical Engineering, College of Information and Biotechnology, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
Conflicto:Declarations. Ethics approval and consent to participate: Written informed consent was obtained from all participants in this study. Sample collection and sequencing were approved by the Institutional Review Board (IRB) of the Ulsan Medical Center (USH.20.013) and Ulsan National Institute of Science and Technology (UNISTIRB-15–19-A). Competing interests: Y.J., Yeo Jin K., S.J., H.R., J.A., H.U., Younghui K., H.B., and B.K....
K. are employees, and J.B. is the CEO of Clinomics Inc. S.J. is the CEO of both AgingLab and Geromics. The authors declare no other competing interests.
Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors Improve Renal Resistive Index in Patients With Type 2 Diabetes: A 26-Week Prospective Observational Real-Life Study.
Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors Improve Renal Resistive Index in Patients With Type 2 Diabetes: A 26-Week Prospective Observational Real-Life Study.
Fuente:Journal of Diabetes Research
Extracto:
GLP1-RA and SGLT2i
improve RRI, demonstrating benefits on cardiovascular risk and renal outcomes.
institución:(a) Interdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", Bari, Italy. (b) Interdisciplinary Department of Medicine, School of Medicine, University of Bari "Aldo Moro", Bari, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of herpes zoster vaccination and cardiovascular risk in patients with diabetes
Association of herpes zoster vaccination and cardiovascular risk in patients with diabetes
Fuente:Bmj Open
Tipo de trabajo:Estudio de cohortes
Extracto:
HZ vaccination is associated with a lower risk of MACE in
patients with diabetes. Further prospective studies are critically needed to
confirm this finding.
institución:(a) School of Medicine, Chung Shan Medical University, Taichung, Taiwan. (b) Department of Internal Medicine, Division of endocrinology and metabolism, Chung Shan Medical University Hospital, Taichung, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.
SGLT2 inhibitors reduce the risk of renal failure in CKD stage 5 patients with Type 2 DM.
Fuente:Scientific Reports
Extracto:
In conclusion, we provide evidence suggesting that
SGLT2 inhibitors may offer renal protection and did not increase infection risks
for CKD5 patients with type2 diabetes.
institución:(a) Department of Cardiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan. (b) Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fusing St., Gueishan District, Taoyuan, 333, Taiwan.
Conflicto:Declarations. Competing interests: All authors disclosure there is no financial conflict of interest.
Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population.
Does low body weight mediate the relationship between tooth loss and cognitive impairment? A longitudinal cohort study of an older Chinese population.
Fuente:Bmc Geriatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
Tooth loss increases the risk of cognitive decline, and low body
weight partially mediates this association. CLINICAL TRIAL NUMBER: This is a
retrospective cohort study targeting a population survey, which does not involve
clinical trials and does not have clinical trial numbers.
Claves:Cognitive impairment, Denture use, Low body weight, Older adults, Tooth loss
Cita:BMC Geriatr 2025 Feb 18; 25 (1) : 111.
Autor/es:Ke, Pan (a) Lu, Zuxun (b)
institución:(a) Cardio-Cerebrovascular & Diabetes Prevention, and Control Dept., Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, 518020, P.R. China. (b) Department of Social Medicine and Health Management, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development and validation of prediction models for stroke and myocardial infarction in type 2 diabetes based on health insurance claims: does machine learning outperform traditional regression approaches?
Development and validation of prediction models for stroke and myocardial infarction in type 2 diabetes based on health insurance claims: does machine learning outperform traditional regression approaches?
Fuente:Cardiovascular Diabetology
Extracto:
Discrimination performance of claims-based models reached a ceiling at around
0.09 AUPRC and 0.7 AUROC. While for AUROC this performance was comparable to
existing epidemiological models incorporating clinical information, comparison of
other, potentially more relevant metrics, such as AUPRC, sensitivity and Positive
Predictive Value was hampered by lack of reporting in the literature. The fact
that machine learning including deep learning methods did not outperform more
traditional approaches may suggest that feature richness and complexity were
exploited before the choice of algorithm could become critical to maximize
performance. Future research might focus on the impact of different feature
derivation approaches on performance ceilings. In the absence of other more
powerful screening alternatives, applying transparent regression-based models in
routine claims, though certainly imperfect, remains a promising scalable low-cost
approach for population-based cardiovascular risk prediction and stratification.
Claves:Claims database analysis, Deep learning, Health insurance, Logistic regression, Machine learning, Myocardial infarction, Prediction model, Predictive algorithms, Risk scores, Stroke, Type 2 diabetes
Cita:Cardiovasc Diabetol 2025 Feb 18; 24 (1) : 80.
Autor/es:Stephan, Anna-Janina (a) Hanselmann, Michael (b)
institución:(a) Professorship for Public Health and Prevention, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. anna-janina.stephan@tum.de. (b) German Center for Diabetes Research (DZD), Munich, Germany. anna-janina.stephan@tum.de.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study.
Association between atherogenic index of plasma and type 2 diabetic complications: a cross-sectional study.
Fuente:Frontiers in Endocrinology
Extracto:
The AIP
may serve as a valuable predictive indicator for evaluating kidney damage in
patients with type 2 diabetes, and regular screening of AIP in this population
could provide significant benefits in the prevention of DKD.
Claves:atherogenic index of plasma, cross-sectional study, diabetic complications, metabolic management center, type 2 diabetes
institución:(a) Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, China. (b) Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Transportation Barriers and Diabetes Outcomes: A Longitudinal Analysis.
Transportation Barriers and Diabetes Outcomes: A Longitudinal Analysis.
Fuente:Journal of Primary Care & Community Health
Tipo de trabajo:Estudio de cohortes
Extracto:
Absence of
transportation barriers was associated with slightly lower hemoglobin A1c and
blood pressure, but the small magnitude of the differences suggests that also
addressing other factors may be needed to improve diabetes outcomes more
meaningfully.
Claves:cardiovascular disease, diabetes mellitus, health inequities, health outcomes, social determinants of health
Cita:J Prim Care Community Health 2025 Jan-Dec; 16 : 21501319251320709.
Autor/es:Berkowitz, Seth A (a) Ochoa, Aileen (b)
institución:(a) University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. (b) University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Conflicto:Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: SAB reports research grants from NIH, North Carolina Department of Health and Human Services, Blue Cross Blue Shield of North Carolina, Feeding America, the American Diabetes Association, and the American Heart Association, and personal fees from the...
Aspen Institute, Rockefeller Foundation, Gretchen Swanson Center for Nutrition, and Kaiser Permanente, outside of the submitted work. ML reports research grant support from North Carolina Department of Health and Human Services. All other authors declare nothing to report.
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes
Fuente:Cardiovascular Diabetology
Tipo de trabajo:Estudio de cohortes
Extracto:
Our
findings extend the knowledge about the previously identified six phenotype-based
clusters in older people without T2D. Differences between clusters were more
pronounced for T2D risk than for prevalent or incident (pre)diabetes-related
complications and absent for mortality. The high cardiometabolic risk
corresponded to the high inflammatory load in cluster 5 but not to the lower
inflammatory load of high-risk clusters 3 and 6.
Cita:Cardiovasc Diabetol 2025 Feb 19; 24 (1) : 83.
Autor/es:Huemer, Marie-Theres (a) Spagnuolo, Maria C (b)
institución:(a) Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. (b) Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine Universität, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Conflicto:Declarations. Ethics approval and consent to participate: The KORA study was carried out in accordance with the Declaration of Helsinki. All study participants gave written informed consent. The Ethics Committee of the Bavarian Medical Association approved the studies (S4 Study: EC No. 99186, F4 study and FF4 study: EC No. 06068). Consent for publication: Not applicable. Competing interests: MR received...
lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). All other authors declare that they have no competing interests.
