Role and molecular mechanism of Salvia miltiorrhiza associated with chemical compounds in the treatment of diabetes mellitus and its complications

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: Despite the established benefits of managing DM and its complications, further research is needed to determine appropriate usage, dosage, long-term health benefits, and safety.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37844.

Autor/es:Li, Jiajie (a)
Liu, Jinxing (b)

institución:(a) School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, PR China.
(b) School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037844

Combinatorial metabolic engineering of Bacillus subtilis enables the efficient biosynthesis of isoquercitrin from quercetin.

Fuente:Microbial Cell Factories

Extracto: The engineered B. subtilis strain developed here holds great potential for initiating the sustainable and large-scale industrial production of isoquercitrin. The strategies proposed in this study provides a reference to improve the production of other flavonoid glycosides by engineered B. subtilis cell factories.

Claves:Bacillus subtilis, Biotransformation, Combinatorial metabolic engineering, Isoquercitrin, UDP-glucose

Cita:Microb Cell Fact 2024 Apr 20; 23 (1) : 114.

Autor/es:Niu, Tengfei (a)
Huang, Chaokang (b)

institución:(a) Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
(b) The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12934-024-02390-5

Prevalence of Pre-Hypertension/Hypertension and Its Associated Factors Among Adults in the Wolaita Zone of Southern Ethiopia: A Cross-Sectional Study.

Fuente:Inquiry a Journal of Medical Care Organization, Provision and Financing

Extracto: Lifestyle modification is demanded for pre-hypertensive/hypertensive patients to prevent progression to severe complications, including premature death and permanent disabilities.

Claves:associated factors, factors associated with prehypertension/hypertension, hypertension, predictors, prehypertension, prevalence of prehypertension/hypertension

Cita:Inquiry 2024 Jan-Dec; 61 : 469580241246968.

Autor/es:Endrias, Eshetu Elfios (a)
Tesfaye Mamito, Teketel (b)

institución:(a) Wolaita Sodo University, Addis Ababa, Ethiopia.
(b) Wachamo University, Hosaina, Ethiopia.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/00469580241246968

The Impact of Behavioral Lifestyle Intervention on Inflammatory Cytokines in Older Adults Living With Type 2 Diabetes: A Feasibility Study.

Fuente:Inquiry a Journal of Medical Care Organization, Provision and Financing

Extracto: DISCUSSION: The study highlights the importance of behavioral lifestyle intervention in improving inflammatory cytokines and frailty in older adults.

Claves:Inflammatory cytokines, behavioral lifestyle interventions, feasibility study, frailty, older adults, overweight/Obesity, type 2 diabetes

Cita:Inquiry 2024 Jan-Dec; 61 : 469580241248126.

Autor/es:Jiwani, Rozmin (a)
Serra, Monica (b)

institución:(a) University of Texas Health Science Center at San Antonio, TX, USA.
(b) South Texas Veterans Health Care System, San Antonio, TX, USA.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/00469580241248126

Charlson comorbidity index and the severity of community-acquired pneumonia caused by SARS-CoV-2: A retrospective analysis.

Fuente:Dental and Medical Problems

Extracto: The use of CCI to evaluate comorbid pathology in hospitalized patients with CAP caused by SARS-CoV-2 can assist the medical staff in developing timely preventive and therapeutic strategies, leading to improved patient prognosis.

Claves:Charlson comorbidity index, SARS-CoV-2, pneumonia, severity

Cita:Dent Med Probl 2024 Mar-Apr; 61 (2) : 173-179.

Autor/es:Marushchak, Mariya (a)
Krynytska, Inna (b)

institución:(a) I. Horbachevsky Ternopil National Medical University, Ukraine.
(b) I. Horbachevsky Ternopil National Medical University, Ukraine.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Polonia

Sitio web:http://dx.doi.org/10.17219/dmp/166666

Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection.

Fuente:Genome Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: Among individuals with and without HIV, multiple gut bacterial genera, blood metabolites, and proinflammatory proteins were associated with diabetes. The observed mediated effects by metabolites and proteins in genera-diabetes associations highlighted the potential involvement of inflammatory and metabolic perturbations in the link between gut dysbiosis and diabetes in the context of HIV infection.

Claves:Blood metabolome, Diabetes, Gut dysbiosis, Gut metagenome, HIV infection, Inflammatory proteome, Multi-omics integration

Cita:Genome Med 2024 Apr 20; 16 (1) : 59.

Autor/es:Luo, Kai (a)
Peters, Brandilyn A (b)

institución:(a) Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
(b) Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential competing interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13073-024-01336-1

Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes.

Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes.

Fuente:Physiological Reports

Extracto: As the individuals with type 2 diabetes did not have vascular dysfunction, these results might not apply to individuals with vascular dysfunction.

Claves:aldosterone, endothelial function, mineralocorticoid receptor, type 2 diabetes

Cita:Physiol Rep 2024 Apr; 12 (7) : e16010.

Autor/es:Finsen, Stine H (a)
Hansen, Mie R (b)

institución:(a) Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
(b) Department of Nephrology, Odense University Hospital, Odense, Denmark.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.14814/phy2.16010

The Senescent Heart-"Age Doth Wither Its Infinite Variety".

The Senescent Heart-"Age Doth Wither Its Infinite Variety".

Fuente:International Journal of Molecular Sciences

Extracto: Incisive studies on the molecular basis of cardiovascular aging and dysregulated fibroblast function in the senescent heart would pave the way for effective strategies to mitigate cardiovascular diseases in a rapidly growing elderly population.

Claves:DDR2, aging, cardiac fibroblasts, cardiac fibrosis, cardiac myocytes, collagen, senescence, vascular cells

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Vijayakumar, Anupama (a)
Wang, Mingyi (b)

institución:(a) Cardiovascular Genetics Laboratory, Department of Biotechnology, Bhupat and Jyothi Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, India.
(b) Laboratory of Cardiovascular Science, National Institute on Aging/National Institutes of Health, Baltimore, MD 21224, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073581

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism.

Fuente:International Journal of Molecular Sciences

Extracto: In-depth understanding of the role and mechanism of exercise in improving DN would pave the way for formulating safe and effective exercise programs for the treatment and prevention of DN.

Claves:AMPK, MicroRNAs, Sirt1, diabetic nephropathy, exercise, exerkine, gut microbiota, heat shock protein, metabolites, nitric oxide, renin-angiotensin system

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Li, Ruo-Ying (a)
Guo, Liang (b)

institución:(a) School of Exercise and Health, Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai 200438, China.
(b) Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073605

The Novel SSTR3 Agonist ITF2984 Exerts Antimitotic and Proapoptotic Effects in Human Non-Functioning Pituitary Neuroendocrine Tumor (NF-PitNET) Cells.

Fuente:International Journal of Molecular Sciences

Extracto: In conclusion, our data support a possible use of ITF2984 in the pharmacological treatment of NF-PitNET.

Claves:ITF2984, NF-PitNETs, SSTRs

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Di Muro, Genesio (a)
Catalano, Rosa (b)

institución:(a) Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.
(b) Department of Experimental Medicine, University Sapienza of Rome, 00100 Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073606

Shedding Light on Photodynamic Therapy in the Treatment of Necrobiosis Lipoidica: A Multicenter Real-Life Experience.

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Consenso

Extracto: The standardization of treatment protocols and consensus guidelines are essential to ensure reproducibility and comparability across studies.

Claves:Necrobiosis Lipoidica, PDT, diabetes, pain, photodynamic therapy, ulcer, wound healing

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Li Pomi, Federica (a)
Motolese, Alfonso (b)

institución:(a) Department of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy.
(b) Dermatology Unit, Department of Surgery, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073608

Aflibercept Off-Target Effects in Diabetic Macular Edema: An In Silico Modeling Approach.

Fuente:International Journal of Molecular Sciences

Extracto: Given the role of VEGFR1 signaling on the modulation of inflammatory-related pathways, IAI may offer therapeutic advantages for DME through sustained VEGFR1 pathway inhibition.

Claves:TPMS, angiogenesis, blood–retinal barrier permeability, inflammation, intravitreal aflibercept injection, machine learning, oxidative stress, systems biology, vascular endothelial growth factor

Cita:Int J Mol Sci 2024 Mar 23; 25 (7)

Autor/es:Blanot, Morgane (a)
Casaroli-Marano, Ricardo Pedro (b)

institución:(a) Anaxomics Biotech S.L., 08007 Barcelona, Spain.
(b) Department of Surgery (FMCS), Universitat de Barcelona, 08007 Barcelona, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073621

Exploring the Impact of Alternative Sources of Dietary Nitrate Supplementation on Exercise Performance.

Fuente:International Journal of Molecular Sciences

Extracto: Red spinach and green spinach have been shown to improve exercise performance or accelerate recovery after physical exertion in healthy subjects (including athletes).

Claves:Amaranthus, alternative dietary nitrate, athletes, exercise performance, nitrate, recovery, spinach

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Jędrejko, Maciej (a)
Jędrejko, Karol (b)

institución:(a) Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Kraków, Poland.
(b) Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Str., 30-688 Kraków, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073650

Unveiling Anti-Diabetic Potential of Baicalin and Baicalein from Baikal Skullcap: LC-MS, In Silico, and In Vitro Studies.

Fuente:International Journal of Molecular Sciences

Extracto: Additionally, we have identified six flavonoid molecules with substantial potential for drug development, thereby augmenting the T2DM pharmacotherapeutic arsenal and promoting the integration of herb-derived treatments into modern pharmacology.

Claves:LC–MS, PTP1B, anti-diabetic mechanisms, cellular assay, molecular docking, network pharmacology

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Zhao, Wencheng (a)
Cui, Huizi (b)

institución:(a) Edmond H. Fischer Signal Transduction Laboratory, Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
(b) Edmond H. Fischer Signal Transduction Laboratory, Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073654

Molecular Mechanisms of Neuroprotection after the Intermittent Exposures of Hypercapnic Hypoxia.

Fuente:International Journal of Molecular Sciences

Extracto: Combining hypercapnic hypoxia with pharmacological modulators of neuro/cardio/cytoprotection signaling pathways is likely to be promising for translating experimental research into clinical medicine.

Claves:A1 adenosine receptors, HIF-1α, antioxidant systems, apoptosis inhibition, blood–brain barrier permeability, chaperones, endoplasmic reticulum, hypercapnia, hypoxia, mitochondrial ATP-dependent potassium channels, neuroprotection

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Tregub, Pavel P (a)
Kulikov, Vladimir P (b)

institución:(a) Department of Pathophysiology, I.M. Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
(b) Brain Science Institute, Research Center of Neurology, 125367 Moscow, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073665

The PD-1/PD-L1 Axis in the Biology of MASLD.

Fuente:International Journal of Molecular Sciences

Extracto: The aim of this review is to illustrate the main pathogenetic mechanisms by which the immune system promotes the progression of MASLD and the transition to HCC, as well as to discuss the possible therapeutic applications of PD-1/PD-L1 target therapy to activate T cells and reinvigorate immune surveillance against cancer.

Claves:CD8+ T cells exhausted, HCC, MASH, MASLD, PD-1, PD-L1, T Reg cells, cytotoxic lymphocytes

Cita:Int J Mol Sci 2024 Mar 25; 25 (7)

Autor/es:Pipitone, Rosaria Maria (a)
Lupo, Giulia (b)

institución:(a) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Piazza delle Cliniche, 90127 Palermo, Italy.
(b) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Piazza delle Cliniche, 90127 Palermo, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073671

Underlying Mechanisms behind the Brain-Gut-Liver Axis and Metabolic-Associated Fatty Liver Disease (MAFLD): An Update.

Fuente:International Journal of Molecular Sciences

Extracto: Finally, hepatokines are decisive in improving or not improving the progression of this disease through the regulation of pro-inflammatory and anti-inflammatory organokines.

Claves:MAFLD, brain–gut–liver axis, diabetes, dyslipidemia, insulin resistance, metabolic-associated fatty liver disease, obesity, organokines

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:De Cól, Júlia Pauli (a)
de Lima, Enzo Pereira (b)

institución:(a) Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), São Paulo 17525-902, Brazil.
(b) Department of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), São Paulo 17525-902, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073694

Hypervolemia in Dialysis Patients Impairs STAT3 Signaling and Upregulates miR-142-3p: Effects on IL-10 and IL-6.

Fuente:International Journal of Molecular Sciences

Extracto: How far degradative mechanisms induced by elevated miR-142-3p levels contribute to an inefficient anti-inflammatory IL-10 signaling remains elusive.

Claves:IL-10, IL-6, SOCS3, STAT3, chronic kidney failure, hemodialysis, hypervolemia, inflammation, miR-142

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Ulrich, Christof (a)
Fiedler, Roman (b)

institución:(a) Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.
(b) Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.

Conflicto:Authors Roman Fiedler and Matthias Girndt were also employees of KfH Nierenzentrum Halle, the outpatient dialysis center of the University medicine of Halle. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073719

MicroRNA Associations with Preterm Labor-A Systematic Review.

Fuente:International Journal of Molecular Sciences

Extracto: In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor.

Claves:MicroRNA expression, pregnancy, preterm labor

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Kondracka, Adrianna (a)
Stupak, Aleksandra (b)

institución:(a) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.
(b) Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 20-081 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073755

Substance P Concentration in Gestational Diabetes and Excessive Gestational Weight Gain and Its Impact on Neonatal Anthropometry.

Fuente:International Journal of Molecular Sciences

Extracto: To our knowledge, it is the first study assessing substance P concentration in GDM and EGWG patients.

Claves:excessive gestational weight gain, fetal programming, gestational diabetes mellitus, substance P

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Niebrzydowska-Tatus, Magdalena (a)
Pełech, Aleksandra (b)

institución:(a) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.
(b) Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073759