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Obesity Is Associated with Fatty Liver and Fat Changes in the Kidneys in Humans as Assessed by MRI.
Obesity Is Associated with Fatty Liver and Fat Changes in the Kidneys in Humans as Assessed by MRI.
Fuente:Nutrients
Tipo de trabajo:Revisión
Extracto:
Obesity is a major risk factor for developing a fatty
liver and fatty kidneys. Individuals with a fatty liver are more likely to have
fatty kidneys. MRI is an accurate modality for diagnosing fatty kidneys.
Reviewing MRI scans of any indication should include assessment of fat fractions
in the kidneys in addition to that of the liver.
Claves:MRI, fatty kidneys, fatty liver, obesity
Cita:Nutrients 2024 May 3; 16 (9)
Autor/es:Raphael, Hadar (a) Klang, Eyal (b)
institución:(a) Arrow Projects for Medical Research Education, The Chaim Sheba Medical Center, Tel Hashomer 5266202, Israel. (b) Department of Imaging, The Chaim Sheba Medical Center, Tel Hashomer 5266202, Israel.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical variables influencing the severity of diabetes ketoacidosis.
Clinical variables influencing the severity of diabetes ketoacidosis.
Fuente:Saudi Medical Journal
Tipo de trabajo:Revisión
Extracto:
Diabetes ketoacidosis was observed to occur more frequently among
males in middle childhood with seasonal variations. Furthermore, the severity of
DKA was associated with lower economic status, early adolescence, and the
presence of hypernatremia.
Autor/es:Alhamdani, Yara F (a) Almadfaa, Lojain O (b)
institución:(a) From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. (b) From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit.
Effect of cortisol and glycosylated-hemoglobin levels on mortality in intensive care unit.
Fuente:Saudi Medical Journal
Extracto:
Cortisol levels at the
time of admission to the ICU were found to affect mortality and can be considered
a predictive factor, while HBA1C levels showed no such effect. Our findings
indicate that neither cortisol nor HBA1C levels had an impact on the duration of
mechanical ventilation or length of stay in the ICU.
Claves:glycated hemoglobin, intensive care units, mortality, steroids
Cita:Saudi Med J 2024 May; 45 (5) : 476-480.
Autor/es:Sen, Oznur (a) Uzun, Ugur (b)
institución:(a) From the Department of Anesthesiology and Reanimation Unit (Sen, Aydin), SBU Haseki Training and Research Hospital, Istanbul; and From the Department of Anesthesiology and Reanimation Unit (Uzun, Guldogan), SBU Tepecik Training and Research Hospital, İzmir, Turkey. (b) From the Department of Anesthesiology and Reanimation Unit (Sen, Aydin), SBU Haseki Training and Research Hospital, Istanbul; and From the Department of Anesthesiology and Reanimation Unit (Uzun, Guldogan), SBU Tepecik Training and Research Hospital, İzmir, Turkey.
Predictors associated with an increase in daily steps among people with prediabetes or type 2 diabetes participating in a two-year pedometer intervention.
Predictors associated with an increase in daily steps among people with prediabetes or type 2 diabetes participating in a two-year pedometer intervention.
Fuente:Bmc Public Health
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
In the Sophia
Step Study pedometer intervention, participants with a lower number of steps at
baseline, male gender, lower age or higher baseline self-efficacy were more
likely to respond to the intervention with a step increase above 500 steps per
day. More knowledge is needed about factors that influence response to pedometer
interventions. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02374788.
Claves:Intervention, Prediabetes, Response, Steps, Type 2 diabetes
Cita:BMC Public Health 2024 May 11; 24 (1) : 1290.
Autor/es:Larsson, Kristina (a) Rossen, Jenny (b)
institución:(a) Department of Health Promotion Science, Sophiahemmet University, Box 5605, Stockholm, 114 86, Sweden. Kristina.larsson@shh.se. (b) Department of Health Promotion Science, Sophiahemmet University, Box 5605, Stockholm, 114 86, Sweden.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The association between pregnancy levels of blood lipids and the risk of preterm birth.
The association between pregnancy levels of blood lipids and the risk of preterm birth.
Fuente:Scientific Reports
Extracto:
Managing lipid abnormalities during
pregnancy may help reduce the risk of PTB.
Claves:Hyperlipidemia, Hyperlipidemia in pregnancy, Hypertriglyceridemia, Preterm delivery, Restricted cubic spline
Cita:Sci Rep 2024 May 11; 14 (1) : 10800.
Autor/es:Lv, Yao (a) Xu, Liang (b)
institución:(a) The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Hengshan Road 910, Shanghai, 200030, China. (b) Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
The aim is to ensure early treatment
and avoid life-threatening complications.
Claves:ACTH-dependent, Pheochromocytoma, case report, paraneoplastic Cushing´s syndrome
Cita:Pan Afr Med J 2024; 47 : 88.
Autor/es:Rifai, Kaoutar (a) Toulali, Fatima (b)
institución:(a) Service d'Endocrinologie et Maladies Métaboliques, Centre Hospitalo-Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Maroc. (b) Service d'Endocrinologie et Maladies Métaboliques, Centre Hospitalo-Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V Souissi, Rabat, Maroc.
Conflicto:Les auteurs ne déclarent aucun conflit d´intérêts.
Extracto:
We will look at topics such as neonatal
anthropometry, thyroid issues, adrenal problems, hypogonadism, bone metabolism
abnormalities, metabolic syndrome resulting from severe obesity caused by
hyperphagia, deficiencies in the GH/IGF-1 axis, and the corresponding responses
to treatment.
Claves:Prader-Willi syndrome (PWS), bone metabolism, genotype-phenotype correlation, growth hormone (GH), hypogonadism, metabolic syndrome, thyroid, type 2 diabetes
institución:(a) Department of Medical and Surgical Sciences for Mother, Children and Adults, Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy. (b) Department of Pediatrics, University of L'Aquila, L'Aquila, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
The impact of empagliflozin and metformin on cardiac parameters in patients with mid-range ejection fraction heart failure without diabetes.
The impact of empagliflozin and metformin on cardiac parameters in patients with mid-range ejection fraction heart failure without diabetes.
Fuente:Journal of Medicine and Life
Extracto:
However, the benefits of EMPA were more
pronounced, particularly regarding improvements in EF and LVESD.
Claves:FFA, Free Fatty Acid, HFmrEF, Heart Failure with mid-range Ejection Fraction, LVEDD, Left Ventricular End-Diastolic Diameter, N-terminal pro-BNP, echocardiography, heart failure, metformin, sodium-glucose transport protein 2 (SGLT2) inhibitors
Cita:J Med Life 2024 Jan; 17 (1) : 57-62.
Autor/es:Sabbar, Reeman (a) Kadhim, Sinaa Abdul Amir (b)
institución:(a) Department of Pharmacology, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq. (b) Department of Pharmacology, College of Medicine, University of Al-Qadisiyah, Al-Qadisiyah, Iraq.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
An overview of neuro-ophthalmic disorders at Jenna Ophthalmic Center, Baghdad, Iraq (2021-2022).
An overview of neuro-ophthalmic disorders at Jenna Ophthalmic Center, Baghdad, Iraq (2021-2022).
Fuente:Journal of Medicine and Life
Extracto:
Ischemic optic neuropathy and sixth nerve palsy,
traumatic/compressive optic neuropathy, and papilledema were the most common
neuro-ophthalmic disorders reported.
institución:(a) Ibn Al-Haitham Teaching Eye Hospital, Baghdad Al-Russafa Health Directorate, Baghdad, Iraq. (b) Department of Surgery, College of Medicine, University of Baghdad, Baghdad, Iraq.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
This case highlights the necessity of considering PSOT in
the differential diagnosis of acute abdominal pain, especially in cases where
symptoms are suggestive of appendicitis but diagnostic findings are negative.
Autor/es:Gavriilidis, Paschalis (a) Di Saverio, Salomone (b)
institución:(a) Department of Surgery, Saint Helena General Hospital, Jamestown, UK. (b) Department of Surgery, San Benedetto del Tronto Hospital, San Benedetto del Tronto, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications.
Wearable laser Doppler flowmetry for non-invasive assessment of diabetic foot microcirculation: methodological considerations and clinical implications.
Fuente:Journal of Biomedical Optics
Extracto:
This study indicated the
potential of using the novel wearable LDF device for tracking vascular
complications and implementing targeted interventions in T2DM patients.
institución:(a) Huashan Hospital, Fudan University, Department of Orthopedic Surgery, Shanghai, China. (b) The Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province, The Eye Hospital of Yunnan Province), Department of Orthopedics and Trauma, Kunming, China.
Autor/es:Jabbar Al-Rikabi, Saad Ayyal (a) Etemadi, Ali (b)
institución:(a) Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. (b) Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The prevention of adverse pregnancy outcomes by periodontal treatment during pregnancy (PROBE) intervention study-A controlled intervention study: Protocol paper.
The prevention of adverse pregnancy outcomes by periodontal treatment during pregnancy (PROBE) intervention study-A controlled intervention study: Protocol paper.
Fuente:Plos One
Tipo de trabajo:Revisión
Extracto:
CLINICAL TRIALS REGISTRATION: The study was registered on
clinicaltrials.gov (NCT06110143).
institución:(a) The Research Unit for Dietary Studies, The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark. (b) The Research Unit for Dietary Studies, The Parker Institute, Copenhagen University Hospital, Copenhagen, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cost-effectiveness of a complex continuum of care intervention targeting women and children: protocol for an economic evaluation of the Bukhali trial in South Africa.
Cost-effectiveness of a complex continuum of care intervention targeting women and children: protocol for an economic evaluation of the Bukhali trial in South Africa.
Claves:community child health, diabetes in pregnancy, economics, health economics, obesity, postpartum period
Cita:BMJ Open 2024 May 13; 14 (5) : e080166.
Autor/es:Palmer, Tom (a) Leiva Granados, Rolando (b)
institución:(a) Institute for Global Health, University College London, London, UK t.palmer@ucl.ac.uk. (b) Institute for Global Health, University College London, London, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
They will give healthcare providers a better awareness of the optimal
analgesic medication for pain treatment in non-severe, acute pancreatitis.
Autor/es:Subramani, Sriya S (a) Berg, Alaina C (b)
institución:(a) Stead Family Department of Pediatrics, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA. (b) The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.
Fuente:Nature Communications
Extracto:
Here, we show that effects of lanifibranor on liver
histology in MASH are accompanied with CMH improvement, indicative of potential
cardiovascular clinical benefits.
Cita:Nat Commun 2024 May 10; 15 (1) : 3962.
Autor/es:Cooreman, Michael P (a) Butler, Javed (b)
institución:(a) Research and Development, Inventiva, New York, NY, USA. Michael.Cooreman@inventivapharma.com. (b) Research and Development, Inventiva, Daix, France. Michael.Cooreman@inventivapharma.com.
Conflicto:M.P.C., L.D., P.H.M., M.B. and P.B. are employees of Inventiva. J.L.J. is a consultant for Inventiva. D.R.B. has received honoraria from Inventiva via Translational Medicine Academy. J.B. has served as a consultant for Abbott, American Regent, Amgen, Applied Therapeutic, AskBio, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, Cardiac Dimension, Cardiocell, Cardior, Cardiorem, CSL Bearing, CVRx, Cytokinetics, Daxor,...
Edwards, Element Science, Faraday, Foundry, G3P, Innolife, Impulse Dynamics, Imbria, Inventiva, Ionis, Lexicon, Lilly, LivaNova, Janssen, Medtronics, Merck, Occlutech, Owkin, Novartis, Novo Nordisk, Pfizer, Pharmacosmos, Pharmain, Prolaio, Regeneron, Renibus, Roche, Salamandra, Sanofi, SC Pharma, Secretome, Sequana, SQ Innovation, Tenex, Tricog, Ultromics, Vifor, and Zoll. RPG received research support or honoraria form Amgen, Anthos Therapeutics, Daiichi Sankyo, Ionis, Dr. Reddy’s Laboratories, Medical Education Resources, Menarini, SAJA Pharmaceuticals, Servier, SUMMEET, and consults for Artivion, Beckman Coulter, Daiichi Sankyo, Gilead, Inari, Inventiva, PhaseBio Pharmaceuticals, Samsung and Aventis. FZ reports personal fees from 89Bio, Abbott, Acceleron, Applied Therapeutics, Bayer, Betagenon, Boehringer, BMS, CVRx, Cambrian, Cardior, Cereno pharmaceutical, Cellprothera, CEVA, Inventiva, KBP, Merck, NovoNordisk, Owkin, Otsuka, Roche Diagnostics, Northsea, USa2, having stock options at G3Pharmaceutical and equities at Cereno, Cardiorenal, Eshmoun Clinical research and being the founder of Cardiovascular Clinical Trialists. MFA received grants from Boehringer-Ingelheim, Gilead, Hanmi, Inventiva, Madrigal, Novo Nordisk; honoraria from Clinical Care Options, Fishawack, Medscape, Terra Firma, CLDF; royalties from Up-to-Date; consults for 89Bio, BMS, Hanmi, Inventiva, Intercept, Madrigal, Merck, Novo Nordisk. SMF received grants from Astellas, Falk Pharma, Genfit, Gilead Sciences, GlympsBio, Janssens Pharmaceutica, Inventiva, Merck Sharp & Dome, Pfizer, Roche; honoraria from Abbvie, Allergan, Bayer, Eisai, Genfit, Gilead Sciences, Janssens Cilag, Intercept, Inventiva, Merck Sharp & Dome, Novo Nordisk, Promethera, Siemens; serves as consultant for Abbvie, Actelion, Aelin Therapeutics, AgomAb, Aligos Therapeutics, Allergan, Alnylam, Astellas, Astra Zeneca, Bayer, Boehringer Ingelheim, Bristoll-Meyers Squibb, CSL Behring, Coherus, Echosens, Dr. Falk Pharma, Eisai, Enyo, Galapagos, Galmed, Genetech, Genfit, Genflow Biosciences, Gilead Sciences, Intercept, Inventiva, Janssens Pharmaceutica, PRO.MED.CS Praha, Julius Clinical, Madrigal, Medimmune, Merck Sharp & Dome, Mursla Bio, NGM Bio, Novartis, Novo Nordisk, Promethera, Roche, Siemens Healthineers.
Lipids as potential mediators linking body mass index to diabetes: evidence from a mediation analysis based on the NAGALA cohort.
Lipids as potential mediators linking body mass index to diabetes: evidence from a mediation analysis based on the NAGALA cohort.
Fuente:Bmc Endocrine Disorders
Extracto:
Our fresh findings
suggested that lipid parameters partially mediated the association of BMI with
diabetes risk; this result indicated that in the context of diabetes risk
screening and disease management, it is important to not only monitor BMI but
also pay attention to lipid parameters, particularly HDL-C and HDL-C-related
lipid ratio parameters.
Claves:Body mass index, Diabetes, Indirect effect, Lipid parameters, Mediation analyses
Cita:BMC Endocr Disord 2024 May 10; 24 (1) : 66.
Autor/es:Lu, Song (a) Wang, Qun (b)
institución:(a) Department of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. (b) Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Affiliated Hospital of Huanghuai University, Zhumadian Central Hospital, Zhumadian, 463000, He'nan, People's Republic of China. renyongcheng@huanghuai.edu.cn. (b) Institute of Health Data Management, Huanghuai University, Zhumadian, 463000, He'nan, People's Republic of China. renyongcheng@huanghuai.edu.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis.
Potential impact of blood cholesterol guidelines on statin treatment in the U.S. population using interrupted time series analysis.
Fuente:Bmc Cardiovascular Disorders
Tipo de trabajo:Guía
Extracto:
The 2013 ACA/AHA Guideline release is associated with trend
improvements in the long-term MACE Survival for Diabetes group and optimal statin
use for ASCVD group. These significant associations might indicate a potential
positive long-term impact of the 2013 ACA/AHA Guideline on better health outcomes
for primary prevention groups and an immediate potential impact on statin
prescribing behaviors in higher-at-risk groups. However, further investigation is
required to confirm the causal effect of the 2013 ACA/AHA Guideline.
Claves:Cardiovascular disease, Diabetes, Generic atorvastatin, Guideline implementation, Interrupted time series analysis, Long-term effect, MACE, Policy effect
Cita:BMC Cardiovasc Disord 2024 May 10; 24 (1) : 245.
Autor/es:Yew, Pui Ying (a) Loth, Matt (b)
institución:(a) Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA. (b) Institute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Association of RASGRP1 polymorphism with vascular complications in Chinese diabetic patients with glycemic control and antihypertensive treatment.
Fuente:Cardiovascular Diabetology
Extracto:
We found that
patients with G allele of RASGRP1 (rs56254815) showed a better antihypertensive
therapy efficacy in T2DM patients. The rs7403531 T allele could reduce the risk
of major microvascular events and major eye diseases in T2DM patients receiving
either hypoglycemic or antihypertensive therapy. Our findings suggest that
RASGRP1 genetic polymorphism might predict the cardiovascular complications in
T2DM patients.
Claves:Individual drug treatment, Polymorphism, RASGRP1, Type 2 diabetes, Vascular complications, rs7403531
Cita:Cardiovasc Diabetol 2024 May 10; 23 (1) : 166.
Autor/es:Zhou, Jiecan (a) Xu, Bo (b)
institución:(a) The First Affiliated Hospital, Hunan Provincial Clinical Medical Research Center for Drug Evaluation of Major Chronic Diseases, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. zhoujiecan@fsyy.usc.edu.cn. (b) The First Affiliated Hospital, Hengyang Clinical Pharmacology Research Center, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. zhoujiecan@fsyy.usc.edu.cn.
Conflicto:All authors declare no conflict of interest relevant to the subject matter or materials discussed in the article.
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