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Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism.
Link between iron-mediated lipid peroxidation and polycystic ovary syndrome (PCOS): exploring the genes underlying iron regulatory mechanism.
Fuente:Journal of Ovarian Research
Extracto:
The present
study postulated the role of iron overload in trigger of ferroptosis following
elevated lipid peroxidation and low peroxidase activity. Moreover, unveil the
association of genes related to iron-regulating metabolism with etiology of
underlying PCOS mechanism.
institución:(a) Cancer Genetics and Epigenetics Lab, Department of Biosciences, COMSATS University, Islamabad, Pakistan. (b) Cancer Genetics and Epigenetics Lab, Department of Biosciences, COMSATS University, Islamabad, Pakistan. zee1524@yahoo.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Gene expression knowledge graph for patient representation and diabetes prediction.
Gene expression knowledge graph for patient representation and diabetes prediction.
Fuente:Journal of Biomedical Semantics
Extracto:
Extensive experiments
demonstrate the efficacy of our approach, revealing weighted F1-score
improvements in diabetes prediction up to 13% when integrating multiple gene
expression datasets and domain-specific knowledge about protein functions and
interactions.
institución:(a) Data and Web Science Group, University of Mannheim, 68159, Mannheim, Germany. rita.sousa@uni-mannheim.de. (b) Data and Web Science Group, University of Mannheim, 68159, Mannheim, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Thyroid nodule with cytological outcome of indeterminate lesion with low risk of malignancy found to be parathyroid adenoma. A case report and minireview of literature.
Thyroid nodule with cytological outcome of indeterminate lesion with low risk of malignancy found to be parathyroid adenoma. A case report and minireview of literature.
Fuente:Frontiers in Endocrinology
Extracto:
To support this diagnostic approach, we
present a mini-review of the literature on this topic, along with a case report
of an IPA misinterpreted as an indeterminate thyroid lesion (TIR3A, according to
the Italian Society for Anatomic Pathology and Cytology-Italian Thyroid
Association 2014 classification system), diagnosed following the preoperative
incidental detection of hypercalcemic PHPT.
institución:(a) Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy. (b) Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision
Global burden of chronic kidney disease due to diabetes mellitus, 1990-2021, and projections to 2050.
Global burden of chronic kidney disease due to diabetes mellitus, 1990-2021, and projections to 2050.
Fuente:Frontiers in Endocrinology
Extracto:
To effectively manage CKD caused by diabetes, more accurate and
cost-effective diagnostic tools and interventions are needed in the future,
especially in low - and middle-income countries with poor healthcare resources.
Claves:chronic kidney disease, diabetes mellitus, diabetic nephropathy, global disease burden, health inequality, years lived with disability
institución:(a) Department of Urology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China. (b) Department of Urology, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Construction of a nomogram for predicting the risk of all-cause mortality in patients with diabetic retinopathy.
Construction of a nomogram for predicting the risk of all-cause mortality in patients with diabetic retinopathy.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Consenso
Extracto:
Our nomogram demonstrates high clinical predictive
accuracy, enabling clinicians to effectively predict the overall mortality risk
in patients with DR, thereby significantly improving their prognosis.
Claves:NHANES, all-cause mortality, diabetic retinopathy, nomogram, type 2 diabetes
institución:(a) School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China. (b) Department of Neurology, Shanghai Pudong New Area Gongli Hospital, Shanghai, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Infections and antibiotic use in early childhood have limited importance in developing manifest type 1 diabetes - The ABIS cohort study.
Infections and antibiotic use in early childhood have limited importance in developing manifest type 1 diabetes - The ABIS cohort study.
Fuente:Frontiers in Endocrinology
Extracto:
Childhood infections could increase the risk of developing type 1
diabetes in a small group of individuals without risk-associated HLA alleles, but
this was not seen in the majority with HLA-risk. More research is required for
this overlooked population, including screening and prevention trials. The
association to frequent gastrointestinal infections in the first years of life
needs to be reproduced in other studies to be confirmed.
Claves:childhood environmental factors, gastroenteritis, infections, sex differences, type 1 diabetes
institución:(a) Crown Princess Victoria's Children´s Hospital, Region Östergötland and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. (b) Department of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Conflicto:The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Association of systemic immune inflammation index with depression among adult type 2 diabetic patients in a tertiary hospital, Ethiopia, 2022.
Association of systemic immune inflammation index with depression among adult type 2 diabetic patients in a tertiary hospital, Ethiopia, 2022.
Fuente:Frontiers in Endocrinology
Extracto:
Therefore, relevant stakeholders should work towards control of systemic
inflammation, avoidance of risky behaviors such as khat chewing, and promotion of
healthy behavior particularly among females.
Autor/es:Ali, Seid Yimam (a) Sadik, Mohammed Ibrahim (b)
institución:(a) School of Medicine, Institute of Health, Jigjiga University, Jigjiga, Somali, Ethiopia. (b) Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus
The relationship of age, sex and prothrombin time related to the severity and mortality of COVID-19 patients with diabetes mellitus
Fuente:F1000research
Tipo de trabajo:Revisión sistemática
Extracto:
Older and male COVID-19
patients have a higher risk of having diabetes compared to younger and female
COVID-19 patients. As diabetes is a comorbidity in COVID-19, it can be concluded
that old age and male sex are associated with a more severe disease.
Claves:COVID-19, age, diabetes mellitus, prothrombine time, sex
institución:(a) Faculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia. (b) Faculty of Medicine, Universitas Sumatera Utara, Medan, Sumatera Utara, 20155, Indonesia.
institución:(a) Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran. (b) Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
FIB-4 Index Can Predict Mortality in Hospitalized Patients with COVID-19 Infection, Independent of CT Severity Score.
FIB-4 Index Can Predict Mortality in Hospitalized Patients with COVID-19 Infection, Independent of CT Severity Score.
Fuente:Archives of Iranian Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
The FIB-4 index, calculable by routine
laboratory tests, may be a valuable prognostic factor for COVID-19 mortality.
This easily obtainable marker could help identify high-risk patients early,
potentially allowing for more rapid intervention and treatment prioritization.
institución:(a) Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran. (b) Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Using gut microbiome metagenomic hypervariable features for diabetes screening and typing through supervised machine learning.
Using gut microbiome metagenomic hypervariable features for diabetes screening and typing through supervised machine learning.
Fuente:Microbial Genomics
Extracto:
ML has the
potential to facilitate early diagnosis of diabetes based on microbial profiles
of the gut microbiome.
Claves:diabetes mellitus, gut microbiome, metabarcoding, microbial markers, random forest, supervised machine learning
Cita:Microb Genom 2025 Mar; 11 (3)
Autor/es:Chavarria, Xavier (a) Park, Hyun Seo (b)
institución:(a) Department of Tropical Medicine, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul 03722, Republic of Korea. (b) Department of Tropical Medicine, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul 03722, Republic of Korea.
LC-MS analysis and antioxidant, antibacterial, and antidiabetic activity of Jumli Marshi rice from Nepal: An in vitro and in silico investigation to validate their potential as a functional food.
LC-MS analysis and antioxidant, antibacterial, and antidiabetic activity of Jumli Marshi rice from Nepal: An in vitro and in silico investigation to validate their potential as a functional food.
Fuente:Plos One
Extracto:
Marshi rice as a functional food used for the
management of diabetes.
institución:(a) School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal. (b) School of Health and Allied Sciences, Pokhara University, Pokhara, Nepal.
Conflicto:All the authors have declared that there are not any competing interests for this work.
Development and Impact of a Community-Delivered, Multisectoral Lifestyle Management Service for People Living With Type 2 Diabetes (Logan Healthy Living): Protocol for a Pragmatic, Single-Arm Intervention Study.
Development and Impact of a Community-Delivered, Multisectoral Lifestyle Management Service for People Living With Type 2 Diabetes (Logan Healthy Living): Protocol for a Pragmatic, Single-Arm Intervention Study.
Fuente:Jmir Research Protocols
Extracto:
While multisectoral responses are needed for
complex community health challenges, the processes for achieving these are rarely
documented, and the description of the development of Logan Healthy Living has
the potential to inform future partnerships. The findings of the evaluation will
provide important new knowledge on the impact of a community-delivered type 2
diabetes program on individuals, the community, and the health system in an area
of high health inequity. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID):
DERR1-10.2196/69477.
Claves:allied health, evaluation, lifestyle management, protocol, type 2 diabetes
Cita:JMIR Res Protoc 2025 Mar 10; 14 : e69477.
Autor/es:Gomersall, Sjaan R (a) Giguere, Denis Y (b)
institución:(a) Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Australia. (b) Logan Healthy Living, UQ Health Care Ltd, Logan, Australia.
The effect of MIND diet on sleep status, mental health, and serum level of BDNF in overweight/obese diabetic women with insomnia: a randomized controlled trial.
The effect of MIND diet on sleep status, mental health, and serum level of BDNF in overweight/obese diabetic women with insomnia: a randomized controlled trial.
Fuente:Scientific Reports
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
This study provides
promising evidence of the effectiveness of the MIND diet in improving the sleep
quality, mental health, and some related biochemical parameters in diabetic women
with insomnia.Trial registration: IRCT20181111041611N8.
Claves:BDNF, Diabetes mellitus, MIND diet, Mental health, Sleep quality
institución:(a) Student Research Committee, Department of Nutritional Sciences, School of Nutrition Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. (b) Department of Biochemistry and Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Risk factors and an optimized prediction model for urosepsis in diabetic patients with upper urinary tract stones.
Risk factors and an optimized prediction model for urosepsis in diabetic patients with upper urinary tract stones.
Fuente:Scientific Reports
Extracto:
The study
developed a prediction model for urosepsis risk in diabetic patients with UUTS,
presenting a convenient tool for timely diagnosis, particularly in non-operated
patients.
Cita:Sci Rep 2025 Mar 10; 15 (1) : 8183.
Autor/es:Gao, Chongxiang (a) Liu, Jiancen (b)
institución:(a) Department of Urology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. (b) Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring patient and health care provider perspectives on barriers to diabetic retinopathy screening in public health facilities in North India.
Exploring patient and health care provider perspectives on barriers to diabetic retinopathy screening in public health facilities in North India.
Fuente:Scientific Reports
Extracto:
Enhancing DR
awareness and promoting public health insurance benefits are crucial for
overcoming barriers and improving screening rates.
Claves:Barriers, Diabetic retinopathy screening, North India, Public health facilities
Cita:Sci Rep 2025 Mar 10; 15 (1) : 8251.
Autor/es:Chauhan, Anshul (a) Duggal, Mona (b)
institución:(a) Advanced Eye Centre (AEC), Post Graduate Institute of Medical Education and Research, Madhya Marg, Sector- 12, Chandigarh, 160012, India. anshsunny88@gmail.com. (b) Advanced Eye Centre (AEC), Post Graduate Institute of Medical Education and Research, Madhya Marg, Sector- 12, Chandigarh, 160012, India. monaduggal2@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between single nucleotide polymorphisms in PNPLA3, TM6SF2 and MBOAT7 genes and markers of cancer aggressiveness in a Sri Lankan NASH-related HCC cohort.
Association between single nucleotide polymorphisms in PNPLA3, TM6SF2 and MBOAT7 genes and markers of cancer aggressiveness in a Sri Lankan NASH-related HCC cohort.
Fuente:Bmc Gastroenterology
Extracto:
We found that in the Sri Lankan NASH-related HCC
cohort, some PNPLA3 variants (rs2281135 and rs2294918) correlate with tumor
nodularity, higher miR-122 expression, and distinct demographic features such as
age and BMI. Our work highlights the role of specific SNPs in tumor
aggressiveness, contributing to the precision screening for HCC in NASH patients.
Claves:PNPLA3, Hepatocellular carcinoma, Non-alcoholic steatohepatitis, Prognosis, Single nucleotide polymorphisms
institución:(a) Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, No 90, Cumarathunga Munidasa Mawatha, Colombo 03, Sri Lanka. (b) Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, No 90, Cumarathunga Munidasa Mawatha, Colombo 03, Sri Lanka. sudeshi@ibmbb.cmb.ac.lk.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Potentially inappropriate medications for geriatric patients in Bahrain: prevalence, predictors, and implications for practice.
Potentially inappropriate medications for geriatric patients in Bahrain: prevalence, predictors, and implications for practice.
Fuente:Bmc Geriatrics
Extracto:
This study highlights the
significant burden of PIM use among older adult patients in Bahrain, with more
than half of the participants receiving at least one PIM. These findings
underscore the urgent need for targeted interventions, particularly among female
patients, those with chronic conditions such as diabetes mellitus, and patients
taking five or more medications. These insights contribute to the broader
understanding of geriatric pharmacotherapy and offer a foundation for policy
development aimed at optimizing medication safety in aging populations.
institución:(a) School of Medicine, RCSI Medical University of Bahrain, Busaiteen, Kingdom of Bahrain. (b) School of Medicine, RCSI Medical University of Bahrain, Busaiteen, Kingdom of Bahrain. 21204313@rcsi-mub.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar.
Prevalence of non-communicable disease and the associated factors among healthcare workers in Qatar.
Fuente:Bmc Primary Care
Extracto:
Over 30% of the newly hired HCWs had an NCD, with diabetes, thyroid
disease, and hypertension being most common. Higher prevalence was observed among
older staff, females, married individuals, and administrative workers. Targeted
workplace health programs are needed for early detection and prevention.
institución:(a) Preventive Medicine Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar. aaldahshan@hamad.qa. (b) Preventive Medicine Division, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Ranking of treatments in network meta-analysis: incorporating minimally important differences.
Ranking of treatments in network meta-analysis: incorporating minimally important differences.
Fuente:Bmc Medical Research Methodology
Tipo de trabajo:Metanálisis
Extracto:
Failure to consider MIDs when ranking treatments can lead to ranking
metrics which are not clinically relevant. Our proposed MID-adjusted Bayesian
ranking metrics address this challenge. Further, we show that the use of the
midpoint method for addressing ties ensures comparability between standard
ranking metrics and MID-adjusted ranking metrics. The methods are easily applied
in a Bayesian framework using the R package mid.nma.rank.
Claves:Clinically important differences, Indirect treatment comparisons, Minimal clinically important differences, Minimally important differences, Network meta-analysis, Ranking metrics
Cita:BMC Med Res Methodol 2025 Mar 10; 25 (1) : 67.
