Genome-wide profiling of angiogenic cis-regulatory elements unravels cis-regulatory SNPs for vascular abnormality.

Fuente:Scientific Data

Extracto: Altogether, this study generated a genome-wide bank of angiogenic cis-regulatory elements and illustrated its utility in identifying novel cis-regulatory SNPs for TAPVC, expanding new horizons of angiogenesis as well as vascular abnormality genetics.

Cita:Sci Data 2024 May 8; 11 (1) : 467.

Autor/es:Jin, Lihui (a)
Han, Zhenyuan (b)

institución:(a) Department of Pediatric Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, China. jinlh1995@sjtu.edu.cn.
(b) Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, 100081, China. zhenyuan_han@163.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41597-024-03272-6

Philadelphia chromosome-positive acute myeloid leukemia successfully treated by allogeneic hematopoietic stem cell transplantation

Fuente:Medicine

Tipo de trabajo:Revisión

Extracto: This case provided strong support for treating Ph + AML with allo-HSCT.

Cita:Medicine (Baltimore) 2024 May 10; 103 (19) : e38110.

Autor/es:Zhang, Zhichen (a)
Wang, Xuan (b)

institución:(a) Department of Hematology, The 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou, China.
(b) First School of Clinical Medicine, Ningxia Medical University, Yinchuan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038110

Serum urate levels and neurodegenerative outcomes

Fuente:Alzheimer's Research & Therapy

Tipo de trabajo:Estudio de cohortes

Extracto: Although the prospective cohort study demonstrated that elevated urate levels were associated with a reduced risk of neurodegenerative outcomes, MR analyses found no evidence of causality.

Claves:Alzheimer’s disease, Dementia, Mendelian randomization, Neurodegenerative-related deaths, Parkinson’s disease, Prospective cohort study, Urate

Cita:Alzheimers Res Ther 2024 May 11; 16 (1) : 106.

Autor/es:Zhang, Tingjing (a)
An, Yu (b)

institución:(a) School of Public Health, Wannan Medical College, Wuhu, China.
(b) Institutes of Brain Science, Wannan Medical College, Wuhu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01476-x

Faecal Volatile Organic Compound Analysis in De Novo Paediatric Inflammatory Bowel Disease by Gas Chromatography-Ion Mobility Spectrometry: A Case-Control Study.

Fuente:Sensors (basel, Switzerland)

Extracto: In conclusion, faecal VOC profiles of paediatric IBD patients differ significantly from those of CGIs.

Claves:faecal volatile organic compounds, gas chromatography–ion mobility spectrometry, paediatric inflammatory bowel disease

Cita:Sensors (Basel) 2024 Apr 25; 24 (9)

Autor/es:Vermeer, Eva (a)
Jagt, Jasmijn Z (b)

institución:(a) Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centre, 1105 AZ Amsterdam, The Netherlands.
(b) Amsterdam Gastroenterology Endocrinology Metabolism (AGEM) Research Institute, Amsterdam University Medical Centre, 1105 AZ Amsterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/s24092727

[Brain characteristics of transgender individuals and consequences of gender assignment treatment].

Fuente:Cuadernos de Bioetica Revista Oficial de la Asociacion Espanola de Bioetica y Etica Medica

Extracto: These rights must be recognized and demanded by the laws.

Cita:Cuad Bioet 2024 Jan-Apr; 35 (113) : 91-102.

Autor/es:López Moratalla, Natalia (a)
Calleja Canelas, Amparo (b)

institución:(a) Facultad de Ciencias de la Universidad de Navarra, Irunlarrea n.1, 31008 Pamplona natalialm@unav.es.
(b) Departamento de Endocrinología y Nutrición, Universidad de Navarra, Pamplona, España. acalleja@unav.es.

Formato:Informe impreso

Idioma:spa

País de fuente:España

Sitio web:http://dx.doi.org/10.30444/CB.168

The Phenotypic Variability Associated with Hepatocyte Nuclear Factor 1B Genetic Defects Poses Challenges in Both Diagnosis and Therapy.

The Phenotypic Variability Associated with Hepatocyte Nuclear Factor 1B Genetic Defects Poses Challenges in Both Diagnosis and Therapy.

Fuente:International Journal of Molecular Sciences

Extracto: Additionally, it underscores that complex clinical presentations may have a retrospectively straightforward explanation through the use of diverse genetic analytical tools.

Claves:cystic kidney disease, genetic variability, hepatic nuclear factor 1B (HNF1B), multiplex ligation-dependent probe amplification (MPLA), whole exome sequencing (WES)

Cita:Int J Mol Sci 2024 Apr 22; 25 (8)

Autor/es:Petrakis, Ioannis (a)
Sfakiotaki, Maria (b)

institución:(a) Department of Nephrology, University of Crete, 71500 Heraklion, Greece.
(b) Department of Endocrinology, University of Crete, 71500 Heraklion, Greece.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25084552

An Ultra-Rare Mixed Phenotype with Combined AP-4 and ERF Mutations

An Ultra-Rare Mixed Phenotype with Combined AP-4 and ERF Mutations

Fuente:Genes

Tipo de trabajo:Revisión

Extracto: Understanding these complex genotypes offers valuable insights into broader syndromic conditions, facilitating comprehensive patient management.

Claves:AP-4, AP-4 deficiency syndrome, ERF, ERF-related craniosynostosis, epilepsy, hereditary spastic paraparesis

Cita:Genes (Basel) 2024 Mar 29; 15 (4)

Autor/es:Orsini, Alessandro (a)
Santangelo, Andrea (b)

institución:(a) Pediatric Neurology, Pediatric Department, AOUP Santa Chiara Hospital, 56100 Pisa, Italy.
(b) Pediatric Neurology, Pediatric Department, AOUP Santa Chiara Hospital, 56100 Pisa, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/genes15040436

A Simplified Screening Model to Predict the Risk of Gestational Diabetes Mellitus in Caucasian and Latin American Pregnant Women.

Fuente:Genes

Extracto: In conclusion, adding genetic variants enhanced the prediction model of GDM risk in CAU and LAT pregnant women.

Claves:Caucasian, Latin American, age, body mass index, fasting plasma glucose, gestational diabetes mellitus, single-nucleotide polymorphisms, women

Cita:Genes (Basel) 2024 Apr 11; 15 (4)

Autor/es:Arnoriaga-Rodríguez, María (a)
Serrano, Irene (b)

institución:(a) Endocrinology and Nutrition Department, Hospital Clínico Universitario San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
(b) Unidad de Apoyo a la Investigación, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Biomedical Research Networking Center in Cancer (CIBERONC), 28040 Madrid, Spain.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/genes15040482

22q11.2 Deletion Syndrome: Influence of Parental Origin on Clinical Heterogeneity.

Fuente:Genes

Extracto: Further studies with larger samples focusing on these specific features could corroborate these findings.

Claves:22q11.2 deletion syndrome, clinical heterogeneity, genomic imprinting, parental origin

Cita:Genes (Basel) 2024 Apr 21; 15 (4)

Autor/es:de Wallau, Melissa Bittencourt (a)
Xavier, Ana Carolina (b)

institución:(a) Medical Genetics and Genomic Medicine, Department of Translational Medicine, School of Medical Sciences, State University of Campinas, Campinas 13083-887, São Paulo, Brazil.
(b) Centrinho Prefeito Luiz Gomes, Joinville 89203-020, Santa Catarina, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/genes15040518

Effects of Different Types of Intermittent Fasting Interventions on Metabolic Health in Healthy Individuals (EDIF)

Effects of Different Types of Intermittent Fasting Interventions on Metabolic Health in Healthy Individuals (EDIF)

Fuente:Nutrients

Tipo de trabajo:Estudio aleatorizado

Extracto: However, adherence to the specific fasting protocols remains challenging even for the healthy population.

Claves:anthropometry, body mass index, metabolism, time-restricted feeding, weight loss

Cita:Nutrients 2024 Apr 10; 16 (8)

Autor/es:Herz, Daniel (a)
Karl, Sebastian (b)

institución:(a) Division of Exercise Physiology and Metabolism, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.
(b) Division of Exercise Physiology and Metabolism, BaySpo-Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081114

Comparative Study of Healthy Older and Younger Adults Shows They Have the Same Skin Concentration of Vitamin D(3) Precursor, 7-Dehydrocholesterol, and Similar Response to UVR.

Fuente:Nutrients

Extracto: This information assists public health guidance on sun exposure/vitamin D nutrition, with particular relevance to the growing populations of healthy ambulant adults ≥65 years.

Claves:7-dehydrocholesterol, elderly, photobiology, skin, ultraviolet radiation, vitamin D

Cita:Nutrients 2024 Apr 12; 16 (8)

Autor/es:Borecka, Oktawia (a)
Dutton, John J (b)

institución:(a) Department of Earth and Environmental Sciences, Faculty of Science and Engineering, University of Manchester, Manchester M13 9PL, UK.
(b) Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PL, UK.

Conflicto:None relevant. A.R.W. acknowledges non-personal funding for unrelated UV equipment characterisation from Signify, Philips (the Netherlands), and for unrelated vitamin D advice from the Walgreen Boots Alliance (UK).

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081147

The Effectiveness of a Lactobacilli-Based Probiotic Food Supplement on Bone Mineral Density and Bone Metabolism in Australian Early Postmenopausal Women: Protocol for a Double-Blind Randomized Placebo-Controlled Trial.

Fuente:Nutrients

Extracto: The trial is registered with Australian New Zealand Clinical Trials Registry (ACTRN12621000810819).

Claves:bone mineral density, gut microbiota, lactobacillus, postmenopausal women, probiotics, study protocol

Cita:Nutrients 2024 Apr 12; 16 (8)

Autor/es:Resciniti, Stephanie M (a)
Biesiekierski, Jessica R (b)

institución:(a) Department of Food, Nutrition and Dietetics, La Trobe University, Bundoora, VIC 3086, Australia.
(b) Department of Food, Nutrition and Dietetics, La Trobe University, Bundoora, VIC 3086, Australia.

Conflicto:This research was funded by Probi. The funder had no role in the study design, data collection, analysis, nor interpretation of results.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081150

Mendelian Randomization Analysis Identifies Inverse Causal Relationship between External Eating and Metabolic Phenotypes.

Fuente:Nutrients

Extracto: Our findings suggest that eating patterns impact both anthropometric and metabolic traits.

Claves:DEBQ, Mendelian randomization, eating behaviour, genetic predictors

Cita:Nutrients 2024 Apr 13; 16 (8)

Autor/es:Timasheva, Yanina (a)
Balkhiyarova, Zhanna (b)

institución:(a) Institute of Biochemistry and Genetics, Ufa Federal Research Centre of Russian Academy of Sciences, Ufa 450054, Russia.
(b) Department of Medical Genetics and Fundamental Medicine, Bashkir State Medical University, Ufa 450008, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081166

Evaluation of Arsenic and Cobalt Levels in Pediatric Patients Receiving Long-Term Parenteral Nutrition.

Fuente:Nutrients

Extracto: In conclusion, children receiving LPN are not exposed to As, and even though the concentrations of Co in serum and urine were higher in the LPN group than in the healthy controls, neither trace element poses a health threat to children requiring LPN.

Claves:arsenic, children, cobalt, parenteral nutrition, trace elements

Cita:Nutrients 2024 Apr 16; 16 (8)

Autor/es:Romanowska, Hanna (a)
Wilk, Aleksandra (b)

institución:(a) Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Developmental Age, Pomeranian Medical University, 71-252 Szczecin, Poland.
(b) Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081179

Sodium and Human Health: What Can Be Done to Improve Sodium Balance beyond Food Processing?

Fuente:Nutrients

Extracto: In conclusion, a reduction in sodium intake, an improvement in body functioning, and educational interventions promoting healthy eating behaviours seem to be essential for the optimal regulation of sodium balance.

Claves:appetite, blood pressure, cardiometabolic, eating behaviour, fitness, obesity, salt

Cita:Nutrients 2024 Apr 18; 16 (8)

Autor/es:Tremblay, Angelo (a)
Gagné, Marie-Pascale (b)

institución:(a) Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, QC G1V 0A6, Canada.
(b) Institute of Nutrition and Functional Foods, Université Laval, Québec, QC G1V 0A6, Canada.

Conflicto:There is no conflict of interest to report about the preparation of this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081199

A Prospective, Observational Study of the Effect of a High-Calorie, High-Protein Oral Nutritional Supplement with HMB in an Old and Malnourished or at-Risk-of-Malnutrition Population with Hip Fractures: A FracNut Study.

Fuente:Nutrients

Extracto: The administration of HC-HP-HMB-ONS markedly enhanced nutritional status and biochemical parameters in older hip-fracture patients, with high compliance and tolerability. Both patients and healthcare professionals expressed satisfaction with HC-HP-HMB-ONS.

Claves:ONS-beta-hydroxy-beta-methylbutyrate, hip fracture, malnutrition

Cita:Nutrients 2024 Apr 19; 16 (8)

Autor/es:Pareja Sierra, Teresa (a)
Hünicken Torrez, Flavia Lorena (b)

institución:(a) Department of Geriatrics, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
(b) Department of Geriatrics, Healthcare Complex of Ávila, 05071 Ávila, Spain.

Conflicto:Authors M.C.R. and A.M.A. work at Abbott Laboratories. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Abbott Laboratories.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16081223

Plasma Lipidomic Profiles in cART-Treated Adolescents with Perinatally Acquired HIV Compared to Matched Controls.

Plasma Lipidomic Profiles in cART-Treated Adolescents with Perinatally Acquired HIV Compared to Matched Controls.

Fuente:Viruses

Extracto: Further research on the influence of cART on lipid composition could further identify these alterations.

Claves:cardiovascular disease, combination antiretroviral therapy, human immunodeficiency virus, lipid profiles, lipidomics

Cita:Viruses 2024 Apr 9; 16 (4)

Autor/es:van der Post, Julie (a)
Guerra, Thiara E J (b)

institución:(a) Department of Pediatric Infectious Diseases, Amsterdam UMC, Location Academic Medical Center, University of Amsterdam, 1100 DD Amsterdam, The Netherlands.
(b) Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/v16040580

Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages.

Imeglimin attenuates NLRP3 inflammasome activation by restoring mitochondrial functions in macrophages.

Fuente:Journal of Pharmacological Sciences

Extracto: These results suggest that imeglimin could be a promising new anti-inflammatory agent for treating diabetic complications.

Claves:Imeglimin, Inflammasome, Mitochondrial permeability transition pore (mPTP), Reactive oxygen species (ROS), THP-1 cells

Cita:J Pharmacol Sci 2024 Jun; 155 (2) : 35-43.

Autor/es:Lee, Ji Yeon (a)
Kang, Yup (b)

institución:(a) Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.
(b) Department of Physiology, Ajou University School of Medicine, Suwon, 16499, Republic of Korea.

Conflicto:Declaration of competing interest The authors declare that there is no conflict of interest regarding the publication of this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.1016/j.jphs.2024.03.004

Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes.

Effect of metformin and metformin/linagliptin on gut microbiota in patients with prediabetes.

Fuente:Scientific Reports

Extracto: GM is partially associated with these improvements since the SEM models suggest a weak association between specific bacterial genera and improvements in IS and Pβf.

Claves:Gut microbiota, Insulin resistance, Linagliptin/metformin, Metformin, Pancreatic β-cell function

Cita:Sci Rep 2024 Apr 27; 14 (1) : 9678.

Autor/es:Estrella, Martínez-López Yoscelina (a)
Daniel, Neri-Rosario (b)

institución:(a) Human Systems Biology Laboratory. Instituto Nacional de Medicina Genómica (INMEGEN), México City, Mexico.
(b) Programa de Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, Mexico.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60081-y

Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes

Diverse impacts of female chromosomal polymorphisms on assisted reproduction outcomes

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Estudio de cohortes

Extracto: Our research unravels the diverse impacts of various FCPs on IVF/ICSI outcomes, highlighting the detrimental effects of FCPs on oocyte maturation and the risk of preterm birth.

Claves:Assisted reproduction, Chromosomal abnormalities, IVF/ICSI outcome, Infertility, Oocyte quality

Cita:BMC Pregnancy Childbirth 2024 Apr 27; 24 (1) : 331.

Autor/es:Lu, Yongjie (a)
Tian, Tian (b)

institución:(a) State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
(b) National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06532-w