Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.

Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.

Fuente:European Journal of Medical Research

Tipo de trabajo:Estudio de cohortes

Extracto: Low ABI is independently associated with higher cardiovascular mortality in NAFLD cases. This correlation remains significant even in the absence of pre-existing cardiovascular disease or diabetes.

Claves:Ankle–brachial index, Mortality, Nonalcoholic fatty liver disease

Cita:Eur J Med Res 2024 May 9; 29 (1) : 276.

Autor/es:Xiong, Guang (a)
Guo, Liuqing (b)

institución:(a) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.
(b) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40001-024-01878-5

Resilient Older Subjects with Heterozygous Familial Hypercholesterolemia, Baseline Differences and Associated Factors.

Resilient Older Subjects with Heterozygous Familial Hypercholesterolemia, Baseline Differences and Associated Factors.

Fuente:International Journal of Molecular Sciences

Extracto: Lp(a) and the presence of ≥3 risk factors were associated with the presence of ACVD.

Claves:cardiovascular disease, heterozygous familial hypercholesterolemia, high-density lipoprotein cholesterol, lipoprotein(a), older, resilient

Cita:Int J Mol Sci 2024 Apr 29; 25 (9)

Autor/es:Climent, Elisenda (a)
González-Guerrero, Antón (b)

institución:(a) Lipid and Vascular Risk Unit, Department of Endocrinology and Nutrition, Hospital del Mar, 08003 Barcelona, Spain.
(b) School of Medicine, Universitat Pompeu Fabra, 08003 Barcelona, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094831

A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.

Fuente:International Journal of Molecular Sciences

Extracto: There were progressive eGFR decrements for PCOS-nonGH, PCOS-GH, and PCOS-SGH in the follow-up period which, in the presence of additional factors affecting renal function, may be clinically important in the development of CKD in PCOS.

Claves:complement protein, glomerular filtration rate, hyperfiltration, inflammation, polycystic ovarian syndrome

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Butler, Alexandra E (a)
Lubbad, Walaa (b)

institución:(a) Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen, Adliya P.O. Box 15503, Bahrain.
(b) Research Department, Royal College of Surgeons in Ireland Bahrain, Busaiteen, Adliya P.O. Box 15503, Bahrain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094899

JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: Hence, JMJD6 autoantibodies may reflect inflammation, thereby serving as a potential biomarker for diagnosing specific inflammation-related diseases, including stroke, AMI, DM, and cancers, and for prediction of the prognosis in patients with EC.

Claves:JMJD6, acute myocardial infarction, atherosclerosis, autoantibody, diabetes mellitus, esophageal cancer, inflammation, ischemic stroke

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Zhang, Bo-Shi (a)
Zhang, Xiao-Meng (b)

institución:(a) Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
(b) Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Conflicto:This present study was performed in collaboration with Fujikura Kasei Co., Ltd., and Hideyuki Kuroda is an employee of Fujikura Kasei Co., Ltd. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094935

Managing Undernutrition in Pediatric Oncology

Managing Undernutrition in Pediatric Oncology

Fuente:Nutrients

Tipo de trabajo:Consenso

Extracto: This consensus statement establishes a standardized approach to nutritional support, aiming to optimize outcomes in pediatric cancer patients.

Claves:childhood cancer, nutrition, nutritional support

Cita:Nutrients 2024 Apr 28; 16 (9)

Autor/es:Budka-Chrzęszczyk, Agnieszka (a)
Szlagatys-Sidorkiewicz, Agnieszka (b)

institución:(a) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland.
(b) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091327

The Impact of a Nutritional Intervention on Glycemic Control and Cardiovascular Risk Markers in Type 2 Diabetes.

Fuente:Nutrients

Tipo de trabajo:Estudio clínico

Extracto: The individualized nutritional intervention improved eating habits, anthropometric, biochemical, and cardiovascular markers in T2D over 12 months, with sustained results during follow-up. The dietary plan inspired by the Mediterranean and DASH diets demonstrated good adaptation to the Brazilian food culture and the patients' socioeconomic contexts. Consistent monitoring and personalized nutritional management are essential for optimizing long-term outcomes. However, more clinical trials are necessary in order to optimize the level of evidence for longitudinal interventions.

Claves:DASH diet, HDL cholesterol, LDL cholesterol, Type 2 diabetes mellitus, blood glucose, blood pressure, cardiovascular risk markers, hemoglobin glycated, mediterranean diet, nutritional intervention, personalized nutrition, total cholesterol, triglycerides, weight

Cita:Nutrients 2024 May 1; 16 (9)

Autor/es:Minari, Tatiana Palotta (a)
Manzano, Carolina Freitas (b)

institución:(a) Department of Hypertension, State Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.
(b) Department of Hypertension, State Faculty of Medicine of São José do Rio Preto (FAMERP), São José do Rio Preto 15090-000, SP, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091378

Effects of Dietary Carbohydrate Concentration and Glycemic Index on Blood Glucose Variability and Free Fatty Acids in Individuals with Type 1 Diabetes.

Fuente:Nutrients

Extracto: Different diets may increase the risk of cardiovascular diseases by affecting GI, FFA, and blood glucose levels.

Claves:carbohydrate, free fatty acid, glycemic index, glycemic load, glycemic variability, type 1 diabetes

Cita:Nutrients 2024 May 2; 16 (9)

Autor/es:Seckiner, Selda (a)
Bas, Murat (b)

institución:(a) Department of Nutrition and Dietetics, Faculty of Health Sciences, İstanbul Beykent University, Istanbul 34520, Turkey.
(b) Institute of Health Sciences, Acibadem Mehmet Ali Aydınlar University, Istanbul 34450, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091383

Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity.

Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity.

Fuente:Scientific Reports

Tipo de trabajo:Estudio abierto

Extracto: Perirenal fat should be considered as a potential target for cardiovascular dapaglifozin beneficial effects.

Claves:Cardiovascular risk, Dapaglifozin, Metabolic syndrome, Metformin, Omental fat, Perirenal fat, Preperitoneal fat, Ultrasound

Cita:Sci Rep 2024 May 11; 14 (1) : 10832.

Autor/es:Cuatrecasas, Guillem (a)
De Cabo, Francisco (b)

institución:(a) CP Endocrinologia SLP, 08037, Barcelona, Spain. gcuatrecasas@cpen.cat.
(b) Center for Obesity Management EASO, Clinica Sagrada Familia, Barcelona, Spain. gcuatrecasas@cpen.cat.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61590-6

Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups.

Pubertal Timing Across Asian American, Native Hawaiian, and Pacific Islander Subgroups.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: In this cohort study of Asian American, Native Hawaiian, and Pacific Islander children and adolescents, pubertal timing varied considerably across ethnic subgroups. Further investigation is warranted to assess whether these differences contribute to observed health disparities in adulthood, such as type 2 diabetes and cardiovascular diseases.

Cita:JAMA Netw Open 2024 May 1; 7 (5) : e2410253.

Autor/es:Kubo, Ai (a)
Acker, Julia (b)

institución:(a) Kaiser Permanente Division of Research, Oakland, California.
(b) School of Public Health, University of California, Berkeley.

Conflicto:Conflict of Interest Disclosures: Dr Kubo reported receiving grants from the National Institute of Mental Health, National Institutes of Health (NIH), during the conduct of the study. Ms Aghaee reported receiving grants from the NIH during the conduct of the study. Dr Kushi reported receiving grants from the NIH during the conduct of the study. Dr Quesenberry reported receiving grants... from the NIH during the conduct of the study. Dr Kanaya reported receiving grants from the NIH during the conduct of the study. Dr. Deardorff reported receiving grants from the NIH during the conduct of the study. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.10253

Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns.

Fuente:Medical Science Monitor International Medical Journal of Experimental and Clinical Research

Extracto: The evaluation of TIMPs in the early stage after burn injury has potential benefits. The important roles of urine TIMP-1 and serum TIMP-3, as novel markers of the risk of AKI development, were confirmed. Other parameters require further analysis.

Cita:Med Sci Monit 2024 May 6; 30 : e943500.

Autor/es:Klimm, Wojciech (a)
Szamotulska, Katarzyna (b)

institución:(a) Department of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
(b) Department of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.12659/MSM.943500

Identification and Economic Evaluation of Differentiated Thyroid Cancer Care Consumption Patterns Using Sequence Analysis.

Fuente:International Journal of Public Health

Extracto: Conclusion: The study underscores the increased costs of managing DTC, shaped by consumption habits and socioeconomic position, emphasising the need for more nuanced DTC management strategies.

Claves:care consumption patterns, clustering, costs, differentiated thyroid cancer, optimal matching

Cita:Int J Public Health 2024; 69 : 1606664.

Autor/es:Demeulemeester, Romain (a)
Grosclaude, Pascale (b)

institución:(a) Unité d'Evaluation Médico-Economique, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
(b) Unité Mixte de Recherche1295 Centre d'Epidémiologie et de Recherche en Santé des Populations (CERPOP), Toulouse, France.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/ijph.2024.1606664

The Association of Micro-RNA 21 and Hypertension

Fuente:Global Heart

Tipo de trabajo:Metanálisis

Extracto: Further high-quality studies are needed to better support the association between miR-21 and hypertension.

Claves:hypertension, meta-analysis, micro-RNA 21

Cita:Glob Heart 2024; 19 (1) : 41.

Autor/es:Xin, Caihong (a)
He, Wei (b)

institución:(a) Department of Endocrinology and Metabolism, The Fourth People's Hospital of Shenyang, Shenyang, P.R. China.
(b) Department of Endocrinology and Metabolism, People's Hospital of Liaoning Province, Shenyang, P.R. China.

Conflicto:The authors have no competing interests to declare.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.5334/gh.1325

General internal medicine: acquiring clinical acumen from bedside to front door with opportunities for undergraduate and postgraduate training.

Fuente:British Journal of Hospital Medicine (london, England 2005)

Extracto: As we strive relentlessly while working on the ward at the bedside and in acute portals, we ought to remind ourselves of what are the attractions of general internal medicine and lead by example for the undergraduates and postgraduate doctors in training who see us as role models for doing clinical medicine, teaching, training and research.

Claves:Bed pressures, Discharges, General medicine, Medical registrar, Teaching, Training

Cita:Br J Hosp Med (Lond) 2024 Apr 30; 85 (4) : 1-4.

Autor/es:Bed pressures, Discharges, General medicine, Medical registrar, Teaching, Training

institución:Bed pressures, Discharges, General medicine, Medical registrar, Teaching, Training

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.12968/hmed.2024.0002

Efficacy of multivitamin support following bariatric surgery in patients with obesity: a prospective observational study.

Fuente:Eating and Weight Disorders Ewd

Tipo de trabajo:Estudio clínico

Extracto: Following VSG or RYGB, Bariatrifast administration was associated with normal values of essential micronutrients, and it was well-tolerated without evidence of gastrointestinal side effects. Clinical Trial Registration ClinicalTrials.gov, identifiers NCT06152965.

Claves:Bariatric surgery, Micronutrients, Multivitamin support, Obesity

Cita:Eat Weight Disord 2024 May 7; 29 (1) : 34.

Autor/es:Basolo, Alessio (a)
Bechi Genzano, Susanna (b)

institución:(a) Obesity and Lipodystrophy Center, Endocrinology Unit, University Hospital of Pisa, 56124, Pisa, Italy.
(b) Obesity and Lipodystrophy Center, Endocrinology Unit, University Hospital of Pisa, 56124, Pisa, Italy.

Conflicto:J.V., R.J., V.A., C.L. have received reimbursement for attending symposia from BIOITALIA S.r.l. The other authors declare no conflict of interest. The sponsor had no role in the collection, analyses, or interpretation of data, and in writing the manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40519-024-01655-7

An interdisciplinary integrated specialized one-stop outpatient clinic for idiopathic intracranial hypertension - an assessment of sick leave, presenteeism, and health care utilization.

Fuente:The Journal of Headache and Pain

Tipo de trabajo:Estudio de cohortes

Extracto: Interdisciplinary integrated management significantly improves the burden of IIH in terms of sick leave, presenteeism and healthcare consultations - particularly in socioeconomically underprivileged patient groups.

Claves:Economic, Idiopathic intracranial hypertension, Management, Neurology, Neuroophthalmology, One-stop outpatient clinic, Outcome, Presenteeism

Cita:J Headache Pain 2024 May 7; 25 (1) : 73.

Autor/es:Bsteh, Gabriel (a)
Macher, Stefan (b)

institución:(a) Department of Neurology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. gabriel.bsteh@meduniwien.ac.at.
(b) Comprehensive Center for Clinical Neurosciences & Mental Health, Medical University of Vienna, Vienna, Austria. gabriel.bsteh@meduniwien.ac.at.

Conflicto:Gabriel Bsteh: has participated in meetings sponsored by, received speaker honoraria or travel funding from Biogen, Celgene/BMS, Lilly, Merck, Novartis, Roche, Sanofi-Genzyme and Teva, and received honoraria for consulting Biogen, Celgene/BMS, Merck, Novartis, Roche, Sanofi-Genzyme and Teva. He has received unrestricted research grants from Celgene/BMS and Novartis. Stefan Macher: declares no conflict of interest relevant to this study. Nik Krajnc:... has participated in meetings sponsored by, received speaker honoraria or travel funding from Alexion, BMS/Celgene, Janssen-Cilag, Merck, Novartis, Roche and Sanofi-Genzyme and held a grant for a Multiple Sclerosis Clinical Training Fellowship Programme from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). Wolfgang Marik: declares no conflict of interest relevant to this study. Martin Michl: declares no conflict of interest relevant to this study. Nina Müller: declares no conflict of interest relevant to this study. Sina Zaic: declares no conflict of interest relevant to this study. Jürgen Harreiter: declares no conflict of interest relevant to this study. Klaus Novak: declares no conflict of interest relevant to this study. Christian Wöber: has received honoraria consultancy/speaking from Apomedica, Curelator, Eli Lilly, Grünenthal, Hermes, Lundbeck, Novartis, Pfizer, Ratiopharm/Teva, and Stada. Berthold Pemp: has received honoraria for consultancy/speaking from Chiesi, GenSight, Novartis and Santen.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s10194-024-01780-9

Ovarian response to controlled stimulation and its predictors in a limited-resource setting.

Fuente:Bmc Women's Health

Extracto: Only two-thirds of our patients achieved a good ovarian response. Induction duration, AMH concentration, and AFC were found to be predictors, with the AFC being the strongest predictor. Therefore, the AFC should be performed on all of our patients, and the AMH is selectively employed. Future research must verify the best cutoff points and investigate additional factors affecting ovarian response.

Claves:Controlled stimulation, Ethiopia, Ovarian response, Predictors

Cita:BMC Womens Health 2024 May 7; 24 (1) : 279.

Autor/es:Dermolo, Munira (a)
Ansa, Meseret (b)

institución:(a) Department of Obstetrics and Gynecology, St.Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
(b) Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, St.Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12905-024-02991-7

Perceptions, attitudes, and behaviors among adolescents living with obesity, caregivers, and healthcare professionals in Italy: the ACTION Teens study.

Fuente:Eating and Weight Disorders Ewd

Extracto: In Italy, the impact of obesity on ALwO was underestimated by caregivers, and ALwO and HCPs had different perceptions of key weight-loss motivators and barriers. Additionally, the internet was a key information source for ALwO, which suggests new education/communication strategies are needed. LEVEL OF EVIDENCE: IV; Evidence obtained from multiple time series with/without intervention, e.g. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05013359.

Claves:Adolescents, Communication barriers, Obesity, Physician attitudes, Weight-loss motivators

Cita:Eat Weight Disord 2024 May 8; 29 (1) : 35.

Autor/es:Maffeis, Claudio (a)
Busetto, Luca (b)

institución:(a) Department of Surgery, Dentistry, Gynecology and Pediatrics, Section of Pediatric Diabetes and Metabolism, University of Verona, Verona, Italy. claudio.maffeis@univr.it.
(b) Department of Medicine, University of Padova, Padova, Italy.

Conflicto:Claudio Maffeis received consultancy fees from Novo Nordisk for his role as a member of the ACTION Teens Steering Committee during the conduct of the study; he also reports honoraria (for lectures) from Aboca, Eli Lilly, Novo Nordisk, Roche, and Sanofi, and participation in advisory boards for Abbott, Eli Lilly, Medtronic, and Sanofi outside the submitted work. Luca Busetto reports... honoraria (for lectures) from PronoKal and Rhythm Pharmaceuticals, and participation in advisory boards for Bruno Farmaceutici, Eli Lilly, Novo Nordisk, and Pfizer outside the submitted work. Malgorzata Wasniewska is a consultant for Merck, Novo Nordisk, Pfizer, and Sandoz. Daniele Di Pauli and Andrea Lenzi have no relevant financial/non-financial interests to disclose. Carla Maccora is a permanent employee of Novo Nordisk.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1007/s40519-024-01663-7

Cancer Health Literacy and Its Correlated Factors in the United Arab Emirates-A Cross Sectional Study.

Fuente:Cancer Control Journal of The Moffitt Cancer Center

Extracto: CHL among the resident UAE population was moderately adequate, therefore implementation of awareness campaigns seems to be warranted. Moreover, evaluation research targeting the CHL impact on cancer prevention practices and screening is also advocated.

Claves:United Arab Emirates, cancer health literacy, cancer screening, health literacy, knowledge

Cita:Cancer Control 2024 Jan-Dec; 31 : 10732748241248032.

Autor/es:Elbarazi, Iffat (a)
Aziz, Faisal (b)

institución:(a) Institute of Public Health, College of Medicine and Health Science, United Arab Emirates University, Al Ain, United Arab Emirates. RINGGOLD: 11239
(b) Interdisciplinary Metabolic Medicine Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria. RINGGOLD: 31475

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/10732748241248032

A High Fibrosis-4 Index is Associated with a Reduction in the Estimated Glomerular Filtration Rate in Non-obese Japanese Patients with Type 2 Diabetes Mellitus.

Fuente:The Kobe Journal of Medical Sciences

Extracto: Our findings may enable the more appropriate treatment of T2DM patients based on BMI level.

Claves:Estimated glomerular filtration rate, Fibrosis-4 index, Non-obese patients, Type 2 diabetes

Cita:Kobe J Med Sci 2024 Apr 30; 70 (1) : E39-E45.

Autor/es:Inoue, Hiroyuki (a)
Asahara, Shun-Ichiro (b)

institución:(a) Clinical Laboratory, Nara Prefecture General Medical Center, Nara, Japan.
(b) Division of Medical Chemistry, Department of Metabolism and Diseases, Kobe University Graduate School of Health Sciences, Kobe, Japan.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Japón

Sitio web:http://dx.doi.org/10.24546/0100489395

Comparative effectiveness of second line oral antidiabetic treatments among people with type 2 diabetes mellitus: emulation of a target trial using routinely collected health data.

Fuente:Bmj (clinical Research Ed.)

Extracto: This emulation study of a target trial found that SGLT-2 inhibitors were more effective than sulfonylureas or DPP-4 inhibitors in lowering mean HbA(1c), BMI, and systolic blood pressure and in reducing the hazards of hospital admission for heart failure (v DPP-4 inhibitors) and kidney disease progression (v sulfonylureas), with no evidence of differences in other clinical endpoints.

Cita:BMJ 2024 May 8; 385 : e077097.

Autor/es:Bidulka, Patrick (a)
Lugo-Palacios, David G (b)

institución:(a) Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK patrick.bidulka1@lshtm.ac.uk.
(b) Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Conflicto:Competing interests: All authors have completed the ICMJE uniform disclosure form at www.icmje.org/disclosure-of-interest/ and declare: support from the National Institute for Health and Care Research (NIHR). AIA receives salary from the NIHR Biomedical Research Centre via the Oxford Centre for Diabetes, Endocrinology and Metabolism. AB is an economic advisor on the DiRECT trial, with ongoing responsibility for economic analysis during... the long term follow-up phase. He serves as a consultant to Salutis Consulting on projects not related to diabetes. JWB has acted as a consultant to AstraZeneca, Bayer, Novartis, and Roche. DN is the UK Kidney Association Director of Informatics Research; she previously was involved in two GSK funded studies in sub-Saharan Africa unrelated to this work. PC sat on an NIHR Health Technology Assessment commissioning committee until September 2021. AHB has acted as consultant to several pharmaceutical companies within the past three years: AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Eli Lilly, Gilead, Idorsia, Novo Nordisk, Rhythm, Roche, and Sanofi. IJD has unrestricted research grants from and shares in GSK and a research grant from AstraZeneca. KK has acted as a consultant and speaker or received grants for investigator initiated studies for AstraZeneca, Bayer, Novartis, Novo Nordisk, Sanofi-Aventis, Lilly and Merck Sharp and Dohme, Boehringer Ingelheim, Oramed Pharmaceuticals, Roche, and Applied Therapeutics.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmj-2023-077097