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Autor/es:Pereyra, Pilar de Las Mercedes (a) Aciar, María de Los Ángeles (b)
institución:(a) Servicio de Endocrinología y Metabolismo, Hospital Público Materno Infantil de Salta, Salta, Argentina. E-mail: pilar_pereyra75@hotmail.com. (b) Servicio de Endocrinología y Metabolismo, Hospital Público Materno Infantil de Salta, Salta, Argentina.
2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima".
2023 Fukushima Medical University International Symposium on the Fukushima Health Management Survey, "Thinking Together about Health, Life, and our Future in Fukushima".
Fuente:Fukushima Journal of Medical Science
Extracto:
The fifth
annual symposium convened at FMU's Ekimae Campus on Saturday, 4 March 2023, with
the theme, "Thinking Together about Health, Life and our Future in Fukushima."
institución:(a) Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University School of Medicine. (b) Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University.
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells.
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells.
Fuente:Cell Death & Disease
Extracto:
Moreover,
transcriptomic analyses highlighted a novel subset of genes commonly modulated in
3D spheroids and potentially capable of driving ferroptosis protection in
LUAD-CSCs, thus allowing to better understand the mechanisms of CSC-mediated drug
resistance in tumors.
institución:(a) Translational Oncology Research Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. (b) Department of Clinical and Molecular Medicine, Sant' Andrea Hospital-Sapienza University of Rome, Rome, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department.
Diastolic/systolic blood pressure ratio for predicting febrile children with sepsis and progress to septic shock in the emergency department.
Fuente:Bmc Emergency Medicine
Tipo de trabajo:Revisión
Extracto:
The D/S ratio is a practical bedside scoring system in the PED and
had good discriminative ability in predicting the progression of septic shock and
in-hospital mortality in PED patients. Further validation is essential in other
settings.
institución:(a) Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. (b) Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Conflicto:CONFLICTS OF INTEREST No potential conflict of interest relevant to this article was reported.
[Interdisciplinary Management of Orbital Diseases].
[Interdisciplinary Management of Orbital Diseases].
Fuente:Laryngo- Rhino- Otologie
Extracto:
The authors tried to highlight the relevant facts despite the
shortness of the text.
Cita:Laryngorhinootologie 2024 May; 103 (S 01) : S43-S99.
Autor/es:Eckstein, A (a) Welkoborsky, H-J (b)
institución:Eckstein, A (a) Welkoborsky, H-J (b)
Conflicto:A. Eckstein erklärt: Vortragshonorare: Sanofi, Amgen,Sling. Mitarbeit an klinischen Studien: Amgen, Immunovant, Novartis.H.-J. Welboborsky war 2021-2022 Präsident der Deutschen Gesellschaft für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie.
Nongestational ovarian choriocarcinoma with bilateral teratoma
Nongestational ovarian choriocarcinoma with bilateral teratoma
Fuente:Medicine
Tipo de trabajo:Revisión
Extracto:
NGCO should be
considered if a female patient exhibits irregular vaginal bleeding and masses in
the adnexal area. The present case and our literature review also highlighted
that fertility-sparing surgery and multidrug chemotherapy are effective methods
for treating NGCO.
Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e36996.
Autor/es:Ao, Xue (a) Hu, Sha (b)
institución:(a) Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China. (b) Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
Conflicto:The authors have no funding and conflicts of interest to disclose.
AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.
AI identifies potent inducers of breast cancer stem cell differentiation based on adversarial learning from gene expression data.
Fuente:Briefings in Bioinformatics
Extracto:
In
particular, the efficacy of triptolide, OTS-167, quinacrine, granisetron and
A-443654 offer a potential avenue for targeted therapies against breast CSCs.
Claves:artificial intelligence, breast cancer, cancer stem cells, domain adaptation, drug repurposing, transcriptomics
institución:(a) Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955, Saudi Arabia. (b) Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, 23955, Saudi Arabia.
Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers
Prevalence of multidrug-resistant bacterial infections in diabetic foot ulcers
Fuente:International Wound Journal
Tipo de trabajo:Metanálisis
Extracto:
Our study also indicated that peripheral vascular disease,
peripheral neuropathy, nephropathy, osteomyelitis, Wagner's grade, previous
hospitalization, and previous use of antibacterial drugs were associated with MDR
bacterial infections in patients with DFUs.
institución:(a) Department of Endocrinology, The Bethune International Peace Hospital, Shijiazhuang, China. (b) Department of Endocrinology, The Bethune International Peace Hospital, Shijiazhuang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Factors associated with venous collaterals in patients with cerebral venous thrombosis.
Factors associated with venous collaterals in patients with cerebral venous thrombosis.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
In this cohort, the prevalence of venous collaterals was 25.3%.
Occlusion in the superior sagittal sinus and hormonal exposure were independently
associated with venous collaterals in patients with cerebral venous thrombosis.
institución:(a) Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand. (b) Division of Neuroradiology, Department of Radiology, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla, Thailand.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The influence of diagnostic subgroups, patient- and hospital characteristics for the validity of cardiovascular diagnoses-Data from a Norwegian hospital trust.
The influence of diagnostic subgroups, patient- and hospital characteristics for the validity of cardiovascular diagnoses-Data from a Norwegian hospital trust.
Fuente:Plos One
Extracto:
The diagnoses of acute myocardial infarction
and stroke had excellent validity when placed during hospital stays. Similarly,
heart failure diagnoses had excellent validity when echocardiography was
performed before placing the diagnosis, while overall the diagnoses of heart
failure and transient ischemic attack were less valid. In conclusion, the results
indicate that cardiovascular diagnoses based on objective findings such as acute
myocardial infarction and stroke have excellent validity and may be used as
endpoints in clinical epidemiological studies with less rigid validation.
Cita:PLoS One 2024; 19 (4) : e0302181.
Autor/es:Rye, Cathrine Sæthern (a) Ofstad, Anne Pernille (b)
institución:(a) Department of Medicine, Namsos Hospital, Nord-Trøndelag Hospital Trust, Namsos, Norway. (b) Clinic of Cardiology, St. Olavs University Hospital, Trondheim, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes
Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes
Fuente:Bmj Open
Tipo de trabajo:Estudio de cohortes
Extracto:
These
findings suggest that dual or triple therapies of evogliptin for the management
of type 2 diabetes in routine clinical practice present no cardiovascular harms,
but could alternatively offer cardiovascular benefits in this patient population.
institución:(a) School of Pharmacy, Sungkyunkwan University, Suwon, South Korea. (b) Research Department of Practice and Policy, School of Pharmacy, University College London, London, UK.
Conflicto:Competing interests: HEJ and I-SO report the receipt of research funding from the National Research Foundation of South Korea, outside the submitted work. J-YS reports the receipt of research funding from the Ministry of Food and Drug Safety, Ministry of Health and Welfare, National Research Foundation and Government-wide R&D Fund for Infectious Disease Research of South Korea, as well as...
grants from Amgen, Pfizer, GSK and Yungjin, outside the submitted work. Authors disclose no other relevant potential conflicts of interest.
Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels.
Long-term trajectories of peak expiratory flow rate in older men and women show linear decline mainly determined by baseline levels.
Fuente:Aging Clinical and Experimental Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Trajectories in both men and women differ
mainly in baseline level of PEFR and not in rate of decline over time. Therefore,
one PEFR measurement might be sufficient to give an indication of the trajectory
that an older adult is likely to follow.
Autor/es:van Schoor, Natasja M (a) de Jongh, Renate T (b)
institución:(a) Epidemiology and Data Science, Amsterdam UMC Location Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. nm.vanschoor@amsterdamumc.nl. (b) Aging & Later Life, Amsterdam Public Health Research Institute, De Boelelaan 1117, Amsterdam, The Netherlands. nm.vanschoor@amsterdamumc.nl.
Conflicto:The authors declare that they do not have competing interests.
Comprehensive geriatric assessment of older patients with renal disease: a cross-sectional survey.
Comprehensive geriatric assessment of older patients with renal disease: a cross-sectional survey.
Fuente:Scientific Reports
Extracto:
Regression analysis revealed that the scores of activities of daily living
(P = 0.024), nutritional status (P = 0.000), total social support (P = 0.014),
and objective support (P = 0.000) decreased with a decline in renal function.
Cita:Sci Rep 2024 Apr 16; 14 (1) : 8758.
Autor/es:Chen, Xiaoyu (a) Hu, Yingchun (b)
institución:(a) Department of Nephropathy and Rheumatology Immunology, Jiulongpo People's Hospital, Chongqing, China. (b) Department of Cardiovascular, Nanfang Hospital, Southern Medical University, Guangzhou, China. yingchunh2013@163.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.
Percutaneous kyphoplasty through unilateral puncture on the convex side for the treatment of painful osteoporotic vertebral compression fracture with scoliosis.
Fuente:Bmc Musculoskeletal Disorders
Extracto:
Combining with the
proper assessment of the pre-injured life status of patients, PKP surgery using
unilateral puncture on the convex side for the treatment of P-OVCF with scoliosis
can achieve safe, excellent clinical, and radiographic outcomes.
institución:(a) Department of Clinical skills center, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China. (b) Department of Orthopedics Surgery, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, China. Jasewangspine@swmu.edu.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study.
Long-term effects of abatacept on atherosclerosis and arthritis in older vs. younger patients with rheumatoid arthritis: 3-year results of a prospective, multicenter, observational study.
Fuente:Arthritis Research & Therapy
Tipo de trabajo:Estudio abierto
Extracto:
ABT may decelerate
atherosclerosis progression and may be useful for patients with high risk of
cardiovascular disease, such as older patients. TRIAL REGISTRATION NUMBER:
UMIN000014913.
institución:(a) Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan. (b) Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
The double lesion detected by surgical exploration is
independently associated with a better prognosis for DPA patients. Comprehensive
intraoperative exploration are crucial measures to avoid missing causative
lesions.
institución:(a) Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China. (b) Eight-Year Program of Clinical Medicine, Peking Union Medical College, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Conflicto:The authors declare the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants.
Clinical phenotype of a Kallmann syndrome patient with IL17RD and CPEB4 variants.
Fuente:Frontiers in Endocrinology
Extracto:
Bioinformatics analysis shows that the IL17RD protein undergoing
Gly701Ser mutation and is speculated to be phosphorylated and modified, thereby
disrupting fibroblast growth factor signaling. This study also suggested that the
CPEB4 might play a crucial role in the key signaling process affecting olfactory
bulb morphogenesis. Overall, the findings of this study broaden the gene
expression profile of KS-related pathogenic genes. This offers a new avenue for
exploring the pathogenic mechanism of KS and provides valuable insights for
precise clinical diagnosis and treatment strategies for this condition.
institución:(a) Department of Pediatric Endocrinology and Genetics, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China. (b) Department of Pediatric Endocrinology and Genetics, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Anastrozole monotherapy further improves near-adult height after the initial combined treatment with leuprorelin and anastrozole in early-maturing girls with compromised growth prediction: results from the second phase of the GAIL study.
Anastrozole monotherapy further improves near-adult height after the initial combined treatment with leuprorelin and anastrozole in early-maturing girls with compromised growth prediction: results from the second phase of the GAIL study.
Fuente:Frontiers in Endocrinology
Extracto:
In early-maturing girls with
compromised growth potential, the combined treatment with leuprorelin and
anastrozole for 2 years or until the age of 11 years resulted in a total gain in
height of +9.7 cm when continuing anastrozole monotherapy until the attainment of
NAH, as opposed to +7.4 cm if they do not continue with the anastrozole
monotherapy and +3.6 cm when treated with leuprorelin alone. Thus, the combined
intervention ends at the shortest distance from the target height if continued
with anastrozole monotherapy until BA 14 years.
Autor/es:Papadimitriou, Dimitrios T (a) Dermitzaki, Eleni (b)
institución:(a) Department of Pediatrics, Faculty of Medicine, University of Thessaly, Larisa, Greece. (b) Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.