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Cardiac Biomarker Change at 1 Year After Tafamidis Treatment and Clinical Outcomes in Patients With Transthyretin Amyloid Cardiomyopathy.
Cardiac Biomarker Change at 1 Year After Tafamidis Treatment and Clinical Outcomes in Patients With Transthyretin Amyloid Cardiomyopathy.
Fuente:Journal of The American Heart Association
Extracto:
Deterioration in cardiac
biomarkers during the first year after tafamidis treatment predicted a worse
prognosis, suggesting the utility of serial assessment of cardiac biomarkers for
monitoring the therapeutic response to tafamidis in patients with wild-type
transthyretin amyloid cardiomyopathy.
Cita:J Am Heart Assoc 2024 May 21; 13 (10) : e034518.
Autor/es:Kuyama, Naoto (a) Takashio, Seiji (b)
institución:(a) Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan. (b) Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University Kumamoto Japan.
Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort.
Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort.
Fuente:Journal of The American Heart Association
Tipo de trabajo:Estudio de cohortes
Extracto:
Our findings posed the dynamic pattern
of brain parenchymal lesions related to DMVs injury, shedding light on the
interactions and chronological roles of various pathological mechanisms.
Claves:brain atrophy, deep medullary veins, longitudinal study, neurodegenerative disease, white matter microstructure
Cita:J Am Heart Assoc 2024 May 21; 13 (10) : e034145.
Autor/es:Liu, Zi-Yue (a) Wang, Pei (b)
institución:(a) Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China. (b) Department of Neurology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES)
ZOom Delivered Intervention Against Cognitive decline (ZODIAC) COVID-19 pandemic adaptations to the Post-Ischaemic Stroke Cardiovascular Exercise Study (PISCES)
Fuente:Trials
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
TRIAL REGISTRATION: Prospectively
ACTRN12616000942459. Registered on July 2016.
institución:(a) Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. amy.brodtmann@monash.edu. (b) The Florey, Melbourne, VIC, Australia. amy.brodtmann@monash.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
These
results reveal a new RNA-dependent etiologic mechanism by which SNVs can
influence gene expression and disease, consequently generating opportunities for
personalized, RNA-based therapeutics targeting these disorders.
institución:(a) Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA. (b) Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Genetic associations between Rapid Eye Movement (REM) sleep behavior disorder and cardiovascular diseases.
Genetic associations between Rapid Eye Movement (REM) sleep behavior disorder and cardiovascular diseases.
Fuente:Plos One
Extracto:
Our study highlighted the potential associations
between RBD and cardiovascular diseases at genetic level, including HF and MI.
More studies were required to clarify the biological mechanisms involved the
associations.
Cita:PLoS One 2024; 19 (5) : e0301112.
Autor/es:Xu, Pengfei (a) Wei, Yitong (b)
institución:(a) Department of Neurosurgery, Nanyang Central Hospital, Nanyang, Henan, China. (b) Department of Neurosurgery, Nanyang Central Hospital, Nanyang, Henan, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Deregulated miR-146a-3p alleviates disease progression in atherosclerosis through inactivating NF-?B: An experimental study.
Deregulated miR-146a-3p alleviates disease progression in atherosclerosis through inactivating NF-?B: An experimental study.
Fuente:Medicine
Extracto:
miR-146a-3p might inhibit inflammation by targeting
NF-κB in AS progression, and miR-146a-3p/ NF-κB might provide novel biomarkers
and therapeutic targets for the prevention of AS and related vascular events.
Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38061.
Autor/es:Tao, Taotao (a) Chen, Linkao (b)
institución:Tao, Taotao (a) Chen, Linkao (b)
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Paroxysmal sympathetic hyperexcitability after brain injury: A clinical analysis of case series.
Paroxysmal sympathetic hyperexcitability after brain injury: A clinical analysis of case series.
Fuente:Medicine
Extracto:
The etiology of PSH is complex. TBI may be the most
common cause of PSH. Non-TBI may also be an important cause of PSH. Therefore,
early identification, prevention and diagnosis are helpful for determining the
prognosis and outcome of the disease.
Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e35375.
Autor/es:Li, Xingru (a) Yang, Xinchen (b)
institución:(a) Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, China. (b) Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The effect of amantadine treatment on neurological outcome and mortality in mechanically ventilated severe head trauma patients in intensive care unit.
The effect of amantadine treatment on neurological outcome and mortality in mechanically ventilated severe head trauma patients in intensive care unit.
Fuente:Medicine
Extracto:
However, further research is needed to investigate this topic.
Cita:Medicine (Baltimore) 2024 May 17; 103 (20) : e38172.
Autor/es:Öner, Özlem (a) Hanci, Volkan (b)
institución:(a) Anesthesiologist and Intensivist Neuroscience, Dokuz Eylül University Faculty of Medicine Department of Anesthesiology and Reanimation, Subdivision of Critical Care Medicine, İzmir, Turkey. (b) Anesthesiologist and Intensivist, Dokuz Eylül University Faculty of Medicine Department of Anesthesiology and Reanimation, Subdivision of Critical Care Medicine, İzmir, Turkey.
Conflicto:The authors have no funding and conflicts of interest to disclose.
Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.
Glycolic acid and D-lactate-putative products of DJ-1-restore neurodegeneration in FUS - and SOD1-ALS.
Fuente:Life Science Alliance
Extracto:
Whereas these data point towards the necessity of individualized (gene-)
specific therapy stratification, it also suggests common therapeutic targets
across different neurodegenerative diseases characterized by mitochondrial
depolarization.
Cita:Life Sci Alliance 2024 Aug; 7 (8)
Autor/es:Pal, Arun (a) Grossmann, Dajana (b)
institución:(a) Division for Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany. (b) Dresden High Magnetic Field Laboratory (HLD-EMFL), Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.
Conflicto:A Hermann has received personal fees and non-financial support from Biogen and Desitin during the conduct of the study outside the submitted work. R Günther has received honoraria from Biogen as an advisory board member and for lectures and as a consultant and advisory board member from Hoffmann-La Roche. He also received travel expenses and research support from Biogen. F...
F Pan-Montojo has a patent on the use of glycolic acid and D-lactate as neuroprotective treatment for neurodegenerative disease. In addition, F Pan-Montojo is the CEO and CSO of Neurevo GmbH, a biotech company developing glycolic acid and D-lactate as neuroprotective treatments for several neurological diseases. INSTITUTIONAL REVIEW BOARD STATEMENT: The performed procedures were in accordance with the Declaration of Helsinki (WMA, 1964) and approved by the Ethical Committee of the Technische Universität Dresden, Germany (EK 393122012 and EK 45022009). INFORMED CONSENT STATEMENT: Written informed consent was obtained from all participants including for publication of any research results.
Integrated bioinformatics analysis for exploring potential biomarkers related to Parkinson's disease progression.
Integrated bioinformatics analysis for exploring potential biomarkers related to Parkinson's disease progression.
Fuente:Bmc Medical Genomics
Extracto:
We identified PD-related
molecular markers and ceRNA regulatory networks, providing new directions for PD
diagnosis and treatment.
Claves:Dopaminergic neurons, Hub genes, Parkinson, ceRNA network, circRNA, s disease
Cita:BMC Med Genomics 2024 May 17; 17 (1) : 133.
Autor/es:Huang, Zhenchao (a) Song, En'peng (b)
institución:(a) Department of Neurosurgery, Lingnan Hospital, Branch of The Third Affiliated Hospital of Sun Yat-Sen University, No 2693, Kaichuang Avenue, Huangpu District, Guangzhou, 510530, Guangdong, China. hzhench3@mail.sysu.edu.cn. (b) Department of Neurosurgery, Lingnan Hospital, Branch of The Third Affiliated Hospital of Sun Yat-Sen University, No 2693, Kaichuang Avenue, Huangpu District, Guangzhou, 510530, Guangdong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Genome-wide identification, classification and expression analysis of the heat shock transcription factor family in Garlic (Allium sativum L.).
Genome-wide identification, classification and expression analysis of the heat shock transcription factor family in Garlic (Allium sativum L.).
Fuente:Bmc Plant Biology
Extracto:
This study is the first to unravel and
analyze the AsHSF genes in garlic, thereby opening up new avenues for
understanding their functions. The insights gained from this research provide a
valuable resource for future investigations, particularly in the functional
analysis of AsHSF genes.
institución:(a) Institute of Neurobiology, Jining Medical University, Jining, China. (b) Institute of Biotechnology and Health, Beijing Academy of Science and Technology, Beijing, China. heshutao@bjast.ac.cn.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE)
Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE)
Fuente:Critical Care (london, England)
Tipo de trabajo:Estudio multicéntrico
Extracto:
Protocolized reduction
of non-resuscitation fluids in patients with septic shock resulted in a large
decrease in fluid administration compared with usual care. A trial using this
design to test if reducing non-resuscitation fluids improves outcomes is
feasible. TRIAL REGISTRATION: Clinicaltrials.gov, NCT05249088, 18 February 2022.
https://clinicaltrials.gov/ct2/show/NCT05249088.
institución:(a) Anesthesiology and Intensive Care, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. anja.linden.icu@gmail.com. (b) Department of Anesthesiology and Intensive Care, Helsingborg Hospital, Charlotte Yhléns Gata 10, 252 23, Helsingborg, Sweden. anja.linden.icu@gmail.com.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.
A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.
Fuente:Acta Neuropathologica Communications
Extracto:
Our findings provide new
insights into the molecular understanding of GBM progression at recurrence and
potential targets for therapeutic treatments.
Claves:Glioblastomas, Patient-matched longitudinal analysis, Prognostic model, Progression-free survival, Time to relapse
Cita:Acta Neuropathol Commun 2024 May 18; 12 (1) : 77.
Autor/es:Ho, Wei-Min (a) Chen, Chia-Ying (b)
institución:(a) Genomics Research Center, Academia Sinica, Taipei, Taiwan. (b) Ph.D. Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.
Conflicto:The authors declare that they do not have any competing interests.
Predictive value of Cmmi-MHR combined with thromboelastography parameters in acute cerebral infarction.
Predictive value of Cmmi-MHR combined with thromboelastography parameters in acute cerebral infarction.
Fuente:Bmc Medical Imaging
Extracto:
The conclusion indicates that the combination of Cmmi-MHR and
thromboelastography parameters provides a new perspective and method for the
diagnosis and treatment of cerebral infarction, and provides important support
for personalized treatment and management of cerebral infarction.
Claves:Acute cerebral infarction, High frame rate imaging, Monocyte to high-density lipoprotein ratio, Predictive value
Cita:BMC Med Imaging 2024 May 18; 24 (1) : 115.
Autor/es:Rao, Zhongxian (a) Tan, Wei (b)
institución:(a) Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China. (b) General Medicine, Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ?4-enriched cognitively unimpaired elderly.
Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE ?4-enriched cognitively unimpaired elderly.
Fuente:Alzheimer's Research & Therapy
Extracto:
Only increased serum NfL concentrations and decreased
hippocampal volume was observed in cognitively unimpaired APOEε4 homozygotes
compared to non-carriers. In the whole population the concentrations of blood
biomarkers were affected in distinct ways by different pathologies.
Claves:Alzheimer’s disease, Blood biomarkers, PET imaging
Cita:Alzheimers Res Ther 2024 May 18; 16 (1) : 112.
Autor/es:Koivumäki, Mikko (a) Ekblad, Laura (b)
institución:(a) Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland. mikkkoi@utu.fi. (b) Turku PET Centre, Turku University Hospital, University of Turku, Turku, Finland.
Conflicto:HZ has served at scientific advisory boards and/or as a consultant for Abbvie, Acumen, Alector, Alzinova, ALZPath, Annexon, Apellis, Artery Therapeutics, AZTherapies, CogRx, Denali, Eisai, Nervgen, Novo Nordisk, Optoceutics, Passage Bio, Pinteon Therapeutics, Prothena, Red Abbey Labs, reMYND, Roche, Samumed, Siemens Healthineers, Triplet Therapeutics, and Wave, has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure, Biogen, and Roche, and...
is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). KB has served as a consultant and at advisory boards for Acumen, ALZPath, BioArctic, Biogen, Eisai, Lilly, Moleac Pte. Ltd, Novartis, Ono Pharma, Prothena, Roche Diagnostics, and Siemens Healthineers; has served at data monitoring committees for Julius Clinical and Novartis; has given lectures, produced educational materials and participated in educational programs for AC Immune, Biogen, Celdara Medical, Eisai and Roche Diagnostics; and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program, outside the work presented in this paper.
Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study.
Prognostic factors and overall survival of breast cancer in Benin: a hospital-based study.
Fuente:Bmc Women's Health
Extracto:
Breast cancer in Beninese is predominant in young
adults and is often diagnosed at a late stage. The survival of breast cancer
patients in Benin can be improved by enhancing early diagnosis and
multidisciplinary management.
Claves:Benin, Breast cancer, Prognostic factors, Sub-saharan africa, Survival
institución:(a) Laboratory of Epidemiology of Chronic and Neurological Diseases, Lemacen, Cotonou, Benin. fredgnang@yahoo.fr. (b) Department of Visceral Surgery, National Teaching Hospital-Hubert Koutoukou Maga, CNHU-HKM, Cotonou, Benin. fredgnang@yahoo.fr.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Social Work, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. RINGGOLD: 26451 (b) Research Center for Neuropsychological Well-Being, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China. RINGGOLD: 26451
Conflicto:Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Tremor and other hyperkinetic movements (New York, N.Y.)
Selección SIIC: 23 Mayo, 2024
Tremor and other hyperkinetic movements (New York, N.Y.)
Validation of a New Patient-Reported Outcome Measure of the Functional Impact of Essential Tremor on Activities of Daily Living.
Validation of a New Patient-Reported Outcome Measure of the Functional Impact of Essential Tremor on Activities of Daily Living.
Fuente:Tremor and Other Hyperkinetic Movements (new York, N.y.)
Tipo de trabajo:Guía
Extracto:
TETRAS PRO is a valid and reliable
scale that is influenced strongly by tremor severity, moderately by mood
(depression), and minimally by coping skills. The MDC for TETRAS PRO is probably
sufficient to detect clinically important change.
Cita:Tremor Other Hyperkinet Mov (N Y) 2024; 14 : 26.
Autor/es:Shih, Ludy C (a) Stevenson, Michael T (b)
institución:(a) Beth Israel Deaconess Medical Center, Department of Neurology, Boston, MA 02215, US. (b) Harvard Medical School, Boston, MA 02215, US.
Conflicto:LCS receives consulting fees from Medtronic, WCG Medavante, and Encora Therapeutics, receives honoraria from Wiley for editorial work, and research grant funding from Praxis Precision Medicines and NIH. MTS is supported by research funds from Praxis, Biogen, and NIH. SB has served as site PI for clinical research trials funded by Sage and AbbVie. AF has stock ownership in Inbrain...
Pharma and has received payments as consultant and/or speaker from Abbvie, Abbott, Boston Scientific, Ceregate, Dompé Farmaceutici, Inbrain Neuroelectronics, Ipsen, Medtronic, Iota, Syneos Health, Merz. He has received research support from Abbvie, Boston Scientific, Medtronic, Praxis, ES and receives royalties from Springer. SHK receives consulting fees from Praxis, Sage, and Jazz. KEL is president of the International Essential Tremor Foundation. HM received consulting fees from Ipsen Pharma and receives research support from MODUS Outcomes LLC, TEVA Pharmaceuticals, SAGE Therapeutics, Bukwang Pharmaceuticals, Neurocrine Biosciences, CDHI Foundation. HAS received research support from Transposon, NINDS, Parkinson Study Group/UCB, Parkinson’s Foundation, MJFF, Jazz Pharmaceuticals, Intra-cellular Therapeutics and Barrow Neurological Foundation. HAS has also served as a consultant for Abbvie, Sage/Biogen, Praxis, KeifeRx, Fasikl and Jazz Pharmaceuticals. AWS reports grant support from the NIH R01 NS122943 as PI and R01 NS121120-01 as a Co-I. She reports past funding from Benign Essential Blepharospasm Research Foundation, Dystonia Coalition, Dystonia Medical Research Foundation, and National Organization for Rare Disorders. AWS has received consultant fees from Merz, Jazz, Fasikl, Encora and Acadia. She is the current Vice President for the Tremor Research Group and recent advisor for Supernus and Biogen-Sage. CS received grant funding from Teva Pharmaceuticals and the Parkinson Foundation. RJE receives consulting fees from Applied Therapeutics, ES Therapeutics, Neurocrine Biosciences, Encora, Fasikl, Jazz, and Sage; and serves on the International Essential Tremor Foundation Medical Advisory Board.
Tremor and other hyperkinetic movements (New York, N.Y.)
Selección SIIC: 23 Mayo, 2024
Tremor and other hyperkinetic movements (New York, N.Y.)
Hyperkinetic and Hypokinetic Movement Disorders in SSPE
Hyperkinetic and Hypokinetic Movement Disorders in SSPE
Fuente:Tremor and Other Hyperkinetic Movements (new York, N.y.)
Tipo de trabajo:Revisión sistemática
Extracto:
SSPE is associated with
diverse movement disorders, predominantly hyperkinetic. The prevalence of
dystonia suggests basal ganglia dysfunction.
Claves:Basal ganglion, Dystonia, Measles, Movement Disorders
Cita:Tremor Other Hyperkinet Mov (N Y) 2024; 14 : 27.
institución:(a) Department of Neurology, King George's Medical University, Lucknow, India. (b) Department of Neurology, King George's Medical University, Lucknow, India.
Conflicto:The authors have no competing interests to declare.
A large and diverse brain organoid dataset of 1,400 cross-laboratory images of 64 trackable brain organoids.
A large and diverse brain organoid dataset of 1,400 cross-laboratory images of 64 trackable brain organoids.
Fuente:Scientific Data
Extracto:
Therefore,
this dataset allows to perform differentiated analyses to delineate strengths,
weaknesses, and generalizability of automated organoid analysis pipelines as well
as analysis of clone diversity and similarity.
Cita:Sci Data 2024 May 20; 11 (1) : 514.
Autor/es:Schröter, Julian (a) Deininger, Luca (b)
institución:(a) Division of Pediatric Epileptology, Center for Pediatrics and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany. (b) Division of Pediatric Neurology and Metabolic Medicine, Department I, Center for Pediatric and Adolescent Medicine, Medical Faculty Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación