Peptides Targeting the IF1-ATP Synthase Complex Modulate the Permeability Transition Pore in Cancer HeLa Cells.

Peptides Targeting the IF1-ATP Synthase Complex Modulate the Permeability Transition Pore in Cancer HeLa Cells.

Fuente:International Journal of Molecular Sciences

Extracto: A third peptide was identified which counteracts the anti-apoptotic role of IF1, showing that OSCP is a promising target for anti-cancer therapies.

Claves:ATP synthase, cancer, inhibitor protein IF1, mitochondria, permeability transition pore, therapy

Cita:Int J Mol Sci 2024 Apr 25; 25 (9)

Autor/es:Grandi, Martina (a)
Fabbian, Simone (b)

institución:(a) Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.
(b) Department of Chemical Science, University of Padova, 35121 Padova, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094655

Nutraceuticals in Psychiatric Disorders

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: This narrative review aims to provide an overview of recent evidence obtained on this topic, pointing out the direction for future research.

Claves:nutraceuticals, omega-3 fatty acids, probiotics, psychiatric disorders

Cita:Int J Mol Sci 2024 Apr 28; 25 (9)

Autor/es:Bozzatello, Paola (a)
Novelli, Roberta (b)

institución:(a) Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy.
(b) Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094824

What Is Considered Healthy Eating? An Exploratory Study among College Students of Nutrition and Food Science.

What Is Considered Healthy Eating? An Exploratory Study among College Students of Nutrition and Food Science.

Fuente:Nutrients

Extracto: The insights obtained on the perceived barriers highlight the importance of considering both individual and environmental factors.

Claves:college students, dietetics, food technology, healthy eating, nutrition, perception

Cita:Nutrients 2024 Apr 30; 16 (9)

Autor/es:de Moraes Prata Gaspar, Maria Clara (a)
Soar, Claudia (b)

institución:(a) Departament d'Antropologia Social, Facultat de Geografia i Història, Universitat de Barcelona (UB), Carrer de Montalegre 6, 08001 Barcelona, Spain.
(b) Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona (UB), Av. Prat de la Riba 171, 08921 Santa Coloma de Gramenet, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091365

Effectiveness of edoxaban in portal vein thrombosis associated with liver cirrhosis.

Effectiveness of edoxaban in portal vein thrombosis associated with liver cirrhosis.

Fuente:Scientific Reports

Extracto: Edoxaban is easy to initiate, even in an outpatient setting, and could become a major therapeutic agent for the treatment of PVT.

Claves:Cirrhosis, Direct-acting oral anticoagulants, Portal vein thrombosis, Warfarin

Cita:Sci Rep 2024 May 11; 14 (1) : 10784.

Autor/es:Tadokoro, Tomoko (a)
Tani, Joji (b)

institución:(a) Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
(b) Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. tani.joji@kagawa-u.ac.jp.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60235-y

Predictors associated with an increase in daily steps among people with prediabetes or type 2 diabetes participating in a two-year pedometer intervention.

Predictors associated with an increase in daily steps among people with prediabetes or type 2 diabetes participating in a two-year pedometer intervention.

Fuente:Bmc Public Health

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: In the Sophia Step Study pedometer intervention, participants with a lower number of steps at baseline, male gender, lower age or higher baseline self-efficacy were more likely to respond to the intervention with a step increase above 500 steps per day. More knowledge is needed about factors that influence response to pedometer interventions. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02374788.

Claves:Intervention, Prediabetes, Response, Steps, Type 2 diabetes

Cita:BMC Public Health 2024 May 11; 24 (1) : 1290.

Autor/es:Larsson, Kristina (a)
Rossen, Jenny (b)

institución:(a) Department of Health Promotion Science, Sophiahemmet University, Box 5605, Stockholm, 114 86, Sweden. Kristina.larsson@shh.se.
(b) Department of Health Promotion Science, Sophiahemmet University, Box 5605, Stockholm, 114 86, Sweden.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18766-6

Endocrine features of Prader-Willi syndrome

Endocrine features of Prader-Willi syndrome

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Revisión

Extracto: We will look at topics such as neonatal anthropometry, thyroid issues, adrenal problems, hypogonadism, bone metabolism abnormalities, metabolic syndrome resulting from severe obesity caused by hyperphagia, deficiencies in the GH/IGF-1 axis, and the corresponding responses to treatment.

Claves:Prader-Willi syndrome (PWS), bone metabolism, genotype-phenotype correlation, growth hormone (GH), hypogonadism, metabolic syndrome, thyroid, type 2 diabetes

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1382583.

Autor/es:Madeo, Simona F (a)
Zagaroli, Luca (b)

institución:(a) Department of Medical and Surgical Sciences for Mother, Children and Adults, Pediatric Unit, University of Modena and Reggio Emilia, Modena, Italy.
(b) Department of Pediatrics, University of L'Aquila, L'Aquila, Italy.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1382583

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis.

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis.

Fuente:Scientific Reports

Extracto: These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.

Claves:Intracranial artery stenosis (ICAS), Low-density lipoprotein cholesterol (LDL-c), Low-density lipoprotein particle (LDL-p)

Cita:Sci Rep 2024 May 10; 14 (1) : 10765.

Autor/es:Vu, Thien (a)
Yano, Yuichiro (b)

institución:(a) NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
(b) Department of Cardiac Surgery, Cardiovascular Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59523-4

Analysis of onset-to-door time and its influencing factors in Chinese patients with acute ischemic stroke during the 2020 COVID-19 epidemic: a preliminary, prospective, multicenter study.

Analysis of onset-to-door time and its influencing factors in Chinese patients with acute ischemic stroke during the 2020 COVID-19 epidemic: a preliminary, prospective, multicenter study.

Fuente:Bmc Health Services Research

Extracto: Most patients with AIS fail to reach a hospital within the critical 3-h window. The following measures are recommended to reduce pre-hospital delays: reasonable distribution of hospitals accessible to nearby residents, minimizing interhospital transfer, paying attention to patients with mild stroke, and encouraging patients to use ambulance services. Pre-hospital delays for patients can be reduced by implementing these measures, ultimately improving the timeliness of treatment and enhancing patient prognosis. This study was carried out amid the COVID-19 pandemic, which presented challenges and constraints.

Claves:Acute ischemic stroke, China, Current situation, Onset-to-door time, Pre-hospital delay, Risk factors

Cita:BMC Health Serv Res 2024 May 10; 24 (1) : 615.

Autor/es:Liao, Yuqi (a)
Qi, Wenwei (b)

institución:(a) School of Medicine, Shenzhen University, Shenzhen, China.
(b) National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-11088-8

Insight into the research history and trends of total anomalous pulmonary venous connection: a bibliometric analysis.

Insight into the research history and trends of total anomalous pulmonary venous connection: a bibliometric analysis.

Fuente:Journal of Cardiothoracic Surgery

Tipo de trabajo:Caso clínico

Extracto: This study conducted a bibliometric analysis to provide a comprehensive overview of TAPVC research. We hope to offer new ideas for promoting development in the field of TAPVC.

Claves:Bibliometrics, CiteSpace, Hot spot, Research progress, Total anomalous pulmonary venous connection, VOSViewer

Cita:J Cardiothorac Surg 2024 May 11; 19 (1) : 285.

Autor/es:Wen, Chen (a)
Shen, Geng (b)

institución:(a) Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. wenchen1993@sjtu.edu.cn.
(b) Division of Cardiology, Peking University First Hospital, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13019-024-02787-8

Spinning Disk Confocal Microscopy for Optimized and Quantified Live Imaging of 3D Mitochondrial Network.

Spinning Disk Confocal Microscopy for Optimized and Quantified Live Imaging of 3D Mitochondrial Network.

Fuente:International Journal of Molecular Sciences

Extracto: Conclusively, our data show that TMRM staining outperformed JC-1 and CMXRos dyes in a (repetitive) 3D analysis of the entire mitochondrial quantity, morphology, and membrane potential in living cells.

Claves:CLSM, JC-1, MitoTracker Red CMX Rox, TMRM, mitochondria, spinning disk confocal microscope

Cita:Int J Mol Sci 2024 Apr 28; 25 (9)

Autor/es:Ahmadian, Somaieh (a)
Lindsey, Patrick J (b)

institución:(a) Department of Toxicogenomics, Maastricht University Medical Centre+, 6229 ER Maastricht, The Netherlands.
(b) GROW Research Institute for Oncology and Reproduction, Maastricht University, 6229 ER Maastricht, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094819

JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: Hence, JMJD6 autoantibodies may reflect inflammation, thereby serving as a potential biomarker for diagnosing specific inflammation-related diseases, including stroke, AMI, DM, and cancers, and for prediction of the prognosis in patients with EC.

Claves:JMJD6, acute myocardial infarction, atherosclerosis, autoantibody, diabetes mellitus, esophageal cancer, inflammation, ischemic stroke

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Zhang, Bo-Shi (a)
Zhang, Xiao-Meng (b)

institución:(a) Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
(b) Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Conflicto:This present study was performed in collaboration with Fujikura Kasei Co., Ltd., and Hideyuki Kuroda is an employee of Fujikura Kasei Co., Ltd. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094935

Endovascular treatment in Danon disease

Endovascular treatment in Danon disease

Fuente:Journal of Medical Case Reports

Tipo de trabajo:Caso clínico

Extracto: To our knowledge, we report the first case of ischemic stroke related to Danon disease treated with endovascular treatment.

Claves:Cardiomyopathy, Case report, Danon, Lysosomal, Stroke

Cita:J Med Case Rep 2024 May 12; 18 (1) : 244.

Autor/es:Jiménez-Bolaños, Rayco (a)
Hernández-Fernández, Francisco (b)

institución:(a) Department of Neurology, Complejo Hospitalario Universitario Insular-Materno Infantil de Canarias, Las Palmas, Spain.
(b) Department of Neurology, Complejo Hospitalario Universitario de Albacete, C/Hermanos Falcó 37, 02006, Albacete, Spain. pacohdezfdez@hotmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13256-024-04555-7

Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity.

Dapagliflozin added to metformin reduces perirenal fat layer in type 2 diabetic patients with obesity.

Fuente:Scientific Reports

Tipo de trabajo:Estudio abierto

Extracto: Perirenal fat should be considered as a potential target for cardiovascular dapaglifozin beneficial effects.

Claves:Cardiovascular risk, Dapaglifozin, Metabolic syndrome, Metformin, Omental fat, Perirenal fat, Preperitoneal fat, Ultrasound

Cita:Sci Rep 2024 May 11; 14 (1) : 10832.

Autor/es:Cuatrecasas, Guillem (a)
De Cabo, Francisco (b)

institución:(a) CP Endocrinologia SLP, 08037, Barcelona, Spain. gcuatrecasas@cpen.cat.
(b) Center for Obesity Management EASO, Clinica Sagrada Familia, Barcelona, Spain. gcuatrecasas@cpen.cat.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61590-6

Effects of repetitive transcranial magnetic stimulation on individual variability of resting-state functional connectivity in major depressive disorder.

Fuente:Journal of Psychiatry & Neuroscience Jpn

Extracto: This was, to our knowledge, the first study to examine individual variability of rs-fc related to rTMS in individuals with MDD. In contrast to our hypotheses, we found that rTMS increased the individual variability of rs-fc. Our results suggest that individual variability of the right sgACC and bilateral precuneus connectivity may be a potential mechanism of rTMS.

Cita:J Psychiatry Neurosci 2024 May-Jun; 49 (3) : E172-E181.

Autor/es:Tan, Vinh (a)
Downar, Jonathan (b)

institución:(a) From the Campbell Family Research Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Tan, Blumberger, Hawco); the Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ont. (Downar, Nestor); the Harquail Centre for Neuromodulation, Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont. (Nestor, Blumberger, Hawco); the Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, BC (Vila-Rodriguez); the Department of Psychiatry, University of California, San Diego (Daskalakis); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Blumberger).
(b) From the Campbell Family Research Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Tan, Blumberger, Hawco); the Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ont. (Downar, Nestor); the Harquail Centre for Neuromodulation, Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ont. (Nestor, Blumberger, Hawco); the Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, BC (Vila-Rodriguez); the Department of Psychiatry, University of California, San Diego (Daskalakis); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Blumberger).

Conflicto:Competing interests:: J. Downar declared grants from the National Institutes of Health (NIH), Canadian Institutes of Health Research (CIHR), Brain Canada, and the Ontario Brain Institute. He also declared consulting fees from TMS Neuro Solutions and Arc Health Partners. He is the co-founder and holds equity in Ampa Health. S. Nestor declared a research project award application to the Labatt... Family Network for Research on the Biology of Depression, Labatt Family Discovery Program, Department of Psychiatry, University of Toronto. F. Vila-Rodriguez declared support from Seedlings Foundation, CIHR, and Brain Canada. He is a volunteer director with the BC Schizophrenia Society board of directors, and he has received in-kind equipment support from Magventure for investigator-initiated research. Z.J. Daskalakis serves on the advisory board of Brainsway Inc. He also declared receipt of research grant materials from Magventure Inc. and Brainsway Inc. D.M. blumberger declared grants from CIHR, Brain Canada, NIH, and the Patient-Centered Outcomes Research Institute. He is a paid scientific advisory board member of Sooma, and serves as co-chair of the clinical standards committee (unpaid) of the Clinical TMS Society. He has stock options from Sooma and has received in-kind equipment support from Magventure Inc. and Brainsway Inc. for investigator-initiated studies. C. Hawco declared funding from the National Institute of Mental Health, CIHR and Centre for Addiction and Mental Health Foundation paid to his institution. No other competing interests were declared.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Canadá

Sitio web:http://dx.doi.org/10.1503/jpn.230135

SAROS: A dataset for whole-body region and organ segmentation in CT imaging.

Fuente:Scientific Data

Extracto: The SAROS dataset serves as an open-access resource for training and evaluating novel segmentation models, covering various scanner vendors and diseases.

Cita:Sci Data 2024 May 10; 11 (1) : 483.

Autor/es:Koitka, Sven (a)
Baldini, Giulia (b)

institución:(a) Institute of Interventional and Diagnostic Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
(b) Institute for Artificial Intelligence in Medicine, University Hospital Essen, Essen, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41597-024-03337-6

Deciphering the functional role of insular cortex stratification in trigeminal neuropathic pain.

Fuente:The Journal of Headache and Pain

Extracto: In addition, the review examines diverse modulation strategies that target the different parts of the IC, thereby suggesting novel diagnostic and therapeutic management of chronic TNP in the future.

Claves:Insular cortex, Neuromodulation, Neuroplasticity, Therapeutic potential of insular cortex, Trigeminal neuropathic pain

Cita:J Headache Pain 2024 May 10; 25 (1) : 76.

Autor/es:Islam, Jaisan (a)
Rahman, Md Taufiqur (b)

institución:(a) Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Korea.
(b) Department of Medical Neuroscience, College of Medicine, Chungbuk National University, Cheongju, Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s10194-024-01784-5

Clinical, genetic, and cognitive correlates of seizure occurrences in Phelan-McDermid syndrome.

Fuente:Journal of Neurodevelopmental Disorders

Extracto: These results begin to eludicate correlates of seizures in individuals with PMS and highlight the importance of early seizure management. Importantly, presence of seizures was associated with adaptive and cognitive functioning. A larger cohort might be able to identify additional associations with medical features. Genetic findings suggest an increased capability to realize genotype-phenotype relationships when deletion size is taken into account.

Claves:22q13, Epilepsy, Phelan-McDermid syndrome, SHANK3, Seizures

Cita:J Neurodev Disord 2024 May 10; 16 (1) : 25.

Autor/es:Levy, Tess (a)
Gluckman, Jacob (b)

institución:(a) Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
(b) Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s11689-024-09541-0

Updated safety results from phase 3 lecanemab study in early Alzheimer's disease.

Fuente:Alzheimer's Research & Therapy

Tipo de trabajo:Estudio abierto

Extracto: Lecanemab was generally well-tolerated, with the most common adverse events being infusion-related reactions, ARIA-H, ARIA-E. Clinicians, participants, and caregivers should understand the incidence, monitoring, and management of these events for optimal patient care. TRIAL REGISTRATION: ClinicalTrials.gov numbers: Clarity AD NCT03887455).

Claves:ARIA, Alzheimer’s disease, Lecanemab, Safety

Cita:Alzheimers Res Ther 2024 May 10; 16 (1) : 105.

Autor/es:Honig, Lawrence S (a)
Sabbagh, Marwan N (b)

institución:(a) Columbia University Irving Medical Center, NYS Center of Excellence for Alzheimer's Disease, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Gertrude H. Sergievsky Center (PH19), & Department of Neurology, Columbia University Vagelos College of Physicians & Surgeons, 630 West 168th Street (P&S UNIT 16), New York, NY, 10032-3795, USA. lh456@cumc.columbia.edu.
(b) Barrow Neurological Institute, Phoenix, AZ, 85013, USA.

Conflicto:LSH receives research funding from Abbvie, Acumen, Alector, Biogen, Bristol-Myers Squibb, Cognition, EIP, Eisai, Ferrer, Genentech/Roche, Janssen/J&J, Transposon, UCB, Vaccinex. LSH is a consultant for Alector, Biogen, Cortexyme, Eisai, Medscape, and Prevail/Lilly. MNS has ownership interest (Stock or stock options): NeuroTau, uMethod Health, Versanum, Athira, TransDermix, Seq BioMarque, NeuroReserve, Cortexyme/Quince Therapeutics, Lighthouse Therapeutics. MNS is a consultant for: Alzheon, Biogen,... Roche-Genentech, Eisai, KeifeRx, Lilly, Synaptogenix, NeuroTherapia, T3D, Signant Health, Novo Nordisk. MNS receives royalties from Humanix. MNS is a Board of Director for EIP Pharma. CHvD is a consultant for Roche, Eisai, Cerevel, and Ono and receives research support from Biogen, Eisai, Roche, Genentech, Eli Lilly, Janssen, UCB, Cerevel, and Biohaven. RAS is a consultant to: AbbVie, AC Immune, Acumen, Alector, Bristol-Myers Squibb, Genentech, Ionis, Janssen, Oligomerix, Prothena, Roche, Shionogi. RAS receives research funding from the National Institute on Aging (P01AG036694; R01AG054029; R01AG061848, U24AG057437; R01 AG03689), the Alzheimer’s Association, GHR Foundation, Eli Lilly, Eisai – Public-Private Partnership Trial Funding, and. Accelerating Medicines Partnership FNIH. SH, AM, LG, MG, MK, DL, SD, MI, and LK are employees of Eisai. DP is an employee of Clario.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01441-8

CBD in the Treatment of Epilepsy.

Fuente:Molecules (basel, Switzerland)

Extracto: In adults, reliable conclusions cannot be drawn due to insufficient data.

Claves:CBD, efficacy, epilepsy, phytocannabinoids, safety, seizure

Cita:Molecules 2024 Apr 25; 29 (9)

Autor/es:Borowicz-Reutt, Kinga (a)
Czernia, Julia (b)

institución:(a) Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
(b) Independent Unit of Experimental Neuropathophysiology, Department of Toxicology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29091981

Human Plasma Butyrylcholinesterase Hydrolyzes Atropine: Kinetic and Molecular Modeling Studies.

Fuente:Molecules (basel, Switzerland)

Extracto: In conclusion, the results provided evidence that plasma BChE slowly hydrolyzes atropine but should have no significant role in its metabolism under current conditions of medical use and even under administration of the highest possible doses of this antimuscarinic drug.

Claves:atropine, atropinesterase, butyrylcholinesterase, molecular dynamics, steady-state hydrolysis

Cita:Molecules 2024 May 4; 29 (9)

Autor/es:Mukhametgalieva, Aliya (a)
Mir, Showkat Ahmad (b)

institución:(a) Laboratory of Biochemical Neuropharmacology, Kazan Federal University, Kremlevskaya Str. 18, 420008 Kazan, Russia.
(b) School of Life Sciences, Sambalpur University, Jyotivihar, Burla 768019, India.

Conflicto:The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29092140