Antioxidant network-based signatures cluster glioblastoma into distinct redox-resistant phenotypes.

Antioxidant network-based signatures cluster glioblastoma into distinct redox-resistant phenotypes.

Fuente:Frontiers in Immunology

Extracto: In summary, we provide a set of transcriptional signatures that unveil the antioxidant potential of GBM, offering a promising prognostic application and a guide for therapeutic strategies in GBM therapy.

Claves:GBM, antioxidant phenotype, bioinformatics, canonical GBM classification, oxidative stress, prognosis, signatures, transcription factors

Cita:Front Immunol 2024; 15 : 1342977.

Autor/es:Yang, Yihan (a)
More, Sanket (b)

institución:(a) Research Group Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium.
(b) Laboratory of Cell Death Research & Therapy, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1342977

Effects of the selective AMPA modulator NBI-1065845 on the pharmacokinetics of midazolam or ethinyl estradiol-levonorgestrel in healthy adults.

Effects of the selective AMPA modulator NBI-1065845 on the pharmacokinetics of midazolam or ethinyl estradiol-levonorgestrel in healthy adults.

Fuente:Clinical and Translational Science

Extracto: NBI-1065845 was generally well tolerated, with no new safety signals observed after coadministration of midazolam, ethinyl estradiol, or levonorgestrel.

Cita:Clin Transl Sci 2024 May; 17 (5) : e13791.

Autor/es:Lin, Swan (a)
Ionescu, Adrian (b)

institución:(a) Neurocrine Biosciences, Inc, San Diego, California, USA.
(b) Neurocrine Biosciences, Inc, San Diego, California, USA.

Conflicto:S.L., A.I., J.M.‐S., M.K., M.F., and J.B.S. are employees of Neurocrine Biosciences, Inc. and own stock or share options. D.W. reports compensation for serving as a consultant or speaker, or research support, paid to the author or the institution they work for, from AbbVie, Acadia Pharmaceuticals, Alkermes, Allergan, Avanir Pharmaceuticals, Biogen, Boehringer Ingelheim, Cerevel Therapeutics, Indivior, Intra‐Cellular Therapies, Johnson &... on & Johnson Pharmaceutical Research & Development, Janssen Pharmaceuticals, Karuna Therapeutics, Lundbeck, Lupin, Lyndra Therapeutics, Neurocrine Biosciences, Novartis, Noven Pharmaceuticals, Otsuka Pharmaceutical, Pfizer, Roche, Sunovion and Takeda.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1111/cts.13791

Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults.

Plasma Leptin and Alzheimer Protein Pathologies Among Older Adults.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: The present findings suggest that plasma leptin may be protective for the development or progression of AD pathology, including both Aβ and tau deposition.

Cita:JAMA Netw Open 2024 May 1; 7 (5) : e249539.

Autor/es:Lee, Seunghoon (a)
Byun, Min Soo (b)

institución:(a) Department of Psychiatry, Myongji Hospital, Hanyang University College of Medicine, Goyang, Republic of Korea.
(b) Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.9539

Cumulative Systolic Blood Pressure and Incident Stroke Type Variation by Race and Ethnicity.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: The findings of this cohort study suggest that cumulative mean SBP was associated with incident stroke type, but the associations did not differ by race and ethnicity. Culturally informed stroke prevention programs should address modifiable risk factors such as SBP along with social determinants of health and structural inequities in society.

Cita:JAMA Netw Open 2024 May 1; 7 (5) : e248502.

Autor/es:Johnson, Kimson E (a)
Li, Hanyu (b)

institución:(a) Department of Health Management and Policy, University of Michigan, Ann Arbor.
(b) Department of Sociology, University of Michigan, Ann Arbor.

Conflicto:Conflict of Interest Disclosures: Dr Springer reported receiving grant funding from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) during the conduct of the study. Dr. Hayward reported receiving grant funding from the NIH and US Department of Veterans Affairs during the conduct of the study. Dr Sidney reported receiving grant funding... from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Risk Development in Young Adults Study (CARDIA) Study during the conduct of the study. Dr. Elkind reported receiving grant funding from NINDS during the conduct of the study and receiving research support from the Bristol Myers Squibb–Pfizer Alliance for Eliquis and Roche and from UpToDate outside the submitted work. Dr Longstreth reported receiving grant funding from the NIH during the conduct of the study. Dr Heckbert reported receiving grant funding from the NIH during the conduct of the study and receiving grant funding from the American Heart Association outside the submitted work. Dr Levine reported receiving grant funding from the NIH outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.8502

Internet-Delivered Exposure and Response Prevention for Pediatric Tourette Syndrome

Fuente:Jama Network Open

Tipo de trabajo:Estudio clínico aleatorizado

Extracto: AND RELEVANCE: There were no statistically significant changes in tic severity from the 3-month through to the 12-month follow-up in either group. The ERP intervention was not superior to psychoeducation at any time point. While ERP was not superior to psychoeducation alone in reducing tic severity at the end of the follow-up period, ERP is recommended for clinical implementation due to its likely cost-effectiveness and support from previous literature. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03916055.

Cita:JAMA Netw Open 2024 May 1; 7 (5) : e248468.

Autor/es:Andrén, Per (a)
Sampaio, Filipa (b)

institución:(a) Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
(b) Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.

Conflicto:Conflict of Interest Disclosures: Dr Davies reported being cofunded by the National Institute for Health and Care Research (NIHR) MindTech Medtech Cooperative and the NIHR Nottingham Biomedical Research Centre. Dr Murphy reported receiving grants from Great Ormond Street Hospital during the conduct of the study; and receiving royalties for authored books in a related area. Dr Fernández de la Cruz... z reported receiving grants from the Swedish Research Council for Health, Working Life and Welfare (Forte), the Swedish Research Council (Vetenskapsrådet [VR]), Hjärt-Lungfonden, Folksam’s Research Foundation (Folksams Forskningsstiftelse), and the Karolinska Institutet; and receiving personal fees from UpToDate, Wolters Kluwer Health, and Elsevier outside the submitted work. Dr Mataix-Cols reported receiving personal fees from UpToDate outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.8468

Memorable first impressions.

Fuente:Elife

Extracto: ur ability to recall details from a remembered image depends on a single mechanism that is engaged from the very moment the image disappears from view.

Claves:delay encoding, human, iconic memory, neuroscience, population coding, short-term memory, temporal dynamics

Cita:Elife 2024 May 3; 13

Autor/es:Salinas, Emilio (a)
Sheikh, Bashirul I (b)

institución:(a) Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, United States.
(b) Neuroscience Graduate Program, Wake Forest University School of Medicine, Winston-Salem, United States.

Conflicto:ES, BS No competing interests declared

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.7554/eLife.98274

Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.

Re-awakening the brain: Forcing transitions in disorders of consciousness by external in silico perturbation.

Fuente:Plos Computational Biology

Extracto: This motivates further work to continue understanding brain function and treatments of disorders of consciousness.

Cita:PLoS Comput Biol 2024 May; 20 (5) : e1011350.

Autor/es:Dagnino, Paulina Clara (a)
Escrichs, Anira (b)

institución:(a) Computational Neuroscience Group, Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.
(b) Computational Neuroscience Group, Center for Brain and Cognition, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.

Conflicto:O.G. is a research associate and S.L. is a research director at the F.R.S-FNRS.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pcbi.1011350

Grandiose narcissism associates with higher cognitive performance under stress through more efficient attention distribution: An eye-tracking study.

Grandiose narcissism associates with higher cognitive performance under stress through more efficient attention distribution: An eye-tracking study.

Fuente:Plos One

Extracto: These findings suggest that grandiose narcissism predicts higher cognitive performance, at least in experimental settings, and call for further research to understand the implications of this seemingly dark trait for performance across various settings.

Cita:PLoS One 2024; 19 (5) : e0302644.

Autor/es:Stefanova, Vasilena (a)
Scheepers, Christoph (b)

institución:(a) College of Psychology, Birmingham City University, Birmingham, United Kingdom.
(b) School of Psychology and Neuroscience, University of Glasgow, Glasgow, United Kingdom.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302644

Trainability of affordance judgments in right and left hemisphere stroke patients.

Fuente:Plos One

Extracto: Future studies applying lesion analysis with a larger sample may shed further light on the dissociation in the trainability of affordance judgments observed in patients with versus without visuo-spatial or motor-cognitive deficits.

Cita:PLoS One 2024; 19 (5) : e0299705.

Autor/es:Bauer, Isabel (a)
Finkel, Lisa (b)

institución:(a) Department of Psychology, University of Konstanz, Konstanz, Germany.
(b) Lurija Institute for Rehabilitation Science and Health Research, Kliniken Schmieder, Allensbach, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299705

Factors influencing the outcomes of non-pharmacological interventions for managing fatigue across the lifespan of people living with musculoskeletal (MSK) conditions

Factors influencing the outcomes of non-pharmacological interventions for managing fatigue across the lifespan of people living with musculoskeletal (MSK) conditions

Fuente:Bmj Open

Tipo de trabajo:Revisión

Extracto: Findings will be disseminated by journal publications, conference presentations and by communicating with relevant healthcare and charity organisations.

Claves:Fatigue, Musculoskeletal disorders, Paediatric rheumatology, RHEUMATOLOGY

Cita:BMJ Open 2024 May 3; 14 (5) : e082555.

Autor/es:Fishpool, Katie (a)
Young, George (b)

institución:(a) School of Health and Social Wellbeing, University of the West of England, Bristol, UK katie.fishpool@uwe.ac.uk.
(b) Academic Rheumatology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.

Conflicto:Competing interests: PMM has received consulting/speaker’s fees from Abbvie, BMS, Celgene, Eli Lilly, Janssen, MSD, Novartis, Orphazyme, Pfizer, Roche and UCB, all unrelated to this project. There are no competing interests in this project.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-082555

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.

A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations.

Fuente:Nature Communications

Extracto: Together, our results sketch a mechanistic framework for the CNA-driven initiation of embryonal tumours.

Cita:Nat Commun 2024 May 3; 15 (1) : 3745.

Autor/es:Saldana-Guerrero, Ingrid M (a)
Montano-Gutierrez, Luis F (b)

institución:(a) Centre for Stem Cell Biology, School of Biosciences, The University of Sheffield, Sheffield, UK.
(b) Neuroscience Institute, The University of Sheffield, Sheffield, UK.

Conflicto:P.W.A. is a member of the Scientific Advisory Board of TreeFrog Therapeutics and receives royalties from the Wistar Institute for antibody sales. All other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47945-7

Functional alterations of the brain default mode network and somatosensory system in trigeminal neuralgia.

Functional alterations of the brain default mode network and somatosensory system in trigeminal neuralgia.

Fuente:Scientific Reports

Extracto: The exact central mechanisms remain to be elucidated.

Claves:Brain mapping, Default mode network, Functional neuroimaging, Somatosensory disorders, Trigeminal neuralgia

Cita:Sci Rep 2024 May 3; 14 (1) : 10205.

Autor/es:Wang, Zairan (a)
Zhao, Zijun (b)

institución:(a) Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing, Dongcheng District, Beijing, China.
(b) Spine Center, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60273-6

Storage conditions affect the composition of the lyophilized secretome of multipotent mesenchymal stromal cells.

Fuente:Scientific Reports

Extracto: Short-term storage at various temperatures maintained over 60% of the studied growth factors and cytokines; long-term preservation was only adequate at -80 °C.

Cita:Sci Rep 2024 May 3; 14 (1) : 10243.

Autor/es:Rogulska, Olena (a)
Vackova, Irena (b)

institución:(a) Laboratory of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14200, Prague, Czech Republic.
(b) Department of Neuroregeneration, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 14200, Prague, Czech Republic.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60787-z

The effects of music combined to paired associative stimulation on motor-evoked potentials and alertness in spinal cord injury patients and healthy subjects.

Fuente:Scientific Reports

Extracto: More research is needed to determine the potential clinical effects of using music during high-PAS.

Cita:Sci Rep 2024 May 3; 14 (1) : 10194.

Autor/es:Holopainen, Kirsi (a)
Sihvonen, Aleksi J (b)

institución:(a) BioMag Laboratory, HUS Diagnostic Centre, Helsinki University Hospital, University of Helsinki and Aalto University School of Science, Helsinki, Finland.
(b) Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60984-w

Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch.

Dynamic changes in somatosensory and cerebellar activity mediate temporal recalibration of self-touch.

Fuente:Communications Biology

Extracto: Together, our results show that sensorimotor predictions in the simplest act of touching one's own body are upheld by a sophisticated and flexible neural mechanism that maintains them accurate in time.

Cita:Commun Biol 2024 May 3; 7 (1) : 522.

Autor/es:Kilteni, Konstantina (a)
Ehrsson, H Henrik (b)

institución:(a) Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden. konstantina.kilteni@ki.se.
(b) Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands. konstantina.kilteni@ki.se.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-06188-4

Oxidative stress in patients with coronavirus disease and end-stage renal disease: a pilot study.

Oxidative stress in patients with coronavirus disease and end-stage renal disease: a pilot study.

Fuente:Bmc Nephrology

Extracto: The role of reactive oxygen species in the pathophysiology of COVID-19 among patients withESRD appears to be non-critical. Therefore, the provision of supplemental antioxidants may not confer a therapeutic advantage, particularly in cases of mild COVID-19 in ESRD patients receiving hemodialysis. Nonetheless, this area merits further research.

Claves:COVID-19, End-stage renal disease, Hemodialysis, Oxidative stress, Reactive oxygen species

Cita:BMC Nephrol 2024 May 4; 25 (1) : 155.

Autor/es:Beck, Nam-Seon (a)
Seo, Yeonju (b)

institución:(a) Department of Pediatrics, Chung-Ang Jeil Hospital, Chungbuk, South Korea.
(b) Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12882-024-03584-0

Remote ischemic conditioning may improve graft function following kidney transplantation

Remote ischemic conditioning may improve graft function following kidney transplantation

Fuente:Bmc Anesthesiology

Tipo de trabajo:Revisión sistemática

Extracto: In this meta-analysis with trial sequential analysis, RIC did not lead to a significant reduction in the incidence of DGF after kidney transplantation. Nonetheless, RIC demonstrated a positive correlation with 3-month eGFR. Given the limited number of patients included in this study, well-designed clinical trials with large sample sizes are required to validate the renoprotective benefits of RIC. TRIAL REGISTRATION: This systematic review and meta-analysis was registered at the International Prospective Register of Systematic Reviews (Number CRD42023464447).

Claves:Graft function, Kidney transplantation, Remote ischemic conditioning, Systematic review

Cita:BMC Anesthesiol 2024 May 3; 24 (1) : 168.

Autor/es:Zhang, Yang (a)
Long, Yuqin (b)

institución:(a) Department of Anesthesiology, Institute of Anesthesiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China.
(b) Institute of Anesthesiology, Soochow University, Suzhou, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02549-y

Quality of care transition, patient safety incidents, and patients' health status: a structural equation model on the complexity of the discharge process.

Quality of care transition, patient safety incidents, and patients' health status: a structural equation model on the complexity of the discharge process.

Fuente:Bmc Health Services Research

Extracto: Quality and safety in the discharge process are critical to safe patient transitions to home care. This study contributes to a better understanding of the complex discharge process by applying a model in which various contextual factors and interactions were considered. The findings revealed that high quality discharge processes are associated with a lower likelihood of patient safety incidents and better health status at home even, when sociodemographic and treatment-related characteristics are taken into account. This study supports the call for developing individualized, patient-centered discharge processes to strengthen patient safety in care transitions.

Claves:Care transitions measure, Discharge, Medication safety, Patient-reported experience measure, Patient-reported outcomes measures, Readmission, Structural equation model, Transitional safety

Cita:BMC Health Serv Res 2024 May 3; 24 (1) : 576.

Autor/es:Marsall, Matthias (a)
Hornung, Thorsten (b)

institución:(a) Institute for Patient Safety (IfPS), University Hospital Bonn, Bonn, Germany. matthias.marsall@ukbonn.de.
(b) University Hospital Bonn, Bonn, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12913-024-11047-3

Trauma exposure across the lifespan among individuals engaged in treatment with medication for opioid use disorder: differences by gender, PTSD status, and chronic pain.

Fuente:Substance Abuse Treatment, Prevention, and Policy

Extracto: The study found a high prevalence of lifetime trauma among people in MOUD. Results highlight the need for comprehensive assessment and mental health services to address trauma among those in MOUD treatment. TRIAL REGISTRATION: NCT04082637.

Claves:Chronic pain, Gender differences, Medication treatment, Opioid use disorder, Post-traumatic stress disorder, Trauma

Cita:Subst Abuse Treat Prev Policy 2024 May 3; 19 (1) : 25.

Autor/es:Rodríguez, Monique N (a)
Colgan, Dana D (b)

institución:(a) Department of Individual, Family, and Community Education, University of New Mexico USA, Simpson Hall MSC053042, 502 Campus, Blvd, Albuquerque, NM, 87131, USA.
(b) Department of Neurology, Oregon Health and Science University USA, 3818 SW Sam Jackson Parkway, Portland, OR, 97229, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13011-024-00608-8

Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16-18-year-olds: recruitment and baseline characteristics.

Brief Educational Workshops in Secondary Schools Trial (BESST trial), a school-based cluster randomised controlled trial of the DISCOVER workshop for 16-18-year-olds: recruitment and baseline characteristics.

Fuente:Trials

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: The BESST study will continue to follow up participants to collect outcome data and results will be analysed once all the data have been collected. TRIAL REGISTRATION: ISRCTN registry ISRCTN90912799. Registered on 28 May 2020.

Claves:Adolescents, Baseline, Mental health, Open access, Recruitment, School based

Cita:Trials 2024 May 4; 25 (1) : 302.

Autor/es:James, Kirsty (a)
Lisk, Stephen (b)

institución:(a) King's College London, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.
(b) Department of Biostatistics and Health Informatics, & King's Clinical Trials Unit (KCTU), Institute of Psychiatry Psychology and Neuroscience, King's College London, Denmark Hill, London, SE5 8AF, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08116-7