Interdisciplinary Management of Skull Base Tumors.

Fuente:Laryngo- Rhino- Otologie

Tipo de trabajo:Revisión

Extracto: Interdisciplinary endonasal endoscopic surgery combines surgical expertise, improves resection rates for many pathologies, and minimizes morbidity by reducing the incidence of surgical complications.

Cita:Laryngorhinootologie 2024 May; 103 (S 01) : S28-S42.

Autor/es:Gerlach, Ruediger (a)
Modesti, Claudia Lodovica (b)

institución:(a) Klinik für Neurochirurgie, Helios Klinikum Erfurt GmbH, Erfurt.
(b) Unit of Otolaryngology and Head and Surgery, ASST Spedali Civili di Brescia, University of Brescia, Italy.

Conflicto:Die Autoren geben an, dass kein Interessenkonflikt besteht.

Formato:Informe impreso

Idioma:eng, ger

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1055/a-2196-8984

Interdisciplinary Management of Vascular Anomalies in the Head and Neck.

Fuente:Laryngo- Rhino- Otologie

Extracto: This article provides an up-to-date overview of the diagnosis, clinic and treatment of vascular anomalies in the head and neck region.

Cita:Laryngorhinootologie 2024 May; 103 (S 01) : S125-S147.

Autor/es:Mattheis, Stefan (a)
Wanke, Isabel (b)

institución:(a) Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsmedizin Essen (Direktor: Prof. Dr. Stephan Lang).
(b) Zentrum für Neuroradiologie, Klinik Hirslanden, Zürich, Schweiz.

Conflicto:S.M. gibt folgendes an: Firma Medtronic GmbH, Meerbusch - Dozenten und Beratertätigkeit; Firma Olympus, Hamburg - Dozenten und Beratertätigkeit I.W. gibt an, dass kein Interessenkonflikt besteht.

Formato:Informe impreso

Idioma:eng, ger

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.1055/a-2225-9932

Predictability of B cell clonal persistence and immunosurveillance in breast cancer.

Fuente:Nature Immunology

Extracto: This work lays a foundation for prioritizing antibody sequences for therapeutic targeting in cancer.

Cita:Nat Immunol 2024 May; 25 (5) : 916-924.

Autor/es:Sammut, Stephen-John (a)
Galson, Jacob D (b)

institución:(a) Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. stephen-john.sammut@icr.ac.uk.
(b) The Royal Marsden Hospital NHS Foundation Trust, London, UK. stephen-john.sammut@icr.ac.uk.

Conflicto:R.J.M.B.-R. is a cofounder of Alchemab Therapeutics and consultant for Alchemab Therapeutics, GSK, Roche, EnaraBio and UCB. S.S., J.D., J.O., R.M., D.K.F. and J.D.G. are, or were, employed by Alchemab Therapeutics. J.S. is a cofounder of Mosaic Biomedicals and has ownership interests in Mosaic Biomedicals and Northern Biologics. J.S. received grant/research support from Mosaic Biomedicals, Northern Biologics, Roche/Glycart, Hoffmann-La Roche... and AstraZeneca. The other authors declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41590-024-01821-0

Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.

Fuente:Acta Neuropathologica Communications

Extracto: In general, microglial reactivity correlated best with the degree of Alzheimer's-linked tauopathy and declined with progression of age in COVID19 + patients.

Claves:Amyloidosis, Anterior olfactory nucleus, COVID-19, Histiocytes, Hyposmia, Inflammation, Microglia, Neurodegeneration, Olfaction, Synucleinopathy, Tauopathy

Cita:Acta Neuropathol Commun 2024 May 3; 12 (1) : 70.

Autor/es:Lengacher, Nathalie A (a)
Tomlinson, Julianna J (b)

institución:(a) Neuroscience Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
(b) Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.

Conflicto:The authors declare they do not have any competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40478-024-01761-8

Neuroinflammation in dementia

Fuente:Medicine

Tipo de trabajo:Metanálisis

Extracto: This study summarizes the existing literature on TSPO expression in specific regions of the brain in patients with dementia, and also provides some preliminary evidence on the possible association between neuroinflammation and dementia. However, the heterogeneity of results and limitations of the study suggest that we need to interpret these findings with caution. Future studies need to adopt a more rigorous and consistent methodological design to more accurately assess the role of neuroinflammation in dementia, thereby providing a more reliable evidence base for understanding pathological mechanisms and developing potential therapeutic strategies.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e38086.

Autor/es:Pan, Jie (a)
Hu, Jin (b)

institución:(a) Department of Neurology, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), Jiaxing City, Zhejiang Province, China.
(b) Department of Neurology, The First Hospital of Jiaxing (Affiliated Hospital of Jiaxing University), Jiaxing City, Zhejiang Province, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038086

Narrow interval dual phase 18F-FDG PET/CT: A practical approach for distinguishing tumor recurrence from radiation necrosis in brain metastasis.

Fuente:Medicine

Extracto: Narrow time interval allows for better patient comfort, greater efficiency of PET/CT scanner, and lower disruption of workflow.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37789.

Autor/es:Aggarwal, Aashri (a)
Aggarwal, Ashwin K (b)

institución:(a) Department of Computer Science, Cornell University, Ithaca, NY.
(b) Research Intern at Johnston Willis Hospital, Department of Radiology, Richmond, VA.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037789

Primary care clinic visits in formerly evacuated areas due to radiation disaster following the Great East Japan Earthquake: A retrospective descriptive study.

Fuente:Medicine

Extracto: Establishing a comprehensive health maintenance system tailored to these areas' unique challenges is crucial for future disaster recovery efforts.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e37942.

Autor/es:Nonaka, Saori (a)
Odaka, Masaaki (b)

institución:(a) Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan.
(b) Research Center for Community Health, Minamisoma Municipal General Hospital, Fukushima, Japan.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037942

How artificial intelligence can provide information about subdural hematoma: Assessment of readability, reliability, and quality of ChatGPT, BARD, and perplexity responses.

Fuente:Medicine

Extracto: The readability levels of the responses of artificial intelligence applications such as ChatGPT, Bard, and perplexity are significantly higher than the recommended 6th grade level.

Cita:Medicine (Baltimore) 2024 May 3; 103 (18) : e38009.

Autor/es:Gül, Şanser (a)
Erdemir, İsmail (b)

institución:(a) Department of Neurosurgery, Ankara Ataturk Sanatory Education and Research Hospital, Ankara, Turkey.
(b) Department of Anesthesiology and Critical Care, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000038009

Structural- and DTI- MRI enable automated prediction of IDH Mutation Status in CNS WHO Grade 2-4 glioma patients: a deep Radiomics Approach.

Fuente:Bmc Medical Imaging

Extracto: Imaging features derived from DTI-based FA and MD maps combined with structural MRI, have superior diagnostic value to that provided by standalone structural or DTI sequences. In combination with demographic information, this CNN-SVM model offers a further enhanced non-invasive prediction of IDH mutation status in gliomas.

Claves:CNN, DTI, Deep neural network, IDH, Mutation status, Prediction, SVM, Supervised learning

Cita:BMC Med Imaging 2024 May 3; 24 (1) : 104.

Autor/es:Yuan, Jialin (a)
Siakallis, Loizos (b)

institución:(a) Department of Radiology, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
(b) Queen Square Institute of Neurology, University College London, London, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12880-024-01274-9

Age-related enhancement of the association between episodic memory and gray matter volume in medial temporal and frontal lobes.

Fuente:Behavioral and Brain Functions Bbf

Extracto: Our study revealed a significant positive correlation between GMV in most regions associated with EM and age, particularly in the frontal and temporal lobes. This discovery offers new insights into the connection between brain structure and the diminishing episodic memory function among older individuals.

Claves:Episodic memory, Gray matter volume, Older adults

Cita:Behav Brain Funct 2024 May 3; 20 (1) : 10.

Autor/es:Zhao, Shaokun (a)
Sang, Feng (b)

institución:(a) State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
(b) BABRI Centre, Beijing Normal University, Beijing, 100875, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12993-024-00237-y

Combined in vivo MRI assessment of locus coeruleus and nucleus basalis of Meynert integrity in amnestic Alzheimer's disease, suspected-LATE and frontotemporal dementia.

Fuente:Alzheimer's Research & Therapy

Extracto: The alteration of LC and NBM in amnestic-AD, presumed-LATE and FTD suggests a common vulnerability of these structures to different proteinopathies. Targeting the noradrenergic and cholinergic systems could be effective therapeutic strategies in LATE and FTD.

Claves:Alzheimer, FTD, LATE, Locus coeruleus, MRI, Nucleus basalis of Meynert

Cita:Alzheimers Res Ther 2024 May 3; 16 (1) : 97.

Autor/es:Lagarde, Julien (a)
Olivieri, Pauline (b)

institución:(a) Department of Neurology of Memory and Language, GHU Paris Psychiatry and Neurosciences, Hôpital Sainte Anne, Paris, France. j.lagarde@ghu-paris.fr.
(b) Université Paris-Saclay, Service Hospitalier Frédéric Joliot CEA, CNRS, Inserm, BioMaps, Orsay, F- 91401, France. j.lagarde@ghu-paris.fr.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01466-z

Extended optical treatment versus early patching with an intensive patching regimen in children with amblyopia in Europe (EuPatch)

Fuente:Lancet (london, England)

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: FUNDING: Action Medical Research, NIHR Clinical Research Network, and Ulverscroft Foundation.

Cita:Lancet 2024 May 4; 403 (10438) : 1766-1778.

Autor/es:Proudlock, Frank A (a)
Hisaund, Michael (b)

institución:(a) Ulverscroft Eye Unit, Department of Psychology and Vision Sciences, University of Leicester, Leicester, UK.
(b) Ulverscroft Eye Unit, Department of Psychology and Vision Sciences, University of Leicester, Leicester, UK.

Conflicto:Declaration of interests FAP, A-DN, and IG were awarded grants from Action Medical Research and the Ulverscroft Foundation for this study. FAP reports travel funding from the main grant body, Action Medical Research, to attend the 2023 Annual Research in Vision and Ophthalmology meeting 2023, New Orleans, LA, USA, to present the findings for the study; and is a consultant... for Leica Microsystems. MH and GM were funded through Action Medical Research, the NIHR Clinical Research Network and the Ulverscroft Foundation. AM reports funding from Action Medical Research to provide statistical support. A-DN is the local principal investigator for commercially sponsored randomised controlled trials (through Moorfields Eye Hospital, London, UK) for MyopiaX, Nevakar/Vyluma, Ocumension/Ora Health, and the UK National Institute for Health and Care Research (NIHR); and reports honoraria for educational activities from Santen, Novartis, Zeiss, and CooperVision, and for participation on advisory boards from Santen, SightGlassVision, Thea, and CooperVision. EP, PK, JS, and CB declare no competing interests.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1016/S0140-6736(23)02893-3

Clinical validity of the Italian adaptation of the Uniform Data Set Neuropsychological Test Battery (I-UDSNB) in Mild Cognitive Impairment and Alzheimer's Disease.

Fuente:Alzheimer's Research & Therapy

Extracto: Our findings indicate that the I-UDSNB is a suitable tool for the harmonized and concise assessment of patients with cognitive decline, showing high sensitivity and specificity for the diagnosis of MCI and AD.

Claves:Alzheimer’s Disease, Cognition, Mild Cognitive Impairment, Neuropsychological tests, UDS

Cita:Alzheimers Res Ther 2024 May 4; 16 (1) : 98.

Autor/es:Conca, Francesca (a)
Esposito, Valentina (b)

institución:(a) ICoN Cognitive Neuroscience Center, Institute for Advanced Studies, IUSS, Pavia, Italy.
(b) IRCCS Mondino Foundation, Pavia, Italy.

Conflicto:V. Silani received compensation for consulting services and/or speaking activities from AveXis, Cytokinetics, Italfarmaco, Liquidweb S.r.l., Novartis Pharma AG and Zambon Biotech SA; he receives or has received research supports form the Italian Ministry of Health, AriSLA, E-Rare Joint Transnational Call, and the ERN Euro-NMD. He is in the Editorial Board of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, European Neurology,... American Journal of Neurodegenerative Diseases, Frontiers in Neurology, and Exploration of Neuroprotective Therapy. E. Canu receives research supports from the Italian Ministry of Health. M. Filippi is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain Mapping, Neurological Sciences, and Radiology; he received compensation for consulting services from Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi and for speaking activities from Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA; participation in Advisory Boards for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda; scientific direction of educational events for Biogen, Merck, Roche, Celgene, Bristol-Myers Squibb, Lilly, Novartis, Sanofi-Genzyme; he receives research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13195-024-01465-0

Study protocol: exercise training for treating major depressive disorder in multiple sclerosis.

Study protocol: exercise training for treating major depressive disorder in multiple sclerosis.

Fuente:Bmc Neurology

Extracto: The registration occurred before we initiated recruitment on June 2, 2023.

Claves:Behavior change, Depression, Exercise, Mental health, Mood, Multiple sclerosis, Neurological disease, Physical activity, Telehealth

Cita:BMC Neurol 2024 Apr 17; 24 (1) : 131.

Autor/es:Motl, Robert W (a)
Bombardier, Charles H (b)

institución:(a) Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, 60612, USA. robmotl@uic.edu.
(b) Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12883-024-03634-y

Potential of niacin skin flush response in adolescent depression identification and severity assessment: a case-control study.

Potential of niacin skin flush response in adolescent depression identification and severity assessment: a case-control study.

Fuente:Bmc Psychiatry

Extracto: The NSFR demonstrates potential as an objective biomarker for adolescent Depressive Disorder, aiding in screening, assessing severity, and enhancing insights into its pathophysiology and diagnostic precision.

Claves:Adolescent depressive disorder, Behavioral and emotional disorders typically emerging in childhood and adolescence, Biomarker, Niacin skin flush response, Precision diagnosis

Cita:BMC Psychiatry 2024 Apr 17; 24 (1) : 290.

Autor/es:Feng, Jie (a)
Min, Wenjiao (b)

institución:(a) Department of Psychosomatics, School of Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 32, West second Section, 1st Ring Road, 610041, Chengdu, Sichuan, China.
(b) Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05728-w

Development of mental health first-aid guidelines for a person after a potentially traumatic event

Fuente:Bmc Psychiatry

Tipo de trabajo:Consenso

Extracto: The study showed a high level of acceptance of the original actions suggested for inclusion in the guidelines for Australia, but also a significant number of new statements that highlight the importance of the adaptation process. Further research on the dissemination of these guidelines into a Mental Health First Aid training course for Chile and Argentina is still required.

Claves:Argentina, Chile, Cultural adaptation, Delphi study, Mental health first aid (MHFA), Trauma

Cita:BMC Psychiatry 2024 Apr 17; 24 (1) : 291.

Autor/es:Agrest, Martín (a)
Tapia-Muñoz, Thamara (b)

institución:(a) Proyecto Suma. Güemes 4130 (1425), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina. magrest66@gmail.com.
(b) Facultad de Psicología, Instituto de Investigaciones, Universidad de Buenos Aires, Buenos Aires, Argentina. magrest66@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05631-4

IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset.

IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset.

Fuente:Journal of Neuroinflammation

Extracto: Circulating IgM anti-GM2 antibodies define a subgroup of patients with MMN that has an earlier onset of disease. These antibodies probably target SCs specifically and activate complement, similarly as IgM anti-GM1 on MNs. Our data indicate that complement activation by IgM antibodies bound to SCs and MNs underlies MMN pathology.

Claves:Anti-ganglioside antibodies, Complement, IgM anti-GM2, Multifocal motor neuropathy, Schwann cells

Cita:J Neuroinflammation 2024 Apr 17; 21 (1) : 100.

Autor/es:Budding, Kevin (a)
Bos, Jeroen W (b)

institución:(a) Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
(b) Department of Neurology and Neurosurgery, University Medical Center Utrecht Brain Center, Utrecht, The Netherlands.

Conflicto:KB, EdZ, KD, LMB are employees of the UMC Utrecht on a research service collaboration with argenx BVBA. JWB reports no disclosures. EMZ reports no disclosures. EJNG reports a research grants from the Prinses Beatrix Spierfonds and has received teaching fees from Biogen, all paid to the institution. BCJ reports grants for research from the GBS/CIDP Foundation International, Prinses Beatrix... Spierfonds, Horizon 2020, NIH, Erasmus MC, Annexon, CSL-Behring, Grifols, Hansa Biopharma, Roche and Octapharma. BCJ is chairing the Steering Committee of the International GBS Outcome Study (IGOS), a member of the Advisory Board of Hansa Biopharma and Annexon and of the Global Medical Advisory Board of the GBS-CIDP Foundation International. RH reports grants from the GBS/CIDP Foundation International, NIH and the T2B collaboration project funded by PPP Allowance made available by Top Sector Life Sciences & Health to Samenwerkende Gezondheidsfondsen (SGF) under project number LSHM18055-SGF to stimulate public-private partnerships and co-financing by health foundations that are part of the SGF. HSG has received research grants from the Prinses Beatrix Spierfonds, speaker fees, and consultancy for Takeda and Quaralis all paid to the institution. EC reports no disclosures. JHWL reports no disclosures. LHvdB received an educational grant from Takeda; serves on the editorial boards of Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration; and receives research support from the Netherlands ALS Foundation. CEH provides consultancy services to argenx BVBA. WLvdP serves on the scientific advisory board for SAB SMA Europe; provides ad hoc consultancy for argenx BVBA, Biogen, and Novartis genetherapies; is the local PI for the ARDA and ARDA + trials and receives research support from the Prinses Beatrix Spierfonds, Vriendenloterij and Stichting Spieren voor Spieren.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12974-024-03090-y

Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial.

Effectiveness of interventions to improve adherence to antidepressant medication in patients with depressive disorders: a cluster randomized controlled trial.

Fuente:Frontiers in Public Health

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: The assessed interventions to improve adherence in patients with depressive disorder were effective for depression symptoms and mental quality of life, even over the long term. However, no effect on antidepressant adherence was observed.

Claves:Spain, antidepressive agents, depression, randomized controlled trial, treatment adherence and compliance

Cita:Front Public Health 2024; 12 : 1320159.

Autor/es:Del Pino-Sedeño, Tasmania (a)
González-Pacheco, Himar (b)

institución:(a) Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain.
(b) Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1320159

Case report: EBV-related eye orbits and sinuses lymphohistiocytic infiltration responsive to rituximab in a patient with X lymphoproliferative syndrome type 1.

Case report: EBV-related eye orbits and sinuses lymphohistiocytic infiltration responsive to rituximab in a patient with X lymphoproliferative syndrome type 1.

Fuente:Frontiers in Immunology

Extracto: We described an unusual presentation of incomplete HLH in a patient affected with XLP1: an EBV-driven infiltration of the orbits and paranasal sinuses. This led us to a challenging differential diagnosis of lymphoma-associated hemophagocytic syndrome, which can be frequently observed in patients with XLP1. Considering the extremely poor prognosis of this clinical finding, we sought for a prompt diagnosis and managed to obtain it and to immediately establish the right treatment on the basis of the pathological finding.

Claves:EBV, SH2D1A, X lymphoproliferative syndrome type 1, eye lymphohistiocytic infiltration, rituximab

Cita:Front Immunol 2024; 15 : 1370991.

Autor/es:Giardino, Giuliana (a)
Lanni, Vittoria (b)

institución:(a) Department of Translational Medical Sciences, Pediatric Section, Federico II University of Naples, Naples, Italy.
(b) Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1370991

Overcoming Methodological Challenges for Advancing Stem Cell Therapies in Parkinson's Disease.

Overcoming Methodological Challenges for Advancing Stem Cell Therapies in Parkinson's Disease.

Fuente:Cell Transplantation

Extracto: Overall, this review underscores the need for further research and innovation to overcome the hurdles in realizing the potential of stem cell-based therapies for PD.

Claves:Parkinson’s disease, methodological challenges, sham surgery, stem cell therapy, treatment algorithm

Cita:Cell Transplant 2024 Jan-Dec; 33 : 9636897241246355.

Autor/es:Polgar, Stephen (a)
Finkelstein, David I (b)

institución:(a) School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.
(b) University of Melbourne, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/09636897241246355