Prevalence and genetic basis of Mycobacterium tuberculosis resistance to pretomanid in China.

Prevalence and genetic basis of Mycobacterium tuberculosis resistance to pretomanid in China.

Fuente:Annals of Clinical Microbiology and Antimicrobials

Extracto: Our results further support a breakpoint of 0.5 mg/L for a non-L1 MTB population, which is characteristic of China. Further, our data point to an unexpected high (14/475, 3%) pre-existing pretomanid resistance rate in the country, as well as to the existence of yet-to-be-discovered pretomanid resistance genes.

Claves:Breakpoint, Mutation, Pretomanid, Resistance

Cita:Ann Clin Microbiol Antimicrob 2024 May 3; 23 (1) : 40.

Autor/es:Zhao, Bing (a)
Zheng, Huiwen (b)

institución:(a) National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
(b) Laboratory of Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Children's Hospital, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Beijing Pediatric Research Institute, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12941-024-00697-0

Ozone as an environmental driver of influenza.

Ozone as an environmental driver of influenza.

Fuente:Nature Communications

Extracto: With O(3) commonly known as air pollutant, the novel findings here on the inhibition effect of O(3) on influenza activity warrant further investigations to inform environmental management and public health protection.

Cita:Nat Commun 2024 May 4; 15 (1) : 3763.

Autor/es:Guo, Fang (a)
Zhang, Pei (b)

institución:(a) School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, PR China.
(b) School of Public Health, The University of Hong Kong, Pok Fu Lam, Hong Kong SAR, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48199-z

Genetic association of inflammatory marker GlycA with lung function and respiratory diseases.

Fuente:Nature Communications

Extracto: Our findings provide insights into biological mechanisms of GlycA in relating to lung function, asthma, and COPD.

Cita:Nat Commun 2024 May 4; 15 (1) : 3751.

Autor/es:Guo, Yanjun (a)
Liu, Quanhong (b)

institución:(a) Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. yanjunguo@hust.edu.cn.
(b) Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. yanjunguo@hust.edu.cn.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47845-w

Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomer.

Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomer.

Fuente:Scientific Reports

Extracto: In conclusion, the fynomer-based vaccine can be considered as a new style in designing and updating vaccines to protect against coronavirus disease.

Cita:Sci Rep 2024 May 4; 14 (1) : 10297.

Autor/es:Sarvmeili, Javad (a)
Baghban Kohnehrouz, Bahram (b)

institución:(a) Department of Plant Breeding and Biotechnology, University of Tabriz, Tabriz, 51666, Iran.
(b) Department of Plant Breeding and Biotechnology, University of Tabriz, Tabriz, 51666, Iran. bahramrouz@yahoo.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61025-2

Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer.

Fuente:Scientific Reports

Extracto: HCY-based prognostic models are effective tools for a comprehensive evaluation of prognosis.

Claves:Colorectal cancer, Homocysteine, Malnutrition, Nomogram, Prognostic

Cita:Sci Rep 2024 May 2; 14 (1) : 10057.

Autor/es:Xie, Hailun (a)
Wei, Lishuang (b)

institución:(a) Department of Gastrointestinal Gland Surgery, The First Affiliated Hospital, Guangxi Medical University, 6 Shuangyong Road, Nanning, 530021, Guangxi, People's Republic of China.
(b) Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, Nanning, 530021, Guangxi, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-60855-4

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study.

Critical COVID-19, Victivallaceae abundance, and celiac disease: A mediation Mendelian randomization study.

Fuente:Plos One

Extracto: In conclusion, our analysis provides genetic evidence supporting the causal connection between critical COVID-19 and lower Victivallaceae abundance, thereby increasing the risk of celiac disease.

Cita:PLoS One 2024; 19 (5) : e0301998.

Autor/es:Zou, Yuxin (a)
Pan, Manyi (b)

institución:(a) Department of Respiratory and Critical Care Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
(b) Department of Respiratory and Critical Care Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Conflicto:The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301998

Unusual presentation of Sjogren's syndrome during pregnancy

Unusual presentation of Sjogren's syndrome during pregnancy

Fuente:Journal of Medical Case Reports

Tipo de trabajo:Caso clínico

Extracto: This case underscores that prompt recognition and management are paramount to prevent life-threatening complications in pregnant patients with autoimmune disease. This report sheds light on the unique challenge of managing hypokalaemic quadriparesis in the context of Sjogren's syndrome during pregnancy.

Claves:Renal tubular acidosis, Respiratory failure, Severe hypokalaemia, Sjogren’s syndrome (SS)

Cita:J Med Case Rep 2024 May 4; 18 (1) : 236.

Autor/es:Sundarsingh, Vijay (a)
Kumar, R Manoj (b)

institución:(a) Department of Critical Care Medicine, Father Muller Medical College, Mangaluru, India. vijayss87pm@gmail.com.
(b) Department of Anaesthesiology, Father Muller Medical College, Mangaluru, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13256-024-04563-7

Protocol implementation during the COVID-19 pandemic: experiences from a randomized trial of stress ulcer prophylaxis.

Fuente:Bmc Medical Research Methodology

Extracto: Protocol implementation adaptations during the pandemic included a shift in the consent model, a sustained high consent rate, and launch of a COVID-19 substudy. Recruitment increased as new centers joined, patient transfers were optimized, and monitoring methods were adapted.

Claves:COVID-19 Pandemic, Critically ill, Gastrointestinal bleeding, Hospital transfers, Randomization, Stress ulceration, Ventilator-associated pneumonia

Cita:BMC Med Res Methodol 2024 May 4; 24 (1) : 109.

Autor/es:Dennis, Brittany (a)
Deane, Adam (b)

institución:(a) Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
(b) Department of Critical Care Or Medicine, Department of Critical Care Medicine, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12874-024-02233-2

Changes in the epidemiology and clinical characteristics of viral gastroenteritis among hospitalized children in the Mainland of China: a retrospective study from 2016 to 2020.

Changes in the epidemiology and clinical characteristics of viral gastroenteritis among hospitalized children in the Mainland of China: a retrospective study from 2016 to 2020.

Fuente:Bmc Pediatrics

Extracto: This finding suggests that viral gastroenteritis, especially those caused by RV, is a prevalent illness among younger children. Co-infections and the presence of other diseases are common. The seasonality and regional variation of viral etiological agents highlight the need for targeted prevention and control measures. Although viral gastroenteritis rarely leads to death, it also results in a significant economic burden on healthcare systems.

Claves:Children, Co-infection, Epidemiology, Viral gastroenteritis

Cita:BMC Pediatr 2024 May 4; 24 (1) : 303.

Autor/es:Li, Fei (a)
Guo, Lingyun (b)

institución:(a) Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
(b) Department of Infectious Disease, National Center for Children's Health, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04776-1

Burden of COVID-19 pandemic on tuberculosis hospitalisation patterns at a tertiary care hospital in Rajasthan, India: a retrospective analysis.

Burden of COVID-19 pandemic on tuberculosis hospitalisation patterns at a tertiary care hospital in Rajasthan, India: a retrospective analysis.

Fuente:Bmj Open

Extracto: The study underscores the influence of the COVID-19 pandemic on the TB landscape and hospitalisation dynamics. Notably, patient burden of TB declined during the COVID-19 era, with a decline in the post-COVID-19 era compared with the pre-COVID-19 era. Prolonged hospitalisation in the post-COVID-19 period indicates the need for adaptive healthcare strategies and the formulation of public health policies in a post-pandemic context. These findings contribute to a comprehensive understanding of the evolving TB scenario, emphasising the necessity for tailored healthcare approaches in the aftermath of a global health crisis.

Claves:COVID-19, Public health, Tuberculosis

Cita:BMJ Open 2024 May 3; 14 (5) : e080623.

Autor/es:Rajotiya, Sumit (a)
Mishra, Shivang (b)

institución:(a) Department of Pharmacy Practice, NIMS University, Jaipur, Rajasthan, India.
(b) Department of Pharmacy Practice, NIMS University, Jaipur, Rajasthan, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-080623

Clinical and immunological comparison of COVID-19 disease between critical and non-critical courses

Clinical and immunological comparison of COVID-19 disease between critical and non-critical courses

Fuente:Frontiers in Immunology

Tipo de trabajo:Revisión sistemática

Extracto: In conclusion, our data suggest that critical patients suffer from a suppressed immune system, and the inflammation level, the risk of organ damage, and co-infections are significantly high in the critical group and suggests the use of bacteriostatic instead of bactericides to treat co-infections.

Claves:COVID-19, co-infection, critical, mortality, sever

Cita:Front Immunol 2024; 15 : 1341168.

Autor/es:Hedayati-Ch, Mojtaba (a)
Ebrahim-Saraie, Hadi Sedigh (b)

institución:(a) Department of Microbiology, Virology and Microbial Toxins, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
(b) Microbial Toxins Physiology Group (MTPG), Universal Scientific Education and Research Network (USERN), Rasht, Iran.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1341168

Multiple Causes of Death Associated with Pediatric Cardiopulmonary Arrest from 1996 to 2019 in Brazil.

Multiple Causes of Death Associated with Pediatric Cardiopulmonary Arrest from 1996 to 2019 in Brazil.

Fuente:Arquivos Brasileiros de Cardiologia

Extracto: Perinatal and external causes were the primary causes of death, with highest MRs under the age of 20 years in Brazil from 1996 to 2019. When multiple causes of death were considered, the main primary causes associated with CPA were respiratory, hematologic, and neoplastic diseases. Most deaths occurred in the hospital environment. Better understanding of the sequence of events in these deaths and improvements in teaching strategies in pediatric cardiopulmonary resuscitation are needed.

Cita:Arq Bras Cardiol 2024; 121 (4) : e20230480.

Autor/es:de Andrade, Thayanne Mendes (a)
Marques, Mariara Lopes da Costa (b)

institución:(a) Programa de Pós-graduação em Cardiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
(b) Programa de Pós-graduação em Cardiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.

Formato:Informe virtual

Idioma:por, eng

País de fuente:Brasil

Sitio web:http://dx.doi.org/10.36660/abc.20230480

Pulmonary Arterial Hypertension with Features of Venous Involvement: A Detective's Task.

Fuente:Arquivos Brasileiros de Cardiologia

Extracto: We present a case of a 58-year-old man with PAH with features of venous/capillary involvement in which clinical suspicion, prompt diagnosis, and early referral for lung transplantation were determinant factors for the successful outcome.

Cita:Arq Bras Cardiol 2024; 121 (4) : e20230565.

Autor/es:Cazeiro, Daniel Inácio (a)
Plácido, Rui (b)

institución:(a) Departamento de Coração e Vasos - Centro Hospitalar Universitário Lisboa Norte - Faculdade de Medicina de Lisboa - Universidade de Lisboa, Lisboa - Portugal.
(b) Departamento de Coração e Vasos - Centro Hospitalar Universitário Lisboa Norte - Faculdade de Medicina de Lisboa - Universidade de Lisboa, Lisboa - Portugal.

Formato:Informe virtual

Idioma:por, eng

País de fuente:Brasil

Sitio web:http://dx.doi.org/10.36660/abc.20230565

Comparable Ventilatory Inefficiency at Maximal and Submaximal Performance in COPD vs. CHF subjects: An Innovative Approach.

Fuente:Arquivos Brasileiros de Cardiologia

Extracto: The η V ˙ E is a valuable method for comparison between cardiopulmonary diseases, with so far distinct physiopathological mechanisms, including ventilatory constraints in COPD.

Cita:Arq Bras Cardiol 2024; 121 (4) : e20230578.

Autor/es:de Campos, Gerson Gatass Orro (a)
Goelzer, Leandro Steinhorst (b)

institución:(a) Universidade Federal de Mato Grosso do Sul (UFMS) - Hospital Maria Aparecida Pedrossian (HUMAP), Laboratório de Fisiopatologia Respiratória (LAFIR), Campo Grande, MS - Brasil.
(b) Universidade Federal de Mato Grosso do Sul (UFMS) - Hospital Maria Aparecida Pedrossian (HUMAP), Laboratório de Fisiopatologia Respiratória (LAFIR), Campo Grande, MS - Brasil.

Formato:Informe virtual

Idioma:por, eng

País de fuente:Brasil

Sitio web:http://dx.doi.org/10.36660/abc.20230578

Adverse outcomes in patients hospitalized with pneumonia at age 60 or more: A prospective multi-centric hospital-based study in India.

Adverse outcomes in patients hospitalized with pneumonia at age 60 or more: A prospective multi-centric hospital-based study in India.

Fuente:Plos One

Tipo de trabajo:Guía

Extracto: High ICU admission and 30-day mortality rates were observed among older adults with pneumonia, with a significant proportion linked to influenza and RSV infections. Comprehensive guidelines for CAP prevention and management in older adults are needed, especially with the co-circulation of SARS-CoV-2.

Cita:PLoS One 2024; 19 (5) : e0297452.

Autor/es:Kanungo, Suman (a)
Bhattacharjee, Uttaran (b)

institución:(a) ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
(b) ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.

Conflicto:All the authors have declared that no competing interests exist.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0297452

Association of chest computed tomography severity score at ICU admission and respiratory outcomes in critically ill COVID-19 patients.

Fuente:Plos One

Extracto: COVID-19 patients with >50% lung involvement on Chest-CT admission presented higher chances to stay longer on invasive mechanical ventilation and more chances to developed ventilator-associated pneumonia.

Cita:PLoS One 2024; 19 (5) : e0299390.

Autor/es:Esper Treml, Ricardo (a)
Caldonazo, Tulio (b)

institución:(a) Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University, Jena, Germany.
(b) Department of Anesthesiology, University of São Paulo, São Paulo, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299390

Assessing the reproducibility and predictive value of objective cough measurement for successful withdrawal of invasive ventilatory support in adult patients.

Assessing the reproducibility and predictive value of objective cough measurement for successful withdrawal of invasive ventilatory support in adult patients.

Fuente:Bmc Pulmonary Medicine

Extracto: The objective measurement of cough using the method employed in our study demonstrates nearly perfect intra-observer reproducibility and agreement. However, its ability to predict success or failure in the weaning process is limited.

Claves:Airway extubation, Cough, Mechanical ventilation

Cita:BMC Pulm Med 2024 May 2; 24 (1) : 218.

Autor/es:Varón-Vega, Fabio (a)
Rincón, Adriana (b)

institución:(a) Critical Care and Lung transplantation Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Bogotá, Colombia. fvaron@neumologica.org.
(b) Critical Care Service, Fundación Neumológica Colombiana, Fundación Cardio Infantil, Cra. 13b #161 - 85., Bogotá, 110131, Colombia. fvaron@neumologica.org.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03033-6

Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry.

Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry.

Fuente:Journal of Immunology Research

Extracto: Cardiovascular symptoms were more prevalent in the ANCA-negative subset than in the MPO-ANCA-positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.

Cita:J Immunol Res 2024; 2024 : 4283928.

Autor/es:Drynda, Anna (a)
Padjas, Agnieszka (b)

institución:(a) Students' Scientific Group of Immune Diseases and Hypercoagulation, Jagiellonian University Medical College, Cracow, Poland.
(b) 2nd Department of Internal Medicine, Jagiellonian University Medical College, Cracow, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Egipto

Sitio web:http://dx.doi.org/10.1155/2024/4283928

Temporal change in multimorbidity prevalence, clustering patterns, and the association with mortality: findings from the China Kadoorie Biobank study in Jiangsu Province.

Temporal change in multimorbidity prevalence, clustering patterns, and the association with mortality: findings from the China Kadoorie Biobank study in Jiangsu Province.

Fuente:Frontiers in Public Health

Extracto: The prevalence of multimorbidity has increased substantially over the past decade. This study has revealed that cardiometabolic multimorbidity and respiratory multimorbidity have significantly increased mortality rates. These findings indicate the need to consider high-risk populations and to provide local evidence for intervention strategies and health management in economically developed regions.

Claves:cluster analysis, cohort study, mortality, multimorbidity, prevalence

Cita:Front Public Health 2024; 12 : 1389635.

Autor/es:Yu, Hao (a)
Tao, Ran (b)

institución:(a) Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
(b) Department of Noncommunicable Chronic Disease and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1389635

Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database).

Bronchiectasis in Türkiye: Data from a Multicenter Registry (Turkish Adult Bronchiectasis Database).

Fuente:Balkan Medical Journal

Tipo de trabajo:Estudio de cohortes

Extracto: This is the first multicenter study of bronchiectasis in Türkiye. The study results will provide important data that can guide the development of health policies in Türkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.

Cita:Balkan Med J 2024 May 3; 41 (3) : 206-212.

Autor/es:Çakır Edis, Ebru (a)
Çilli, Aykut (b)

institución:(a) Department of Pulmonary Medicine, Trakya University Faculty of Medicine, Edirne, Türkiye.
(b) Department of Pulmonary Medicine, Akdeniz University Faculty of Medicine, Antalya, Türkiye.

Conflicto:Conflict of Interest: No conflict of interest was declared by the authors.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Turquía

Sitio web:http://dx.doi.org/10.4274/balkanmedj.galenos.2024.2023-12-57