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Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS
Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS
Fuente:Frontiers in Cellular and Infection Microbiology
Tipo de trabajo:Estudio de cohortes
Extracto:
The improvements in pulmonary
function and exercise capacity, imaging, and health-related quality of life had
different time phase and impact on each other during 12 months of follow-up.
Long-term outcomes of pulmonary fibrosis might be related to the lung injury and
excessive lung fibroproliferation at the early stage during ICU admission.
Claves:acute respiratory distress syndrome (ARDS), influenza A (H1N1) virus, pulmonary fibrosis, pulmonary function, severe community-acquired pneumonia (SCAP)
institución:(a) Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. (b) Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Wound healing rates in COPD patients undergoing traditional pulmonary rehabilitation versus tailored Wound-Centric interventions.
Wound healing rates in COPD patients undergoing traditional pulmonary rehabilitation versus tailored Wound-Centric interventions.
Fuente:International Wound Journal
Extracto:
These findings supported
the adoption of customized, multidisciplinary care plans, suggesting that
tailored interventions can offer a comprehensive solution to the complex needs of
COPD patients, potentially redefining best practices in chronic disease
management.
institución:(a) Department of Respiratory and Critical Care Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai, China. (b) Department of Thoracic Care Unit, Shanghai Pulmonary Hospital, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
YAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma.
YAP/TAZ-TEAD signalling axis: A new therapeutic target in malignant pleural mesothelioma.
Fuente:Journal of Cellular and Molecular Medicine
Extracto:
Several inhibitors of the YAP/TAZ-TEAD signalling axis are presently undergoing
clinical development, with the goal of advancing them to clinical use in the near
future.
Autor/es:Papavassiliou, Kostas A (a) Sofianidi, Amalia A (b)
institución:(a) First University Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. (b) Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Conflicto:The authors declare no competing financial or non‐financial interests.
The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38-S100A8 Feed-Forward Regulatory Loop.
The Natural Product Secoemestrin C Inhibits Colorectal Cancer Stem Cells via p38-S100A8 Feed-Forward Regulatory Loop.
Fuente:Cells
Extracto:
This showed that Sec C could act as a promising clinical candidate in
colorectal cancer treatment, and S100A8 could be a prospective drug target.
institución:(a) State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Antibiotic Bioengineering, Ministry of Health, Laboratory of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. (b) NHC Key Laboratory of Biotechnology of Antibiotics, National Center for New Microbial Drug Screening, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1 Tiantan Xili, Beijing 100050, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Department of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. (b) Department of Respiratory Medicine, NHO Fukuoka National Hospital, Fukuoka, Japan.
Conflicto:TY This research was supported by the Kakihara Foundation and Boehringer Ingelheim, KH, KM, KK, KS, KT, SI, YB, YF, IO No competing interests declared
Empowering Little Fighters: Post-Cardiotomy Pediatric ECMO and the Journey to Recovery.
Empowering Little Fighters: Post-Cardiotomy Pediatric ECMO and the Journey to Recovery.
Fuente:Annals of Cardiac Anaesthesia
Extracto:
The early initiation of ECMO for paediatric cardiotomies
could be a beacon of hope for families and medical teams confronting these
challenging situations. Improvement in indicators of adequate perfusion and
ventricular recoveries like pH and serum lactate and absence of arrhythmia and
sepsis are associated with good outcomes.
institución:(a) Department of Anaesthesia and Critical Care, Armed Forces Medical College, Pune, Maharashtra, India. (b) Department of Anaesthesia, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, Delhi, India.
Pecto-intercostal Fascial Plane Block: A Novel Technique for Analgesia in Patients with Sternal Dehiscence.
Pecto-intercostal Fascial Plane Block: A Novel Technique for Analgesia in Patients with Sternal Dehiscence.
Fuente:Annals of Cardiac Anaesthesia
Extracto:
The authors concluded that bilateral
PIFB can be effectively used as an adjunct to multimodal analgesia with general
anesthesia and as a sole anesthesia technique in selected cases of sternal wound
debridement.
institución:(a) Department of Cardiac Anaesthesia, Ozone Anaesthesia Group, Aurangabad, Maharashtra, India. (b) Department of Cardiac Anaesthesia, Ozone Anaesthesia Group, Aurangabad, Maharashtra, India.
Association of blood eosinophils with corticosteroid treatment failure stratified by smoking status among inpatients with AECOPD.
Association of blood eosinophils with corticosteroid treatment failure stratified by smoking status among inpatients with AECOPD.
Fuente:Bmj Open Respiratory Research
Extracto:
Elevated blood eosinophils are associated with
a lower rate of corticosteroid treatment failure, regardless of smoking status.
Smoking does not modify the association between blood eosinophil level and
corticosteroid treatment failure among inpatients with AECOPD.
Claves:COPD epidemiology
Cita:BMJ Open Respir Res 2024 Apr 12; 11 (1)
Autor/es:Li, Jiachen (a) Zuo, Yingting (b)
institución:(a) Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. (b) Department of Clinical Epidemiology, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A prospective observational cohort study of covid-19 epidemiology and vaccine seroconversion in South Western Sydney, Australia, during the 2021-2022 pandemic period.
A prospective observational cohort study of covid-19 epidemiology and vaccine seroconversion in South Western Sydney, Australia, during the 2021-2022 pandemic period.
Fuente:Bmc Nephrology
Tipo de trabajo:Estudio de cohortes
Extracto:
COVID-19 was associated with a high mortality rate. Older age,
respiratory disease and prior smoking exposure may be risk factors for increased
mortality. Vaccination of 3 doses is protective against acquiring COVID-19 and
death, however not hospitalisation. Antibody response is protective for acquiring
COVID-19, however seroconversion rates are low.
institución:(a) University of Western Sydney, Sydney, NSW, Australia. daniela.potter@health.nsw.gov.au. (b) University of New South Wales, Sydney, NSW, Australia. daniela.potter@health.nsw.gov.au.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer - a monocenter retrospective study.
One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer - a monocenter retrospective study.
Fuente:Bmc Anesthesiology
Tipo de trabajo:Estudio de cohortes
Extracto:
When necessary, transatlantic air
transfer of patients with suspected aSAH after management according to local
guidelines seems feasible and safe.
Autor/es:Martino, Frédéric (a) Fleuri, Antoine (b)
institución:(a) Réanimation Médicale et Chirurgicale, CHU de la Guadeloupe, Route de Chauvel, Pointe à Pitre Cedex, Guadeloupe, 97159, France. frederic.martino@chu-guadeloupe.fr. (b) Université Paris Cité and Université des Antilles, INSERM, Biologie intégrée du globule rouge, Paris, France. frederic.martino@chu-guadeloupe.fr.
Conflicto:I have read the journal’s policy and the authors of this manuscript have the following competing interests: AD reports grants, personal fees and non-financial support from Philips, personal fees from Baxter, personal fees and non-financial support from Fisher & Paykel, grants from French Ministry of Health, personal fees from Getinge, grants, personal fees and non-financial support from Respinor, grants, personal...
al fees and non-financial support from Lungpacer, personal fees from Lowenstein, personal fees from Gilead, outside the submitted work. This does not alter our adherence on sharing data and materials. FM has no conflict of interest to report. AF has no conflict of interest to report. NE has no conflict of interest to report. AR has no conflict of interest to report. MP has no conflict of interest to report. MC has no conflict of interest to report. DD has no conflict of interest to report. LD has no conflict of interest to report. AP has no conflict of interest to report. PP has no conflict of interest to report. MS has no conflict of interest to report. MV has no conflict of interest to report. LC has no conflict of interest to report. JDP has no conflict of interest to report.
Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.
Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology.
Fuente:Bmc Pulmonary Medicine
Extracto:
The differential gene analysis of Chip
GSE38974-GPL7723 and the retrieval results from the Vesiclepedia database
identified candidate miRs, specifically miR-422a. Further analysis involved the
intersection of predictions from TargetScan, miRWalk, and RNA22 databases, gene
search on COPD-related genes from the GeneCards database, WGCNA analysis from
Chip GSE38974-GPL4133, and differential gene analysis, combined with KEGG
functional enrichment analysis and protein interaction analysis. Ultimately, the
target gene SPP1 and its upstream regulatory gene miR-422a were selected. KEGG
functional enrichment analysis on mRNAs correlated with SPP1 revealed the
involvement of the IL-17 signaling pathway. In vitro experiments showed that
miR-422a targeted inhibition suppressed the expression of SPP1 in myofibroblast
cells, inhibiting differentiation phenotype. Furthermore, bronchial epithelial
cells could compensate for myofibroblast differentiation phenotype under
cigarette smoke extract (CSE) stress by altering the miR-422a content in their
extracellular vesicles (EVs).
institución:(a) Department of Respiratory and Critical Care Medicine, Yongkang First People's Hospital, Hangzhou Medical College, No. 599 Jinshan West Road, 321300, Yongkang, Zhejiang Province, P. R. China. (b) Department of Respiratory and Critical Care Medicine, Yongkang First People's Hospital, Hangzhou Medical College, No. 599 Jinshan West Road, 321300, Yongkang, Zhejiang Province, P. R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Lung adenocarcinoma discovered during the follow-up of lung-dominant connective tissue disease
Lung adenocarcinoma discovered during the follow-up of lung-dominant connective tissue disease
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Revisión
Extracto:
The available literatures about the differential diagnosis of
clinical manifestations, imaging, treatment and prognosis of LD-CTD are reviewed
and discussed in this study.
Claves:Case report, Interstitial lung disease, Literature review, Lung cancer, Lung-dominant
Cita:BMC Pulm Med 2024 Apr 12; 24 (1) : 175.
Autor/es:Zhu, Zi Heng (a) Guo, Yi (b)
institución:(a) Department of Respiratory Medicine and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (b) Department of Respiratory Medicine, Qingyang Hospital of Traditional Chinese Medicine, 745000, Qingyang, Gansu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries.
The World Health Organization Antenatal CorTicosteroids for Improving Outcomes in preterm Newborns (ACTION-III) Trial: study protocol for a multi-country, multi-centre, double-blind, three-arm, placebo-controlled, individually randomized trial of antenatal corticosteroids for women at high probability of late preterm birth in hospitals in low- resource countries.
Fuente:Trials
Tipo de trabajo:Guía
Extracto:
Registered on 7 June 2021.
Claves:Antenatal corticosteroids, Betamethasone, Dexamethasone, Late preterm birth, Low- resource setting
Cita:Trials 2024 Apr 12; 25 (1) : 258.
Autor/es:Antenatal corticosteroids, Betamethasone, Dexamethasone, Late preterm birth, Low- resource setting
institución:Antenatal corticosteroids, Betamethasone, Dexamethasone, Late preterm birth, Low- resource setting
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Understanding the association between pain and delirium in older hospital inpatients
Understanding the association between pain and delirium in older hospital inpatients
Fuente:Age and Ageing
Tipo de trabajo:Revisión sistemática
Extracto:
An increase in pain was associated with a higher risk of
developing delirium. Adequate pain management with appropriate analgesia may
reduce incidence and severity of delirium.
Claves:analgesia, delirium, general hospitals, older people, pain, systematic review
Cita:Age Ageing 2024 Apr 1; 53 (4)
Autor/es:White, Nicola (a) Bazo-Alvarez, Juan Carlos (b)
institución:(a) Marie Curie Palliative Care Research Department, Division of Psychiatry, Faculty of Brain Sciences, University College London, London, UK. (b) Research Department of Primary Care and Population Health, University College London, London, UK.
Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist's Key Role.
Multidisciplinary Approach to the Diagnosis of Idiopathic Interstitial Pneumonias: Focus on the Pathologist's Key Role.
Fuente:International Journal of Molecular Sciences
Extracto:
Therefore, the pathologist's aim is to
recognize the pathologic-morphologic pattern of disease in this clinical setting,
and only after multi-disciplinary evaluation, if there is concordance between
clinical and radiological findings, a definitive diagnosis of specific IIP can be
established, allowing the optimal clinical-therapeutic management of the patient.
institución:(a) Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Naples, Italy. (b) Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Naples, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autor/es:Pulito-Cueto, Verónica (a) Sebastián Mora-Gil, María (b)
institución:(a) Immunopathology Group, Marqués de Valdecilla University Hospital-Valdecilla Research Institute (IDIVAL), 39008 Santander, Spain. (b) Department of Rheumatology, Marqués de Valdecilla University Hospital, 39008 Santander, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Effects of Anti-Fibrotic Drugs on Transcriptome of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis.
Effects of Anti-Fibrotic Drugs on Transcriptome of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis.
Fuente:International Journal of Molecular Sciences
Extracto:
This study embraces a novel approach by using RNA sequencing to examine PBMCs in
IPF, potentially revealing systemic biomarkers or pathways that could be targeted
for therapy.
institución:(a) Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. (b) Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Conflicto:Mitsuhiro Abe reports personal speaking and lecture fees from Boehringer Ingelheim, Japan. Takuji Suzuki reports on the personal speaking and lecture fees received from Boehringer Ingelheim, Japan.
A Potential Role of Interleukin-5 in the Pathogenesis and Progression of Amyotrophic Lateral Sclerosis: A New Molecular Perspective.
A Potential Role of Interleukin-5 in the Pathogenesis and Progression of Amyotrophic Lateral Sclerosis: A New Molecular Perspective.
Fuente:International Journal of Molecular Sciences
Extracto:
To the best of our knowledge, this is the first
study reporting a "protective" role of IL-5 in ALS.
Claves:ALS, ALS pattern of progression, ALS progression rate, IL-5, cytokines
Cita:Int J Mol Sci 2024 Mar 28; 25 (7)
Autor/es:Moțățăianu, Anca (a) Andone, Sebastian (b)
institución:(a) 1st Neurology Clinic, Mures County Clinical Emergency Hospital, 540136 Targu Mures, Romania. (b) Department of Neurology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
More than Just Bread and Wine: Using Yeast to Understand Inherited Cytochrome Oxidase Deficiencies in Humans.
More than Just Bread and Wine: Using Yeast to Understand Inherited Cytochrome Oxidase Deficiencies in Humans.
Fuente:International Journal of Molecular Sciences
Extracto:
We conclude with
an overview of the areas in which studies in yeast are likely to continue to
contribute to progress in understanding disease arising from inherited COX
deficiencies.
Claves:COX assembly, copper transfer, heme A biosynthesis, mitochondrial disease, yeast model
Cita:Int J Mol Sci 2024 Mar 29; 25 (7)
Autor/es:Caron-Godon, Chenelle A (a) Collington, Emma (b)
institución:(a) Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada. (b) Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Mechanotransduction Circuits in Human Pathobiology.
Mechanotransduction Circuits in Human Pathobiology.
Fuente:International Journal of Molecular Sciences
Extracto:
t is widely acknowledged that mechanical forces exerted throughout the human
body are critical for cellular and tissue homeostasis [...].
Cita:Int J Mol Sci 2024 Mar 29; 25 (7)
Autor/es:Gargalionis, Antonios N (a) Papavassiliou, Kostas A (b)
institución:(a) Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. (b) 'Sotiria' Hospital, Medical School, First University Department of Respiratory Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación