Changes in the intestinal microbiota of individuals with non-alcoholic fatty liver disease based on sequencing

Changes in the intestinal microbiota of individuals with non-alcoholic fatty liver disease based on sequencing

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: Increasing the species diversity and altering the abundance of specific gut microbiota, including Coprococcus, Faecalibacterium, Ruminococcus, and Escherichia, may be beneficial for improving NAFLD.

Cita:PLoS One 2024; 19 (3) : e0299946.

Autor/es:Cai, Wenpin (a)
Qiu, Ting (b)

institución:(a) Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
(b) Department of Gastroenterology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299946

The burden of mental disorders in Asian countries, 1990-2019: an analysis for the global burden of disease study 2019.

The burden of mental disorders in Asian countries, 1990-2019: an analysis for the global burden of disease study 2019.

Fuente:Translational Psychiatry

Extracto: To reduce this burden, urgent measures for prevention, treatment, and rehabilitation for mental disorders need to be taken by Asian governments.

Cita:Transl Psychiatry 2024 Mar 28; 14 (1) : 167.

Autor/es:Chen, Qi (a)
Huang, Shu (b)

institución:(a) Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
(b) Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41398-024-02864-5

The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86.

The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86.

Fuente:Nature Communications

Extracto: This mutation has now emerged in several sublineages including BA.2.86, reflecting selection pressure on the virus exerted by the increasing prominence of the anti-SD1 response.

Cita:Nat Commun 2024 Mar 28; 15 (1) : 2734.

Autor/es:Zhou, Daming (a)
Supasa, Piyada (b)

institución:(a) Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
(b) Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, Centre for Human Genetics, Oxford, UK.

Conflicto:G.R.S. sits on the GSK Vaccines Scientific Advisory Board, consults for AstraZeneca and is a founder member of RQ Biotechnology. D.I.S. consults for AstraZeneca. Oxford University holds intellectual property related to SARS-CoV-2 mAbs discovered in G.R.S’s laboratory. S.J.D. is a Scientific Advisor to the Scottish Parliament on COVID-19. The remaining authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-46982-6

Gut microbiota profile in CDKL5 deficiency disorder patients.

Gut microbiota profile in CDKL5 deficiency disorder patients.

Fuente:Scientific Reports

Extracto: It adds to the growing body of research emphasizing the role of the gut microbiota in neurodevelopmental disorders and opens doors to potential interventions that target intestinal microbes with the aim of improving the lives of patients with CDD.

Claves:CDKL5 deficiency disorder, Gastrointestinal disturbances, Gut microbiota, Gut-brain-axis

Cita:Sci Rep 2024 Mar 28; 14 (1) : 7376.

Autor/es:Borghi, Elisa (a)
Xynomilakis, Ornella (b)

institución:(a) Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy.
(b) Department of Health Sciences, Università Degli Studi di Milano, Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-56989-0

Effect of endoscopic therapy and drug therapy on prognosis and rebleeding in patients with esophagogastric variceal bleeding.

Fuente:Scientific Reports

Extracto: Compared with drug therapy, endoscopic treatment of EVB has short-term efficacy advantages, and can effectively reduce the incidence of rebleeding and mortality within 3 months.

Claves:Drug therapy, Endoscopic therapy, Esophagogastric variceal bleeding, Propensity score matching

Cita:Sci Rep 2024 Mar 28; 14 (1) : 7364.

Autor/es:Jiang, Jing-Jing (a)
Gao, Chun (b)

institución:(a) Department of Gastroenterology, The 940 Hospital of Joint Logistic Support Forces of PLA, Qilihe District, 333Rd Binhenan Road, Lanzhou, 730050, Gansu, China.
(b) The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou, 730000, Gansu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-57791-8

High OXPHOS efficiency in RA-FUdr-differentiated SH-SY5Y cells: involvement of cAMP signalling and respiratory supercomplexes.

Fuente:Scientific Reports

Extracto: Our results suggest that the observed high oxidative phosphorylation (OXPHOS) capacity may be related to the activation of the cyclic adenosine monophosphate (cAMP) pathway and the assembly of respiratory supercomplexes (SCs), highlighting the change in mitochondrial phenotype during neuronal differentiation.

Cita:Sci Rep 2024 Mar 28; 14 (1) : 7411.

Autor/es:Matrella, Maria Laura (a)
Valletti, Alessio (b)

institución:(a) Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.
(b) Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, 70124, Bari, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-57613-x

Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer.

Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer.

Fuente:Bmc Genomics

Extracto: Upregulated 3-SMGs signature are excellent predictive diagnosed and prognostic biomarkers, providing a new perspective for future GC immunotherapy.

Claves:Gastric cancer, Immune infiltration, Multi omics, Nomogram, Prognosis, Sphingolipid metabolism

Cita:BMC Genomics 2024 Mar 28; 25 (1) : 319.

Autor/es:Yan, Jianing (a)
Yu, Xuan (b)

institución:(a) Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, 315020, Ningbo, China.
(b) Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, 315020, Ningbo, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12864-024-10243-z

Atypical Duplex appendix arising from the ascending colon

Atypical Duplex appendix arising from the ascending colon

Fuente:Journal of Medical Case Reports

Tipo de trabajo:Caso clínico

Extracto: Duplex appendicitis, though rare, should be considered in the differential diagnosis of recurrent acute abdomen even after appendectomy.

Claves:Appendectomy, Appendicitis, Ascending colon, Duplex appendix, Recurrent acute abdomen

Cita:J Med Case Rep 2024 Mar 29; 18 (1) : 188.

Autor/es:Elsherbini, Ahmed Taha (a)
Atta, Mohamed A (b)

institución:(a) Surgery Department, Faculty of Medicine, Mansoura University, Mansoura, 33516, Egypt.
(b) Surgery Department, Alyousif Hospital, Al-Khobar, Saudi Arabia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13256-023-04259-4

Time for micro-RNAs in steatotic liver disease: a case-control study.

Time for micro-RNAs in steatotic liver disease: a case-control study.

Fuente:Frontiers in Endocrinology

Extracto: Manipulating micro-RNAs through agomirs or antagomirs can be the answer to the yet unsolved problem of efficient therapy in MAFLD.

Claves:MAFLD, NAFLD, case-control study, fatty liver disease, micro-RNA

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1349524.

Autor/es:Stoica, Victor Constantin (a)
Apostol, Dimitri (b)

institución:(a) Department of Gastroenterology, Fundeni Clinical Institute, Bucharest, Romania.
(b) Immunology and Transplant Immunology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer IB declared a shared affiliation with the authors DA, IM, and IC to the handling editor at the time of review.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1349524

High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B.

High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B.

Fuente:Frontiers in Immunology

Extracto: Male >30 or female >19 and Male >29 or female>15 are suggested to be better thresholds for normal ALT. Having a high normal ALT in CHB provides a potential benefit in antiviral therapy.

Claves:HBV DNA clearance, antiviral therapy, chronic hepatitis B, high-normal alanine aminotransferase, histological disease, liver biopsy, predict model

Cita:Front Immunol 2024; 15 : 1367265.

Autor/es:Cai, Chao (a)
Shang, Wen-Xuan (b)

institución:(a) Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
(b) Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1367265

Mevalonate kinase-deficient THP-1 cells show a disease-characteristic pro-inflammatory phenotype.

Fuente:Frontiers in Immunology

Extracto: MK-deficient THP-1 cells show the biochemical and pro-inflammatory phenotype of MKD and are a good model to study underlying disease mechanisms and therapeutic options of this autoinflammatory disorder.

Claves:autoinflammatory disorders, cytokines, hyper IgD syndrome, innate immune response, isoprenoid biosynthesis, mevalonate kinase deficiency

Cita:Front Immunol 2024; 15 : 1379220.

Autor/es:Politiek, Frouwkje A (a)
Turkenburg, Marjolein (b)

institución:(a) Laboratory Genetic Metabolic Diseases, Department of Laboratory Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, Netherlands.
(b) Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1379220

Identification and validation of hub genes expressed in ulcerative colitis with metabolic dysfunction-associated steatotic liver disease.

Fuente:Frontiers in Immunology

Extracto: This bioinformatics analysis highlights CXCR4, THY1, CCL20, and CD2 as crucial genes involved in the co-occurrence of UC and MASLD, providing insights into the underlying mechanisms of these two conditions.

Claves:M1 macrophages, bioinformatics, immune, metabolic dysfunction-associated steatotic liver disease, ulcerative colitis

Cita:Front Immunol 2024; 15 : 1357632.

Autor/es:Liu, Yupei (a)
Li, Jiao (b)

institución:(a) Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
(b) Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1357632

NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study.

NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study.

Fuente:Hepatology Communications

Extracto: In summary, NGS of BC samples increased the sensitivity of detecting biliary neoplasia compared with traditional cytology. Performing NGS on BC samples may help diagnose HGD or early CCA, benefiting the timing of liver transplantation.

Cita:Hepatol Commun 2024 Apr 1; 8 (4)

Autor/es:Boyd, Sonja (a)
Mustamäki, Taru (b)

institución:(a) Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
(b) Department of Pathology, Hospital Nova of Central Finland University of Jyväskylä, Jyväskylä, Finland.

Conflicto:Nelli Sjöblom consults for Aiforia Technologies. Teijo Kuopio advises Amgen and received grants from Pfizer. The remaining authors have no conflicts to report.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/HC9.0000000000000415

A natural language processing algorithm accurately classifies steatotic liver disease pathology to estimate the risk of cirrhosis.

Fuente:Hepatology Communications

Extracto: The NLP algorithm accurately scores histological features of MASLD from pathology free-text. This algorithm enabled the construction of a large and high-quality MASLD cohort across a multihospital health care system and disclosed an accelerating risk for cirrhosis based on the index MASLD fibrosis stage.

Cita:Hepatol Commun 2024 Apr 1; 8 (4)

Autor/es:Sherman, Marc S (a)
Challa, Prasanna K (b)

institución:(a) Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
(b) Brigham Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Conflicto:Hamed Khalili consults for Aditium Bio. Tracey G. Simon received grants from Amgen. The remaining authors have no conflicts to report.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/HC9.0000000000000403

Estimated Average-Risk Colorectal Cancer Screening-Eligible Population in the US.

Estimated Average-Risk Colorectal Cancer Screening-Eligible Population in the US.

Fuente:Jama Network Open

Cita:JAMA Netw Open 2024 Mar 4; 7 (3) : e245537.

Autor/es:Ebner, Derek W (a)
Kisiel, John B (b)

institución:(a) Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
(b) Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Conflicto:Conflict of Interest Disclosures: Dr Ebner reported having a consulting agreement with Exact Sciences to provide support regarding research design and methodology, with proceeds paid to Mayo Clinic, during the conduct of the study. Dr Kisiel reported having a patent (11542557) licensed to Exact Sciences. Dr Fendrick reported receiving personal fees from Exact Sciences outside the submitted work; being a... consultant for AbbVie, CareFirst BlueCross BlueShield, Centivo, Community Oncology Association, Covered California, EmblemHealth, EBRI, GRAIL, Harvard University, Health & Wellness Innovations, Health at Scale Technologies, Hopewell Fund, Johnson and Johnson, Medtronic, MedZed, Merck, Mother Goose Health, Phathom Pharmaceuticals, Proton Intelligence, RA Capital, Sempre Health, the state of Minnesota, US Department of Defense, Virginia Center for Health Innovation, Washington Health Benefit Exchange, Wellth, Yale–New Haven Health System, and Zansors; receiving research support from the Agency for Healthcare Research and Quality, Gary and Mary West Health Policy Center, Arnold Ventures, National Pharmaceutical Council, Patient-Centered Outcomes Research Institute, Pharmaceutical Research and Manufacturers of America, the Robert Wood Johnson Foundation, the state of Michigan, and the Centers for Medicare and Medicaid Services; serving as co–editor in chief of the American Journal of Managed Care; and being a partner in VBIDHealth, LLC. Dr. Limburg reported holding stock in Exact Sciences outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.5537

Gut microbiota differences in stunted and normal-lenght children aged 36-45 months in East Nusa Tenggara, Indonesia.

Gut microbiota differences in stunted and normal-lenght children aged 36-45 months in East Nusa Tenggara, Indonesia.

Fuente:Plos One

Extracto: Trial registration: the trial was registered at ClinicalTrials.gov with identifier number NCT05119218.

Cita:PLoS One 2024; 19 (3) : e0299349.

Autor/es:Surono, Ingrid S (a)
Popov, Ilia (b)

institución:(a) Faculty of Engineering, Food Technology Department, Bina Nusantara University, Jakarta, Indonesia.
(b) Faculty of Engineering, Food Technology Department, Bina Nusantara University, Jakarta, Indonesia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299349

High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis

Fuente:Plos One

Tipo de trabajo:Estudio clínico aleatorizado

Extracto: Four weeks of high-dose oral thiamine treatment in patients with PBC was well tolerated and safe. However, high-dose thiamine was not superior to placebo in reducing PBC-related fatigue. TRIAL REGISTRATION: The trial was registered in the ClinicalTrials.gov (NCT04893993) and EudraCT (2020-004935-26).

Cita:PLoS One 2024; 19 (3) : e0301354.

Autor/es:Bager, Palle (a)
Bossen, Lars (b)

institución:(a) Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
(b) Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Conflicto:None of the authors declare competing interests regarding the present study. Henning Gronbaek received research funding from Intercept, Abbvie, NOVO Nordisk Foundation, ARLA Food for Health, and ADS AIPHIA Development Services. Consultant AstraZeneca, NOVO Nordisk, Ipsen, and data monitoring committee at CAMURUS.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0301354

Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms.

Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms.

Fuente:Nature Communications

Extracto: In conclusion, our work provides a step forward in understanding the gene expression landscapes of IPMN and the critical transcriptional networks related to PDAC progression.

Cita:Nat Commun 2024 Mar 29; 15 (1) : 2764.

Autor/es:Agostini, Antonio (a)
Piro, Geny (b)

institución:(a) Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
(b) Medical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-46994-2

No gender differences in the 24-month course of non-invasive liver fibrosis markers after DAA therapy in HCV-mono and HCV/HIV-coinfected patients.

No gender differences in the 24-month course of non-invasive liver fibrosis markers after DAA therapy in HCV-mono and HCV/HIV-coinfected patients.

Fuente:Scientific Reports

Extracto: No gender differences in the 24 month LF decline after DAA with independence of having HCV mono or HCV/HIV coinfection were found.

Claves:Direct-acting antivirals, Gender, HIV, Hepatitis C, Liver fibrosis, Transient elastometry

Cita:Sci Rep 2024 Mar 29; 14 (1) : 7534.

Autor/es:Collazos, Julio (a)
Pérez-Is, Laura (b)

institución:(a) Infectious Diseases Unit, Hospital of Galdakao-Usansolo, Galdácano Vizcaya, Spain.
(b) Biochemistry and Molecular Biology, University of Oviedo Medical School, Oviedo, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-57845-x

Diagnostic value of IgG antibody and stool antigen tests for chronic Helicobacter pylori infections in Ibb Governorate, Yemen.

Fuente:Scientific Reports

Extracto: pylori infection durations.

Cita:Sci Rep 2024 Mar 29; 14 (1) : 7536.

Autor/es:Al Ofairi, Bashir A (a)
Saeed, Marwan K (b)

institución:(a) Section of Microbiology, Departement of Biological Sciences, Faculty of Science, Sana'a University, Sana'a, Yemen. b.alafiri@su.edu.ye.
(b) Departement of Medical Laboratory, Faculty of Medical Sciences, Queen Arwa University, Sana'a, Yemen. b.alafiri@su.edu.ye.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-58165-w