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institución:(a) Department of Pediatrics of the Faculty of Medicine, University of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain. (b) Section of Pediatric Endocrinology, University Clinical Hospital of Valladolid, Avenida Ramón y Cajal, 7, 47005 Valladolid, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Rifaximin plus lactulose versus lactulose alone for reducing the risk of HE recurrence.
Rifaximin plus lactulose versus lactulose alone for reducing the risk of HE recurrence.
Fuente:Hepatology Communications
Tipo de trabajo:Estudio abierto
Extracto:
Rifaximin plus lactulose was more efficacious than lactulose alone for reducing
the risk of overt HE recurrence and HE-related hospitalization in adults grouped
by select baseline disease characteristics.
Cita:Hepatol Commun 2024 Jun 1; 8 (6)
Autor/es:Sanyal, Arun J (a) Kowdley, Kris V (b)
institución:(a) Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA. (b) Department of Gastroenterology and Hepatology, Elson Floyd College of Medicine, Spokane, Washington, USA.
Conflicto:Arun J. Sanyal consults and received grants from Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Gilead, Intercept, Inventiva, Madrigal, Mallinckrodt, Merck, Novartis, Novo Nordisk, and Pfizer. He consults and owns stock in GENFIT and HemoShear. He consults for 89bio, Albireo, Alnylam, Amgen, AstraZeneca, Covance, Genentech, HistoIndex, Janssen, NGM Bio, PathAI, Poxel, ProSciento, Regeneron, Roche, Salix, Siemens, and Terns. He received...
grants from Fractyl. He owns stock in Durect, Exhalenz, Indalo, NorthSea, Rivus, and Tiziana. He receives royalties from Elsevier and UpToDate. Kris V. Kowdley consults, is on the speakers' bureau, and received grants from Gilead and Intercept. He consults and received grants from 89bio, CymaBay, GENFIT, Madrigal, Mirum, NGM, and Pfizer. He consults and owns stock in Inipharm. He consults for Enanta, HighTide, and Salix. He is on speakers' bureau for AbbVie. He received grants from Corcept, GlaxoSmithKline, Hanmi, Novo Nordisk, Pliant, Terns, and Viking. Nancy S. Reau consults for AbbVie, Gilead, Intercept, and Salix. She received grants from Eiger. Nikolaos T. Pyrsopoulos consults for Salix. Christopher Allen is employed by Salix. Zeev Heimanson is employed by Salix. Jasmohan S. Bajaj consults for Merz. He received grant from Cosmo, Grifols, Mallinckrodt, Salix, and Sequana Medical.
Clinical characteristics of pyogenic liver abscess with and without biliary surgery history: a retrospective single-center experience.
Clinical characteristics of pyogenic liver abscess with and without biliary surgery history: a retrospective single-center experience.
Fuente:Bmc Infectious Diseases
Extracto:
Patients with
BS history, especially those who have undergone BEA, have an increased
susceptibility to PLA formation without affecting prognosis.
institución:(a) Department of Hepatobiliary Surgery, Shaanxi Provincial People's Hospital, 256 West Youyi Road, Xi'an, Shaanxi Province, 710068, China. (b) Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Er Road, Shanghai, 200025, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Interactions between host and gut microbiota in gestational diabetes mellitus and their impacts on offspring.
Interactions between host and gut microbiota in gestational diabetes mellitus and their impacts on offspring.
Fuente:Bmc Microbiology
Extracto:
Finally, we compared offspring microbiota
composition from GDM with that from normal pregnancies, and described the
possible mechanism.
Claves:Gestational diabetes mellitus (GDM), Gut microbiota, Host-microbiome interactions, Metabolism, Offspring
Cita:BMC Microbiol 2024 May 10; 24 (1) : 161.
Autor/es:Wang, Shuxian (a) Cui, Zifeng (b)
institución:(a) Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China. (b) Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Vitamin K Status Based on K1, MK-4, MK-7, and Undercarboxylated Prothrombin Levels in Adolescent and Adult Patients with Cystic Fibrosis: A Cross-Sectional Study.
Vitamin K Status Based on K1, MK-4, MK-7, and Undercarboxylated Prothrombin Levels in Adolescent and Adult Patients with Cystic Fibrosis: A Cross-Sectional Study.
Fuente:Nutrients
Extracto:
There do
not seem to be any good clinical predictive factors for vitamin K status.
Autor/es:Krzyżanowska-Jankowska, Patrycja (a) Nowak, Jan (b)
institución:(a) Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, Poland. (b) Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Street 27/33, 60-572 Poznan, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Clinical variables influencing the severity of diabetes ketoacidosis.
Clinical variables influencing the severity of diabetes ketoacidosis.
Fuente:Saudi Medical Journal
Tipo de trabajo:Revisión
Extracto:
Diabetes ketoacidosis was observed to occur more frequently among
males in middle childhood with seasonal variations. Furthermore, the severity of
DKA was associated with lower economic status, early adolescence, and the
presence of hypernatremia.
Autor/es:Alhamdani, Yara F (a) Almadfaa, Lojain O (b)
institución:(a) From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. (b) From the Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
Extracto:
They will give healthcare providers a better awareness of the optimal
analgesic medication for pain treatment in non-severe, acute pancreatitis.
Autor/es:Subramani, Sriya S (a) Berg, Alaina C (b)
institución:(a) Stead Family Department of Pediatrics, The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA. (b) The University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.
The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis.
Fuente:Nature Communications
Extracto:
Here, we show that effects of lanifibranor on liver
histology in MASH are accompanied with CMH improvement, indicative of potential
cardiovascular clinical benefits.
Cita:Nat Commun 2024 May 10; 15 (1) : 3962.
Autor/es:Cooreman, Michael P (a) Butler, Javed (b)
institución:(a) Research and Development, Inventiva, New York, NY, USA. Michael.Cooreman@inventivapharma.com. (b) Research and Development, Inventiva, Daix, France. Michael.Cooreman@inventivapharma.com.
Conflicto:M.P.C., L.D., P.H.M., M.B. and P.B. are employees of Inventiva. J.L.J. is a consultant for Inventiva. D.R.B. has received honoraria from Inventiva via Translational Medicine Academy. J.B. has served as a consultant for Abbott, American Regent, Amgen, Applied Therapeutic, AskBio, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Bristol Myers Squibb, Cardiac Dimension, Cardiocell, Cardior, Cardiorem, CSL Bearing, CVRx, Cytokinetics, Daxor,...
Edwards, Element Science, Faraday, Foundry, G3P, Innolife, Impulse Dynamics, Imbria, Inventiva, Ionis, Lexicon, Lilly, LivaNova, Janssen, Medtronics, Merck, Occlutech, Owkin, Novartis, Novo Nordisk, Pfizer, Pharmacosmos, Pharmain, Prolaio, Regeneron, Renibus, Roche, Salamandra, Sanofi, SC Pharma, Secretome, Sequana, SQ Innovation, Tenex, Tricog, Ultromics, Vifor, and Zoll. RPG received research support or honoraria form Amgen, Anthos Therapeutics, Daiichi Sankyo, Ionis, Dr. Reddy’s Laboratories, Medical Education Resources, Menarini, SAJA Pharmaceuticals, Servier, SUMMEET, and consults for Artivion, Beckman Coulter, Daiichi Sankyo, Gilead, Inari, Inventiva, PhaseBio Pharmaceuticals, Samsung and Aventis. FZ reports personal fees from 89Bio, Abbott, Acceleron, Applied Therapeutics, Bayer, Betagenon, Boehringer, BMS, CVRx, Cambrian, Cardior, Cereno pharmaceutical, Cellprothera, CEVA, Inventiva, KBP, Merck, NovoNordisk, Owkin, Otsuka, Roche Diagnostics, Northsea, USa2, having stock options at G3Pharmaceutical and equities at Cereno, Cardiorenal, Eshmoun Clinical research and being the founder of Cardiovascular Clinical Trialists. MFA received grants from Boehringer-Ingelheim, Gilead, Hanmi, Inventiva, Madrigal, Novo Nordisk; honoraria from Clinical Care Options, Fishawack, Medscape, Terra Firma, CLDF; royalties from Up-to-Date; consults for 89Bio, BMS, Hanmi, Inventiva, Intercept, Madrigal, Merck, Novo Nordisk. SMF received grants from Astellas, Falk Pharma, Genfit, Gilead Sciences, GlympsBio, Janssens Pharmaceutica, Inventiva, Merck Sharp & Dome, Pfizer, Roche; honoraria from Abbvie, Allergan, Bayer, Eisai, Genfit, Gilead Sciences, Janssens Cilag, Intercept, Inventiva, Merck Sharp & Dome, Novo Nordisk, Promethera, Siemens; serves as consultant for Abbvie, Actelion, Aelin Therapeutics, AgomAb, Aligos Therapeutics, Allergan, Alnylam, Astellas, Astra Zeneca, Bayer, Boehringer Ingelheim, Bristoll-Meyers Squibb, CSL Behring, Coherus, Echosens, Dr. Falk Pharma, Eisai, Enyo, Galapagos, Galmed, Genetech, Genfit, Genflow Biosciences, Gilead Sciences, Intercept, Inventiva, Janssens Pharmaceutica, PRO.MED.CS Praha, Julius Clinical, Madrigal, Medimmune, Merck Sharp & Dome, Mursla Bio, NGM Bio, Novartis, Novo Nordisk, Promethera, Roche, Siemens Healthineers.
Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.
Low ankle-brachial index is associated with higher cardiovascular mortality in individuals with nonalcoholic fatty liver disease.
Fuente:European Journal of Medical Research
Tipo de trabajo:Estudio de cohortes
Extracto:
Low ABI is independently
associated with higher cardiovascular mortality in NAFLD cases. This correlation
remains significant even in the absence of pre-existing cardiovascular disease or
diabetes.
institución:(a) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China. (b) Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
JMJD6 Autoantibodies as a Potential Biomarker for Inflammation-Related Diseases.
Fuente:International Journal of Molecular Sciences
Extracto:
Hence, JMJD6 autoantibodies may
reflect inflammation, thereby serving as a potential biomarker for diagnosing
specific inflammation-related diseases, including stroke, AMI, DM, and cancers,
and for prediction of the prognosis in patients with EC.
institución:(a) Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. (b) Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Conflicto:This present study was performed in collaboration with Fujikura Kasei Co., Ltd., and Hideyuki Kuroda is an employee of Fujikura Kasei Co., Ltd. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health
The Mediterranean Diet, Its Microbiome Connections, and Cardiovascular Health
Fuente:International Journal of Molecular Sciences
Tipo de trabajo:Revisión
Extracto:
This review will
focus on the effects of MD on cardiovascular health through its action on gut
microbiota.
Claves:Mediterranean-type diet, Western-type diet, atherosclerosis, bile acids, cardiovascular disease, gut microbiota, nutrients, short-chain fatty acid, trimethylamine N-oxide
Cita:Int J Mol Sci 2024 Apr 30; 25 (9)
Autor/es:Abrignani, Vincenzo (a) Salvo, Andrea (b)
institución:(a) Internal Medicine and Stroke Care Ward, University of Palermo, 90127 Palermo, Italy. (b) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
This
consensus statement establishes a standardized approach to nutritional support,
aiming to optimize outcomes in pediatric cancer patients.
Claves:childhood cancer, nutrition, nutritional support
institución:(a) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland. (b) Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical University of Gdansk, 80-210 Gdansk, Poland.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults
Effect of Sustainably Sourced Protein Consumption on Nutrient Intake and Gut Health in Older Adults
Fuente:Nutrients
Tipo de trabajo:Revisión sistemática
Extracto:
Future research should focus on dietary
interventions combining sustainable proteins and fibre to evaluate gut barrier
function and consider inflammatory and body composition outcomes in older adults.
Claves:gut health, gut microbiota, healthy ageing, plant based diet, sustainable diet, sustainably sourced protein
Cita:Nutrients 2024 May 6; 16 (9)
Autor/es:Jones, Debra (a) Celis-Morales, Carlos (b)
institución:(a) School of Health Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK. (b) School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow G12 8TA, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method.
Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method.
Fuente:Bmc Medicine
Tipo de trabajo:Consenso
Extracto:
Explicit indicators of antidepressant
high-risk and overprescribing may be used directly by patients and health care
providers, and integrated within clinical decision support tools, in order to
improve the overall risk/benefit balance of this commonly prescribed class of
prescription drugs.
Claves:Adverse drug events, Antidepressants, Deprescribing, High-risk prescribing, Overprescribing
Cita:BMC Med 2024 May 13; 22 (1) : 193.
Autor/es:Brisnik, Vita (a) Vukas, Jochen (b)
institución:(a) Institute of General Practice and Family Medicine, LMU University Hospital, LMU Munich, Munich, Germany. (b) Graduate Program "POKAL - Predictors and Outcomes in Primary Care Depression Care", (DFG - GrK 2621), Munich, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autor/es:Rezkitha, Yudith Annisa Ayu (a) Panenggak, Nur Syahadati Retno (b)
institución:(a) Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. (b) Helicobacter pylori and Microbiota Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Perfusion outcomes with near-infrared indocyanine green imaging system in laparoscopic total mesorectal excision for mid-rectal or low-rectal cancer (POSTER): a study protocol.
Perfusion outcomes with near-infrared indocyanine green imaging system in laparoscopic total mesorectal excision for mid-rectal or low-rectal cancer (POSTER): a study protocol.
Fuente:Bmj Open
Tipo de trabajo:Consenso
Extracto:
TRIAL REGISTRATION NUMBER: NCT04012645.
Claves:Colorectal surgery, Gastrointestinal tumours, SURGERY
Cita:BMJ Open 2024 May 9; 14 (5) : e079858.
Autor/es:Sun, Liting (a) Gao, Jiale (b)
institución:(a) Department of General Surgery, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China. (b) Department of General Surgery, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Journal of investigative surgery the official journal of the Academy of Surgical Research
Selección SIIC: 16 Mayo, 2024
Journal of investigative surgery the official journal of the Academy of Surgical Research
Correlation Between Basal Metabolic Rate and Clinical Outcomes in Gastric Cancer Patients: A Retrospective Study.
Correlation Between Basal Metabolic Rate and Clinical Outcomes in Gastric Cancer Patients: A Retrospective Study.
Fuente:Journal of Investigative Surgery The Official Journal of The Academy of Surgical Research
Extracto:
Overall, LBMR on admission is
associated with the occurrence of postoperative complications in gastric cancer
patients, and this population has a poorer long-term survival. Therefore, there
should be more focus on the perioperative management of patients with this risk
factor before surgery.
institución:(a) Department of Trauma & Emergency Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. (b) Department of Acupuncture Massage & Physical Therapy, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Transfer RNA-derived fragment tRF-23-Q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB.
Transfer RNA-derived fragment tRF-23-Q99P9P9NDD promotes progression of gastric cancer by targeting ACADSB.
Fuente:Journal of Zhejiang University. Science. B
Extracto:
It provides a theoretical basis for the diagnostic and
prognostic monitoring value of GC and opens up new possibilities for treatment.
Claves:Acyl-coenzyme A dehydrogenase short/branched chain (ACADSB), Ferroptosis, Gastric cancer (GC), Molecular mechanism, Transfer RNA (tRNA)-derived small RNA (tsRNA), Treatment
Cita:J Zhejiang Univ Sci B 2024 May 15; 25 (5) : 438-450.
Autor/es:Zhang, Yu (a) Gu, Xinliang (b)
institución:(a) Medical School of Nantong University, Nantong University, Nantong 226001, China. (b) Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China.
Camrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC
Camrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC
Fuente:Cancer Immunology, Immunotherapy Cii
Tipo de trabajo:Estudio abierto
Extracto:
Camrelizumab plus famitinib
demonstrated favorable benefits in PFS and OS, along with manageable safety
profiles, in patients with advanced NSCLC who progressed after platinum-doublet
chemotherapy and immunotherapy. This finding warrants further exploration.
Cita:Cancer Immunol Immunother 2024 May 10; 73 (7) : 124.
Autor/es:Ren, Shengxiang (a) Xiong, Anwen (b)
institución:(a) Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China. (b) Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433, China.
Conflicto:HD, SW, and XY report being employed by Jiangsu Hengrui Pharmaceuticals Co., Ltd. All remaining authors have declared no conflict of interest.
Identification of the new molecular subtypes related to inflammation in breast cancer.
Identification of the new molecular subtypes related to inflammation in breast cancer.
Fuente:Medicine
Extracto:
The integration of multiple key
genes was a new characterization that could promote more immunotherapy strategies
and contribute to predicting the efficacy of the chemotherapeutic drugs.
Cita:Medicine (Baltimore) 2024 May 10; 103 (19) : e38146.
Autor/es:Yu, Ke (a) Xu, Chi (b)
institución:(a) Department of Breast and Thyroid Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. (b) Department of Breast and Thyroid Surgery, Clinical Medicine, Medical College, Nantong University, Nantong, Jiangsu Province, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación