Multiparametric ultrasound as a new concept of assessment of liver tissue damage.

Multiparametric ultrasound as a new concept of assessment of liver tissue damage.

Fuente:World Journal of Gastroenterology

Extracto: MPUS, in the hands of skilled clinicians, becomes an invaluable predictive tool for diagnosing, staging, and monitoring CLD.

Claves:Liver steatosis assessment, Liver stiffness, Multiparametric ultrasound, Noninvasive diagnostic test for chronic liver disease, Portal hypertension evaluation, Ultrasound-based elastography

Cita:World J Gastroenterol 2024 Mar 28; 30 (12) : 1663-1669.

Autor/es:Peltec, Angela (a)
Sporea, Ioan (b)

institución:(a) Department of Internal Medicine, Discipline of Gastroenterology, State University of Medicine and Pharmacy "Nicolae Testemitanu", Chishinev 2019, Moldova. apeltec@yahoo.com.
(b) Department of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy, Timisoara 300736, Romania.

Conflicto:Conflict-of-interest statement: All authors have nothing to disclose related to this paper.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.3748/wjg.v30.i12.1663

Pediatric stricturing Crohn's disease.

Fuente:World Journal of Gastroenterology

Extracto: Thus, new and emerging strategies, advanced diagnostic tools, and minimally invasive approaches are under investigation to improve the outcomes and overall quality of life of pediatric patients with SCD.

Claves:Crohn’s disease, Future perspectives, Insights, Pediatrics, Stricturing

Cita:World J Gastroenterol 2024 Mar 28; 30 (12) : 1651-1654.

Autor/es:Boscarelli, Alessandro (a)
Bramuzzo, Matteo (b)

institución:(a) Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it.
(b) Department of Gastrointestinal Endoscopy and Nutrition, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste 34137, Italy.

Conflicto:Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.3748/wjg.v30.i12.1651

Predictive value of red blood cell distribution width and hematocrit for short-term outcomes and prognosis in colorectal cancer patients undergoing radical surgery.

Fuente:World Journal of Gastroenterology

Extracto: A higher preoperative RDW and lower hematocrit were associated with more postoperative complications. However, only hematocrit was an independent risk factor for OS and DFS in CRC patients who underwent radical surgery, while RDW was not.

Claves:Colorectal cancer, Red blood cell distribution width, Short-term outcomes, Survival

Cita:World J Gastroenterol 2024 Mar 28; 30 (12) : 1714-1726.

Autor/es:Peng, Dong (a)
Li, Zi-Wei (b)

institución:(a) Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
(b) Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Conflicto:Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.3748/wjg.v30.i12.1714

TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.

TOB1 modulates neutrophil phenotypes to influence gastric cancer progression and immunotherapy efficacy.

Fuente:Frontiers in Immunology

Extracto: DISCUSSION: This study significantly advances our comprehension of TOB1's role within the immune microenvironment of gastric cancer, offering promising therapeutic targets for immunotherapy in this context.

Claves:TOB1, gastric cancer, immune cells, immunotherapy, neutrophils apoptosis

Cita:Front Immunol 2024; 15 : 1369087.

Autor/es:Zhang, Jinfeng (a)
Li, Yunlong (b)

institución:(a) Scientific Research Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
(b) Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1369087

Exploring the regulatory mechanism of intestinal flora based on PD-1 receptor/ligand targeted cancer immunotherapy.

Fuente:Frontiers in Immunology

Extracto: This review focuses on the modulation of intestinal flora in the context of PD-1 immunotherapy, which may offer a new avenue for combination therapy in tumor immunotherapy.

Claves:ICI, PD-1, anti-PD-1, immunotherapy, intestinal flora

Cita:Front Immunol 2024; 15 : 1359029.

Autor/es:Gao, Xinran (a)
Jiang, Jingting (b)

institución:(a) Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.
(b) Jiangsu Engineering Research Center for Tumor lmmunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1359029

The PERSIAN Cohort: Prevalence of Psychiatric Disorders Among Employees.

The PERSIAN Cohort: Prevalence of Psychiatric Disorders Among Employees.

Fuente:Archives of Iranian Medicine

Extracto: Considering the relatively high prevalence of GAD and MDD among the employees of Tabriz University of Medical Sciences, strengthening counseling centers in the university and encouraging employees to participate in these centers, and examining them in terms of mental health help identify people at risk of mental disorders in time and provide counseling services to these people.

Claves:Anxiety, Depression, Mental disorder, Obsession, Prevalence

Cita:Arch Iran Med 2024 Feb 1; 27 (2) : 72-78.

Autor/es:Farahbakhsh, Mostafa (a)
Faramarzi, Elnaz (b)

institución:(a) Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
(b) Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Irán

Sitio web:http://dx.doi.org/10.34172/aim.2024.12

Hepatitis delta testing trends in a US national cohort: An analysis of patient and provider-level predictive factors.

Hepatitis delta testing trends in a US national cohort: An analysis of patient and provider-level predictive factors.

Fuente:Hepatology Communications

Tipo de trabajo:Estudio de cohortes

Extracto: HDV screening rates in the VHA remain low overall. Participants who are Black, living in the Midwest, patients who are HIV-positive, and patients who are HCV-positive are less likely to be tested for HDV. These results suggest that risk-based screening strategies are ineffective in the VHA and highlight the need for refining testing strategies to increase HDV screening rates.

Cita:Hepatol Commun 2024 May 1; 8 (5)

Autor/es:John, Binu V (a)
Amoli, Mahmoud Manouchehri (b)

institución:(a) Department of Medicine, Division of Gastroenterology and Hepatology, Miami VA Medical System, Miami, Florida, USA.
(b) Division of Medical Education, University of Miami Miller School of Medicine, Miami, Florida, USA.

Conflicto:Binu V. John received institutional research support from Exact Sciences, Gilead, and Glycotest, Inc. Robert Wong received institutional research support from Gilead Sciences, Exact Sciences, Thera Technologies, and Durect Corporation. The remaining authors have no conflicts to report.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/HC9.0000000000000401

Alpha-fetoprotein: Past, present, and future.

Fuente:Hepatology Communications

Extracto: In this review article, we aim to provide an overview of AFP, encompassing the discovery, biological role, and utility as an HCC biomarker in combination with other biomarkers and how it impacts clinical practice and future direction.

Cita:Hepatol Commun 2024 May 1; 8 (5)

Autor/es:Yeo, Yee Hui (a)
Lee, Yi-Te (b)

institución:(a) Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
(b) Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Conflicto:Ju Dong Yang consults for AstraZeneca, Eisai, Exact, Exelixis, Fujifilm Medical Sciences, and Merck. Vatche G. Agopian consults for Early Diagnostics and Eximius Diagnostics. Yazhen Zhu owns stock in Eximius Diagnostics. The remaining authors have no conflicts to report.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/HC9.0000000000000422

Local recurrence in malignant peripheral nerve sheath tumours

Local recurrence in malignant peripheral nerve sheath tumours

Fuente:Bjs Open

Tipo de trabajo:Estudio de cohortes

Extracto: Large, high-grade MPNSTs with R1 resections are at higher LR1 risk, potentially reduced by radiotherapy. Surgically treated recurrences may provide improved survival in highly selected cases.

Cita:BJS Open 2024 Mar 1; 8 (2)

Autor/es:Jansma, Christianne Y M N (a)
Acem, Ibtissam (b)

institución:(a) Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
(b) Department of Plastic and Reconstructive Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/bjsopen/zrae024

Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease

Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease

Fuente:Scientific Reports

Tipo de trabajo:Estudio abierto

Extracto: This study suggested that empagliflozin may promote colonic mucosal healing and reduce hyperplasia, stenosis, and obstruction in children with GSD-associated IBD.

Claves:Children, Clinical trial, Empagliflozin, Glycogen storage disease, Inflammatory bowel disease

Cita:Sci Rep 2024 Apr 15; 14 (1) : 8630.

Autor/es:Li, Zhiling (a)
Zhang, Xiaoyan (b)

institución:(a) Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
(b) Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-59320-z

Integrating trans-omics, cellular experiments and clinical validation to identify ILF2 as a diagnostic serum biomarker and therapeutic target in gastric cancer.

Integrating trans-omics, cellular experiments and clinical validation to identify ILF2 as a diagnostic serum biomarker and therapeutic target in gastric cancer.

Fuente:Bmc Cancer

Extracto: Trans-omics analysis of proteomics and transcriptomics is an efficient approach for discovering serum biomarkers, and ILF2 is a potential diagnostic biomarker and therapeutic target of gastric cancer.

Claves:Chemotherapy, Diagnosis, Gastric cancer, ILF2, Immune infiltration, Immunotherapy, Serum biomarker, Trans-omics analysis

Cita:BMC Cancer 2024 Apr 15; 24 (1) : 465.

Autor/es:Liu, Shao-Song (a)
Wan, Qin-Si (b)

institución:(a) Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University; Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, China, No 17, Yongwai Zheng Street, 330006, Nanchang, China.
(b) Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University; Jiangxi Institute of Gastroenterology & Hepatology, Nanchang, China, No 17, Yongwai Zheng Street, 330006, Nanchang, China.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12885-024-12175-z

Level of interleukin 17 in inflammatory bowel disease and its relation with disease activity.

Level of interleukin 17 in inflammatory bowel disease and its relation with disease activity.

Fuente:Bmc Gastroenterology

Extracto: Serum IL-17 increases in colonic inflammation significantly more than in control group, however its increase is not correlated to IBD activity.

Claves:IBD, Interleukin 17, Markers of activity

Cita:BMC Gastroenterol 2024 Apr 15; 24 (1) : 135.

Autor/es:Menesy, Ayman (a)
Hammad, Mohamed (b)

institución:(a) Professor of Internal Medicine, Hepatology and Gastroenterology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
(b) Resident of Hepatology and Gastroenterology, Mansoura University, Mansoura, Egypt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12876-024-03218-7

Hepatitis C screening in Lithuania: first-year results and scenarios for achieving WHO elimination targets.

Hepatitis C screening in Lithuania: first-year results and scenarios for achieving WHO elimination targets.

Fuente:Bmc Public Health

Extracto: During the first year of the Lithuanian screening program, GPs were able to screen 44% of the target population. However, the country will not meet elimination targets as it currently stands without increasing treatment levels and lifting fibrosis restrictions.

Claves:Elimination, Hepatitis C, Lithuania, Mathematical modelling, Screening, World Health Organisation targets

Cita:BMC Public Health 2024 Apr 15; 24 (1) : 1055.

Autor/es:Petkevičienė, Janina (a)
Voeller, Alexis (b)

institución:(a) Health Research Institute, Faculty of Public Health, Lithuanian University of Health Sciences, Tilžės str. 18, LT47181, Kaunas, Lithuania. janina.petkeviciene@lsmu.lt.
(b) Department of Preventive Medicine, Faculty of Public Health, Lithuanian University of Health Sciences, Tilžės str. 18, LT47181, Kaunas, Lithuania. janina.petkeviciene@lsmu.lt.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18470-5

The effect of respiratory muscle training on children and adolescents with cystic fibrosis

The effect of respiratory muscle training on children and adolescents with cystic fibrosis

Fuente:Bmc Pediatrics

Tipo de trabajo:Revisión sistemática

Extracto: This systematic review and meta-analysis indicate that although the level of evidence indicating the benefits of respiratory muscle training is low, its clinical significance suggests that we further study the methodological quality to determine the effectiveness of training. TRIAL REGISTRATION: The protocol for this review was recorded in the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42023441829.

Claves:Adolescent, Cystic fibrosis, Pediatrics, Pulmonary rehabilitation, Respiratory muscle training

Cita:BMC Pediatr 2024 Apr 15; 24 (1) : 252.

Autor/es:Cai, WenQian (a)
Li, Meng (b)

institución:(a) School of Pediatrics, Nanjing Medical University, Jiangsu Province, China.
(b) Department of Nursing, Children's Hospital of Nanjing Medical University, Nanjing, China.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04726-x

Pregnancy period and early-life risk factors for inflammatory bowel disease: a Northern Finland birth cohort 1966 study.

Pregnancy period and early-life risk factors for inflammatory bowel disease: a Northern Finland birth cohort 1966 study.

Fuente:Bmc Public Health

Extracto: Smoking during pregnancy was associated with the risk of CD while Breastfeeding and oral iron supplementation at infancy were negatively associated with the risk of CD later in life.

Claves:Cohort studies, Crohn’s disease, Early life, Epidemiology, Inflammatory bowel diseases, Smoking, Ulcerative colitis

Cita:BMC Public Health 2024 Apr 15; 24 (1) : 1038.

Autor/es:Blomster, Timo M (a)
Koivurova, Olli-Pekka (b)

institución:(a) Department of Internal Medicine, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
(b) Terveystalo Oulu, Medical Center, Oulu, Finland.

Conflicto:Not applicable.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18549-z

A retrospective study of morbidity and mortality of chronic acid sphingomyelinase deficiency in Germany.

A retrospective study of morbidity and mortality of chronic acid sphingomyelinase deficiency in Germany.

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Estudio de cohortes

Extracto: This study highlights considerable morbidity and mortality associated with ASMD type B and type A/B in Germany. It further emphasises the importance of effective therapy for chronic ASMD to reduce disease complications.

Claves:Acid sphingomyelinase deficiency, Morbidity, Mortality, Overall survival, Standardised mortality ratio

Cita:Orphanet J Rare Dis 2024 Apr 13; 19 (1) : 161.

Autor/es:Mengel, Eugen (a)
Muschol, Nicole (b)

institución:(a) Institute of Clinical Science for LSD, SphinCS, Hochheim, Germany.
(b) International Center for Lysosomal Disorders (ICLD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Conflicto:EM has received research grants, speakers’ honoraria, and consultation fees from Sanofi, Takeda, Orphazyme, Avrobio, Idorsia, Cyclo Therapeutics, Alexion, and Amicus. NM has received research grants, speakers’ honoraria, and/or consultation fees from Sanofi, Takeda, Amicus, Chiesi, JCR, and Lysogene. NW has received research grants, speakers’ honoraria, travel grants, and/or consultation fees from Sanofi, Takeda, and Biomarin. AZ has received speakers’... akers’ honoraria and consultation fees from Sanofi, Genzyme, Takeda, and Biomarin. JN has received travel grants from Sanofi, Takeda, and Biomarin. BA and LL are employees of IQVIA. MG, SG, MF, and RPJ are employees and may hold stock and/or stock options in Sanofi. FL was an employee of Sanofi at the time of study conduct.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03174-1

Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope.

Advancements in medical treatment for pancreatic neuroendocrine tumors: A beacon of hope.

Fuente:World Journal of Gastroenterology

Extracto: This review underscores the evolving landscape of pan-NET treatment, offering renewed hope and improved outcomes for patients facing this complex disease.

Claves:Everolimus, Immunotherapy, Medical management, Pancreatic neuroendocrine tumor, Somatostatin analog

Cita:World J Gastroenterol 2024 Mar 28; 30 (12) : 1670-1675.

Autor/es:Giri, Somdatta (a)
Sahoo, Jayaprakash (b)

institución:(a) Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.
(b) Department of Endocrinology and Metabolism, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India. jppgi@yahoo.com.

Conflicto:Conflict-of-interest statement: All authors have no conflict of interest to report.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.3748/wjg.v30.i12.1670

Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays.

Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays.

Fuente:International Journal of Molecular Sciences

Extracto: This research supports the concept of food-medicine homology and broadens the range of medical treatments for diabetes and AD, highlighting the prospect of integrating traditional herbal remedies with modern medical research.

Claves:Alzheimer’s disease, molecular dynamics simulation, mulberry leaf compounds, network pharmacology, type 2 diabetes mellitus

Cita:Int J Mol Sci 2024 Apr 5; 25 (7)

Autor/es:Bai, Xue (a)
Zhao, Xinyi (b)

institución:(a) Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.
(b) Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074062

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.

Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.

Fuente:Nutrients

Extracto: Dietary inflammatory potential was associated with a reduction in the consumption of vitamins and minerals and predicted gut microbiota metabolic dysregulation.

Claves:diet, dietary inflammatory index, food frequency questionnaire, galactose, gut microbiota, inflammation, pregnancy

Cita:Nutrients 2024 Mar 24; 16 (7)

Autor/es:Alvernaz, Suzanne A (a)
Wenzel, Elizabeth S (b)

institución:(a) Department of Biomedical Engineering, University of Illinois, Chicago, IL 60607, USA.
(b) Department of Psychology, University of Illinois, Chicago, IL 60607, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070935

Association of Gut Microbiota-Related Metabolites and Type 2 Diabetes in Two Puerto Rican Cohorts.

Fuente:Nutrients

Tipo de trabajo:Metanálisis

Extracto: These observations demonstrate the importance of gut microbiota metabolites for human cardiometabolic health.

Claves:Puerto Rican, betaine, cardiometabolic risk factors, glycemia, gut microbiota metabolites, type 2 diabetes

Cita:Nutrients 2024 Mar 27; 16 (7)

Autor/es:Sawicki, Caleigh M (a)
Pacheco, Lorena S (b)

institución:(a) Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA.
(b) Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070959