Dysregulation of CD4(+) and CD8(+) resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

Fuente:Journal For Immunotherapy of Cancer

Extracto: These findings nominate CD4(+) RM and MAdCAM-1(+) endothelial cells for targeting in specific subsets of CPI colitis patients.

Claves:Colitis, Immune Checkpoint Inhibitor, Immune related adverse event - irAE, Memory

Cita:J Immunother Cancer 2024 Apr 19; 12 (4)

Autor/es:He, Jun Yan (a)
Kim, Yang-Joon (b)

institución:(a) Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
(b) Chan Zuckerberg Biohub, San Francisco, California, USA.

Conflicto:Competing interests: DYO has received research support from Merck, PACT Pharma, the Parker Institute for Cancer Immunotherapy, Poseida Therapeutics, TCR2 Therapeutics, Roche/Genentech, and Nutcracker Therapeutics; travel and accommodations from Roche/Genentech; and has consulted for Revelation Partners. LF has received research support from Roche/Genentech, AbbVie, Bavarian Nordic, Bristol Myers Squibb, Dendreon, Janssen, Merck, and Partner Therapeutics; and has served on scientific... advisory boards for Actym, AstraZeneca, Atreca, Bioatla, Bolt, Bristol Myers Squibb, Daiichi Sankyo, Immunogenesis, Innovent, Merck, Merck KGA, Nutcracker, RAPT, Scribe, Senti, Sutro, and Roche/Genentech. The Combes laboratory has received research support from Eli Lilly and Genentech and AC consults for Foundery Innovations. The Kattah laboratory receives research support from Eli Lilly, and MGK has consulted for Sonoma Biotherapeutics and Morphic Therapeutic.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/jitc-2023-008628

A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases.

A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: IBD hepcidin-25 best correlates with ferritin, and both parameters reflected inflammation extent and IBD activity.

Claves:Crohn’s disease, anemia, cytokine, ferritin, hepcidin, inflammation, ulcerative colitis

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Petrović, Stanko (a)
Tarabar, Dino (b)

institución:(a) Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia.
(b) Clinic for Gastroenterology and Hepatology, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073564

Special Issue "Dietary Bioactive Components in Inflammatory Bowel Disease".

Fuente:International Journal of Molecular Sciences

Extracto: nflammatory bowel diseases (IBD) comprise chronic debilitating inflammatory disorders that can affect different parts of the gastrointestinal tract and are commonly correlated to two main diseases: Crohn's disease (CD) and ulcerative colitis (UC) [...].

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Gasparrini, Massimiliano (a)
Mazzoni, Luca (b)

institución:(a) Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche 10, 60131 Ancona, Italy.
(b) Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche 10, 60131 Ancona, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073569

Impact of STAT6 Variants on the Response to Proton Pump Inhibitors and Comorbidities in Patients with Eosinophilic Esophagitis.

Fuente:International Journal of Molecular Sciences

Extracto: Further research is warranted to clarify the clinical relevance of these variants.

Claves:CYP2C19, STAT6, eosinophilic esophagitis, pharmacogenetics

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:Soria-Chacartegui, Paula (a)
Navares-Gómez, Marcos (b)

institución:(a) Clinical Pharmacology Department, Hospital Universitario de La Princesa, Faculty of Medicine, Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
(b) Instituto de Investigación Sanitaria La Princesa (IIS-IP), 28006 Madrid, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073685

ETV6

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: Additionally, the presence of abundant lymphoid infiltration in the present case may prompt further research into immunotherapy as a possible additional therapeutic option.

Claves:ETV6::NTRK3 gene fusion, GIST wild-type, lymphoid infiltration, therapeutic implication

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:Machado, Isidro (a)
Claramunt-Alonso, Reyes (b)

institución:(a) Pathology Department, Instituto Valenciano de Oncología, Calle Gregorio Gea 31, 4to Piso, 46009 Valencia, Spain.
(b) Patologika Laboratory, Hospital Quiron-Salud, 46010 Valencia, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073707

Genetic Variants Associated with Biological Treatment Response in Inflammatory Bowel Disease

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: The most significant SNPs potentially useful as predictive biomarkers of treatment response are linked to immunity, cytokine production, and immunorecognition.

Claves:Crohn’s disease, adalimumab, anti-tumor necrosis factor, biological drugs, inflammatory bowel disease, infliximab, ulcerative colitis, ustekinumab

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Plaza, Javier (a)
Mínguez, Alejandro (b)

institución:(a) Inflammatory Bowel Disease Research Group, Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain.
(b) Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073717

Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer.

Fuente:International Journal of Molecular Sciences

Extracto: This study offers a thorough analysis of the stool glycoproteome, laying the groundwork for harnessing glycosylation alterations to improve non-invasive cancer detection.

Claves:cancer glycosylation, colorectal cancer, glycoproteomics, pre-cancerous lesions, stool glycoproteins

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Soares, Janine (a)
Eiras, Mariana (b)

institución:(a) Experimental Pathology and Therapeutics Group, Research Center of IPO Porto (CI-IPOP), RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), 4200-072 Porto, Portugal.
(b) Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

Conflicto:J.A.F. and L.L.S. are founders and associate partners of GlycoMatters Biotech. The remaining authors declare no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073722

Anti-Inflammatory Effects of a Novel Acetonitrile-Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 Cells.

Fuente:International Journal of Molecular Sciences

Extracto: More research is required to understand their mechanisms and explore therapeutic applications, especially for gastrointestinal inflammatory conditions.

Claves:ATP-sensitive K+ channels, aquaporin, calcium-activated K+ channels, functional gastrointestinal disorders, intestinal dismicrobism, ion channels, irritable bowel syndrome (IBS), transient receptor potential, transporters, voltage-dependent sodium channels

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Maqoud, Fatima (a)
Orlando, Antonella (b)

institución:(a) Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, BA, Italy.
(b) Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, BA, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073802

Targeting HER2 in Gastroesophageal Adenocarcinoma: Molecular Features and Updates in Clinical Practice.

Fuente:International Journal of Molecular Sciences

Extracto: This review will summarise historical and emerging therapies for the treatment of HER2-positive GEA, with a section dedicated to the HER2 molecular pathway and the use of novel blood biomarkers, such as circulating tumour DNA and circulating tumour cells, which may be helpful in the future to guide treatment decisions.

Claves:HER2, ct-DNA, gastroesophageal adenocarcinoma, heterogeneity, immunotherapy, trastuzumab, trastuzumab deruxtecan

Cita:Int J Mol Sci 2024 Mar 30; 25 (7)

Autor/es:Bonomi, Maria (a)
Spada, Daniele (b)

institución:(a) Oncology Unit, ASST Cremona, 26100 Cremona, Italy.
(b) Oncology Unit, ASST Cremona, 26100 Cremona, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073876

Helicobacter pylori Eradication Reverses DNA Damage Response Pathway but Not Senescence in Human Gastric Epithelium.

Fuente:International Journal of Molecular Sciences

Extracto: Increased senescent cells may favor IM persistence, thus potentially contributing to gastric carcinogenesis.

Claves:DNA damage response, H. pylori, eradication, intestinal metaplasia, senescence, tumorigenesis

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Kalisperati, Polyxeni (a)
Spanou, Evangelia (b)

institución:(a) Gastroenterology Unit, Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece.
(b) Gastroenterology Unit, Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Mikras Asias 75, 11527 Athens, Greece.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073888

A Review of the Use of Native and Engineered Probiotics for Colorectal Cancer Therapy.

Fuente:International Journal of Molecular Sciences

Extracto: Genetically engineered probiotics might be designed to produce particular molecules or to target cancer cells more effectively and cure CRC patients.

Claves:colorectal cancer, probiotics and engineered strain, synthetic biology

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Han, Huawen (a)
Zhang, Yifan (b)

institución:(a) State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730000, China.
(b) College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073896

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children.

Fuente:International Journal of Molecular Sciences

Extracto: Here, we suggest some therapeutic strategies that can be applied at two levels of intervention to recover the microbiome and consequently prevent/delay ALL or arrest its progression.

Claves:GM, acute lymphoblastic leukemia (ALL), microbiome, therapeutic strategies

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Aronica, Tommaso Silvano (a)
Carella, Miriam (b)

institución:(a) Complex Operative Unit of Clinical Pathology, ARNAS Civico Di Cristina e Benfratelli Hospitals, 90127 Palermo, Italy.
(b) Complex Operative Unit of Clinical Pathology, ARNAS Civico Di Cristina e Benfratelli Hospitals, 90127 Palermo, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073928

Mobocertinib in Patients with EGFR Exon 20 Insertion-Positive Non-Small Cell Lung Cancer (MOON): An International Real-World Safety and Efficacy Analysis.

Fuente:International Journal of Molecular Sciences

Extracto: Mobocertinib demonstrated meaningful efficacy in a real-world setting but was associated with considerable gastrointestinal and cutaneous toxicity.

Claves:EGFR exon 20 inhibitors, exon 20 insertion, mobocertinib, non-small cell lung cancer, real-world data

Cita:Int J Mol Sci 2024 Apr 3; 25 (7)

Autor/es:Illini, Oliver (a)
Saalfeld, Felix Carl (b)

institución:(a) Department of Respiratory and Critical Care Medicine, Klinik Floridsdorf, Vienna Healthcare Group, Bruenner Straße 68, A-1210 Vienna, Austria.
(b) Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, A-1210 Vienna, Austria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073992

Innovative Molecular Targets and Therapeutic Approaches in Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis (NAFLD/NASH) 3.0.

Fuente:International Journal of Molecular Sciences

Extracto: he aim of this Special Issue is to provide an update on the diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD), which is the most prevalent liver disease worldwide; however, there are still no specific treatment agents [...].

Cita:Int J Mol Sci 2024 Apr 3; 25 (7)

Autor/es:Vairetti, Mariapia (a)
Colucci, Giuseppe (b)

institución:(a) Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy.
(b) Division of Gastroenterology and Hepatology, Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074010

Modeling Dynamics of Human Gut Microbiota Derived from Gluten Metabolism: Obtention, Maintenance and Characterization of Complex Microbial Communities.

Fuente:International Journal of Molecular Sciences

Extracto: This method enables the analysis of microbial metabolism of gluten in the gut from a community perspective.

Claves:gluten, gluten metabolism, gut microbiota, in vitro digestion, microbial communities

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Carnicero-Mayo, Yaiza (a)
Sáenz de Miera, Luis E (b)

institución:(a) Área de Microbiología, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, 24007 León, Spain.
(b) Área de Genética, Facultad de Ciencias Biológicas y Ambientales, Universidad de León, 24007 León, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074013

Hypophosphatemia after Start of Medical Nutrition Therapy Indicates Early Refeeding Syndrome and Increased Electrolyte Requirements in Critically Ill Patients but Has No Impact on Short-Term Survival.

Hypophosphatemia after Start of Medical Nutrition Therapy Indicates Early Refeeding Syndrome and Increased Electrolyte Requirements in Critically Ill Patients but Has No Impact on Short-Term Survival.

Fuente:Nutrients

Extracto: Therefore, stringent monitoring of electrolyte levels is indicated to prevent life-threatening complications.

Claves:ICU, critical care, hypophosphatemia, nutrition, refeeding syndrome

Cita:Nutrients 2024 Mar 22; 16 (7)

Autor/es:Schneeweiss-Gleixner, Mathias (a)
Haselwanter, Patrick (b)

institución:(a) Department of Medicine III, Clinical Division of Gastroenterology and Hepatology, Intensive Care Unit 13H1, Medical University of Vienna, 1090 Vienna, Austria.
(b) Department of Medicine III, Clinical Division of Gastroenterology and Hepatology, Intensive Care Unit 13H1, Medical University of Vienna, 1090 Vienna, Austria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070922

Interaction of Vitamin D Supplements and Marine n-3 Fatty Acids on Digestive Tract Cancer Prognosis.

Fuente:Nutrients

Extracto: These results suggest that vitamin D supplementation may reduce the risk of relapse or death by interacting with marine n-3 PUFAs.

Claves:DHA, EPA, digestive tract cancers, n-3 PUFA, vitamin D

Cita:Nutrients 2024 Mar 22; 16 (7)

Autor/es:Fukuzato, Soichiro (a)
Ohdaira, Hironori (b)

institución:(a) Division of Molecular Epidemiology, Jikei University School of Medicine, Tokyo 105-8461, Japan.
(b) Department of Surgery, International University of Health and Welfare Hospital, Narita-shi 286-0048, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070921

Herbal Medicines for the Treatment of Active Ulcerative Colitis

Fuente:Nutrients

Tipo de trabajo:Revisión sistemática

Extracto: Research with larger scale and well-designed RCTs, manufacturing regulations, and education are needed.

Claves:complementary therapies, dietary supplements, herbal medicines, integrative medicine, phytotherapy, plant extracts, ulcerative colitis

Cita:Nutrients 2024 Mar 23; 16 (7)

Autor/es:Iyengar, Preetha (a)
Godoy-Brewer, Gala (b)

institución:(a) Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA.
(b) Department of Medicine, University of Miami, Miami, FL 33136, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070934

Preventative Effects of Milk Fat Globule Membrane Ingredients on DSS-Induced Mucosal Injury in Intestinal Epithelial Cells.

Fuente:Nutrients

Extracto: This preliminary in silico evidence, combined with our in vitro findings, suggests the role of MFGM in inducing repair and maintenance of the mucosal barrier.

Claves:HT29-MTX, cell culture, in vitro digestion, milk fat globule membrane, mucin, phospholipids, scanning electron microscopy

Cita:Nutrients 2024 Mar 26; 16 (7)

Autor/es:Kosmerl, Erica (a)
Miller, Celeste (b)

institución:(a) Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA.
(b) Department of Food Science and Technology, The Ohio State University, Columbus, OH 43210, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070954

Is There Evidence of Crohn's Disease Exclusion Diet (CDED) in Remission of Active Disease in Children and Adults? A Systematic Review.

Fuente:Nutrients

Extracto: Therefore, the CDED + PEN appears to be a viable alternative for induction remission in active disease for both children and adults with CD.

Claves:Crohn’s disease, Crohn’s disease exclusion diet, exclusive enteral nutrition, partial enteral nutrition, remission

Cita:Nutrients 2024 Mar 28; 16 (7)

Autor/es:Correia, Inês (a)
Oliveira, Patrícia Almeida (b)

institución:(a) ESTeSL-Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa, 1990-096 Lisboa, Portugal.
(b) Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070987