Building CapaCITY/É for sustainable transportation: protocol for an implementation science research program in healthy cities.

Building CapaCITY/É for sustainable transportation: protocol for an implementation science research program in healthy cities.

Fuente:Bmj Open

Tipo de trabajo:Revisión

Extracto: A Knowledge Mobilization Hub will coordinate dissemination of findings via a website; presentations to academic, community organisations and practitioner audiences; and through peer-reviewed articles.

Claves:Health Equity, Implementation Science, PUBLIC HEALTH, QUALITATIVE RESEARCH, Safety, Surveys and Questionnaires

Cita:BMJ Open 2024 Apr 17; 14 (4) : e085850.

Autor/es:Winters, Meghan (a)
Fuller, Daniel (b)

institución:(a) Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada mwinters@sfu.ca.
(b) Department of Community Health and Epidemiology, University of Saskatchewan College of Medicine, Saskatoon, Saskatchewan, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2024-085850

Fetal alcohol spectrum disorder and attention deficit hyperactivity disorder stimulant trial in children: an N-of-1 pilot trial to compare stimulant to placebo (FASST): protocol.

Fuente:Bmj Open

Tipo de trabajo:Estudio aleatorizado

Extracto: TRIAL REGISTRATION NUMBER: NCT04968522.

Claves:Developmental neurology & neurodisability, Protocols & guidelines, STATISTICS & RESEARCH METHODS

Cita:BMJ Open 2024 Apr 17; 14 (4) : e071266.

Autor/es:Crichton, Alison (a)
Harris, Katrina (b)

institución:(a) Department of Paediatrics, Monash University, Clayton, Victoria, Australia ali.crichton@monash.edu.
(b) Department of Paediatrics, Monash University, Clayton, Victoria, Australia.

Conflicto:Competing interests: JN has a commercial interest in N-of-1 Hub Pty Ltd consultancy company.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2022-071266

Genetic barriers more than environmental associations explain Serratia marcescens population structure.

Genetic barriers more than environmental associations explain Serratia marcescens population structure.

Fuente:Communications Biology

Extracto: These results suggest that genetic isolation has preceded ecological adaptations in the shaping of the species diversity, an evolutionary scenario coherent with the Evolutionary Extended Synthesis.

Cita:Commun Biol 2024 Apr 17; 7 (1) : 468.

Autor/es:Sterzi, Lodovico (a)
Nodari, Riccardo (b)

institución:(a) Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center "Romeo and Enrica Invernizzi", Università Di Milano, 20157, Milan, Italy.
(b) Department of Biomedical and Clinical Sciences, Pediatric Clinical Research Center "Romeo and Enrica Invernizzi", Università Di Milano, 20157, Milan, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-06069-w

Prevention and management of dental erosion and decay.

Prevention and management of dental erosion and decay.

Fuente:Bmc Oral Health

Extracto: This Editorial invites researchers to contribute to the collection, 'Prevention and management of dental erosion and decay'.

Claves:Dental caries, Dental erosion, Management, Prevention, Tooth decay

Cita:BMC Oral Health 2024 Apr 17; 24 (1) : 468.

Autor/es:Campus, Guglielmo (a)
Niu, John Yun (b)

institución:(a) Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin Zahnmedizinische Kliniken, University of Bern, Bern, Switzerland.
(b) Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.

Conflicto:The authors declare that they are Guest Editors of the Collection ‘Prevention and management of dental erosion and decay’.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04257-y

Comment on Ombashi, van der Goes, Versnel, Khonsari, van der Molen

Comment on Ombashi, van der Goes, Versnel, Khonsari, van der Molen

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Revisión sistemática

Extracto: in their research.

Claves:Cleft lip and palate, Orthodontics, Registry, Speech, Surgery

Cita:Orphanet J Rare Dis 2024 Apr 17; 19 (1) : 162.

Autor/es:Klintö, Kristina (a)
Becker, Magnus (b)

institución:(a) Department of Clinical Sciences in Lund, Lund University, Lund, Sweden. kristina.klinto@med.lu.se.
(b) Department of Otorhinolaryngology, Skåne University Hospital, Malmö, Sweden. kristina.klinto@med.lu.se.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03123-y

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires.

Detecting T-cell clonal expansions and quantifying clone survival using deep profiling of immune repertoires.

Fuente:Frontiers in Immunology

Extracto: We demonstrate its utility by measuring the T-cell repertoire stability in healthy donors, by quantifying the effect of donor lymphocyte infusion (DLI), and by tracking the fate of the different T-cell subsets in HSCT patients and the expansion of pathogen-specific clones in vaccinated individuals.

Claves:T cell receptor (TCR), T cell repertoire analysis, TCR sequencing, adaptive immune receptor repertoire (AIRR), clonal tracking, hematopoietic (stem) cell transplantation (HCST), immune monitoring, immune reconstitution

Cita:Front Immunol 2024; 15 : 1321603.

Autor/es:Pavlova, Anastasia V (a)
Zvyagin, Ivan V (b)

institución:(a) Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.
(b) Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1321603

Somatic and Posttraumatic Stress Symptoms in Children and Adolescents in France.

Somatic and Posttraumatic Stress Symptoms in Children and Adolescents in France.

Fuente:Jama Network Open

Extracto: AND RELEVANCE: In this cross-sectional study, somatic symptoms were positively correlated with PTSS both in frequency and intensity among youths. These results suggest that the systematic screening for somatic symptoms in youths with traumatic exposure should be a routine evaluation procedure.

Cita:JAMA Netw Open 2024 Apr 1; 7 (4) : e247193.

Autor/es:Fernandez, Arnaud (a)
Askenazy, Florence (b)

institución:(a) Nice Pediatric Psychotrauma Center, University Department of Child and Adolescent Psychiatry, Children's Hospitals of Nice CHU-Lenval, Nice, France.
(b) CoBTek, Université Côte d'Azur, Nice, France.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.7193

Gender distribution of Top Doctors in otolaryngology-head and neck surgery.

Gender distribution of Top Doctors in otolaryngology-head and neck surgery.

Fuente:Plos One

Extracto: The percentage of women named as Top Doctors was less than the proportion of women in otolaryngology. This may be attributed to gender differences we found in fellowship type and certification. Further research into the role of otolaryngology subspecialties in selection of Top Doctors is needed to better understand gender differences.

Cita:PLoS One 2024; 19 (4) : e0300659.

Autor/es:DiNardo, Lauren A (a)
Reese, Alyssa D (b)

institución:(a) Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, United States of America.
(b) Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, New York, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300659

Pathophysiology of non-cystic fibrosis bronchiectasis in children and adolescents with asthma

Fuente:Plos One

Tipo de trabajo:Revisión sistemática

Extracto: SYSTEMATIC REVIEW REGISTRATION: The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) in July 2023 (registration number CRD42023440355).

Cita:PLoS One 2024; 19 (4) : e0294921.

Autor/es:da Silva, Natali Caroline (a)
Malagutti, Beatriz Cocato (b)

institución:(a) Postgraduate Program in Child and Adolescent Health of the School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
(b) Medical School, Pontifical Catholic University of Campinas, Campinas, São Paulo, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0294921

Paternal depression in the postpartum year and children's behaviors at age 5 in an urban U.S. birth cohort.

Fuente:Plos One

Extracto: Fathers' depression at age 1 was associated with children's externalizing behaviors at age 5, an important developmental stage when children transition to school. These findings suggest a need to identify and support fathers with depressive symptoms to promote optimal child development.

Cita:PLoS One 2024; 19 (4) : e0300018.

Autor/es:Schmitz, Kristine (a)
Jimenez, Manuel E (b)

institución:(a) Department of Pediatrics, Division of Population Health, Quality and Implementation, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey, United States of America.
(b) Child Health Institute of New Jersey, Rutgers University, New Brunswick, New Jersey, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0300018

Transcriptome analysis of Burkitt lymphoma cells treated with anti-convulsant drugs that are inhibitors of Epstein-Barr virus lytic reactivation.

Fuente:Plos One

Extracto: This study generates new hypotheses for control of the latency to lytic cycle switch of EBV and provides the first description of effects of the anti-convulsant drug VPM on global human cellular gene expression.

Cita:PLoS One 2024; 19 (4) : e0299198.

Autor/es:Gorres, Kelly L (a)
Reineke, David M (b)

institución:(a) Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut, United States of America.
(b) Department of Mathematics and Statistics and Statistics Consulting Center, University of Wisconsin-La Crosse, La Crosse, Wisconsin, United States of America.

Conflicto:The authors have declared that no competing interests exit.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299198

Pain experiences of marginalized children in the emergency department

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: Results of this scoping review will inform subsequent quantitative and qualitative studies regarding pain experiences and treatment of marginalized children in the ED.

Cita:PLoS One 2024; 19 (4) : e0296518.

Autor/es:Kammerer, Elise (a)
Elliott, Sarah A (b)

institución:(a) Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
(b) Alberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0296518

Evaluation of radiological capacity and usage in paediatric TB diagnosis: A mixed-method protocol of a comparative study in Mozambique, South Africa and Spain.

Fuente:Plos One

Tipo de trabajo:Estudio multicéntrico

Extracto: It will inform clinicians and radiologists on best practices and means to optimise the use of radiological technology in paediatric TB management.

Cita:PLoS One 2024; 19 (4) : e0299293.

Autor/es:Munyangaju, Isabelle (a)
José, Benedita (b)

institución:(a) Barcelona Institute for Global Health, Barcelona, Catalonia, Spain.
(b) Medicine and Translational Research Department, University of Barcelona, Barcelona, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299293

Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology - application to amikacin.

Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology - application to amikacin.

Fuente:Swiss Medical Weekly

Extracto: Pharmacometric in silico studies using high-quality real-world demographic data can provide a scientific rationale for national paediatric dose optimisation. This may increase clinical acceptance of fine-tuned standardised dosing recommendations and support their implementation, including in vulnerable subpopulations.

Cita:Swiss Med Wkly 2024 Apr 8; 154 : 3632.

Autor/es:Gotta, Verena (a)
Bielicki, Julia Anna (b)

institución:(a) SwissPedDose/SwissPedNet collaboration expert team, Zürich/Basel/Lausanne, Switzerland.
(b) Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.57187/s.3632

Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment.

Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment.

Fuente:Nature Communications

Extracto: This study highlights key clinical factors that impact response to VSTs and demonstrates the feasibility and efficacy of this therapy in pediatric HSCT.

Cita:Nat Commun 2024 Apr 18; 15 (1) : 3258.

Autor/es:Keller, Michael D (a)
Hanley, Patrick J (b)

institución:(a) Center for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.
(b) Division of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.

Conflicto:C.M.B. has filed patents in the arena of cell therapies, was a scientific co-founder of Mana Therapeutics and Catamaran Bio, is on the Board of Directors of Cabaletta Bio and holds stock in Repertoire Immune Medicine and Neximmune all of which are developing cell therapies for cancer or immune mediated disorders. In addition, she serves on the drug safety monitoring... boards (DSMB) for SOBI and on the SAB of Minovia TX Ltd. M.A.P. is on Advisory boards—Novartis, Gentibio, Bluebird, Vertex, Medexus, Equillium; and Study Support—Adaptive, Miltenyi. P.J.H. was a Co-founder and Board of Directors: Mana Therapeutics and is on the Scientific Advisory Boards for Cellevolve, Cellenkos, Capsida, MicrofluidX, Discovery Life Sciences M.R.V. is on the Ad boards for Qihan, Sanofi, the Adjudication board for Allovir, and DSMBs for Forge and Omeros. P.S. is a consultant for Sobi BJD is an Ad hoc consultant for Sobi and on the DSMB for Orchard Therapeutics S.C. is an Ad hoc advisory board member of Pharming, SOBI, X4 therapeutics and Electra therapeutics T.C.Q. is on the speakers bureau for Jazz Pharmaceuticals and Alexion Pharmaceuticals. C.C.D. is a consultant for Alexion Pharmaceuticals and Jazz Pharmaceuticals. M.D.K. is an author for Elsevier (Uptodate). All other authors have no competing interests to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-47057-2

Epidemiological study of pediatric nutritional deficiencies: an analysis from the global burden of disease study 2019.

Epidemiological study of pediatric nutritional deficiencies: an analysis from the global burden of disease study 2019.

Fuente:Nutrition Journal

Extracto: Pediatric ND remains a major public health challenge, especially in areas with low SDI. Therefore, primary healthcare services in developing countries should be improved, and effective measures, such as enhanced pre-school education, strengthened nutritional support, and early and aggressive treatment, need to be developed.

Claves:Children, Epidemiology, Global burden of Disease (GBD), Joinpoint regression analysis, Nutritional deficiencies

Cita:Nutr J 2024 Apr 18; 23 (1) : 44.

Autor/es:Mao, Chenhan (a)
Shen, Zhuyang (b)

institución:(a) Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
(b) Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12937-024-00945-1

Multidrug-resistant pathogens and ventilator-associated pneumonia in critically ill COVID-19 and non-COVID-19 patients: a prospective observational monocentric comparative study.

Multidrug-resistant pathogens and ventilator-associated pneumonia in critically ill COVID-19 and non-COVID-19 patients: a prospective observational monocentric comparative study.

Fuente:Respiratory Research

Tipo de trabajo:Estudio de cohortes

Extracto: COVID-19 patients with VAP appear to have a significantly higher ICU and in-hospital mortality risk regardless of the presence of MDR and DTR pathogens. Tracheostomy and a shorter duration of mechanical ventilation appear to be associated with better outcomes.

Claves:Antimicrobial resistance, COVID-19, Critical care, Difficult to treat organisms, Multidrug resistant organisms, Ventilator-acquired pneumonia

Cita:Respir Res 2024 Apr 18; 25 (1) : 168.

Autor/es:Montrucchio, Giorgia (a)
Balzani, Eleonora (b)

institución:(a) Department of Surgical Sciences, University of Turin, Turin, Italy. giorgiagiuseppina.montrucchio@unito.it.
(b) Department of Anesthesia, Intensive Care and Emergency, Città della Salute e della Scienza Hospital, Turin, Italy. giorgiagiuseppina.montrucchio@unito.it.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12931-024-02779-1

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients.

Altered oral microbiome, but normal human papilloma virus prevalence in cartilage-hair hypoplasia patients.

Fuente:Orphanet Journal of Rare Diseases

Extracto: Individuals with CHH exhibit similar prevalence of HPV DNA but different bacterial microbiota on their oral mucosa compared to healthy controls. This may partly explain the previously observed high prevalence of oral diseases in CHH, and regular oral examination is warranted.

Claves:Cartilage-hair hypoplasia, Human papilloma virus, Inborn errors of immunity, Microbiome

Cita:Orphanet J Rare Dis 2024 Apr 18; 19 (1) : 169.

Autor/es:Arponen, Heidi (a)
Vakkilainen, Svetlana (b)

institución:(a) Department of Oral and Maxillofacial Diseases, Helsinki University Hospital Head and Neck Center, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland. heidi.arponen@helsinki.fi.
(b) Pediatric Research Center, Children's Hospital, University of Helsinki, Helsinki University Hospital, Helsinki, Finland. heidi.arponen@helsinki.fi.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03164-3

Exploring adolescent mental health during the COVID-19 crisis - strengths and difficulties.

Exploring adolescent mental health during the COVID-19 crisis - strengths and difficulties.

Fuente:Frontiers in Public Health

Extracto: Our study contributes to understanding the psychosocial impact of the COVID-19 pandemic on German adolescents. Compared to other symptoms, we observed a particular worsening in "Emotional Symptoms" based on our data. Despite the moderate correlation between parental and self-reported evaluations, there appears to be a certain discrepancy in the perception of adolescent quality of life. Therefore, it seems prudent to assess both the external and self-reported evaluations and amalgamate the results from both parties to obtain a comprehensive problem profile of the individual. These findings underscore the importance of using country-specific cutoff values and reaffirm the utility of the SDQ as a valuable assessment tool, even within the unique circumstances posed by a pandemic.

Claves:COVID-19 pandemic, SDQ-questionnaire, adolescents, crisis, mental health, mental health assessment

Cita:Front Public Health 2024; 12 : 1357766.

Autor/es:Loy, Johanna K (a)
Klam, Janina (b)

institución:(a) Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
(b) Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1357766

Enhanced peer-group strategies to support the prevention of mother-to-child HIV transmission leads to increased retention in care in Uganda: A randomized controlled trial.

Enhanced peer-group strategies to support the prevention of mother-to-child HIV transmission leads to increased retention in care in Uganda: A randomized controlled trial.

Fuente:Plos One

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Our findings suggest that programmatic interventions that provide group support, community-based ART distribution, and income-generation activities may contribute to retention in PMTCT care, HIV-free survival of children born to women living with HIV, and ultimately, to the elimination of mother-to-child HIV transmission (EMTCT). TRIAL REGISTRATION: NCT02515370 (04/08/2015) on ClinicalTrials.gov.

Cita:PLoS One 2024; 19 (4) : e0297652.

Autor/es:Amone, Alexander (a)
Gabagaya, Grace (b)

institución:(a) Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.
(b) Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda.

Conflicto:PM received funding from NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) grant # IR01HD080476-01.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0297652