Circadian Gene Variants: Effects in Overweight and Obese Pregnant Women.

Circadian Gene Variants: Effects in Overweight and Obese Pregnant Women.

Fuente:International Journal of Molecular Sciences

Extracto: These data suggest a potential role of the polymorphisms in clock systems and in fat taste perception in both susceptibility to overweight/obesity and influencing the related metabolic traits in pregnant women.

Claves:BMAL1, CD36, CLOCK, GDM, Mediterranean diet, obesity, pregnancy

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Franzago, Marica (a)
Borrelli, Paola (b)

institución:(a) Department of Medicine and Aging, School of Medicine, and Health Sciences, "G. D'Annunzio" University, Via dei Vestini, Chieti-Pescara, 66100 Chieti, Italy.
(b) Center for Advanced Studies and Technology (CAST), "G. D'Annunzio" University, Chieti-Pescara, 66100 Chieti, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073838

Targeting Vascular Impairment, Neuroinflammation, and Oxidative Stress Dynamics with Whole-Body Cryotherapy in Multiple Sclerosis Treatment.

Fuente:International Journal of Molecular Sciences

Extracto: Whole-body cryotherapy (WBCT) emerges as one of the potential avenues for holistic MS management approaches which may alleviate the triad of MS progression factors in multiple ways.

Claves:multiple sclerosis, neurodegeneration, neuroinflammation, oxidative stress, vascular impairment, whole-body cryotherapy

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Dziedzic, Angela (a)
Maciak, Karina (b)

institución:(a) Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
(b) Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073858

Exosomal miRNA Changes Associated with Restoration to Sinus Rhythm in Atrial Fibrillation Patients.

Fuente:International Journal of Molecular Sciences

Extracto: Monitoring these serum exosomal miRNA and mRNA expression patterns may be beneficial for optimizing treatment outcomes in AF patients.

Claves:DESeq2, DIABLO model, atrial fibrillation, biomarkers, early recurrence, exosomal miRNA, rhythm control treatment, sinus rhythm restoration

Cita:Int J Mol Sci 2024 Mar 29; 25 (7)

Autor/es:Tsai, Pei-Chien (a)
Ko, Albert Min-Shan (b)

institución:(a) Department of Biomedical Sciences, Chang Gung University, Taoyuan City 33302, Taiwan.
(b) Healthy Aging Research Center, Chang Gung University, Taoyuan City 33302, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073861

Chemokine Fractalkine and Non-Obstructive Coronary Artery Disease-Is There a Link?

Fuente:International Journal of Molecular Sciences

Extracto: In this review, we critically overview the current data on FKN/CX3CL1 in the context of NO-CAD and present the novel clinical implications of the unique structure and function of FKN/CX3CL1 as a compound which distinctively contributes to the pathomechanism of this condition.

Claves:fractalkine/CX3CL1, non-obstructive coronary artery disease

Cita:Int J Mol Sci 2024 Mar 30; 25 (7)

Autor/es:Stangret, Aleksandra (a)
Sadowski, Karol Artur (b)

institución:(a) Chair and Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, Banacha 1b, 02-097 Warsaw, Poland.
(b) 1st Department of Cardiology, Medical University of Warsaw, Banacha 1a, 01-267 Warsaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073885

Skin Autofluorescence as a Potential Adjunctive Marker for Cardiovascular Risk Assessment in Type 2 Diabetes

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: SAF levels are influenced by prolonged hyperglycemia, lifestyle, aging, and other chronic diseases such as depression, and it can be used as a predictive tool for CVE.

Claves:AGE, CV risk factors, SAF, T2DM

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Reurean-Pintilei, Delia (a)
Pantea Stoian, Anca (b)

institución:(a) Doctoral School of Medicine and Pharmacy, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
(b) Centre for Molecular Research in Nephrology and Vascular Disease, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073889

The Role of Stem Cells in the Treatment of Cardiovascular Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: The aim of the present review is to summarize the current evidence on the role of stem cells in the treatment of CVDs, and how to improve their efficacy.

Claves:cardiovascular diseases, induced pluripotent stem cells, mesenchymal stem cells, stem cells

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Bakinowska, Estera (a)
Kiełbowski, Kajetan (b)

institución:(a) Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.
(b) Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073901

The Role of Inflammation in Lymphedema

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: Furthermore, we highlight the interplay between current therapeutic modalities and the underlying inflammatory microenvironment, as well as opportunities for future therapeutic development.

Claves:inflammation, lymphatic disease, lymphatic system, lymphedema, lymphoedema, pathogenesis, review, therapeutic

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Bowman, Catharine (a)
Rockson, Stanley G (b)

institución:(a) Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
(b) Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.

Conflicto:C.B. has no disclosures. S.G.R. has an ongoing consulting relationship with Koya, Inc. and receives financial compensation from them; SGR receives grant support from Celltaxis, Inc.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073907

Protein Disulfide Isomerase 4 Is an Essential Regulator of Endothelial Function and Survival.

Fuente:International Journal of Molecular Sciences

Extracto: Our findings help elucidate the role of PDIA-4 in endothelial autophagy and endothelial function and provide a potential target to modulate endothelial function and/or limit autophagy and EndMT in (patho-)physiological conditions.

Claves:PDIA-4, apoptosis, autophagy, cardiovascular diseases, endothelial function, endothelial-to-mesenchymal transition

Cita:Int J Mol Sci 2024 Mar 31; 25 (7)

Autor/es:Bu, Shuhan (a)
Singh, Aman (b)

institución:(a) Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St. N., London, ON N6A 3K7, Canada.
(b) Department of Medical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, 1151 Richmond St. N., London, ON N6A 3K7, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073913

IGF-1 and IGF-2 as Molecules Linked to Causes and Consequences of Obesity from Fetal Life to Adulthood

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: Imbalances in IGF levels are linked to a range of health conditions (e.g., insulin resistance, glucose intolerance, metabolic syndrome, and diabetes), prompting researchers to seek novel therapies and preventive strategies, offering challenges and opportunities in healthcare.

Claves:IGF-1, IGF-2, IGFs, cancer development, diabetes, metabolic syndrome, metabolic-associated fatty liver disease (MAFLD), obesity, pediatric obesity, puberty onset

Cita:Int J Mol Sci 2024 Apr 2; 25 (7)

Autor/es:Szydlowska-Gladysz, Justyna (a)
Gorecka, Adrianna Edyta (b)

institución:(a) Department of Pediatric Endocrinology and Diabetology with Endocrine-Metabolic Laboratory, Medical University in Lublin, 20-093 Lublin, Poland.
(b) Department of Pediatric Endocrinology and Diabetology with Endocrine-Metabolic Laboratory, Medical University in Lublin, 20-093 Lublin, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073966

Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: Current limitations and potential avenues for clinical translation of anti-NET treatments are discussed.

Claves:abdominal aortic aneurysm, aortic disease, cardiovascular disease, inflammation, neutrophil extracellular traps (NETs)

Cita:Int J Mol Sci 2024 Apr 3; 25 (7)

Autor/es:Ibrahim, Nahla (a)
Eilenberg, Wolf (b)

institución:(a) Division of Vascular Surgery, Department of General Surgery, Medical University of Vienna, University Hospital Vienna, 1090 Vienna, Austria.
(b) Division of Vascular Surgery, Department of General Surgery, Medical University of Vienna, University Hospital Vienna, 1090 Vienna, Austria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073983

Prevalence of Selected Polymorphisms of Il7R, CD226, CAPSL, and CLEC16A Genes in Children and Adolescents with Autoimmune Thyroid Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: Similarly, the presence of the T allele in the CAPSL locus (rs1010601) seems to reduce the risk of HT development in all patients.

Claves:CAPSL, CD226, CLEC16A, Graves’ disease (GD), Hashimoto’s thyroiditis (HT), Il7R, autoimmune thyroid diseases (AITDs), children, genetic susceptibility, single-nucleotide polymorphism (SNP)

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Borysewicz-Sańczyk, Hanna (a)
Wawrusiewicz-Kurylonek, Natalia (b)

institución:(a) Department of Pediatrics, Endocrinology, Diabetology with Cardiology Divisions, Medical University of Bialystok, J. Waszyngtona 17, 15-274 Bialystok, Poland.
(b) Department of Clinical Genetics, Medical University of Bialystok, J. Waszyngtona 13, 15-089 Bialystok, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074028

Renin-Angiotensin-Aldosterone System: From History to Practice of a Secular Topic.

Fuente:International Journal of Molecular Sciences

Extracto: Furthermore, we address why more studies are needed to establish a new standard of care away from generally prescribing ACEi or ARB toward an improved approach to combine drugs tailored to the needs of individual patients.

Claves:CKD, ESKD, RAAS, albuminuria, aldosterone

Cita:Int J Mol Sci 2024 Apr 4; 25 (7)

Autor/es:Ksiazek, Sara H (a)
Hu, Lilio (b)

institución:(a) 6th Medical Department of Internal Medicine with Nephrology & Dialysis, Clinic Ottakring, 1160 Vienna, Austria.
(b) Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, 40138 Bologna, Italy.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074035

Proteomic Profiling of Endothelial Cells Exposed to Mitomycin C: Key Proteins and Pathways Underlying Genotoxic Stress-Induced Endothelial Dysfunction.

Fuente:International Journal of Molecular Sciences

Extracto: The obtained results could improve our understanding of the fundamental basis of atherogenesis and help in the justification of genotoxic stress as a risk factor for atherosclerosis.

Claves:DNA damage, atherogenesis, bioinformatic analysis, differentially expressed proteins, endothelial disfunction, genotoxic stress, mass spectrometry, mutagenesis, proteome

Cita:Int J Mol Sci 2024 Apr 5; 25 (7)

Autor/es:Sinitsky, Maxim (a)
Repkin, Egor (b)

institución:(a) Laboratory of Genome Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 6 Academician Barbarash Boulevard, 650002 Kemerovo, Russia.
(b) Centre for Molecular and Cell Technologies, St. Petersburg State University, 7/9 Universitetskaya Embankment, 199034 St. Petersburg, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074044

Effect of Empagliflozin with or without the Addition of Evolocumab on HDL Subspecies in Individuals with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EXCEED-BHS3 Trial.

Fuente:International Journal of Molecular Sciences

Extracto: The rise in smaller-sized HDL particles was heterogeneous amongst the treatment combinations.

Claves:PCSK9i, empagliflozin, evolocumab, high-density lipoprotein, type 2 diabetes mellitus

Cita:Int J Mol Sci 2024 Apr 8; 25 (7)

Autor/es:Bonilha, Isabella (a)
Gomes, Érica Ivana Lázaro (b)

institución:(a) Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (Unicamp), Sao Paulo 13083-887, Brazil.
(b) Laboratory of Vascular Biology and Atherosclerosis (Aterolab), State University of Campinas (Unicamp), Sao Paulo 13083-887, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074108

Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation.

Fuente:International Journal of Molecular Sciences

Extracto: Signaling via FIIa might be a presumed link between the coagulation system (tissue factor-FXa/FIIa-PAR1 axis), inflammation, and pro-fibrotic pathways (thrombo-inflammation) in FDAF.

Claves:MACE, PAR1, atrial fibrillation, atrial myopathy, protease-activated receptor 1, thrombin, thrombo-inflammation, tissue factor

Cita:Int J Mol Sci 2024 Apr 8; 25 (7)

Autor/es:Friebel, Julian (a)
Wegner, Max (b)

institución:(a) Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, 12203 Berlin, Germany.
(b) DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 10785 Berlin, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074109

Overexpression of AtMYB2 Promotes Tolerance to Salt Stress and Accumulations of Tanshinones and Phenolic Acid in Salvia miltiorrhiza.

Fuente:International Journal of Molecular Sciences

Extracto: miltiorrhiza varieties.

Claves:AtMYB2, Salvia miltiorrhiza, phenolic acid, salt tolerance, tanshinones

Cita:Int J Mol Sci 2024 Apr 8; 25 (7)

Autor/es:Li, Tianyu (a)
Zhang, Shuangshuang (b)

institución:(a) College of Life Sciences, Nankai University, Tianjin 300071, China.
(b) College of Life Sciences, Nankai University, Tianjin 300071, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25074111

Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity.

Assessing Sarcocornia as a Salt Substitute: Effects on Lipid Profile and Gelatinase Activity.

Fuente:Nutrients

Extracto: perennis in the regulation of MMP-9 activity in healthy individuals, along with the need for the further study of these proteases in individuals with pathologies.

Claves:Sarcocornia perennis, cholesterol, matrix metalloproteinase 2, matrix metalloproteinase 9, salt-tolerant plants, sodium chloride

Cita:Nutrients 2024 Mar 23; 16 (7)

Autor/es:Louçano, Beatriz (a)
Maletti, Sara (b)

institución:(a) Polytechnic Institute of Coimbra, Coimbra Health School, Biomedical Laboratory Sciences, Rua 5 de Outubro, S. Martinho do Bispo, 3046-854 Coimbra, Portugal.
(b) Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, Faculty of Medicine and Surgery, University of Modena and Reggio Emilia, Policlinico, via del Pozzo, 7141124 Modena, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070929

Chlorogenic Acid

Fuente:Nutrients

Tipo de trabajo:Revisión sistemática

Extracto: Further studies for defining its specific targeting molecules, improving its bioavailability, and validating its clinical efficacy are required to corroborate the therapeutic effects of CGA.

Claves:AMPK, NF-kB, chlorogenic acid, chronic metabolic diseases, inflammation, metabolic homeostasis, neuromodulation, oxidation

Cita:Nutrients 2024 Mar 23; 16 (7)

Autor/es:Nguyen, Vi (a)
Taine, Elaine G (b)

institución:(a) Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29209, USA.
(b) TritaliMed, Inc., Columbia, SC 29223, USA.

Conflicto:EGT is an employee of TritaliMed, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070924

The Circulating Selenium Concentration Is Positively Related to the Lipid Accumulation Product: A Population-Based Cross-Sectional Study.

Fuente:Nutrients

Extracto: Future research is warranted to explore their relationship and better understand the mechanisms underlying this association.

Claves:lipid accumulation product, obesity, selenium

Cita:Nutrients 2024 Mar 23; 16 (7)

Autor/es:Zhao, Kunsheng (a)
Zhang, Yun (b)

institución:(a) National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China.
(b) National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070933

The Impact of Excessive Fructose Intake on Adipose Tissue and the Development of Childhood Obesity.

Fuente:Nutrients

Extracto: Consumers also need scientific education to understand potential health risks to themselves and their children.

Claves:adipose tissue, childhood obesity, fructose

Cita:Nutrients 2024 Mar 25; 16 (7)

Autor/es:Azevedo-Martins, Anna Karenina (a)
Santos, Matheus Pedro (b)

institución:(a) Group of Study in Endocrinology and Metabolism, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.
(b) Group of Study in Endocrinology and Metabolism, School of Arts, Sciences and Humanities, University of São Paulo, São Paulo 03828-000, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16070939