Deep learning methods in metagenomics

Fuente:Microbial Genomics

Tipo de trabajo:Revisión

Extracto: These methods aggregate contextualized data and pave the way for improved patient care and a better understanding of the microbiome's key role in our health.

Claves:binning, deep learning, disease prediction, embedding, metagenomics, microbiome, neural network

Cita:Microb Genom 2024 Apr; 10 (4)

Autor/es:Roy, Gaspar (a)
Prifti, Edi (b)

institución:(a) IRD, Sorbonne University, UMMISCO, 32 avenue Henry Varagnat, Bondy Cedex, France.
(b) IRD, Sorbonne University, UMMISCO, 32 avenue Henry Varagnat, Bondy Cedex, France.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1099/mgen.0.001231

Germline homozygosity and allelic imbalance of HLA-I are common in esophagogastric adenocarcinoma and impair the repertoire of immunogenic peptides.

Fuente:Journal For Immunotherapy of Cancer

Extracto: The high frequency of germline homozygosity in EGA patients suggests reduced cancer immunosurveillance leading to an increased cancer risk. Therapeutic targeting of allelic imbalance of HLA-I molecules should be considered in EGA.

Claves:Antigen Presentation, Antigens, Computational Biology, Gastrointestinal Neoplasms, Tumor Escape

Cita:J Immunother Cancer 2024 Apr 17; 12 (4)

Autor/es:Garcia-Marquez, Maria Alejandra (a)
Thelen, Martin (b)

institución:(a) Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany maria.garcia-marquez@uk-koeln.de.
(b) Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/jitc-2023-007268

Efficacy of Linezolid in the management of pneumonic COVID-19 patients. Bioinformatics-based clinical study.

Fuente:Journal of Infection in Developing Countries

Tipo de trabajo:Guía

Extracto: Linazolid is considered an effective antiviral weapon against SARS-COV-2. It could be used in the management plan of pneumonic individuals due to SARS-COV-2 infection. We recommend using it to combat the current wave caused by Omicron EG-5 Variant.

Claves:Linazolid, SARS CoV-2, bioinformatics, pneumonia

Cita:J Infect Dev Ctries 2024 Mar 31; 18 (3) : 326-331.

Autor/es:Eid, Ragaey A (a)
Elgendy, Marwa O (b)

institución:(a) Department of Gastroenterology, Hepatology, and Infectious Diseases (Tropical Medicine Department), Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
(b) Department of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Conflicto:No Conflict of Interest is declared

Formato:Informe virtual

Idioma:Inglés

País de fuente:Italia

Sitio web:http://dx.doi.org/10.3855/jidc.19205

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application.

Fuente:Cell Communication and Signaling Ccs

Extracto: Emphasis is placed on the considerable potential of manipulating gut microbiota within clinical settings for managing mCRC.

Claves:Colorectal cancer, Gut microbiota, Metastasis, “seed and soil” hypothesis

Cita:Cell Commun Signal 2024 Apr 18; 22 (1) : 232.

Autor/es:Fan, Shiying (a)
Zhou, Lujia (b)

institución:(a) Clinical Medical College, Yangzhou University, 225000, Yangzhou, P. R. China.
(b) Clinical Medical College, Yangzhou University, 225000, Yangzhou, P. R. China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12964-024-01615-9

Effects of bone marrow mesenchymal stem cell-conditioned medium on the proliferation and migration of liposarcoma cells.

Fuente:Folia Histochemica Et Cytobiologica

Extracto: These findings provide new insights into the impact of BMSC-CM on liposarcoma and suggest its possible involvement in liposarcoma cell growth.

Claves:YAP1 silencing, conditioned medium, human BMSC, liposarcoma, migration, proliferation

Cita:Folia Histochem Cytobiol 2024; 62 (1) : 50-60.

Autor/es:Chen, Hua (a)
Sha, Na (b)

institución:(a) Department of Emergency, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, China. chenhua88@163.com.
(b) Department of Emergency, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, Guangdong, China.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Polonia

Sitio web:http://dx.doi.org/10.5603/fhc.98379

Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer.

Fuente:Science Advances

Extracto: This study suggests distinct putative causal pathways between adiposity subtypes and CRC.

Cita:Sci Adv 2024 Apr 19; 10 (16) : eadj1987.

Autor/es:Peruchet-Noray, Laia (a)
Sedlmeier, Anja M (b)

institución:(a) International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366 Lyon CEDEX 07, France.
(b) Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1126/sciadv.adj1987

Endoscopic submucosal dissection for the treatment of a large inflammatory fibroid polyp in the gastric antrum prolapsing into the duodenum

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: LESSONS: While IFPs have traditionally been managed surgically, ESD demonstrates promising treatment outcomes, avoiding the need for surgical distal gastrectomy, and emerges as a safe and effective treatment option.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37877.

Autor/es:Wang, Xiaoyun (a)
Ma, Ru (b)

institución:(a) Department of Gastroenterology, The First People's Hospital of Shizuishan, Affiliated to Ningxia Medical University, Shizuishan, China.
(b) Department of Gastroenterology, The First People's Hospital of Shizuishan, Affiliated to Ningxia Medical University, Shizuishan, China.

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037877

Exploring the pathogenesis of chronic atrophic gastritis with atherosclerosis via microarray data analysis.

Fuente:Medicine

Extracto: Such joint pathways and hub genes provide new insights for further studies.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37798.

Autor/es:Men, Xiaoxiao (a)
Shi, Xiuju (b)

institución:(a) Department of Gastroenterology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
(b) Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037798

A comprehensive review on the hepatotoxicity of herbs used in the Indian (Ayush) systems of alternative medicine.

Fuente:Medicine

Extracto: This review also aims to provide adequate knowledge regarding herbalism in traditional practices, pertinent for medical doctors to diagnose, treat, and prevent avoidable liver disease burdens within communities, and improve public health and education.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37903.

Autor/es:Philips, Cyriac Abby (a)
Theruvath, Arif Hussain (b)

institución:(a) Clinical and Translational Hepatology, The Liver Institute, Center of Excellence in Gastrointestinal Sciences, Rajagiri Hospital, Aluva, India.
(b) Department of Clinical Research, Division of Complementary and Alternative Medicine and the Liver, The Liver Institute, Center of Excellence in Gastrointestinal Sciences, Rajagiri Hospital, Aluva, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037903

Successful treatment of gastric cancer 10 years after heart transplantation

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: This case underscores the potential risk of malignancy from immunosuppressive agents in transplant recipients. The successful management of this complex scenario underscores the indispensable role of an MDT approach in treating such unique and challenging cases.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37841.

Autor/es:Zhao, Lin (a)
Wang, Ye (b)

institución:Zhao, Lin (a)
Wang, Ye (b)

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037841

Over-the-scope clip as a rescue treatment for massive bleeding due to Dieulafoy lesion at the colorectal anastomosis

Fuente:Medicine

Tipo de trabajo:Caso clínico

Extracto: LESSONS: As far as we know, there is no reported case of lower gastrointestinal bleeding caused by Dieulafoy lesion at the colorectal anastomosis, OTSC is a safe and effective rescue treatment for Dieulafoy lesions.

Cita:Medicine (Baltimore) 2024 Apr 19; 103 (16) : e37871.

Autor/es:Han, Ping (a)
Li, Demin (b)

institución:Han, Ping (a)
Li, Demin (b)

Conflicto:The authors have no funding and conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037871

Dysregulation of CD4(+) and CD8(+) resident memory T, myeloid, and stromal cells in steroid-experienced, checkpoint inhibitor colitis.

Fuente:Journal For Immunotherapy of Cancer

Extracto: These findings nominate CD4(+) RM and MAdCAM-1(+) endothelial cells for targeting in specific subsets of CPI colitis patients.

Claves:Colitis, Immune Checkpoint Inhibitor, Immune related adverse event - irAE, Memory

Cita:J Immunother Cancer 2024 Apr 19; 12 (4)

Autor/es:He, Jun Yan (a)
Kim, Yang-Joon (b)

institución:(a) Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
(b) Chan Zuckerberg Biohub, San Francisco, California, USA.

Conflicto:Competing interests: DYO has received research support from Merck, PACT Pharma, the Parker Institute for Cancer Immunotherapy, Poseida Therapeutics, TCR2 Therapeutics, Roche/Genentech, and Nutcracker Therapeutics; travel and accommodations from Roche/Genentech; and has consulted for Revelation Partners. LF has received research support from Roche/Genentech, AbbVie, Bavarian Nordic, Bristol Myers Squibb, Dendreon, Janssen, Merck, and Partner Therapeutics; and has served on scientific... advisory boards for Actym, AstraZeneca, Atreca, Bioatla, Bolt, Bristol Myers Squibb, Daiichi Sankyo, Immunogenesis, Innovent, Merck, Merck KGA, Nutcracker, RAPT, Scribe, Senti, Sutro, and Roche/Genentech. The Combes laboratory has received research support from Eli Lilly and Genentech and AC consults for Foundery Innovations. The Kattah laboratory receives research support from Eli Lilly, and MGK has consulted for Sonoma Biotherapeutics and Morphic Therapeutic.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/jitc-2023-008628

A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases.

A Prospective Observational Study Analyzing the Diagnostic Value of Hepcidin-25 for Anemia in Patients with Inflammatory Bowel Diseases.

Fuente:International Journal of Molecular Sciences

Extracto: IBD hepcidin-25 best correlates with ferritin, and both parameters reflected inflammation extent and IBD activity.

Claves:Crohn’s disease, anemia, cytokine, ferritin, hepcidin, inflammation, ulcerative colitis

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Petrović, Stanko (a)
Tarabar, Dino (b)

institución:(a) Medical Faculty of the Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia.
(b) Clinic for Gastroenterology and Hepatology, Military Medical Academy, University of Defence, 11 000 Belgrade, Serbia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073564

Special Issue "Dietary Bioactive Components in Inflammatory Bowel Disease".

Fuente:International Journal of Molecular Sciences

Extracto: nflammatory bowel diseases (IBD) comprise chronic debilitating inflammatory disorders that can affect different parts of the gastrointestinal tract and are commonly correlated to two main diseases: Crohn's disease (CD) and ulcerative colitis (UC) [...].

Cita:Int J Mol Sci 2024 Mar 22; 25 (7)

Autor/es:Gasparrini, Massimiliano (a)
Mazzoni, Luca (b)

institución:(a) Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche 10, 60131 Ancona, Italy.
(b) Department of Agricultural, Food and Environmental Sciences, Università Politecnica delle Marche, Via Brecce Bianche 10, 60131 Ancona, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073569

Impact of STAT6 Variants on the Response to Proton Pump Inhibitors and Comorbidities in Patients with Eosinophilic Esophagitis.

Fuente:International Journal of Molecular Sciences

Extracto: Further research is warranted to clarify the clinical relevance of these variants.

Claves:CYP2C19, STAT6, eosinophilic esophagitis, pharmacogenetics

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:Soria-Chacartegui, Paula (a)
Navares-Gómez, Marcos (b)

institución:(a) Clinical Pharmacology Department, Hospital Universitario de La Princesa, Faculty of Medicine, Universidad Autónoma de Madrid (UAM), 28006 Madrid, Spain.
(b) Instituto de Investigación Sanitaria La Princesa (IIS-IP), 28006 Madrid, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073685

ETV6

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: Additionally, the presence of abundant lymphoid infiltration in the present case may prompt further research into immunotherapy as a possible additional therapeutic option.

Claves:ETV6::NTRK3 gene fusion, GIST wild-type, lymphoid infiltration, therapeutic implication

Cita:Int J Mol Sci 2024 Mar 26; 25 (7)

Autor/es:Machado, Isidro (a)
Claramunt-Alonso, Reyes (b)

institución:(a) Pathology Department, Instituto Valenciano de Oncología, Calle Gregorio Gea 31, 4to Piso, 46009 Valencia, Spain.
(b) Patologika Laboratory, Hospital Quiron-Salud, 46010 Valencia, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073707

Genetic Variants Associated with Biological Treatment Response in Inflammatory Bowel Disease

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: The most significant SNPs potentially useful as predictive biomarkers of treatment response are linked to immunity, cytokine production, and immunorecognition.

Claves:Crohn’s disease, adalimumab, anti-tumor necrosis factor, biological drugs, inflammatory bowel disease, infliximab, ulcerative colitis, ustekinumab

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Plaza, Javier (a)
Mínguez, Alejandro (b)

institución:(a) Inflammatory Bowel Disease Research Group, Health Research Institute La Fe (IIS La Fe), 46026 Valencia, Spain.
(b) Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073717

Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer.

Fuente:International Journal of Molecular Sciences

Extracto: This study offers a thorough analysis of the stool glycoproteome, laying the groundwork for harnessing glycosylation alterations to improve non-invasive cancer detection.

Claves:cancer glycosylation, colorectal cancer, glycoproteomics, pre-cancerous lesions, stool glycoproteins

Cita:Int J Mol Sci 2024 Mar 27; 25 (7)

Autor/es:Soares, Janine (a)
Eiras, Mariana (b)

institución:(a) Experimental Pathology and Therapeutics Group, Research Center of IPO Porto (CI-IPOP), RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto), Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), 4200-072 Porto, Portugal.
(b) Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal.

Conflicto:J.A.F. and L.L.S. are founders and associate partners of GlycoMatters Biotech. The remaining authors declare no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073722

Anti-Inflammatory Effects of a Novel Acetonitrile-Water Extract of Lens Culinaris against LPS-Induced Damage in Caco-2 Cells.

Fuente:International Journal of Molecular Sciences

Extracto: More research is required to understand their mechanisms and explore therapeutic applications, especially for gastrointestinal inflammatory conditions.

Claves:ATP-sensitive K+ channels, aquaporin, calcium-activated K+ channels, functional gastrointestinal disorders, intestinal dismicrobism, ion channels, irritable bowel syndrome (IBS), transient receptor potential, transporters, voltage-dependent sodium channels

Cita:Int J Mol Sci 2024 Mar 28; 25 (7)

Autor/es:Maqoud, Fatima (a)
Orlando, Antonella (b)

institución:(a) Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, BA, Italy.
(b) Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "Saverio de Bellis", 70013 Castellana Grotte, BA, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073802

Targeting HER2 in Gastroesophageal Adenocarcinoma: Molecular Features and Updates in Clinical Practice.

Fuente:International Journal of Molecular Sciences

Extracto: This review will summarise historical and emerging therapies for the treatment of HER2-positive GEA, with a section dedicated to the HER2 molecular pathway and the use of novel blood biomarkers, such as circulating tumour DNA and circulating tumour cells, which may be helpful in the future to guide treatment decisions.

Claves:HER2, ct-DNA, gastroesophageal adenocarcinoma, heterogeneity, immunotherapy, trastuzumab, trastuzumab deruxtecan

Cita:Int J Mol Sci 2024 Mar 30; 25 (7)

Autor/es:Bonomi, Maria (a)
Spada, Daniele (b)

institución:(a) Oncology Unit, ASST Cremona, 26100 Cremona, Italy.
(b) Oncology Unit, ASST Cremona, 26100 Cremona, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25073876