Uterine leiomyoma causes an increase in systolic blood pressure: a two-sample Mendelian randomization study.

Uterine leiomyoma causes an increase in systolic blood pressure: a two-sample Mendelian randomization study.

Fuente:Frontiers in Endocrinology

Extracto: Based on large-scale population GWAS data, our MR analysis suggested a causal relationship between UL and SBP. Therefore, women with UL, especially pregnant women, should pay attention to monitoring their blood pressure levels. For patients with hypertension who already have UL, interventions for UL may serve as potential therapeutic methods for managing blood pressure.

Claves:Mendelian randomization, causal relationship, hypertension, hypertensive disorders of pregnancy, uterine leiomyoma

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1373724.

Autor/es:Xu, Hui (a)
Ma, Yuxia (b)

institución:(a) Obstetrics and Gynecology Department, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
(b) The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1373724

The impact of ovarian endometrioma and endometriotic cystectomy on anti-Müllerian hormone, and antral follicle count

Fuente:Frontiers in Endocrinology

Tipo de trabajo:Revisión sistemática

Extracto: It is necessary to conduct further targeted RCTs, systematic reviews, and meta-analyses based on solid methodological grounds to increase the level of evidence, refine quantitative estimates, investigate open questions, and decrease heterogeneity.

Claves:Anti-Müllerian hormone, antral follicle count, endometrioma, endometriotic cystectomy, meta-analysis, ovarian reserve

Cita:Front Endocrinol (Lausanne) 2024; 15 : 1397279.

Autor/es:Younis, Johnny S (a)
Taylor, Hugh S (b)

institución:(a) Reproductive Medicine, Department of Obstetrics and Gynecology, Tzafon Medical Center, Poriya, Israel.
(b) Azrieili Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fendo.2024.1397279

Impact of social determinants of health on progression from potentially life-threatening complications to near miss events and death during pregnancy and post partum in a middle-income setting: an observational study.

Impact of social determinants of health on progression from potentially life-threatening complications to near miss events and death during pregnancy and post partum in a middle-income setting: an observational study.

Fuente:Bmj Open

Extracto: This study demonstrates the independent contribution of SDH to SMO among those sustaining PLTC in a middle-income setting, highlighting the need to formulate preventive strategies beyond clinical considerations.

Claves:maternal medicine, observational study, obstetrics

Cita:BMJ Open 2024 May 27; 14 (5) : e081996.

Autor/es:Keepanasseril, Anish (a)
Pal, Koustav (b)

institución:(a) Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India keepanasseril.a@jipmer.ac.in.
(b) Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-081996

Knowledge, attitudes and practice on sudden infant death

Fuente:Bmj Open

Tipo de trabajo:Revisión

Extracto: The results will be disseminated to the health science community through professional networks, conference presentations and publication in a scientific journal.

Claves:Family, Health, Health Education, Health Services, NEONATOLOGY, Nursing Care

Cita:BMJ Open 2024 May 27; 14 (5) : e080107.

Autor/es:Rodrigues, Larissa (a)
De Souza, Ariane Vitória (b)

institución:(a) Obstetrics & Gynecology, Universidade Estadual de Campinas Faculdade de Ciencias Medicas, Campinas, Brazil rodrigues-larissa@uol.com.br.
(b) Nursing, Centro Universitario Nossa Senhora do Patrocinio, Itu, São Paulo, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-080107

First external validity study of the Fagotti score in ovarian cancer.

First external validity study of the Fagotti score in ovarian cancer.

Fuente:Scientific Reports

Extracto: The explorable Fagotti score has an equivalent or better inter-observer concordance than the Fagotti score.

Cita:Sci Rep 2024 May 27; 14 (1) : 12133.

Autor/es:Sarah, Aida (a)
Mathieu, Levaillant (b)

institución:(a) Department of Gynecology, University Hospital, 49100, Angers, France.
(b) Department of Public Health, University Hospital, 49100, Angers, France.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62568-0

Development and validation of a prenatal predictive nomogram for the risk of NICU admission in infants born to Chinese mothers over 35 years of age

Development and validation of a prenatal predictive nomogram for the risk of NICU admission in infants born to Chinese mothers over 35 years of age

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Estudio de cohortes

Extracto: The nomogram demonstrates favorable performance in predicting the risk of neonatal NICU transfer after delivery by mothers older than 35 years. The model serves as an accurate and effective tool for clinicians to predict NICU admission in a timely manner.

Claves:Advanced maternal age, Neonatal intensive care unit, Pre-delivery factors, Prediction nomogram, Retrospective cohort study

Cita:BMC Pregnancy Childbirth 2024 May 27; 24 (1) : 390.

Autor/es:Wei, Yihong (a)
Xu, Shuai (b)

institución:(a) Department of Obstetrical, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
(b) Department of Obstetrical, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06582-0

Comparative performance of contact plate metod and swab method for surface microbial contamination on medical fabrics.

Comparative performance of contact plate metod and swab method for surface microbial contamination on medical fabrics.

Fuente:Bmc Infectious Diseases

Extracto: Contact plate method is superior to swab method in strain isolation. Swab method is more suitable for evaluating the bacterial contamination of fabrics.

Claves:Contact plate method, Hospital-acquired infection, Linear mixed-effects model, Medical fabrics

Cita:BMC Infect Dis 2024 May 27; 24 (1) : 530.

Autor/es:Chen, Feng (a)
Li, Yaru (b)

institución:(a) Department of Nosocomial Infection Management, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin South Road,Wuhou District, Chengdu, Sichuan Province, 610041, PR China.
(b) Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, No. 20, Section 3, Renmin South Road,Wuhou District, Chengdu, Sichuan Province, 610041, PR China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09416-8

Does higher performance in a national licensing examination predict better quality of care? A longitudinal observational study of Ethiopian anesthetists.

Does higher performance in a national licensing examination predict better quality of care? A longitudinal observational study of Ethiopian anesthetists.

Fuente:Bmc Anesthesiology

Tipo de trabajo:Revisión

Extracto: The NLE score had an inverse relationship with the occurrence of critical incidents, supporting the validity of the examination in assessing graduates' ability to provide safe and effective care. The lack of an association with the other two QoC indicators requires further investigation. Our findings may help improve education quality and the impact of NLEs in Ethiopia and beyond.

Claves:Anesthetists, Associate clinicians, Licensing examination, Patient outcome, Quality of care

Cita:BMC Anesthesiol 2024 May 27; 24 (1) : 188.

Autor/es:Asemu, Yohannes Molla (a)
Yigzaw, Tegbar (b)

institución:(a) Health Workforce Improvement Program, Jhpiego, an affiliate of Johns Hopkins University, Ethiopia country office, Addis Ababa, Ethiopia. Yohannes.Asemu@jhpiego.org.
(b) Athena Institute, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Yohannes.Asemu@jhpiego.org.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12871-024-02575-w

Development, validation and reliability testing of the hospice care environment scale.

Development, validation and reliability testing of the hospice care environment scale.

Fuente:Bmc Palliative Care

Tipo de trabajo:Revisión

Extracto: The Hospice Care Environment Scale to assess the environment of hospice care services, has good content and construct validity and reliability. This scale can provide guidance to evaluate the hospice care environment.

Claves:Delphi, Hospice care, Psychometric testing, Scale development, Validation

Cita:BMC Palliat Care 2024 May 28; 23 (1) : 135.

Autor/es:Zhong, Junping (a)
Zhang, Wei (b)

institución:(a) School of Nursing, Wuhan University, Located on No. 115 Donghu Road, Wuhan, Hubei province, 430071, China.
(b) Minxi Vocational & Technical College, Located on No.8 Caoxi Road, Longyan, Fujian province, 364021, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12904-024-01450-2

Challenges to the implementation of a multi-level intervention to reduce mistreatment of women during childbirth in Iran: a qualitative study using the Consolidated Framework for Implementation Research.

Challenges to the implementation of a multi-level intervention to reduce mistreatment of women during childbirth in Iran: a qualitative study using the Consolidated Framework for Implementation Research.

Fuente:Reproductive Health

Tipo de trabajo:Guía

Extracto: This study provides a clear understanding of the challenges of implementing a multi-level intervention to reduce mistreatment of women during childbirth and highlights potential implications for policy makers and practitioners of maternal health programs. We encourage them to take the lessons learned from this study and revise their current programs and policies regarding the quality of maternity care by focusing on the identified challenges.

Claves:CFIR, Childbirth, Implementation research, Iran, Maternity care, Mistreatment, Multi-level intervention, Qualitative study

Cita:Reprod Health 2024 May 27; 21 (1) : 70.

Autor/es:Mirzania, Marjan (a)
Shakibazadeh, Elham (b)

institución:(a) Department of Health Education and Promotion, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
(b) Department of Health Education and Promotion, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. shakibazadeh@tums.ac.ir.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12978-024-01813-1

Educational telerehabilitation program for women with pelvic floor dysfunctions after gynecological pelvic cancer treatment: protocol study for a randomized and controlled clinical trial.

Educational telerehabilitation program for women with pelvic floor dysfunctions after gynecological pelvic cancer treatment: protocol study for a randomized and controlled clinical trial.

Fuente:Trials

Tipo de trabajo:Estudio clínico

Extracto: DISCUSSION: Activities in the context of telerehabilitation using PFMT and self-care can represent a viable and effective solution to minimize the side effects of gynecological cancer treatment and improve women's quality of life.

Claves:Brachytherapy, Dyspareunia, Neoplasm, Pelvic floor, Telerehabilitation, Urinary incontinence

Cita:Trials 2024 May 28; 25 (1) : 347.

Autor/es:Bem Fretta, Tatiana de (a)
Dacanal, Gabriela Dassie (b)

institución:(a) Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP: 14049-900, Brazil.
(b) Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, 3900, Monte Alegre, Ribeirão Preto, São Paulo, CEP: 14049-900, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13063-024-08138-1

The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth.

The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth.

Fuente:Microbiome

Extracto: In these nulliparous pregnant women, vaginal microbiota composition is strongly associated with sPTB. Our results support that vaginal mucosal Igs might play a pivotal role in microbiota composition, microbiota-related inflammation, and vaginal community disparity within and between ethnicities. This study provides insight in host-microbe interaction, suggesting that vaginal mucosal Igs play an immunomodulatory role similar to that in the intestinal tract. Video Abstract.

Claves:Ethnicity, Host-microbiota interaction, Immunoglobulins, Nulliparous women, Spontaneous preterm birth, Vaginal microbiota

Cita:Microbiome 2024 May 28; 12 (1) : 99.

Autor/es:Schuster, H J (a)
Breedveld, A C (b)

institución:(a) Amsterdam UMC location Vrije Universiteit Amsterdam, Medical Microbiology and Infection Control, Boelelaan 1117, Amsterdam, The Netherlands. h.schuster@amsterdamumc.nl.
(b) Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands. h.schuster@amsterdamumc.nl.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40168-024-01787-z

Childbirth Acquired Perineal Trauma study (CHAPTER)

Childbirth Acquired Perineal Trauma study (CHAPTER)

Fuente:Bmj Open

Tipo de trabajo:Estudio de cohortes

Extracto: After the conclusion of this study, findings will be used to work with governmental organisations and Royal Colleges to target resources and ultimately improve care.

Claves:Natural Childbirth, OBSTETRICS, Postpartum Period, Postpartum Women, Pregnancy, WOUND MANAGEMENT

Cita:BMJ Open 2024 May 24; 14 (5) : e086724.

Autor/es:Hodgetts Morton, Victoria (a)
Man, Rebecca (b)

institución:(a) Birmingham Women's Hospital, Birmingham, UK.
(b) Institute of Applied Health Research, University of Birmingham, Birmingham, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2024-086724

Pregnancy Outcomes and Obstetrical Complications of Twin Pregnancies with Endometriosis

Pregnancy Outcomes and Obstetrical Complications of Twin Pregnancies with Endometriosis

Fuente:Yonsei Medical Journal

Tipo de trabajo:Estudio de cohortes

Extracto: Twin pregnancies with endometriosis were not related to adverse effects on pregnancy outcomes and obstetrical complications. To confirm these outcomes, further large prospective studies are required.

Claves:Twin pregnancy, endometriosis, placenta previa, postpartum hemorrhage, pregnancy outcome, small for gestational age

Cita:Yonsei Med J 2024 Jun; 65 (6) : 356-362.

Autor/es:Shin, Joong Sik (a)
Kim, Sujin (b)

institución:(a) Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
(b) Department of Obstetrics and Gynecology, Dong-A University Hospital, Dong-A University College of Medicine, Busan, Korea.

Conflicto:The authors have no potential conflicts of interest to disclose.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Corea del Sur

Sitio web:http://dx.doi.org/10.3349/ymj.2023.0099

Neurodevelopment and Metabolism in the Maternal-Placental-Fetal Unit.

Neurodevelopment and Metabolism in the Maternal-Placental-Fetal Unit.

Fuente:Jama Network Open

Tipo de trabajo:Estudio de cohortes

Extracto: AND RELEVANCE: In this cohort study of children with high familial risk of ASD, placental and cord serum metabolism at delivery were highly correlated. Furthermore, placental and cord serum metabolic profiles were associated with risk of non-TD.

Cita:JAMA Netw Open 2024 May 1; 7 (5) : e2413399.

Autor/es:Parenti, Mariana (a)
Schmidt, Rebecca J (b)

institución:(a) Department of Nutrition, University of California, Davis.
(b) Now with Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, Washington.

Conflicto:Conflict of Interest Disclosures: Dr Schmidt reported receiving personal fees from Linus Technology and Beasley Law Firm outside the submitted work. Dr Tancredi reported receiving personal fees from Deerland Probiotics outside the submitted work. No other disclosures were reported.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1001/jamanetworkopen.2024.13399

Assessment of the localization of chondroitin sulfate in various types of endometrial carcinoma.

Assessment of the localization of chondroitin sulfate in various types of endometrial carcinoma.

Fuente:Plos One

Extracto: The characteristic localization of CS in various EC types was elucidated. The present study provides new information on endometrial stromal assessment.

Cita:PLoS One 2024; 19 (5) : e0304420.

Autor/es:Hosokawa, Sho (a)
Norimatsu, Yoshiaki (b)

institución:(a) Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.
(b) Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences, Ehime, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0304420

Prognostic impact of suspicious extraabdominal lymph nodes on patient survival in advanced ovarian cancer.

Fuente:Plos One

Extracto: Suspicious EALNs did not worsen the prognosis of patients with advanced ovarian cancer. However, its impact on survival is not yet clarified. Further investigation is required to assess the clinical significance of suspicious EALNs on preoperative imaging studies.

Cita:PLoS One 2024; 19 (5) : e0299205.

Autor/es:Park, Kena (a)
Kwon, Ji Young (b)

institución:(a) Department of Obstetrics and Gynecology, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
(b) Department of Medicine, Graduate School of Medicine, Kyung Hee University, Seoul, Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0299205

Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.

Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.

Fuente:Plos Neglected Tropical Diseases

Extracto: SIGNIFICANCE: This novel paradigm using ICT identifies likely false positives or raises suspicion that a result is truly positive, rapidly needing prompt follow up and treatment. Thus, ICT enables well-accepted gestational screening programs that facilitate rapid treatment saving lives, sight, cognition and motor function. This reduces anxiety, delays, work, and cost at point-of-care and clinical laboratories. TRIAL REGISTRATION: NCT04474132, https://clinicaltrials.gov/study/NCT04474132 ClinicalTrials.gov.

Cita:PLoS Negl Trop Dis 2024 May; 18 (5) : e0011335.

Autor/es:Zhou, Ying (a)
Leahy, Karen (b)

institución:(a) Departments of Ophthalmology and Visual Science, The University of Chicago, Chicago, Illinois, United States of America.
(b) Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois, United States of America.

Conflicto:We have read the journal’s policy and the authors of this manuscript have the following competing interests: DL and RP are/were affiliated with LDBIO Diagnostics, DL is the scientist and CEO share holder and RP was the R&D Director Scientist until January 13, 2023. A patent application was submitted by DL with the scientists at the University of Chicago and... nd in Lyon, France in August 2018. This application is pending review in the United States in accordance with US Bayh Dole Laws. This is for the development of the whole blood point of care test and the practical clinical utility of the ICT to guide treatment for gestational infection to prevent congenital toxoplasmosis. This is to insure its continued high-quality performance and reproducibility of the results described herein. It is pending in review at the US patent office. All other authors have declared no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pntd.0011335

Human Milk Microbiome-A Review of Scientific Reports.

Human Milk Microbiome-A Review of Scientific Reports.

Fuente:Nutrients

Extracto: Unfortunately, despite increasingly more precise methods for assessing microorganisms in human milk, the topic of the human milk microbiome is still quite limited and requires scientific research that takes into account various conditions.

Claves:breastfeeding, human milk, infant, microbiome

Cita:Nutrients 2024 May 8; 16 (10)

Autor/es:Dombrowska-Pali, Agnieszka (a)
Wiktorczyk-Kapischke, Natalia (b)

institución:(a) Department of Perinatology, Gynecology and Gynecologic Oncology, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Łukasiewicza 1, 85-821 Bydgoszcz, Poland.
(b) Department of Microbiology, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie-Skłodowskiej 9, 85-094 Bydgoszcz, Poland.

Conflicto:Author Maciej W. Socha was employed by the Copernicus Healthcare Entity LLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16101420

Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy

Fuente:Nutrients

Tipo de trabajo:Estudio de cohortes

Extracto: The changes were found to be not statistically significant after post-multiple comparison adjustment.

Claves:anxiety, depression, gut microbiota, pregnancy

Cita:Nutrients 2024 May 12; 16 (10)

Autor/es:Chi, Ruixin (a)
Li, Muxia (b)

institución:(a) Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China.
(b) Department of Scientific Research, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16101460