New blood biomarkers and imaging for disease stratification and monitoring of giant cell arteritis.

New blood biomarkers and imaging for disease stratification and monitoring of giant cell arteritis.

Fuente:Rmd Open

Extracto: Future studies are required to investigate the outcome of patients with GCA whose treatment decisions are based on traditional plus novel (laboratory and imaging) biomarkers as compared with those undergoing conventional monitoring strategies.

Claves:Cytokines, Giant Cell Arteritis, Outcome and Process Assessment, Health Care, Ultrasonography, Vasculitis

Cita:RMD Open 2024 Feb 23; 10 (1)

Autor/es:Tomelleri, Alessandro (a)
Dejaco, Christian (b)

institución:(a) Unit of Immunology, Rheumatology, Allergy and Rare Diseases, San Raffaele Hospital, Milan, Italy.
(b) Department of Rheumatology and Immunology, Medical University of Graz, Graz, Austria christian.dejaco@gmx.net.

Conflicto:Competing interests: AT received speaker’s fees from Novartis (unrelated to this manuscript). CD has received consulting/speaker’s fees from AbbVie, Eli Lilly and Company, Janssen, Novartis, Pfizer, Roche, Sparrow, Galapagos and Sanofi (all unrelated to this manuscript). CD is an editorial board member of ARD.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/rmdopen-2023-003397

Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential.

Fuente:Rmd Open

Extracto: Our results shed light on a new molecular mechanism by which T cells may selectively migrate to inflammatory loci, promote new bone formation and contribute to the pathological ossification process observed in AS.

Claves:Chemokines, Spondylitis, Ankylosing, T-Lymphocyte subsets

Cita:RMD Open 2024 Feb 23; 10 (1)

Autor/es:Martini, Veronica (a)
Silvestri, Ylenia (b)

institución:(a) Institute for Research in Biomedicine, Universitá della Svizzera italiana, Bellinzona, Switzerland.
(b) Institute for Research in Biomedicine, Universitá della Svizzera italiana, Bellinzona, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/rmdopen-2023-003926

Biomechanical comparison of all-polyethylene total knee replacement and its metal-backed equivalent on periprosthetic tibia using the finite element method.

Biomechanical comparison of all-polyethylene total knee replacement and its metal-backed equivalent on periprosthetic tibia using the finite element method.

Fuente:Journal of Orthopaedic Surgery and Research

Extracto: The effect of APT implantation on the periprosthetic tibia was shown as equal or even superior to that of MBT despite maximum strain values occurring in different locations. On the basis of the strain distribution, the state of the bone tissue was analysed to determine whether bone tissue remodelling or remodelling would occur. Following clinical validation, outcomes could eventually modify the implant selection criteria and lead to more frequent implantation of APT components.

Claves:All-polyethylene tibial component, Computational modeling, FEA, Finite element method, Knee replacement, Metal-backed tibial component, TKR, Total knee arthroplasty

Cita:J Orthop Surg Res 2024 Feb 23; 19 (1) : 153.

Autor/es:Apostolopoulos, Vasileios (a)
Boháč, Petr (b)

institución:(a) First Department of Orthopaedic Surgery, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czech Republic.
(b) Institute of Solid Mechanics, Mechatronics and Biomechanics, Faculty of Mechanical Engineering, University of Technology, Brno, Czech Republic.

Conflicto:The authors declare no competing interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13018-024-04631-0

The Effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors.

The Effects of Fucoidan Derived from Sargassum filipendula and Fucus vesiculosus on the Survival and Mineralisation of Osteogenic Progenitors.

Fuente:International Journal of Molecular Sciences

Extracto: This research underscores the multifaceted impact of fucoidans on osteoprogenitor cells and highlights the delicate balance between potential therapeutic benefits and the challenges involved in using fucoidans for post-surgery treatments in patients with osteosarcoma.

Claves:apoptosis, bone healing, brown algae, fucoidan, human embryonic-derived mesenchymal progenitor cells, mitochondria, necrosis, osteosarcoma

Cita:Int J Mol Sci 2024 Feb 8; 25 (4)

Autor/es:Gupta, Dhanak (a)
Martinez, Diana C (b)

institución:(a) Department of Materials Science and Engineering, University of Sheffield, Sheffield S1 3JD, UK.
(b) INSIGNEO Institute for in Silico Medicine, University of Sheffield, Sheffield S1 3JD, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042085

Carbon-TiO(2) Hybrid Quantum Dots for Photocatalytic Inactivation of Gram-Positive and Gram-Negative Bacteria.

Fuente:International Journal of Molecular Sciences

Extracto: Also considered and discussed is the possibility of additional contributions to the antibacterial activities due to the photosensitization of the nanoscale TiO(2) by its doped core carbon nanoparticles.

Claves:Gram-negative bacteria, antibacterial function, carbon dots, carbon–TiO2 hybrid dots, fluorescence performance, photosensitization

Cita:Int J Mol Sci 2024 Feb 12; 25 (4)

Autor/es:Dong, Xiuli (a)
Liu, Yamin (b)

institución:(a) Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
(b) Department of Microbiology and Immunology, School of Osteopathic Medicine, Campbell University, Buies Creek, NC 27506, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042196

High Frequencies of Genetic Variants in Patients with Atypical Femoral Fractures.

Fuente:International Journal of Molecular Sciences

Extracto: Larger studies are needed to confirm the utility of gene set analysis in identifying patients at high risk of AFF during anti-resorptive therapy.

Claves:SNPs, atypical femur fractures, genetics

Cita:Int J Mol Sci 2024 Feb 15; 25 (4)

Autor/es:Del Real, Álvaro (a)
Cruz, Raquel (b)

institución:(a) Departamento de Medicina y Psiquiatría, Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Facultad de Medicina, Universidad de Cantabria, 39011 Santander, Spain.
(b) Grupo de Medicina Xenómica, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Universidade de Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042321

Statins-Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers.

Fuente:International Journal of Molecular Sciences

Extracto: This paper outlines various carrier types, characterizing their structures and underscoring various statins' potential as local treatments for bone diseases.

Claves:bone tissue metabolism, local application, simvastatin, statin carriers, statins

Cita:Int J Mol Sci 2024 Feb 17; 25 (4)

Autor/es:Granat, Marcin Mateusz (a)
Eifler-Zydel, Joanna (b)

institución:(a) Department of Clinical and Experimental Pharmacology, Faculty of Medicine, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
(b) Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25042378

Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus

Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus

Fuente:International Journal of Environmental Research and Public Health

Tipo de trabajo:Revisión

Extracto: Hydroxymethylation in the SOCS3-related region of blood DNA is promising to investigate for its mediation in the influences of environment on incident T2DM.

Claves:blood, human, hydroxymethylation, peripheral, twin, type 2 diabetes mellitus

Cita:Int J Environ Res Public Health 2024 Feb 4; 21 (2)

Autor/es:Luong, Ryan Anh Minh (a)
Guan, Weihua (b)

institución:(a) Doctoral Program of Osteopathic Medicine, College of Osteopathic Medicine, Des Moines University, West Des Moines, IA 50266, USA.
(b) Division of Biostatistics & Health Data Science, University of Minnesota School of Public Health, Minneapolis, MN 55414, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijerph21020177

Enhancing Behavioural Changes

Fuente:International Journal of Environmental Research and Public Health

Tipo de trabajo:Revisión

Extracto: Various concerns regarding the excessive use of APPs need to be addressed.

Claves:chronic disease, eHealth, physical exercise, telemedicine, weight control

Cita:Int J Environ Res Public Health 2024 Feb 16; 21 (2)

Autor/es:Di Martino, Giulia (a)
Della Valle, Carlo (b)

institución:(a) Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.
(b) Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijerph21020233

Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.

Rosuvastatin as a Supplemental Treatment for the Clinical Symptoms of Nephropathia Epidemica: A Pilot Clinical Study.

Fuente:Viruses

Extracto: The data from our study provide evidence supporting the therapeutic potential of rosuvastatin in NE cases.

Claves:nephropathia epidemica, rosuvastatin, statins

Cita:Viruses 2024 Feb 17; 16 (2)

Autor/es:Shakirova, Venera (a)
Markelova, Maria (b)

institución:(a) Department of Infection Diseases, Kazan State Medical Academy, Kazan 420012, Russia.
(b) Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/v16020306

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation.

Fuente:Communications Biology

Extracto: This mode of antigen delivery strengthens the evidence for post-ER ligand exchange pathways for MR1, which could represent an important avenue by which MR1 acquires antigens derived from endocytosed pathogens.

Cita:Commun Biol 2024 Feb 24; 7 (1) : 228.

Autor/es:Kulicke, Corinna A (a)
Swarbrick, Gwendolyn M (b)

institución:(a) Division of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, OR, 97239, USA.
(b) Division of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, 97239, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-05912-4

CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.

CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.

Fuente:Frontiers in Immunology

Extracto: CSF Chitinase 3 like1 might provide prognostic information for predicting disease activity in the first years after initiation of cladribine. The drug's effect on chronic macrophage and microglia activation deserves further evaluation.

Claves:biomarkers, chemokines, cladribine, cytokines, disease activity, relapsing multiple sclerosis

Cita:Front Immunol 2024; 15 : 1343892.

Autor/es:Marastoni, Damiano (a)
Foschi, Matteo (b)

institución:(a) Neurology B, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
(b) Neurology Unit, Department of Neuroscience, Multiple Sclerosis Center, S. Maria delle Croci Hospital, AUSL, Romagna, Ravenna, Italy.

Conflicto:DM received honoraria for research or speaking and funds for travel from Biogen Idec, Roche, Sanofi-Genzyme, Novartis. MC received honoraria for research or speaking and funds for travel from Roche, Sanofi-Genzyme, Merck Serono S.p.a Italy, Biogen Idec, Teva and Novartis. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could... be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1343892

The effect of the whole-process care model of the medical union on the improvement of kinesiophobia and bone mineral density in patients with osteoporosis.

The effect of the whole-process care model of the medical union on the improvement of kinesiophobia and bone mineral density in patients with osteoporosis.

Fuente:Journal of Orthopaedic Surgery and Research

Extracto: The whole-process care model of the medical association is used for osteoporosis patients, which might reduce the risk of kinesiophobia and improve the bone density of the lumbar spine and total hip in patients. But further promotion and improvement of relevant support systems are needed to achieve comprehensive promotion and maximize clinical benefits in this field.

Claves:Bone density, Full care, Medical association, Osteoporosis, Phobia

Cita:J Orthop Surg Res 2024 Feb 27; 19 (1) : 154.

Autor/es:Qian, Xiaoli (a)
Cao, Xiaodong (b)

institución:(a) Department of Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China.
(b) Department of Nursing, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13018-024-04616-z

In Vitro Assessment of Cortisol Release Inhibition, Bioaccessibility and Bioavailability of a Chemically Characterized Scutellaria lateriflora L. Hydroethanolic Extract.

Fuente:Molecules (basel, Switzerland)

Extracto: In vivo studies and clinical trials remain necessary to draw a conclusion on the efficacy and tolerability of this plant extract.

Claves:Scutellaria lateriflora L., bioaccessibility, bioavailability, cortisol, osteoporosis, stress

Cita:Molecules 2024 Jan 25; 29 (3)

Autor/es:Buccato, Daniele Giuseppe (a)
Ullah, Hammad (b)

institución:(a) Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.
(b) Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030586

The Extraction, Determination, and Bioactivity of Curcumenol

Fuente:Molecules (basel, Switzerland)

Tipo de trabajo:Revisión

Extracto: This review of curcumenol provides a theoretical basis for further research and clinical applications.

Claves:Curcuma wenyujin, TCM, biological activity, curcumenol

Cita:Molecules 2024 Jan 30; 29 (3)

Autor/es:Li, Jie (a)
Sun, Yitian (b)

institución:(a) State Key Laboratory of Quality Research in Chinese Medicines, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau 999078, China.
(b) College of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030656

Bergaptol, a Major Furocoumarin in Citrus: Pharmacological Properties and Toxicity.

Fuente:Molecules (basel, Switzerland)

Extracto: Further in vivo and clinical studies are warranted to identify the safe and effective doses of bergaptol for its multimodal application.

Claves:bergaptol, citrus, furanocoumarin, pharmacologic actions, toxicity

Cita:Molecules 2024 Feb 4; 29 (3)

Autor/es:Phucharoenrak, Pakkapong (a)
Trachootham, Dunyaporn (b)

institución:(a) Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.
(b) Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/molecules29030713

Non-Athletic Cohorts Enrolled in Longitudinal Whole-Body Electromyostimulation Trials-An Evidence Map.

Fuente:Sensors (basel, Switzerland)

Extracto: In summary, the evidence gaps in WB-EMS research were particular evident for cohorts with diseases of the nervous and cerebrovascular system.

Claves:body composition, cohorts, diseases, electromyostimulation, function, longitudinal studies, whole-body electrostimulation

Cita:Sensors (Basel) 2024 Feb 2; 24 (3)

Autor/es:Beier, Miriam (a)
Schoene, Daniel (b)

institución:(a) Institute of Radiology, University Hospital Erlangen, 91054 Erlangen, Germany.
(b) Institute of Radiology, University Hospital Erlangen, 91054 Erlangen, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/s24030972

[Prescription of osteoporosis drugs and secondary fracture prevention still at low levels and with large regional variation].

Fuente:Lakartidningen

Extracto: Our results show that medical treatment with osteoporosis drugs is still at low levels, covering approximately 5 percent of the population aged 70 or older, with clear differences between regions.

Cita:Lakartidningen 2024 Jan 30; 121

Autor/es:Modig, Karin (a)
Meyer, Anna (b)

institución:(a) **** med dr enheten för epidemiologi, Institutet för miljömedicin, Karo-linska institutet.
(b) leg sjukgymnast, med dr, enheten för epidemiologi, Institutet för miljö-medicin, Karolinska institutet.

Formato:Informe virtual

Idioma:swe

País de fuente:Suecia

Sitio web:

Alignment of substance use community benefit prioritization and service lines in US hospitals: a cross-sectional study.

Fuente:Addiction Science & Clinical Practice

Extracto: The availability of service offerings is related both to a hospital's prioritization of substance use and to its size, indicating that these factors are likely inter-related regarding a hospital's sense of its ability to address substance use as a community need. Policymakers should consider why a hospital may not prioritize a need that is prevalent within their community; e.g., whether the organization believes it lacks resources to take such steps. This study also highlights the value of the assessment and implementation strategy process as a way for hospitals to engage with community needs.

Claves:Community benefit, Hospitals, Substance use

Cita:Addict Sci Clin Pract 2024 Feb 13; 19 (1) : 11.

Autor/es:Cronin, Cory E (a)
Kubacki, Luke (b)

institución:(a) College of Health Sciences and Professions, Ohio University, Athens, OH, 45701, USA. croninc@ohio.edu.
(b) Appalachian Institute to Advance Health Equity Science, Ohio University, Athens, OH, 45701, USA. croninc@ohio.edu.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13722-024-00442-0

Effects of metabolic syndrome on bone mineral density in postmenopausal Turkish women.

Fuente:African Health Sciences

Extracto: Our findings support that MetS is associated with increased BMD at the femoral neck and spine in postmenopausal women. A significant positive association was observed among the MetS components, especially with abdominal obesity, and also a weak positive association with serum triglycerides, and systolic and diastolic blood pressure.

Claves:Postmenopausal women, bone mineral density, metabolic syndrome, osteoporosis

Cita:Afr Health Sci 2023 Sep; 23 (3) : 99-108.

Autor/es:Bahtiyarca, Zeynep T (a)
Serçe, Azize (b)

institución:(a) Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey.
(b) Department of Algology, Ankara Training and Research Hospital, Ankara, Turkey.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Uganda

Sitio web:http://dx.doi.org/10.4314/ahs.v23i3.13