APO E: ¿UN CANDIDATO IMPORTANTE PARA LA INTERACCION ENTRE GENES Y NUTRIENTES

APO E: ¿UN CANDIDATO IMPORTANTE PARA LA INTERACCION ENTRE GENES Y NUTRIENTES

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Aunque muchos evaluaron si las interacciones entre los distintos genotipos de la apolipoproteína E y la dieta podrían afectar los lípidos plasmáticos, este tema no está dilucidado. Hallazgos no uniformes indican que es prematuro sugerir estos genotipos para el diseño de dietas terapéuticas.
berg9.jpg Autor:
Berglund, Lars
Columnista Experto de SIIC

Institución:
Department of Medicine University of California, Davis UCD Medical Center California, USA


Artículos publicados por Berglund, Lars
Coautor
Guijing Lu* 
Department of Medicine, University of California Davis, Davis, USA. Department of Medicine, Xiangya Hospital of Xiangya Medical School, Central. South University, R. P. China*
Recepción del artículo
13 de Mayo, 2004
Aprobación
21 de Junio, 2004
Primera edición
23 de Febrero, 2005
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
La APOE (apolipoproteína E) tiene funciones clave en el metabolismo de las lipoproteínas, y el polimorfismo de su gen está asociado con los distintos patrones que se observan en estas apolipoproteinas. La posibilidad de que existan diferentes interacciones entre el gen de la apo E y los nutrientes fue evaluada en muchos estudios. Aunque los resultados en general no son uniformes, los indicios de tal interacción son más frecuentes en los estudios que se realizaron en condiciones que representaban exigencia metabólica. Se necesitan estudios directamente diseñados para dilucidar esta interacción entre el gen de la apoE y los nutrientes en forma concluyente, lo cual incrementará nuestro conocimiento de los mecanismos involucrados en el metabolismo lipídico y mejorará nuestra comprensión del papel que cumple la dieta en la reducción del riesgo de aterosclerosis.

Palabras clave
Apolipoproteína E, isoformas genéticas, metabolismo lipídico, aterosclerosis


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Abstract
ApoE has key functions in lipoprotein metabolism, and polymorphisms in the apoE gene are associated with distinct lipoprotein patterns. The possibility of gene-nutrient interactions for apoE has been addressed in many studies. Although results have generally been mixed, indications of such an interaction have been more common in studies employing a metabolic challenge. Studies directly designed to conclusively resolve gene-nutrient interactions for apoE are needed and will increase our knowledge of the mechanisms involved in lipid metabolism and improve our understanding of the role of diet in reducing atherosclerosis risk.

Key words
Apolipoprotein E, atherosclerosis, genetics, lipoproteins, nutrition


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Clasificación en siicsalud
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Especialidades
Principal: Endocrinología y Metabolismo, Genética Humana
Relacionadas: Bioquímica, Diagnóstico por Laboratorio, Gastroenterología, Medicina Interna, Nutrición



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Enviar correspondencia a:
Berglund, Lars
Patrocinio y reconocimiento:
Agradecimientos. Agradecemos el apoyo del National Heart, Lung and Blood Institute, subsidios HL62705 y HL65938.
Bibliografía del artículo
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