RELACION DE LOS CANCERES DE PROSTATA Y DE MAMA CON EL CONSUMO DE ALCOHOL




Artículos relacionadosArtículos relacionadosArtículos relacionados
Artículos afines de siicsalud publicados en los últimos 4 meses
EL AGREGADO DE PEMBROLIZUMAB A LA QUIMIOTERAPIA ES BENEFICIOSA EN EL CÁNCER DE ENDOMETRIO AVANZADO
New England Journal of Medicine 388:2159-2170
Difundido en siicsalud: 2 mar 2024
FALTA DE CONSENSO ENTRE LOS ONCÓLOGOS ACERCA DE LA CURABILIDAD DEL CÁNCER OLIGOMETASTÁSICO
Advances in Radiation Oncology 8(5):1-10
Difundido en siicsalud: 2 mar 2024

RELACION DE LOS CANCERES DE PROSTATA Y DE MAMA CON EL CONSUMO DE ALCOHOL

(especial para SIIC © Derechos reservados)
Los cánceres de mama y de próstata están entre las principales causas de mortalidad en Occidente. Su relación, probada o probable, con el consumo de bebidas alcohólicas, adquiere una relevancia particular, teniendo en cuenta el aumento alarmante en el consumo de alcohol en todas las edades.
castro9_80310.jpg Autor:
Gerardo Castro
Columnista Experto de SIIC

Institución:
Asociación Toxicológica Argentina


Artículos publicados por Gerardo Castro
Coautor
José A. Castro* 
Asociación Toxicológica Argentina, Buenos Aires, Argentina*
Recepción del artículo
30 de Mayo, 2010
Aprobación
30 de Julio, 2010
Primera edición
27 de Septiembre, 2010
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Además del hábito de fumar y de la alimentación, el consumo de alcohol es uno de los factores de riesgo más importantes para los cánceres humanos. Las localizaciones del organismo asociadas con este riesgo incluyen el tracto aerodigestivo superior, hígado, mama, colon, recto y, con algún grado de incertidumbre, estómago, próstata y pulmón. Aquí analizamos el mecanismo por el cual el consumo de alcohol promueve la inducción de cáncer en las etapas del proceso de iniciación y promoción de los cánceres de mama y de próstata. Se hace énfasis especialmente en la necesidad de una biotransformación del etanol al mutágeno/carcinógeno acetaldehído y de la estimulación de un proceso de generación de radicales libres del propio alcohol y de especies reactivas de oxígeno. En recientes estudios en nuestro laboratorio encontramos nuevas vías metabólicas para la generación in situ de metabolitos reactivos del etanol, en mama y próstata de rata y la aparición de un daño celular asociado. Visualizamos el efecto estimulador del consumo de alcohol sobre la activación de otros carcinógenos ambientales, su capacidad para inhibir procesos de reparación de daños en el ADN, sobre el sistema inmunitario y en la progresión del proceso carcinogénico. Señalamos posibilidades preventivas que surgen más allá de evitar el consumo de bebidas alcohólicas, que involucran sustancias protectoras componentes de la dieta.

Palabras clave
alcohol, mama, próstata, cáncer


Artículo completo

(castellano)
Extensión:  +/-9.1 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

Abstract
In addition to smoking and diet, alcohol intake is one of the most important risk factors for human cancers. Body areas associated with this risk include the upper aero-digestive tract, liver, colon, and rectum, and with a lesser degree of certainty, the stomach, prostate, and lungs. Here we discuss the mechanism by which alcohol consumption advances cancer induction at the initiation and promotion stages of breast and prostate cancers. Special emphasis is placed on the need for ethanol biotransformation into mutagenic/carcinogenic acetaldehyde, and the stimulation of a free radical generation process of the alcohol itself and the production of some reactive oxygen species (ROS). In recent studies in our laboratory we have found new metabolic pathways for the in situ production of reactive metabolites of ethanol in the prostate and breasts of rats and the occurrence of associated cellular damage. We were able to visualize the stimulatory effect of alcohol consumption on the activation of other environmental carcinogens, its ability to hinder the repair process of damaged DNA, its effects on the immune system and on the progression of the carcinogenic process. We also suggest some preventive measures that could be applied apart from avoiding the consumption of alcoholic beverages, which contain protective substances that are components of the usual daily diet.

Key words
alcohol, breast, prostate, cancer


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Oncología, Toxicología
Relacionadas: Anatomía Patológica, Atención Primaria, Medicina Interna, Nutrición, Obstetricia y Ginecología



Comprar este artículo
Extensión: 9.1 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Enviar correspondencia a:
Gerardo Castro, Centro de Investigaciones Toxicológicas (Ceitox, Citedef-Conicet)., Buenos Aires, Argentina
Patrocinio y reconocimiento:
Las investigaciones de nuestro laboratorio mencionadas en este trabajo han contado con el financiamiento de CONICET, de ANPCyT y de la Universidad Nacional de General San Martín.
Bibliografía del artículo


1. World Health Organization - Department of Mental Health and Substance Abuse. Global Status Report on Alcohol. WHO, Ginebra, 2004.
2. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans IARC Monographs Vol. 44: Alcohol drinking. IARC Press, Lyon, 1988.
3. Bevan CL. Hormones and cancer. En: Introduction to the cellular and molecular biology of cancer (Knowles MA, Selby PJ, eds.). Oxford University Press, Nueva York, pp. 257-263, 2005.
4. Thompson A. Role of androgens and fibroblast growth factors in prostatic development. Reproduction 121:187-195, 2001.
5. Liehr JG. Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev 21:40-54, 2000.
6. World Cancer Research Fund - American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: A global perspective. Washington DC, AICR, pp. 157-171, 2007.
7. Tonnesen H, Moller H, Andersen JR, Jensen E, Juel K. Cancer morbidity in alcohol abusers. Br J Cancer 69:327-332, 1994.
8. De Stefani E, Fierro L, Barrios E, Ronco A. Tobacco, alcohol, diet and risk of prostate cancer. Tumori 81:315-320, 1995.
9. Breslow RA, Weed DL. Review of epidemiologic studies of alcohol and prostate cancer: 1971-1996. Nutr Cancer 30:1-13, 1988.
10. Putnam SD, Cerhan JR, Parker AS, Wallace RB, Cantor KP, Lynch CF. Alcohol consumption and prostate cancer in a cohort of Iowa males. Am J Epidemiol 147:S42, 1998.
11. Schuurman AG, Goldbohm RA, Van den Braandt PA. A prospective cohort study on consumption of alcoholic beverages in relation to prostate cancer incidence (The Netherlands). Cancer Causes Control 10:597-605, 1999.
12. Dennis LK, Hayes RB. Alcohol and prostate cancer. Epidemiol Rev 23:110-114, 2001.
13. Gong Z, Kristal AR, Schenk JM, Tangen CM, Goodman PJ, Thompson IM. Alcohol consumption, finasteride, and prostate cancer risk: Results from the Prostate Cancer Prevention Trial. Cancer 115:3661-3669, 2009.
14. Klein EA, Casey G, Silverman R. Genetic susceptibility and oxidative stress in prostate cancer: Integrated model with implications for prevention. Urology 68:1145-1151, 2006.
15. Khandrika L, Kumar B, Koul S, Maroni P, Koul HK. Oxidative stress in prostate cancer. Cancer Lett 282:125-136, 2009.
16. Minelli A, Belleza I, Conte C, Culig Z. Oxidative stress-related aging: A role for prostate cancer? Biochim Biophys Acta 1795:83-91, 2009.
17. Adler RA. Clinical review 33: Clinically important effects of alcohol on endocrine function. J Clin Endocrinol Metab 74:957-960, 1992.
18. Emanuele MA, Emanuele NV. Alcohol's effects on male reproduction. Alcohol Health Res World 22:195-201, 1998.
19. Quintans LN, Castro GD, Castro JA. Oxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomes. Arch Toxicol 79:25-30, 2005.
20. Quintans LN. Bioactivación del etanol en el testículo de rata y su rol en la toxicidad reproductiva en el alcoholismo. Tesis doctoral, Doctorado en Ciencia y Tecnología mención Química, UNSAM, 2008.
21. Castro JA, Castro GD. Mechanisms in prostate damage by alcohol. En: Comprehensive handbook of alcohol related pathology (Preedy VR, Watson RR, eds.). Academic Press, Nueva York, pp. 1007-1015, 2005.
22. Platz EA, Rimm EB, Kawachi I, Colditz GA, Stampfer MJ, Willett WC, Giovannuci E. Alcohol consumption, cigarette smoking and risk of benign prostatic hyperplasia. Am J Epidemiol 149:106-115, 1999.
23. Gass R. Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake. B J U Int 90:649-654, 2002.
24. Plante MK, Folson JB, Zvara P. Prostatic tissue ablation by injection: a literature review. J Urol 172:20-26, 2004.
25. Lieber CS. Alcohol metabolism: General aspects. En: Comprehensive handbook of alcohol related pathology (Watson RR, Preedy V, eds.), Volumen 1. Elsevier Science Ltd, Academic Press, Londres, pp. 1211-1222, 2005.
26. Garro AJ, Lieber CS. Alcohol and cancer. Ann Rev Pharmacol Toxicol 30:219-249, 1990.
27. Nagy LE. Molecular aspects of alcohol metabolism: Transcription factors involved in early ethanol-induced liver injury. Annu Rev Nutr 24:55-78, 2004.
28. Castro GD, Rodríguez de Castro C, Maciel ME, Fanelli SL, Cignoli de Ferreyra E, Díaz Gómez MI, Castro JA. Ethanol-induced oxidative stress and acetaldehyde formation in rat mammary tissue: potential factors involved in alcohol drinking promotion of breast cancer. Toxicology 219:208-219, 2006.
29. Singletary KW, Gapstur SM. Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 286:2143-2151, 2001.
30. Dumitrescu RG, Shields PG. The etiology of alcohol-induced breast cancer. Alcohol 35:213-225, 2005.
31. Castro GD, Delgado de Layño AMA, Costantini MH, Castro JA. Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals. Analysis of its potential role in heavy alcohol drinking tumor promoting effects. Teratog Carcinog Mutagen 21:109-119, 2001.
32. Castro GD, Delgado de Layño AMA, Costantini MH;, Castro JA. Rat ventral prostate microsomal biotransformation of ethanol to acetaldehyde and 1-hydroxyethyl radicals. Its potential contribution to prostate cancer promotion in heavy alcohol drinkers. Teratog Carcinog Mutagen 22:335-341, 2002.
33. Díaz Gómez MI, Rodríguez de Castro C, Fanelli SL;, Quintans LN, Costantini MH, Castro JA, Castro GD. Biochemical and ultrastructural alterations in the rat ventral prostate due to repetitive alcohol drinking. J Appl Toxicol 27:391-398, 2007.
34. Castro GD, Costantini MH, Castro JA. Rat ventral prostate cytosolic xanthine oxidase mediated metabolism of acetaldehyde to acetyl radicals. Human Exp Toxicol 28:203-208, 2009.
35. Díaz Gómez MI, Valles E, Fanelli SL, Delgado de Layño AMA, Castro GD, Castro JA. Alcohol induction of nuclear ethanol and N-nitrosodimethylamine metabolism to reactive metabolites. Teratog, Carcinog, Mutagen 22:139-145, 2002.
36. González FJ. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat Res 569:101-110, 2005.
37. Keshava C, McCanlies EC, Weston A. CYP3A4 polymorphisms-potential risk factors for breast and prostate cancer: a HuGE review. Am J Epidemiol 160:825-841, 2004.
38. Yang J, Qian LX, Wu HF, Xu ZQ, Sui YG, Wang XR, Zhang W. Genetic polymorphisms in the cytochrome P450 1A1 and 2E1 genes, smoking, drinking and prostate cancer susceptibility: a case-control study in a Han nationality population in Southern China. Int J Urol 13:773-80, 2006.
39. Yang J, Wu HF, Zhang W, Gu M, Hua LX, Sui YG, Zhang ZD, Zhou JW, Wang XR, Zou C, Qian LX. Polymorphisms of metabolic enzyme genes, living habits and prostate cancer susceptibility. Front Biosci 11:2052-2060, 2006.
40. Leskelä S, Honrado E, Montero-Conde C, Landa I, Cascón A, Letón R, Talavera P, Cózar JM, Concha A, Robledo M, Rodríguez-Antona C. Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer. Endocr Relat Cancer 14:645-654, 2007.
41. Trottier G, Boström PJ, Lawrentschuk N, Fleshner NE. Nutraceuticals and prostate cancer prevention: a current review. Nat Rev Urol 7:21-30, 2010.
42. Chao C, Haque R, Van den Eeden SK, Caan BJ, Poon KY, Quinn VP. Red wine consumption and risk of prostate cancer: the California men's health study. Int J Cancer 126:171-179, 2010.
43. Allen NE, Key TJ. Prostate cancer: neither vitamin E nor selenium prevents prostate cancer. Nat Rev Urol 6:187-188, 2009.
44. Patel AR, Klein EA. Risk factors for prostate cancer. Nat Clin Pract Urol 6:87-95, 2009.
45. Pelucchi C, Galeone C, Talamini R, Negri E, Parpinel M, Franceschi S, Montella M, La Vecchia C. Dietary folate and risk of prostate cancer in Italy. Cancer Epidemiol Biomarkers Prev 14:944-948, 2005.
46. Collaborative Group on Hormonal Factors in Breast Cancer. Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer 87:1234-1245, 2002.
47. Stewart BW, Kleihues P. World Cancer Report. WHO. International Agency for Research on Cancer, pp. 29-32. Lyon: IARC Press, 2003.
48. Allen NE, Beral V, Casabonne D, et al. Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst 101:296-305, 2009.
49. Ginsburg ES. Estrogen, alcohol and breast cancer risk. J Steroid Biochem Mol Biol 69:299-306, 1999.
50. Przylipiak A, Rabe T, Hafner J, Przylipiak M, Runnebaum R. Influence of ethanol on in vitro growth of human mammary carcinoma cell line MCF-7. Arch Gynecol Obstet 258:137-140, 1996.
51. Singletary KW, Frey RS, Yan W. Effect of ethanol on proliferation and estrogen receptor-alpha expression in human breast cancer cells. Cancer Lett 165:131-137, 2001.
52. Izevbigie EB, Ekunwe SI, Jordan J, Howard CB. Ethanol modulates the growth of human breast cancer cells in vitro. Exp Biol Med 227:260-265, 2002.
53. Coutelle C, Höhn B, Benesova M, Oneta CM, Quattrochi P, Roth HJ, Schmidt-Gayk H, Schneeweiss A, Bastert G, Seitz HK. Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens. Int J Oncol 25:1127-1132, 2004.
54. Etique N, Chardard D, Chesnel A, Merlin JL, Flament S, Grillier-Vuissoz I. Ethanol stimulates proliferation, ER and aromatase expression in MCF-7 human breast cancer cells. Int J Mo Med 13:149-155, 2004.
55. Izevbigie EB. Signalling pathways in human breast cells in response to alcohol: mechanisms for alcohol-induced breast cancer. En: Comprehensive Handbook of Alcohol-Related Pathology, vol. 2, (Watson RR, Preedy V, eds.). Elsevier Science Ltd. Academic Press, Londres, pp. 1017-1025, 2005.
56. Seitz HK, Stickel F. Molecular mechanisms of alcohol mediated carcinogenesis. Nat Rev Cancer 7:599-612, 2007.
57. Castro GD, Delgado de Layño AMA, Costantini MH, Castro JA. Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer. Toxicology 160:11-18, 2001.
58. Bartel LC, Montalto de Mecca M, Castro JA. Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions. Food Chem Toxicol 47:140-144, 2009.
59. Castro GD, Delgado de Layño AMA, Costantini MH, Castro JA. Rat breast microsomal biotransformation of ethanol to acetaldehyde but not to free radicals: Its potential role in the association between alcohol drinking and breast tumor promotion. Teratog Carcinog Mutagen 23(Suppl.1):61-70, 2003.
60. Fanelli SL, Maciel ME, Díaz Gómez MI, Delgado de Layño AMA, Bietto FM, Castro JA, Castro GD. Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer. J Appl Toxicol (en prensa).
61. Castro GD, Delgado de Layño AMA, Fanelli SL, Maciel ME, Díaz Gómez MI, Castro JA. Acetaldehyde accumulation in rat mammary tissue after an acute treatment with alcohol. J Appl Toxicol 28:315-321, 2008.
62. Cai Y, Luo Q, Sun M, Corke H. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 74:2157-2184, 2004.
63. Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signaling molecules? Free Radic Biol Med 36:838-849, 2004.
64. Wiseman H. Isoflavonoids and human health. En: Flavonoids: chemistry, biochemistry and applications (Andersen OM, Markham KR, eds.). Boca Raton, CRC Press, Taylor and Francis Group, pp. 371-388, 2006.
65. Liu JR, Dong HW, Chen BQ, Zhao P, Liu RH. Fresh apples suppress mammary carcinogenesis and proliferative activity and induce apoptosis in mammary tumors of the Sprague-Dawley rat. J Agric Food Chem 57:297-304, 2009.
66. Maciel ME, Castro GD, Castro JA. Inhibition of the rat breast cytosolic bioactivation of ethanol to acetaldehyde by some plant polyphenols and folic acid. Nutr Cancer 49:94-99, 2004.
67. Maciel ME. Bioactivación del etanol en el tejido mamario de rata, su relación con los efectos promotores del cáncer por alcohol. Inhibidores con potencial uso preventivo. Tesis doctoral, Doctorado en Ciencia y Tecnología mención Química, UNSAM, 2006.
68. Maciel ME, Castro JA, Castro GD. Inhibition of rat mammary microsomal oxidation of ethanol to acetaldehyde by plant polyphenols. Human Exp Toxicol (en prensa).

 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
Artículos relacionadosMás relacionadosAtículos relacionados
TRATAMIENTOS DE FISIOTERAPIA MÁS EFICACES PARA LA REHABILITACIÓN DEL SÍNDROME DE LA RED AXILAR
Supportive Care in Cancer 31(257):1-14
Difundido en siicsalud: 22 feb 2024
INCIDENCIA ELEVADA DE RADIODERMATITIS EN MUJERES CON CÁNCER DE MAMA
Anais Brasileiros de Dermatologia 99(1):57-65
Difundido en siicsalud: 2 mar 2024
BLANCOS MOLECULARES EN EL CÁNCER DE CUELLO UTERINO
Enfermería Investiga 8(2):1-5
Difundido en siicsalud: 2 feb 2024
ua31618