Fabio Firmbach Pasqualotto *

Autor invitado por SIIC

Este estudo demonstra como devemos academicamente investigar o homem com infertilidade, assim como a melhor maneira de tratar este homem seja com tratamento clinico, cirurgico ou ate com reproducao assistida

FATOR MASCULINO DA INFERTILIDADE PODE SER TRATADO COM REPRODUCAO ASSISTIDA

A injecao intracitoplasmatica de espermatozoide (ICSI) foi um marco importante no tratamento do homem infértil, mas sua eficácia e efeitos tardios ainda necessitam investigação intensiva. Apenas com o emprego de uma relação harmoniosa entre o urologista e o ginecologista pode resultar em um tratamento eficaz do casal infértil sem riscos maiores.

*Fabio Firmbach Pasqualotto
describe para SIIC los aspectos relevantes de su trabajo
INVESTIGAÇÃO E REPRODUÇÃO ASSISTIDA NO TRATAMENTO DA INFERTILIDADE MASCULINA
Institución principal de la investigación
*Universidade de Caxias do Sul, Caxias do Sul, Brasil
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Referencias bibliográficas
1. World Health Organization. WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction, Cambridge, Cambridge University Press, 1999.

2. Galarneau CJ, Nagler HM. Cost-effective infertility therapies in the ‘90s: To treat or to cure? Contemporary Urology 1999, 11: 32-45.

3. Carlsen E, Giwercman A, Keiding N, Skakkebaek NE. Evidence for decreasing quality of semen during past 50 years. BMJ 1992, 305: 609-13.

4. Pasqualotto FF, Pasqualotto EB, Agarwal A, Thomas Jr AJ. Detection of testicular cancer in men presenting with infertility. Rev Hosp Clin Fac Med Sao Paulo 2003, 58(2): 75-80.

5. Pasqualotto FF, Sobreiro BP, Hallak J, Athayde KS, Pasqualotto EB, Lucon AM. High percentage of abnormal semen parameters in a prevasectomy population. Fertil Steril 85(4): 954-60, 2006.

6. Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Jr., Agarwal A: Relationship between oxidative stress, semen characteristics and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 2000, 73: 459-64.

7. Turek PJ. Practical approaches to the diagnosis and management of male infertility. Nature Clin Pract Urol 2005, 2(5): 226-38.

8. Shefi S, Turek PJ. Definition and current evaluation of subfertile men. Int Braz J Urol 2006, 32(4): 385-97.

9. Pasqualotto EB, Pasqualotto FF. Espermograma e testes de função espermática. Femina 2006, 34: 91-98.

10. Miisell LM, Holochwost D, Boban D, Santi N, Shefi S, Hellerstein MK, et al. A stable isotope-mass spectrometric method for measuring human spermatogenesis kinetics in vivo. J Urol 2006, 175: 242-6.

11. Guzick DS, Overstreet JW, Factor-Litvak P, Brazil CK, Nakajima ST, Coutifaris C, et al. Sperm morphology, motility, and concentration in fertile and infertile men. N Engl J Med 2001, 345: 1388-93.

12. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S: Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril 1988, 49: 112-7.

13. Pasqualotto FF, Pasqualotto EB. The role of biochemical markers in male reproduction. OBS & GYNAE Today 2004, 9(5): 301-307.

14. Carrara RC, Yamasaki R, Braganca W, Raskin S, Sartorato EL, Pina-Neto JM. Etiologic investigations on male infertility before intracytoplasmic sperm injection (ICSI). Genet Couns 2006, 17(3): 385-9.

15. Tesarik J, Mendoza G. Treatment of severe male infertility by micromanipulation-assisted fertilization: an update. Front Biosci 2007, 1(12): 105-14.

16. Pasqualotto FF, Lucon AM, Goes PM, Sobreiro BP, Hallak J, Pasqualotto EB, Arap S. Is it worthwhile to operate subclinical right varicocele in patients with grade II-III varicocele in the left testicle? J Assist Reprod Genet 2005, 22(5): 227-231.

17. Li Z, Wang L, Cai J, Huang H. Correlation of sperm DNA damage with IVF and ICSI outcomes: a systematic review and meta-analysis. J Assist Reprod Genet 2006, 23(9-10): 367-376.

18. Pasqualotto FF, Rossi LM, Guilherme P, Ortiz V, Iaconelli, A Jr., Borges, E Jr. Etiology specific outcomes of ICSI in azoospermic patients. Fertil Steril 2005, 83: 606-611.

19. Meng MV, Greene KL, Turek PJ. Surgery or assisted reproduction? A decision analysis of treatment costs in male infertility. J Urol 2005, 174: 1926-31.

20. Pasqualotto FF, Lucon AM, Sobreiro BP, Pasqualotto EB, Arap S. The best infertility treatment for vasectomized men: assisted reproduction or vasectomy reversal. Rev Hosp Clin Fac Med Sao Paulo 2004, 59(3): 312-5.

21. Pasqualotto FF, Lucon AM, Sobreiro BP, Pasqualotto EB, Arap S. Effects of medical therapy, alcohol, smoking and endocrine disruptors on male infertility. Rev Hosp Clin São Paulo 2004, 59(6): 375-382.

22. Potts JM, Pasqualotto FF. Relationship between chronic prostatitis and oxidative stress. Andrologia 2003, 35(5): 304-8.

23. Pasqualotto FF, Lucon AM, Goes PM, Sobreiro BP, Hallak J, Arap S. Semen profile, testicular volume, and hormonal levels in infertile patients with varicoceles compared with fertile men with and without varicoceles. Fertil Steril 2005, 83(1): 74-77.

24. Pasqualotto FF, Pasqualotto EB. Tratamento do homem infértil com varicocele. Jornal Brasileiro de Medicina (JBM) 2006, 90(1/2): 38-46.

25. Daitch JA, Bedaiwy MA, Pasqualotto EB, Hendin BN, Hallak J, Falcone T, et al. Varicocelectomy improves intrauterine insemination success rates among men with varicocele. J Urol 2001, 165: 1510-1513.

26. Schlegel PN. Is assisted reproduction the optimal treatment for varicocele-associated male infertility? A cost-effectiveness analysis. Urology. 1997, 49: 83-90.

27. Jarow J, Sharlip ID, Belker AM, Lipshultz LY, Sigman M, Thomas AJ Jr, et al. Best practice policies for male infertility. J Urol 2002, 167: 2133-44.

28. Evers JL, Collins JA: Assessment of efficacy of varicocele repair for male subfertility: a systematic review. Lancet. 2003, 361: 1849-52.

29. Potts J, Pasqualotto FF, Nelson DR, Agarwal A, Thomas AJ Jr. Patients characteristics associated with vasectomy reversal. J Urol 1999, 161: 1835-1839.

30. Pasqualotto EB, Agarwal A. Effect of Male Factor on Pregnancy Outcome in patients undergoing Intrauterine Insemination. In Allahbadia G (Ed.): Mumbai: Editora Rotunda, 1998 (1st ed), cap 12, pp 117-127. In: ALLAHBADIA, Gautam. (Org.). Intrauterine Insemination.

31. Pasqualotto FF, Sobreiro BP,Hallak J, Pasqualotto EB, Lucon AM. Induction of spermatogenesis in azoospermic men after varicocelectomy repair: an update. Fertil Steril 2006, 85(3): 635-639.

Otros artículos de Fabio Firmbach Pasqualotto

Pasqualotto FF, Agarwal A, Srivastava M, Thomas, AJ, Jr.: Fertility outcome after repeat-vasoepididymostomy. J Urol, 162: 1626-1628, 1999. Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Jr., Agarwal A: Relationship between oxidative stress, semen characteristics and clinical diagnosis in men undergoing infertility investigation. Fertil Steril 73: 459-64, 2000. Pasqualotto FF, Sharma, RK, Potts JM, Nelson DR, Thomas AJ, Jr., Agarwal A: Seminal Oxidative Stress in Chronic Prostatitis Patients. Urology 55: 881-885, 2000. Pasqualotto FF, Sharma RK, Kobayashi H, Nelson DR, Thomas AJ, Jr., Agarwal A: Oxidative stress in normospermic men undergoing fertility evaluation. J. Androl., 22(2): 316-322, 2001. Pasqualotto FF, Rossi-Ferragut LM, Rocha C, Iaconelli A, Jr., Borges E, Jr. Outcome of in vitro fertilization and intracytoplasmic injection of epididymal and testicular sperm obtained from patients with obstructive and nonobstructive azoospermia. J Urol, 167: 1753-56, 2002. Pasqualotto FF, Lucon AM, Hallak J, Saldanha LB, Góes PM, Arap S. Induction of spermatogenesis in azoospermic men undergoing varicocele repair. Hum Reproduction, 18(1): 108-112, 2003. Pasqualotto FF, Rossi-Ferragut LM, Rocha CC, Iaconelli, A Jr., Ortiz V, Borges, E Jr. Sperm retrieval and fertilization in repeated percutaneous epididymal sperm aspiration. J Urology 169: 1779-1781, 2003. Pasqualotto FF, Lucon AM, Sobreiro BP, Hallak K, Góes PM, Pasqualotto EB, Arap S. Semen profile, testicular volume and hormonal levels in infertile patients with varicocele compared to fertile men with and without varicocele. Fertil. Steril 83: 74-77, 2005. Pasqualotto FF, Lucon AM, Sobreiro BP, Hallak K, Góes PM, Pasqualotto EB, Arap S. Testicular growth, sperm concentration, percent motility and pregnancy outcome following varicocelectomy based on testicular histology Fertil. Steril 83: 362-366, 2005. Pasqualotto FF, Rossi LM, Guilherme P, Ortiz V, Iaconelli, A Jr., Borges, E Jr. Etiology specific outcomes of ICSI in azoospermic patients. Fertil Steril 83: 606-611, 2005.

Para comunicarse con Fabio Firmbach Pasqualotto mencionar a SIIC como referencia:
fabio@conception-rs.com.br

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Acerca del trabajo completo

FATOR MASCULINO DA INFERTILIDADE PODE SER TRATADO COM REPRODUCAO ASSISTIDA

Título original en castellano
Investigação e Reprodução assistida no tratamento da infertilidade masculina

Autor
Fabio Firmbach Pasqualotto¹
1 Medico, Centro De Reproducao Humana, Universidade de Caxias do Sul, Caxias do Sul, Brasil, Professor e Medico Urologista

Acceso a la fuente original
Revista Brasileira de Ginecologia e Obstetrícia
http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-7203&nrm=iso&rep=&lng=pt

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