Crónicas de autores

Flávio Reis *

Autor invitado por SIIC


A PLAQUETA COMO MARCADOR PRECOCE DE RISCO CARDIOVASCULAR NA DEFICIÊNCIA DE HORMONA DE CRESCIMENTO

Nos doentes com deficiência de hormona de crescimento (DHC) com início na infância e que mantêm a deficiência após supressão da terapêutica com HC, mas não nos que recuperam os níveis normais, verifica-se uma hiperactivação plaquetar na ausência de outros indicadores de risco cardiovascular, podendo constituir um marcador precoce e eventualmente recomendar terapia anti-agregante preventiva.

*Flávio Reis
describe para SIIC los aspectos relevantes de su trabajo
PLATELET HYPERACTIVATION IN MAINTAINED GROWTH HORMONE-DEFICIENT CHILDHOOD PATIENTS AFTER THERAPY WITHDRAWAL AS A PUTATIVE EARLIER MARKER OF INCREASED CARDIOVASCULAR RISK
Journal of Clinical Endocrinology and Metabolism,
90(1):98-105 Ene, 2005

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Unit of Therapeutics, Institute of Pharmacology and Experimental Therapeutics, Medicina Faculty, Coimbra, Portugal, Coimbra, Portugal
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Otros artículos escogidos
Referencias bibliográficas
1. Rosén T, Bengtsson BA. 1990 Premature mortality due to cardiovascular diseases in hypopituitarism. Lancet 336:285-288.
2. Besson A, Salemi S, Gallati S, Jenal A, Horn R, Mullis PS, Mullis PE 2003 Reduced longevity in untreated patients with isolated growth hormone deficiency. J Clin Endocrinol Metab 88:3664-3667.
3. Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G 2002 The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 87:1088-1093.
4. Bulow B, Hagmar L, Mikoczy Z, Nordstrom CH, Erfurth EM 1997 Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol 46:75-81.
5. Carrol PV, Christ ER, Bengtsson B-A, Carlsson L, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenko P, Sonksen PH, Tanaka T, Thorner M 1998 Growth hormone deficiency in adulthood and effect of growth hormone replacement: a review. J Clin Endocrinol Metab 83:382-395.
6. Colao A, Di Somma C, Salerno M, Spinelli L, Orio F, Lombardi G 2002 The cardiovascular risk of adult GH deficiency adolescents. J Clin Endocrinol Metab 87:3650-3655.
7. Sas T, Mulder P, Hokken-Koelega A 2000 Body composition, and lipid metabolism before and during long-term growth hormone (GH) treatment in children with short stature born small for gestational age either with or without GH deficiency. J Clin Endocrinol Metab 85:3786-3792.
8. Whitehead HM, Boreham C, McIlrath EM, Sheridan B, Kennedy L, Atkinson AB, Hadden DR 1992 Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin Endocrinol 36:45-52.
9. Florkowski CM, Collier GR, Zimmet PZ, Livesey JH, Espiner EA, Donald RA 1996 Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol 45:769-773.
10. Vahl N, Jorgensen JOL, Hansen TB, Klausen IB, Jurik A-G, Hagen C, Christiansen JS 1998 The favourable effects of growth hormone (GH) substitution on hypercholesterolaemia in GH-deficient adults are not associated with concomitant reductions in adiposity. A 12-month placebo-controlled study. Int J Obesity 22:529-536.
Otros artículos de Flávio Reis

Reis F, Ponte L, Rocha L, Almeida L, Alcobia T, Lourenço M, Palmeiro A, Ferrer-Aantunes CA, Costa-Almeida C, Teixeira F. Curative isosorbide-5-mononitrate treatment, in opposition to the beneficial preventive one, aggravates the prothrombotic and proconstrictor state in cyclosporin-induced hypertensive rats. Clin Exp Pharmacol Physiol 2005; (in press).

Reis F, Rocha L, Ponte L, Alcobia T, Almeida L, Costa-Almeida C, Teixeira F. Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats. Life Sciences 2005; (in press).

HM Teixeira, Reis F, Quintela O, López-Rivadulla M, Proença P, Angelines C, Pipo P, Marques E, Vieira DN. Vitreous humor as a complementary sample to blood for the detection/confirmation of diazepam: ante-mortem and post-mortem studies in an animal model. Human & Exp Toxicol 2004; 23(12):571-577.

Santiago M, Reis F, Almeida L, Alcobia T, Dionísio J, Teixeira F. Impairment of vascular and platelet nitric oxide and 3',5' cyclic guanosine monophosphate content in cyclosporin A-induced hypertensive rats. Fund Clin Pharmacol 2003; 17:43-50.

Reis F, Almeida L, Alcobia T, Santos-Dias JD, Lourenço M, Palmeiro A, Ferrer-Antunes CA, Mesquita JF, Pontes F, Teixeira F. Isosorbide-5-mononitrate treatment prevents cyclosporin A-induced platelet hyperactivation and the underlying nitric oxide-cyclic guanosine-3’,5’-monophosphate disturbances. Thromb Res 2003; 110:107-115.

Reis F, Hermida RC, Souza I, Maldonado J, Tavares P, Fontes-Ribeiro CA, Teixeira HM, Alcobia T, Almeida L, Teixeira F. Circadian and seasonal variations of endogenous ubiquinone plasma levels. Chronobiol Int 2002; 19(3):599-614.

Tavares P, Reis F, Fontes-Ribeiro CA, Teixeira F. Cardiovascular effects of cyclosporine A in an experimental model. Rev Port Cardiol 2002; 21(2):141-155.

Reis F, Tavares P, Rito LC, Teixeira HM, Santos-Dias JD, Ferrer-Antunes C, Mesquita JF, Teixeira F. Platelet activation is increased in cyclosporin A-induced hypertensive rats. J Cardiovasc Pharmacol 2000; 36(1):56-64.

Reis F, Tavares P, Teixeira F. The distribution of catecholamines between plasma and platelets in cyclosporin A-induced hypertensive rats. Pharmacol Res 2000; 41(2):129-135.

Reis F, Tavares P, Fontes Ribeiro CA, Ferrer Antunes CA, Teixeira F. The peripheral serotonergic system and platelet aggregation in cyclosporin A-induced hypertensive rats. Thromb Res 1999; 96:365-372.

Para comunicarse con Flávio Reis mencionar a SIIC como referencia:
flavio@ci.uc.pt

Autor invitado
8 de abril, 2005
Descripción aprobada
22 de julio, 2005
Reedición siicsalud
11 de septiembre, 2024

Acerca del trabajo completo
A PLAQUETA COMO MARCADOR PRECOCE DE RISCO CARDIOVASCULAR NA DEFICIÊNCIA DE HORMONA DE CRESCIMENTO

Título original en castellano
A HIPERACTIVAÇÃO PLAQUETAR COMO UM POSSIVEL MARCADOR PRECOCE DE RISCO CARDIOVASCULAR AUMENTADO EM DOENTES COM DEFICIÊNCIA DE HORMONA DE CRESCIMENTO EM CRIANÇA MANTIDA APOS A SUPRESSÃO DA TERAPÊUTICA

Autor
Flávio Reis1
1 Investigador, Licenciado, Unidade de Terapêutica – Instituto de Farmacologia e Terapêutica Experimental, Técnico Superior Principal

Acceso a la fuente original
Journal of Clinical Endocrinology and Metabolism
http://jcem.endojournals.org
Acceso al texto original completo (full text)
http://jcem.endojournals.org/cgi/content/full/90/1/98
Acceso al resumen/abstract original
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15494463&dopt=Abstract
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