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M Ángeles Muñoz-Fernández *

Autor invitado por SIIC

El uso del dendrímero carbosilano 2G-NN16 como transfectante de ARNsi anti-VIH, en células del SNC, constituye una estrategia novedosa para el tratamiento antiviral en reservorios anatómicos del VIH.

LOS DENDRÍMEROS CARBOSILANO SON CAPACES DE TRANSFECTAR ASTROCITOS HUMANOS CON ARNSI CONTRA EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH)

Las manifestaciones neurológicas de la infección por el VIH son refractarias al tratamiento antirretroviral actual (TARGA). En este trabajo se propone el uso del dendrímero carbosilano 2G-NN16 como transfectante de siRNA anti-VIH en células del SNC y como tratamiento para la infección de astrocitos por aislados X4-VIH y R5-VIH.

*M Ángeles Muñoz-Fernández
describe para SIIC los aspectos relevantes de su trabajo
CARBOSILANE DENDRIMERS TO TRANSFECT HUMAN ASTROCYTES WITH SMALL INTERFERING RNA TARGETING HUMAN IMMUNODEFICIENCY VIRUS
Biodrugs,
24(5):331-343, 2010

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital General Universitario Gregorio Marañón, Madrid, España
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Otros artículos de M Ángeles Muñoz-Fernández

Gonzalo T, Clemente MI, Chonco L, Weber ND, Díaz L, Serramía MJ, Gras R, Ortega P, de la Mata FJ, Gómez R, Lopez-Fernández LA, Muñoz-Fernández MA, Jiménez JL. Gene therapy in HIV-infected cells to decrease viral impact by using an alternative delivery method. ChemMedChem 5(6):921-929, 2010.
Posadas I, López-Hernández B, Clemente MI, Jiménez JL, Ortega P, de la Mata J, Gómez R, Muñoz-Fernández MA, Ceña V. Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity. Pharm Res 26(5):1181-1191, 2009.
Pedziwiatr E, Shcharbin D, Chonco L, Ortega P, de la Mata FJ, Gómez R, Klajnert B, Bryszewska M, Muñoz-Fernandez MA. Binding properties of water-soluble carbosilane dendrimers. J Fluoresc 19(2):267-275, 2009. Epub 2008 Aug 3
Weber N, Ortega P, Clemente MI, Shcharbin D, Bryszewska M, de la Mata FJ, Gómez R, Muñoz-Fernández MA. Characterization of carbosilane dendrimers as effective carriers of siRNA to HIV-infected lymphocytes.J Control Release 132(1):55-64, 2008. Epub 2008 Aug 5.
Blanco A, Alvarez S, Fresno M, Muñoz-Fernández MA. Extracellular HIV-Tat induces cyclooxygenase-2 in glial cells through activation of nuclear factor of activated T cells. J Immunol 180(1):530-540, 2008.
Alvarez S, Serramía MJ, Fresno M, Muñoz-Fernández MA. HIV-1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in astrocytoma cells through a nuclear factor-kappaB-dependent mechanism. Neuromolecular Med 9(2):179-193, 2009.
Shcharbin D, Pedziwiatr E, Chonco L, Bermejo-Martín JF, Ortega P, de la Mata FJ, Eritja R, Gómez R, Klajnert B, Bryszewska M, Muñoz-Fernandez MA. Analysis of interaction between dendriplexes and bovine serum albumin. Biomacromolecules 8(7):2059-2062, 2007. Epub 2007 Jun 21.
Chonco L, Bermejo-Martín JF, Ortega P, Shcharbin D, Pedziwiatr E, Klajnert B, de la Mata FJ, Eritja R, Gómez R, Bryszewska M, Muñoz-Fernandez MA. Water-soluble carbosilane dendrimers protect phosphorothioate oligonucleotides from binding to serum proteins. Org Biomol Chem 5(12):1886-1893, 2007. Epub 2007 May 14.
Alvarez S, Jiménez JL, Serramía MJ, González M, Cantó-Nogués C, Muñoz-Fernández MA. Lack of association of HIV-1 biological or molecular properties with neurotropism for brain cells. J Mol Neurosci 29(2):131-134, 2006.

Para comunicarse con M Ángeles Muñoz-Fernández mencionar a SIIC como referencia:
mmunoz.hgugm@salud.madrid.org

Autor invitado
14 de octubre, 2010
Descripción aprobada
13 de diciembre, 2010
Reedición siicsalud
13 de junio, 2011

Acerca del trabajo completo
LOS DENDRÍMEROS CARBOSILANO SON CAPACES DE TRANSFECTAR ASTROCITOS HUMANOS CON ARNSI CONTRA EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH)

Título original en castellano
LOS DENDRIMEROS CARBOSILANO SON CAPACES DE TRANSFECTAR ASTROCITOS HUMANOS CON SIRNAS CONTRA EL VIRUS DE LA INMUNODEFICIENCIA HUMANA (VIH).

Autor


Acceso a la fuente original
Biodrugs
http://link.springer.com/journal/40259

El artículo se relaciona estrictamente con las especialidades de siicsalud


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