Angela Silva Barbosa *

Autora invitada por SIIC

O trabalho descreve uma nova estratégia usada pelo microorganismo causador da leptospirose para escapar aos mecanismos de defesa inata do hospedeiro

ESPÉCIES PATOGÊNICAS DE LEPTOSPIRA INTERAGEM COM A PROTEÍNA LIGANTE DE C4B PARA EVADIR AO SISTEMA IMUNE

Espécies patogênicas de Leptospira são capazes de interagir com C4b Binding Protein (C4BP) humano, um regulador plasmático da via clássica do sistema complemento. Esta molécula ligada à membrana da bactéria retém atividade de co-fator de Fator I, uma serinoprotease ativa no soro do hospedeiro responsável pela clivagem de C4b. A aquisição deste regulador do sistema complemento por leptospiras patogênicas deve contribuir para a resistência à atividade bactericida do soro.

*Angela Silva Barbosa
describe para SIIC los aspectos relevantes de su trabajo
IMMUNE EVASION OF LEPTOSPIRA SPECIES BY ACQUISITION OF HUMAN COMPLEMENT REGULATOR C4BP
Institución principal de la investigación
*Instituto Butantan, São Paulo, Brasil
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Referencias bibliográficas
1. Faine S, Adler B, Bolin C, Perolat P. Leptospira and leptospirosis, 2nd ed. MediSci, Armadale, Australia, 1999.
2. Tsuchimoto M, Niikura M, Ono E, Kida H, Yanagawa R. Leptospiral attachment to cultured cells. Zentralbl Bakteriol Mikrobiol Hyg [A] 258:268-274, 1984.
3. Vinh T, Faine S, Adler B. Adhesion of leptospires to mouse fibroblasts (L929) and its enhancement by specific antibody. J Med Microbiol 18:73-85, 1984.
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7. Barbosa AS, Abreu PA, Neves FO, Atzingen MV, Watanabe MM, Vieira ML, Morais ZM, Vasconcellos SA, Nascimento AL. A newly identified leptospiral adhesin mediates attachment to laminin. Infect Immun 74:6356-6364, 2006.
8. Choy HA, Kelley MM, Chen TL, Møller AK, Matsunaga J, Haake DA. Physiological osmotic induction of Leptospira interrogans adhesion: LigA and LigB bind extracellular matrix proteins and fibrinogen. Infect Immun 75:2441-2450, 2007.
9. Stevenson B, Choy HA, Pinne M, Rotondi ML, Miller MC, Demoll E, Kraiczy P, Cooley AE, Creamer TP, Suchard MA, Brissette CA, Verma A, Haake DA. Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement. PLoS ONE 2:e1188, 2007.
10. Hoke DE, Egan S, Cullen PA, Adler B. LipL32 is an extracellular matrix-interacting protein of Leptospira and Pseudoalteromonas tunicata. Infect Immun 76:2063-2069, 2008.
11. Hauk P, Macedo F, Romero EC, Vasconcellos SA, De Morais ZM, Barbosa AS, Ho PL. In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectin. Infect Immun 76:2642-2650, 2008.
12. Atzingen MV, Barbosa AS, De Brito T, Vasconcellos SA, De Morais ZM, Lima DM, Abreu PA, Nascimento AL. Lsa21, a novel leptospiral protein binding adhesive matrix molecules and present during human infection. BMC Microbiol 8:70, 2008.
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15. Meri T, Murgia R, Stefanel P, Meri S, Cinco M. Regulation of complement activation at the C3-level by serum resistant Leptospires. Microb Pathog 39:139-147, 2005.
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17. Walport MJ. Fist of two parts. N Engl J M 344:1058-1066, 2001.
18. Gigli I, Sorvillo J, Halbwachs-Mecarelli L. Regulation and deregulation of the fluid-phase classical pathway C3 convertase. J Immunol 135:440-444, 1985.
19. Misasi R, Huemer HP, Schwaeble W, Solder E, Larcher C, Dierich MP. Human complement factor H: an additional gene product of 43 kDa isolated from human plasma shows cofactor activity for the cleavage of the third component of complement. Eur J Immunol 19:1765-1768, 1989.
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Otros artículos de Angela Silva Barbosa

Barbosa AS, Abreu PA, Neves FO, Atzingen MV, Watanabe MM, Vieira ML, Morais ZM, Vasconcellos SA, Nascimento AL. A newly identified leptospiral adhesin mediates attachment to laminin. Infect Immun 74:6356-6364, 2006.
Barbosa AS, Abreu PA, Vasconcellos SA, Morais ZM, Gonçales AP, Silva AS, Daha MR, Isaac L. Immune evasion of Leptospira spp. by acquisition of human complement regulator C4BP. Infect Immun 77:1137-1143, 2009.
Hauk P, Macedo F, Romero EC. Vasconcellos SA, De Morais ZM, Barbosa AS, Ho PL. In LipL32, the major leptospiral lipoprotein, the C terminus is the primary immunogenic domain and mediates interaction with collagen IV and plasma fibronectin. Infect Immun 76:2642-2650, 2008.

Para comunicarse con Angela Silva Barbosa mencionar a SIIC como referencia:
angelabarbosa@butantan.gov.br

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Acerca del trabajo completo

ESPÉCIES PATOGÊNICAS DE LEPTOSPIRA INTERAGEM COM A PROTEÍNA LIGANTE DE C4B PARA EVADIR AO SISTEMA IMUNE

Título original en castellano
EVASÃO IMUNE DE LEPTOSPIRAS PATOGÊNICAS PELA AQUISIÇÃO DO REGULADOR DO SISTEMA COMPLEMENTO HUMANO C4BP

Autor
Angela Silva Barbosa¹, Patrícia Abreu², Sílvio Vasconcellos³, Zenaide Morais⁴, Amane Gonçales⁵, Aldacilene Silva⁶, Mohamed Daha⁷, Lourdes Isaac⁸
1 Bióloga, Instituto Butantan, São Paulo, Brasil, Pesquisadora
2 Bióloga, Instituto Butantan, Pesquisadora
3 Médico Veterinário, Universidade de São Paulo, Professor
4 Bióloga, Universidade de São Paulo, Técnica
5 Médica Veterinária, Universidade de São Paulo, Estudante de Doutorado
6 Médica Veterinária, Universidade de São Paulo, Estudante de Doutorado
7 Bioquímico, Universidade de Leiden, Professor
8 Bióloga, Universidade de São Paulo, Professora

Acceso a la fuente original
Infection and Immunity
http://iai.asm.org