Crónicas de autores

Jose Moltó Marhuenda *

Autor invitado por SIIC

El trabajo contribuye a optimizar la dosis de darunavir a utilizar en el tratamiento de rescate de pacientes infectados por el VIH previamente tratados con otros inhibidores de la proteasa.

COCIENTE INHIBITORIO DE DARUNAVIR EN EL TRATAMIENTO DE RESCATE

El objetivo de este estudio fue evaluar la relación entre la respuesta virológica y el cociente inhibitorio de Darunavir en 37 pacientes que iniciaban un tratamiento de rescate basado en Darunavir. El cociente inhibitorio virtual (vIQ) predijo la respuesta virológica mejor que las concentraciones de Darunavir o el número de mutaciones de resistencia por separado. Los pacientes con un vIQ ≥12.5 tenían una probabilidad 5 veces mayor de conseguir una carga viral <50 copias/ml tras 48 semanas de seguimiento.

*Jose Moltó Marhuenda
describe para SIIC los aspectos relevantes de su trabajo
DARUNAVIR INHIBITORY QUOTIENT PREDICTS THE 48-WEEK VIROLOGICAL RESPONSE TO DARUNAVIR-BASED SALVAGE THERAPY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PROTEASE INHIBITOR-EXPERIENCED PATIENTS
Antimicrobial Agents and Chemotherapy,
52(11):3928-3932 Nov, 2008

Esta revista, clasificada por SIIC Data Bases, integra el acervo bibliográfico
de la Biblioteca Biomédica (BB) SIIC.

Institución principal de la investigación
*Hospital Universitari Germans Trias I Pujol, Barcelona, España
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Referencias bibliográficas
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Otros artículos de Jose Moltó Marhuenda

Moltó J, Valle M, Santos JR, Mothe B, Miranda C, Cedeño S, Negredo E, Yritia M, Videla S, Barbanoj MB, Clotet B. Pilot study assessing treatment simplification to darunavir/ritonavir 900/100 mg once daily guided by the darunavir inhibitory quotient in heavily pretreated HIV-infected patients. Antivir Ther 15:219-225, 2010.
Moltó J, Valle M, Santos JR, Miranda C, Cedeño S, Negredo E, Yritia M, Videla S, Clotet B. Efficacy and safety of ritonavir dose reduction based on the tipranavir inhibitory quotient in HIV-infected patients on salvage antiretroviral therapy with tipranavir/ritonavir. AIDS Research and Human Retroviruses 26:1191-6, 2010.
Moltó J, Valle M, Ferrer E, Domingo P, Curran A, Santos JR, Mateo MG, Di Yacovo MS, Miranda C, Podzamczer D, Clotet B; on behalf of the DRV600 Study Group. Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically uppressed HIV-infected patients: a randomized clinical trial. J Antimicrob Chemother 70(4):1139-45, 2015.

Para comunicarse con Jose Moltó Marhuenda mencionar a SIIC como referencia:
jmolto@flsida.org

Autor invitado
3 de febrero, 2009
Descripción aprobada
26 de octubre, 2015
Reedición siicsalud
2 de febrero, 2023

Acerca del trabajo completo
COCIENTE INHIBITORIO DE DARUNAVIR EN EL TRATAMIENTO DE RESCATE

Título original en castellano
EL COCIENTE INHIBITORIO PREDICE LA RESPUESTA VIROLOGICA A 48 SEMANAS DEL TRATAMIENTO DE RESCATE BASADO EN DARUNAVIR EN PACIENTES INFECTADOS POR EL VIRUS DE INMUNODEFICIENCIA HUMANA PREVIAMENTE TRATADOS CON INHIBIDORES DE LA PROTEASA.

Autor
Jose Moltó Marhuenda1, José Ramon Santos2, Núria Perez Alvarez3, Cristina Miranda Sánchez4
1 Médico, Hospital Universitari Germans Trias I Pujol, Barcelona, España, Physician
2 Médico, Fundació Lluita Contra la Sida, Consultant
3 Estadistica, Fundació Lluita Contra la Sida, Estadistica
4 Nurse, Fundació Lluita Contra la Sida, Nurse

Acceso a la fuente original
Antimicrobial Agents and Chemotherapy
http://aac.asm.org/
Acceso al texto original completo (full text)
http://aac.asm.org/content/52/11/3928.long
Acceso al resumen/abstract original
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573097/
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