Authors' Reports

Tomáš Fait
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Prospective clinical study in menopausal women
The estradiol metered-dose transdermal spray in clinical practice

The metered-dose transdermal spray with 1,53 mg estradiol was given to symptomatic menopausal women for 24 weeks. There was a statistically significant drop (p < 0.001) in menopause rating scale (MRS) values. The average MRS values improved by 66.2% between the first and the third visit.

The article was published by
El artículo fue publicado por
Volume / Volumen: 21
Number / Número: 6
First and last pages / Páginas inicial-final: 549-553
Year / Año: 2018
Month / Mes: december

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
ČMAS ČLS JEP, Praha 2, Czecchia, Czech Republic

Authors' Report

Crónica del Autor

Estudio Clínico Prospectivo en Mujeres Posmenopáusicas
Solución para pulverización transdérmica de estradiol en dosis medida en la práctica diaria

Se indicó solución para pulverización transdérmica en dosis medida con 1.53 mg de estradiol en mujeres menopáusicas sintomáticas durante 24 semanas. Se registró una disminución significativa de los puntajes en la escala de menopausia (menopause rating scale [MRS], p < 0.001). Los valores promedio en la MRS mejoraron en un 66.2% entre la primera y la tercera visitas.
Crónica del Autor

Imprimir nota

Bibliographic references
Referencias bibliográficas

Ibrahim SA: Spray-on transdermal drug delivery systems. Expert Opin Drug Delivery 2015, 12(2): 195-205 Derzko C., Sergerie M., Siliman G. et al. Comparative efficacy and safety of oestradiol transdermal preparations for the treatment of vasomotor symptoms in postmenopausal women: an indirect comparison meta-analysis. Menopause 2016, 23(3):294-303
Morton TL., Gattermeir DJ., Petersen CA. et al.: Steady state pharmacokinetics following application of a novel transdermal oestradiol spray in healthy postmenopausal women. J Clin Pharmacol 2009, 49(9): 1037-46
Acher D.: Menopausal hot flashes are treated effectively by a transdermal, low dose oestradiol spray. Nature Review Endocrinology 2009, 5: 18-9
Buster JE., Koltun WD., Pascual ML. et al.: Low-dose oestradiol spray to treat vasomotor symptoms: a randomize controlled trial. Obstet Gynecol 2008, 111(6): 1343-51

Other articles written by the author Tomáš Fait
Otros artículos de Tomáš Fait

Fait T., Vrablik M., Cibula D. et al.: Oral but not Transdermal Estrogen Replacement Therapy Reduced Level of Tissue Factor Pathway Inhibitor: Cross-over Designed Study. Neuro Endocrinol Lett 2006, 27(5): 557-61 Fait T., Vrablík M., Zizka Z., Kostirova M.: Changes in Haemostatic Variables Induced by Estrogen Replacement Therapy: Comparison of Transdermal and Oral Methods of Administration in Cross-over Designed Study, Gynecol Obstet Invest 2008, 65(1): 47-51 Fait T.: Combined Hormone Contraceptive Choice Experience in Czech Republic. Central European Journal of Medicine 2011, 6(5): 582-7 ISSN: 1644-3640 IF 0,312 Fait T., Vrablik M.: Coronary heart disease and hormone replacement therapy - from primary and secondary prevention to the window of opportunity. Neuro Endocrinol Lett 2012, 33, Suppl. 2: 17-21 ISSN 0172-780X IF 1,296 Fait T., Sailer M., Regidor PA.: Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys® in the management of women with menopausal symptoms. Gynecol Endocrinol 2019, 35(4): 360-3 Fait T., Buryak D., Cîrstoiu M., Luczai E., Janczura R.: Needs and preferences of women users of oral contraceptives in selected countries in Central and Eastern Europe. Drugs in Context 2018, 7: 2125ID Fait T.: Hormone replacement therapy: latest developments and clinical practice. Drugs in Context 2019, 8: 212551

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Tomáš Fait was invited by SIIC on
Tomáš Fait fue invitado por SIIC el
2019, december 16
  The authors' report was accepted on
La crónica del autor fue aprobada el
2022, august 24
The authors' report was accepted on
La crónica del autor fue aprobada el
2022, august 24
Published in siicsalud
Publicado en siicsalud
2022, november 22

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

Endocrinology and Metabolism
/ Endocrinología y Metabolismo
Gynaecology and Obstetrics
/ Obstetricia y Ginecología

and secondarily related to the following sections

y secundariamente con las siguientes secciones


Clinical Pharmacology
Farmacología Clínica


Climacteric and Menopause
Climaterio y Menopausia

Family Planning
Planificación Familiar

Mental Health
Salud Mental

Public Health
Salud Pública

Information about the full text
Acerca del trabajo completo

The use of estradiol metered-dose transdermal spray in clinical practice

Author / Autor
Tomáš Fait1

1 Assoc. Prof., Md., Phd., Gynecologicko-porodnická Klinika 2. Lf Uk A Fn Motol, Prague, República Checa, Doctor

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