Authors' Reports

Roberto Codella
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Exercise talks with the brain and distracts it from sugar

Sugar over-consumption alters the reward system resulting in a deficiency that preludes to a sugar addiction. This vicious circle may be attenuated by physical exercise via enhancement of the neurotrophic factors (BDNF) and the dopaminergic system.

The article was published by
El artículo fue publicado por
Journal of Affective Disorders
Volume / Volumen: 224
Number / Número:
First and last pages / Páginas inicial-final: 76-86
Year / Año: 2017
Month / Mes: december

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Università degli Studi di Milano - Dipartimento Biomediche per la Salute, Segrate, MILANO, Italy

Authors' Report

Crónica del Autor

El ejercicio estimula la actividad del cerebro y desvía la atención por el azúcar

El consumo excesivo de azúcar compromete el sistema de la recompensa y esta anormalidad anticipa la adicción al azúcar. El círculo vicioso puede atenuarse con el ejercicio físico, asociado con aumento de los factores neurotróficos y del sistema dopaminérgico.
Crónica del Autor

Imprimir nota

Bibliographic references
Referencias bibliográficas

1. Codella R, Terruzzi I, Luzi L. Sugars, exercise and health. J Affect Disord, 2017. doi:10.1016/j.jad.2016.10.035.
2. Codella R, Luzi L, Inverardi L, Ricordi C. The anti-inflammatory effects of exercise in the syndromic thread of diabetes and autoimmunity. Eur Rev Med Pharmacol Sci 19:3709-22, 2015.
3. Codella R, Luzi L, Terruzzi I. Exercise has the guts: How physical activity may positively modulate gut microbiota in chronic and immune-based diseases. Dig Liver Dis, 2017. doi:10.1016/j.dld.2017.11.016.

Other articles written by the author Roberto Codella
Otros artículos de Roberto Codella

Codella R, Benedini S, Paini S, Caumo A, Adamo M, Terruzzi I, Ferrulli A, Macrì C, Andreoni L, Sterlicchio M, Luzi L. Effect of sugar versus mixed breakfast on metabolic and neurofunctional responses in healthy individuals. J Diabetes Res 2017:9634585, 2017.
Codella R, Adamo M, Piemonti L, Maffi P, Secchi A, Luzi L. Why should people with type 1 diabetes exercise regularly? Acta Diabetol 54(7):615-630, 2017.
Adamo M, Codella R, Casiraghi F, Ferrulli A, Macrì C, Bazzigaluppi E, Terruzzi I, Inverardi L, Ricordi C, Luzi L. Active subjects with autoimmune type 1 diabetes have better metabolic profiles than sedentary controls. Cell Transplant 26(1):23-32, 2017.
Codella R, Adamo M, Piemonti L, Maffi P, Secchi A, Luzi L. Ultra-marathon 100 km in an islet-transplanted runner. Acta Diabetol, Nov 2016.
Codella R, Lanzoni G, Zoso A, Caumo A, Montesano A, Terruzzi IM , Ricordi C, Luzi L, Inverardi L. Moderate intensity training impact on the inflammatory status and glycemic profiles in NOD mice. J Diabetes Res 2015:737586, 2015.
Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Petersen KF, Shulman GI. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance. Hepatology 53(4):1175-81, 2011.
Codella R, Choi CS, Befroy DE, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman B, Shulman GI. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin stimulated muscle glucose metabolism. PNAS 105(50):19926-31, 2008.
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. Continuous fat oxidation in Acetyl-CoA carboxylase 2 mutant mice increases total energy expenditure, reduces fat mass and improves insulin sensitivity. PNAS 104(42):16480-5, 2007.

SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Roberto Codella was invited by SIIC on
Roberto Codella fue invitado por SIIC el
2018, february 19
  The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
The authors' report was accepted on
La crónica del autor fue aprobada el
2021, march 9
Published in siicsalud
Publicado en siicsalud
2021, june 7

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Neurología
Mental Health
/ Salud Mental

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Endocrinology and Metabolism
Endocrinología y Metabolismo

Sports Medicine
Medicina Deportiva

Family Medicine
Medicina Familiar


Public Health
Salud Pública

Information about the full text
Acerca del trabajo completo

Sugar, Exercise and Health

Author / Autor
Roberto Codella1, Ileana Terruzzi2, Livio Luzi3

3 M.d., Metabolism Research Center, Irccs Policlinico San Donato, San Donato Milanese, Italy, Full Professor

Access to the original source
Journal of Affective Disorders

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