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Prachi Atram
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Gingival crevicular fluid: a diagnostic marker in HIV positive patients

ELISA is the most commonly used test for screening HIV patients. Generally it is found that people are scared of pricking injections, reluctant to give blood sample (quantity), think about cost effectiveness and also causes disturbances their social life. In the present era investigators are searching for alternative to serological testing. Recently it is proved that oral fluids testing can be used as an alternative to blood testing. New investigational devices are introduced like Orasure and others which collects the oral saliva, oral mucosal transudate. In the present study we used calibrated 5 µl disposable microcapillaries so that the uncontaminated gingival crevicular fluid (GCF) is obtained. According to Goodson the IgG content of GCF in periodontal pocket is approximately 100 times more than found in saliva and is now widely appreciated that GCF is formed as blood ultrafiltrate. In this study we studied many parameters and reached to the conclusion that GCF can also be of choice instead of serum because of non-invasivensess, painless, low cost effective, less sample, easy collection, safer disposal and better for clinicians because of patients better compliance. The above findings suggestive of GCF being better alternative and better diagnostic medium than serum and saliva so it can be used for detection of HIV.

The article was published by
El artículo fue publicado por
Journal of International Society of Preventive and Community Dentistry
Volume / Volumen: 5
Number / Número: 1
First and last pages / Páginas inicial-final: 24-30
Year / Año: 2015
Month / Mes: january

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación

Authors' Report

Crónica del Autor

Bibliographic references
Referencias bibliográficas

1. Soto Ramírez LE, Hernández Gómez L, Sifuentes Osornio J, Barriga Angulo G, Duarte de Lima D, López Portillo M, et al. Detection of specific antibodies in gingival crevicular transudate by ELISA for diagnosis of HIV type1 infection. J Clin Microbiol 30:2780-3, 1992.
2. Reichart PA, Gelderblom HR, Becker J, Kuntz A. AIDS and the oral cavity. The HIV-infection: Virology, etiology, origin, immunology, precautions and clinical observation in 110 patients. Int J Oral Maxillofac Surg 16:129-53, 1987.
3. Balasundaram S. HIV Antibody Screening: Saliva as Alternative to Serum. Chennai, India: Ragas Dental College, 2002.
4. Mandel ID. Salivary diagnosis: More than a lick and a promise. J Am Dent Assoc 124:20-1, 1993.
5. Constantine N. HIV antibody assay: HIV in site, knowledge based chapter. United States: University of Maryland School of Medicine, 2006.
6. Jackson MM, Lynch P. The epidemiology of HIV infection, AIDS, and health care worker risk issues. Fam Community Health 12:34-42, 1989.
7. Goodson JM. Gingival crevice fluid flow. Periodontol 2000. 31:43-54, 2003.

Other articles written by the author Prachi Atram
Otros artículos de Prachi Atram

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/ Sistema SIIC de Edición Asistida (SSEA)

Prachi Atram was invited by SIIC on
Prachi Atram fue invitado por SIIC el
2016, june 7
  The authors' report was accepted on
La crónica del autor fue aprobada el
2023, november 17
The authors' report was accepted on
La crónica del autor fue aprobada el
2023, november 17
Published in siicsalud
Publicado en siicsalud
2024, february 15

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Odontología
Public Health
/ Salud Pública

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Health Care Management
Administración Hospitalaria

Medical Education
Educación Médica

Infectious Diseases


Information about the full text
Acerca del trabajo completo

Gingival Crevicular Fluid: As a Diagnostic Marker in HIV Positive Patients

Author / Autor
Prachi Atram1, Pallavi Patil2, Fatema Saify3, Vanita Rathod4, Swati Gotmore5, Pallavi Patil6, Fatema Saify7, Vanita Rathod8, Swati Gotmore9, Pallavi Patil10, Fatema Saify11, Vanita Rathod12, Swati Gotmore13, Pallavi Patil14, Fatema Saify15, Vanita Rathod16, Swati Gotmore17, Pallavi Patil18, Fatema Saify19, Vanita Rathod20, Swati Gotmore21

21 Proffessor, Department Of Oral Pathology, D.y.patil University ,school Of Dentistry,navi Mumbai, Maharashtra, India., Fifth

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Journal of International Society of Preventive and Community Dentistry

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