Authors' Reports

Jiji Mathews
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo


Metformin and glibenclamide were compared in women with moderate hyperglycaemia after medical nutritional therapy in a South Indian population. Very low rates of neonatal hypoglycaemia were seen with the use of metformin. Maternal glycaemic control was similar in both groups. Thus, metformin is the preferred oral hypoglycaemic agent in gestational diabetes.

The article was published by
El artículo fue publicado por
Volume / Volumen: 55
Number / Número: 1
First and last pages / Páginas inicial-final: 47-52
Year / Año: 2015
Month / Mes: february

This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.

Principal institution where the research took place
Institución principal de la investigación
Christian Medical College & Hospital, Vellore, Tamilnadu, India

Authors' Report

Crónica del Autor

Evolución Neonatal con el Uso de Hipoglucemiantes en Mujeres con Hiperglucemia Moderada

Se compararon los efectos de la metformina y la glibenclamida en mujeres con hiperglucemia moderada luego de la terapia médica nutricional en una población del sur de la India. Con el uso de metformina se observaron índices muy bajos de hipoglucemia neonatal. El control materno de la glucemia fue similar en los dos grupos. Por lo tanto, la metformina es el agente hipoglucemiante oral preferido en la diabetes gestacional.
Crónica del Autor

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Bibliographic references
Referencias bibliográficas

1. Langer O, Conway DL, Berkus MD et al. A comparison of glyburide and insulin in women with gestational diabetes mellitus. N Engl J Med 343:1134-1138, 2000.
2. Rowan JA, Hague WM, Gao W et al. Metformin versus insulin for the treatment of gestational diabetes. N Engl J Med 358:2003-2015, 2008.
3. Elliot BD, Langer O, Schenker S et al. Insignificant transfer of glyburide occurs across the human placenta. Am J Obstet Gynecol 338:1222, 1991.
4. Hebert MF, Ma X, Naraharisetti SB et al. Are we optimizing gestational diabetes treatment with glyburide? The pharmacologic basis for better clinical practice. Clin Pharmacol Ther 85:607-614, 2009.
5. Bailey C, Turner R. Drug therapy: metformin. N Engl J Med 334:574-579, 1996.
6. Inzucchi S, Maggs DG, Spollett GR et al. Efficacy and metabolic effects of metformin and troglitazone in type 2 diabetes mellitus. N Engl J Med 338:867-872, 1998.
7. Mathews JE, Biswas B, Samuel P et al. Retrospective cohort study comparing neonatal outcomes of women treated with glyburide or insulin in gestational diabetes: a 5 year experience in a South Indian teaching hospital. Indian J Med Sci 65:476-81, 2011.
8. Coetzee EJ, Jackson WP. Pregnancy in established non-insulindependent diabetics. A five-and-a-half year study at Groote Schuur Hospital. S Afr Med J 58:795-802, 1980.
9. Coetzee EJ, Jackson WP. Metformin in management of pregnant insulin-independent diabetics. Diabetologia 16:241-245, 1979.
10. Silva JC, Fachin DR, Coral ML, Bertini AM. Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus. J Perinat Med 40:225-228, 2012.

Other articles written by the author Jiji Mathews
Otros artículos de Jiji Mathews

Mathews JE, George SS, Mathews P, Mathai E, Brahmadathan KN, Seshadri L. The Griess test: An inexpensive screening test for asymptomatic bacteriuria in pregnancy. Aust NZ J Obstet Gynaecol 38:407-10, 1998.
Mathews JE, Mathai M, Peedicayil A, Mathews KP, Ponnaiya J, Jasper MP. Subclinical chorioamnionitis as a causal factor in unexplained stillbirths. Int J Gynaecol Obstet 74(2):195-7, 2001.
Mathews JE, Rajaratnam A, George A, Mathai M. Comparison of two WHO partographs. Int Jr of Gyn & Obst 96:147-150, 2007.
Mathews JE. Misoprostol for induction of labour to terminate pregnancy in the second or third trimester for women with a fetal anomaly or after intrauterine fetal death: RHL commentary (last revised: 1 October 2010). The WHO Reproductive Health Library; Geneva: World Health Organization.
Kavitha A, Chacko KP, Thomas E, Rathore S, Christoper S, Biswas B, Mathews JE. A randomized controlled trial to study the effect of IV hydration on the duration of labor in nulliparous women. Archives of Gynecololgy and Obstetrics. Arch Gyne Obstet 285:343-346, 2012.
Mathews JE, Biswas B, Jana A, Samuel P, Muliyil J, Mathai M. Retrospective cohort study comparing neonatal outcomes of women treated with glyburide or insulin in gestational diabetes - A 5 year experience in a South Indian teaching hospital. Indian Journal of Medical Sciences. Indian J Med Sci 65(11):476-81, 2011. Doi: 10.4103/0019-5359.109534.
Abraham A, Mathews JE, Sebastian A, Chacko KP, Sam D. A nested case control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency (ANZJOG-2012-0278.R1). The Australian and New Zealand Journal of Obstetrics and Gynaecology. Aust N Z J Obstet Gynaecol doi: 10.1111/ajo.12057, 2013.
The CORONIS Collaborative Group. Caesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial. The Lancet 382(9888):234-248, 2013.
Samuel R, Ramanathan K, Mathews J, Seshadri M. Back to the future: examining type 2 diabetic vasculature using the gestational diabetic placenta. Diabetes and Vascular Disease Research 11(5):363-365, 2014.
Raj P, Benjamin S, Abraham A, Vaibhav H, Jeyaseelan V, Mathews JE. Misoprostol verses foley catheter for induction of labour in fetal growth restriction. Int J Gynaecol Obstet 129(2):152-5, 2015. doi: 10.1016/j.ijgo.2014.11.018. Epub 2015 Jan 29.

SIIC System of Assisted Editing (SSEA)
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Jiji Mathews was invited by SIIC on
Jiji Mathews fue invitado por SIIC el
2015, may 5
  The authors' report was accepted on
La crónica del autor fue aprobada el
2024, february 17
The authors' report was accepted on
La crónica del autor fue aprobada el
2024, february 17
Published in siicsalud
Publicado en siicsalud
2024, may 17

The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

/ Diabetología
Gynaecology and Obstetrics
/ Obstetricia y Ginecología

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Primary Care
Atención Primaria

Diabetology in Adults
Diabetología en Adultos

Family Medicine
Medicina Familiar

High Risk Pregnancy
Embarazo de Alto Riesgo

Information about the full text
Acerca del trabajo completo

Comparison of Neonatal Outcomes in Women With Gestational Diabetes With Moderate Hyperglycaemia on Metformin or Glibenclamide - A Randomised Controlled Trial

Author / Autor
Jiji Mathews1, Anne George2, Dibu Sam3, Manisha Beck4, Santosh Benjamin5, Anuja Abraham6, Balevendra Antonisamy7, Atanu Kumar Jana8, Nihal Thomas9

9 Dr, Christian Medical College, Vellore, Tamilnadu, India, Professor

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