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Shih-Che Huang
describes for SIIC the most significant aspects of his article
describe para SIIC los aspectos relevantes de su artículo

Bile acid receptor as potential therapeutic target
BILE ACIDS RELAX LOWER ESOPHAGEAL SPHINCTER VIA G-PROTEIN COUPLED RECEPTORS

Bile acids help fat digestion in the gastrointestinal tract. Bile acids can also act as hormones. Activation of G-protein coupled bile receptors by bile acids relaxes gastrointestinal muscles including the lower esophageal sphincter. The bile acid receptor might be a potential therapeutic target for treating gastro-esophageal reflux disease.

The article was published by
El artículo fue publicado por
Tzu Chi Medical Journal
Volume / Volumen: 25
Number / Número: 2
First and last pages / Páginas inicial-final: 90-93
Year / Año: 2013
Month / Mes: june


This journal, which is covered by SIIC Data Bases,
is part of the bibliographic collections of the Biblioteca Biomédica (BB) SIIC.
Esta revista, clasificada por SIIC Data Bases,
integra el acervo bibliográfico de la Biblioteca Biomédica (BB) SIIC.
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Principal institution where the research took place
Institución principal de la investigación
Department of Internal Medicine, E-Da Hospital and School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan, Kaohsiung, Taiwan, Taiwan


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Authors' Report

Crónica del Autor
Print

Bibliographic references
Referencias bibliográficas

Fryer RM, Ng KJ, Nodop Mazurek SG, et al. G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism. J Pharmacol Exp Ther 348:421-431, 2014.
Huang SC. Bile acids cause relaxation of the lower esophageal sphincter through G-protein-coupled bile acid receptors. Tzu Chi Med Journal 25:90-93, 2013.
Kuipers F, Bloks VW, Groen AK. Beyond intestinal soap-bile acids in metabolic control. Nat Rev Endocrinol 10:488-498, 2014.
McQuaid KR, Laine L, Fennerty MB, Souza R, Spechler SJ. Systematic review: the role of bile acids in the pathogenesis of gastro-oesophageal reflux disease and related neoplasia. Aliment Pharmacol Ther 34:146-165, 2011.
Taegtmeyer AB, Haschke M, Tchambaz L, et al. A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls. PLoS One 9:e97885, 2014.

Other articles written by the author Shih-Che Huang
Otros artículos de Shih-Che Huang

1. Chang BS, Chang JC, Huang SC. Proteinase-activated receptors 1 and 2 mediate contraction of human oesophageal muscularis mucosae. Neurogastroenterol Motil. 2010;22:93-7, e32. 2. Huang SC. Endothelin A receptors mediate relaxation of guinea pig internal anal sphincter through cGMP pathway. Neurogastroenterol Motil. 2010;22:1009-1, e264. 3. Huang SC. Dendroaspis natriuretic peptide is the most potent natriuretic peptide to cause relaxation of lower esophageal sphincter. Regul Pept. 2011;167:246-9. 4. Huang SC. Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. Life Sci. 2011;88:819-24. 5. Huang SC. Effects of trypsin, thrombin and proteinase-activated receptors on guinea pig common bile duct motility. Regul Pept. 2012;179:1-5. 6. Lee MC, Yang YC, Chen YC, Huang SC. Muscarinic receptor M(3) mediates human gallbladder contraction through voltage-gated Ca(2+) channels and Rho kinase. Scand J Gastroenterol. 2013;48:205-12. 7. Huang SC. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014;189:46-50.




SIIC System of Assisted Editing (SSEA)
/ Sistema SIIC de Edición Asistida (SSEA)

Shih-Che Huang was invited by SIIC on
Shih-Che Huang fue invitado por SIIC el
2013, october 11
  The authors' report was accepted on
La crónica del autor fue aprobada el
2019, february 14
The authors' report was accepted on
La crónica del autor fue aprobada el
2019, february 14
Published in siicsalud
Publicado en siicsalud
2019, may 15





The article is strictly related to the following sections of siicsalud
El artículo se relaciona estrictamente con las siguientes secciones de siicsalud

 
Pharmacology
/ Farmacología
 
Gastroenterology
/ Gastroenterología
 

and secondarily related to the following sections

y secundariamente con las siguientes secciones

Endocrinology and Metabolism
Endocrinología y Metabolismo

Internal Medicine
Medicina Interna

Information about the full text
Acerca del trabajo completo


Bile Acids Cause Relaxation of the Lower Esophageal Sphincter Through G-Protein-Coupled Bile Acid Receptors


Author / Autor
Shih-Che Huang1

1 Md, Phd, Department Of Internal Medicine, E-da Hospital, And School Of Medicine, I-shou University, Kaohsiung, Taiwan, Kaohsiung, Taiwán (Republica Nacionalista China), Professor


Access to the original source
Tzu Chi Medical Journal

Article URL:
/ URL del artículo:
http://www.tcmjmed.com

URL of Abstract:
/ URL del abstract:
http://www.tzuchimedjnl.com/article/S1016-3190(13)00040-2/abstract

URL of Abstract page in Medline:
/ URL del abstract en Medline:

URL of Abstract page in Scielo:
/ URL del abstract en Scielo:

URL of Abstract page in Scopus:
/ URL del abstract en Scopus:

URL of Abstract page in Embase:
/ URL del abstract en Embase:

Other data bases:
/ Otras bases de datos:

siic DB:
/ siic DB:
http://www.siicsalud.com/main/distriprinrel.php
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