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The increasing number of Open Access articles widens the reading offer
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SIIC created, produced and handles the AFT software that deciphers
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study: specialty, study style, source, publication and selection
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While most of the selected texts belong to original articles,
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Impact of 1-Year Supplementation with High-Rich Docosahexaenoic Acid (DHA) on Clinical Variables and Inflammatory Biomarkers in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial.
Impact of 1-Year Supplementation with High-Rich Docosahexaenoic Acid (DHA) on Clinical Variables and Inflammatory Biomarkers in Pediatric Cystic Fibrosis: A Randomized Double-Blind Controlled Trial.
Fuente:Nutrients
Extracto:
In summary, the use of a highly
concentrated DHA supplement for 1 year as compared with placebo improved
pulmonary function and reduced exacerbations in pediatric CF.
Physiologically based modeling reveals different risk of respiratory depression after fentanyl overdose between adults and children.
Physiologically based modeling reveals different risk of respiratory depression after fentanyl overdose between adults and children.
Fuente:Clinical and Translational Science
Extracto:
Our work indicates that when developing intervention
strategies to protect children from opioid overdose in a community setting, these
pediatric-specific factors may need to be considered.
institución:(a) Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. (b) Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Conflicto:The authors declare no competing interest for this work.
Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China.
Critically ill children with SARS-COV-2 Omicron infection at a national children medical center, Guangdong, China.
Fuente:Bmc Pediatrics
Extracto:
We present a case series of
critically ill children infected with the SARS-CoV-2 omicron variant. While there
is evidence suggesting that Omicron may cause less severe symptoms, it is
important to continue striving for measures that can minimize the pathogenic
impact of SARS-CoV-2 infection in children.
institución:(a) Precision Medical Lab Center, Chaozhou Central Hospital, Chaozhou, Guangdong Province, P. R. China. (b) Department of Allergy, Immunology and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Province, P. R. China.
Conflicto:The authors have no relevant financial or non-financial interests to disclose.
Antimicrobial resistance prediction by clinical metagenomics in pediatric severe pneumonia patients.
Antimicrobial resistance prediction by clinical metagenomics in pediatric severe pneumonia patients.
Fuente:Annals of Clinical Microbiology and Antimicrobials
Extracto:
mNGS exhibits variable
predictive performance among different pathogens and antibiotics, indicating its
potential as a supplementary tool to conventional PST. However, mNGS currently
cannot replace conventional PST.
Claves:Antimicrobial resistance, Metagenomic next-generation sequencing, Pediatric, Severe pneumonia
institución:(a) Center for Molecular Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, People's Republic of China. (b) Department of Neonatology, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
RSV Disease Burden in Primary Care in Italy: A Multi-Region Pediatric Study, Winter Season 2022-2023.
RSV Disease Burden in Primary Care in Italy: A Multi-Region Pediatric Study, Winter Season 2022-2023.
Fuente:Influenza and Other Respiratory Viruses
Extracto:
Our findings describe a baseline of
the RSV disease burden in primary care in Italy before the introduction of
upcoming immunization strategies.
Claves:RSV, acute respiratory infections, primary care, respiratory infection surveillance
Cita:Influenza Other Respir Viruses 2024 Apr; 18 (4) : e13282.
Autor/es:Scarpaci, Michela (a) Bracaloni, Sara (b)
institución:(a) Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. (b) Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Nutrition Postgraduate Program, Universidade Federal de São Paulo, São Paulo 04530-050, SP, Brazil. (b) Medical Engagement Nestlé, São Paulo 07730-090, SP, Brazil.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Hidradenitis suppurativa as a potential risk factor of periodontitis
Hidradenitis suppurativa as a potential risk factor of periodontitis
Fuente:International Journal of Medical Sciences
Tipo de trabajo:Estudio de cohortes
Extracto:
Conclusion:
The observed increased risk suggests the need for heightened awareness and
potential interdisciplinary care for individuals with HS to address periodontal
health.
Claves:cohort, electronic medical records, epidemiology, hidradenitis suppurativa, periodontitis
Cita:Int J Med Sci 2024; 21 (5) : 874-881.
Autor/es:Gau, Shuo-Yan (a) Guo, Yu-Chen (b)
institución:(a) School of Medicine, Chung Shan Medical University, Taichung, Taiwan. (b) Department of Medical Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Conflicto:Competing Interests: The authors have declared that no competing interest exists.
Extracto:
Thus,
new and emerging strategies, advanced diagnostic tools, and minimally invasive
approaches are under investigation to improve the outcomes and overall quality of
life of pediatric patients with SCD.
institución:(a) Department of Pediatric Surgery and Urology, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste 34137, Italy. alessandro.boscarelli@burlo.trieste.it. (b) Department of Gastrointestinal Endoscopy and Nutrition, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste 34137, Italy.
Conflicto:Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease
Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease
Fuente:Scientific Reports
Tipo de trabajo:Estudio abierto
Extracto:
This study suggested that
empagliflozin may promote colonic mucosal healing and reduce hyperplasia,
stenosis, and obstruction in children with GSD-associated IBD.
institución:(a) Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. (b) Department of Pediatrics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The effect of respiratory muscle training on children and adolescents with cystic fibrosis
The effect of respiratory muscle training on children and adolescents with cystic fibrosis
Fuente:Bmc Pediatrics
Tipo de trabajo:Revisión sistemática
Extracto:
This systematic review and meta-analysis indicate that although the level of
evidence indicating the benefits of respiratory muscle training is low, its
clinical significance suggests that we further study the methodological quality
to determine the effectiveness of training. TRIAL REGISTRATION: The protocol for
this review was recorded in the International Prospective Register of Systematic
Reviews (PROSPERO) under registration number CRD42023441829.
Claves:Adolescent, Cystic fibrosis, Pediatrics, Pulmonary rehabilitation, Respiratory muscle training
Cita:BMC Pediatr 2024 Apr 15; 24 (1) : 252.
Autor/es:Cai, WenQian (a) Li, Meng (b)
institución:(a) School of Pediatrics, Nanjing Medical University, Jiangsu Province, China. (b) Department of Nursing, Children's Hospital of Nanjing Medical University, Nanjing, China.
An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions.
An Adapted Questionnaire Tailored for Assessing the Risk of Vitamin D Deficiency in Children That Is Proving Useful in Guiding Clinical Interventions.
Fuente:Nutrients
Extracto:
This study
confirms that the EVIDENCe-Q is a valid instrument for assessing the risk of
vitamin D deficiency and insufficiency in children. It offers a practical
approach for determining the need for clinical intervention and dietary
supplementation of VitD in the pediatric population.
Claves:children, deficiency, questionnaire, screening, vitamin D
Cita:Nutrients 2024 Mar 27; 16 (7)
Autor/es:Calcaterra, Valeria (a) Cena, Hellas (b)
institución:(a) Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, Italy. (b) Pediatric Department, Buzzi Children's Hospital, 20154 Milano, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Burdens and resources of Austrian clinical psychologists: results of a qualitative study two years into the COVID-19 pandemic.
Burdens and resources of Austrian clinical psychologists: results of a qualitative study two years into the COVID-19 pandemic.
Fuente:Bmc Psychology
Extracto:
Overall, it seems that clinical
psychologists have a high awareness of mental health-related problems related to
the pandemic and use adaptive coping strategies to deal with them.
institución:(a) Department for Psychosomatic Medicine and Psychotherapy, University for Continuing Education Krems, Krems, 3500, Austria. (b) Faculty of Psychotherapy Science, Sigmund Freud University Vienna, Vienna, 1020, Austria.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A retrospective study of morbidity and mortality of chronic acid sphingomyelinase deficiency in Germany.
A retrospective study of morbidity and mortality of chronic acid sphingomyelinase deficiency in Germany.
Fuente:Orphanet Journal of Rare Diseases
Tipo de trabajo:Estudio de cohortes
Extracto:
This study highlights considerable morbidity and
mortality associated with ASMD type B and type A/B in Germany. It further
emphasises the importance of effective therapy for chronic ASMD to reduce disease
complications.
Claves:Acid sphingomyelinase deficiency, Morbidity, Mortality, Overall survival, Standardised mortality ratio
institución:(a) Institute of Clinical Science for LSD, SphinCS, Hochheim, Germany. (b) International Center for Lysosomal Disorders (ICLD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Conflicto:EM has received research grants, speakers’ honoraria, and consultation fees from Sanofi, Takeda, Orphazyme, Avrobio, Idorsia, Cyclo Therapeutics, Alexion, and Amicus. NM has received research grants, speakers’ honoraria, and/or consultation fees from Sanofi, Takeda, Amicus, Chiesi, JCR, and Lysogene. NW has received research grants, speakers’ honoraria, travel grants, and/or consultation fees from Sanofi, Takeda, and Biomarin. AZ has received speakers’...
akers’ honoraria and consultation fees from Sanofi, Genzyme, Takeda, and Biomarin. JN has received travel grants from Sanofi, Takeda, and Biomarin. BA and LL are employees of IQVIA. MG, SG, MF, and RPJ are employees and may hold stock and/or stock options in Sanofi. FL was an employee of Sanofi at the time of study conduct.
Brain magnetic resonance imaging review suggests unrecognised hypoglycaemia in childhood.
Brain magnetic resonance imaging review suggests unrecognised hypoglycaemia in childhood.
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Revisión
Extracto:
We have
identified the existence of unrecognised childhood hypoglycaemia through
neuroimaging review. This study highlights the need for heightened awareness of
early life hypoglycaemia to prevent adverse neurological outcomes later in
childhood.
Claves:brain injury, child, glucose, hypoglycaemia, magnetic resonance imaging
institución:(a) Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, United Kingdom. (b) Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, United Kingdom.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome.
Carnitine palmitoyltransferase II (CPT II) deficiency responsible for refractory cardiac arrhythmias, acute multiorgan failure and early fatal outcome.
Fuente:Italian Journal of Pediatrics
Extracto:
CPTII deficiency may be suspected in newborns showing cardiac
arrhythmias, associated or not with hypertrophic cardiomyopathy, polycystic
kidneys, brain malformations, hepatomegaly. Its diagnosis should be even more
suspected and investigated in cases of increased plasmatic levels of creatine
phosphokinase and acylcarnitines in addition to kidney, heart and liver
dysfunctions, as occurred in the present patient. Accurate family history,
extended metabolic screening, and multidisciplinary approach are necessary for
diagnosis and adequate management of affected subjects. Next generation
sequencing (NGS) techniques allow the identification of the CPTII gene mutation,
essential to confirm the diagnosis before or after birth, as well as to calculate
the recurrence risk for family members. Our report broads the knowledge of the
genetic and molecular bases of such rare disease, improving its clinical
characterization, and provides useful indications for the treatment of patients.
Claves:CPTII, Fatty acid oxidation defect, Neonatal screening, Next generation sequencing
Cita:Ital J Pediatr 2024 Apr 14; 50 (1) : 67.
Autor/es:Serra, Gregorio (a) Antona, Vincenzo (b)
institución:(a) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy. gregorio.serra@unipa.it. (b) Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Palermo, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Autor/es:Farzat, Mahmoud (a) Wagenlehner, Florian M (b)
institución:(a) Department of Urology, Pediatric Urology and Andrology, Justus-Liebig University of Giessen, Wichernstraße 40, 57074, Siegen, Germany. mahmoudfarzat@live.com. (b) Department of Urology and Robotic Urology, Diakonie Klinikum, Siegen, Germany. mahmoudfarzat@live.com.
Conflicto:All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding author.
Autor/es:Postma, Laura (a) Luchtenberg, Malou L (b)
institución:(a) Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. (b) Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The effectiveness and safety of centralized early rehabilitation care for critically ill children with severe acquired brain injury: A retrospective cohort and implementation study.
The effectiveness and safety of centralized early rehabilitation care for critically ill children with severe acquired brain injury: A retrospective cohort and implementation study.
Fuente:Science Progress
Tipo de trabajo:Estudio de cohortes
Extracto:
The
centralized pediatrics early rehabilitation unit is effective and safe for
children with severe acquired brain injury. Further multicenter prospective
implementation studies on effectiveness, safety, and economic evaluation are
needed.
Claves:Brain injury, child, implementation science, outcome assessment, rehabilitation center
institución:(a) Department of Rehabilitation, Children's Hospital of Chongqing Medical University, Chongqing, China. (b) National Clinical Research Center for Child Health and Disorders, Chongqing, China.
Conflicto:Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Safety and immunogenicity of the Euvichol-S oral cholera vaccine for prevention of Vibrio cholerae O1 infection in Nepal: an observer-blind, active-controlled, randomised, non-inferiority, phase 3 trial.
Safety and immunogenicity of the Euvichol-S oral cholera vaccine for prevention of Vibrio cholerae O1 infection in Nepal: an observer-blind, active-controlled, randomised, non-inferiority, phase 3 trial.
Fuente:The Lancet. Global Health
Extracto:
TRANSLATION: For the Nepali translation of the abstract
see Supplementary Materials section.
Cita:Lancet Glob Health 2024 May; 12 (5) : e826-e837.
Autor/es:Song, Katerina Rok (a) Chapagain, Ram Hari (b)
institución:(a) Clinical, Assessment, Regulatory, Evaluation Unit, International Vaccine Institute, Seoul, South Korea. Electronic address: katerina.song@ivi.int. (b) Department of Pediatric Medicine, Kanti Children's Hospital, Kathmandu, Nepal.
Conflicto:Declaration of interests The authors include staff at the International Vaccine Institute who developed the oral cholera vaccine technology and Eubiologics, the manufacturers of Euvichol, Euvichol-Plus, and Euvichol-S. The five-component whole-cell oral cholera vaccines Shanchol, Euvichol, and EuvicholPlus and two-component Euvichol-S were based on technology developed at the International Vaccine Institute. EuBiologics is the commercial manufacturer of Euvichol, EuvicholPlus, and...
Euvichol-S.
Cita:Zhong Nan Da Xue Xue Bao Yi Xue Ban 2024 Jan 28; 49 (1) : 122-127.
Autor/es:Zhou, Lingyan (a) Yin, Xiaocheng (b)
institución:(a) Department of Pediatrics, First Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang Hunan 421600, China. 225085713@qq.com. (b) Department of Pediatrics, First Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang Hunan 421600, China. xcyin108@sina.com.