Impact of FilmArray respiratory panel test for hospitalized pediatric respiratory tract infection in Taiwan

Fuente:Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: Given its limited adoption, the tool may not aid clinicians in the diagnosis of mild cases.

Cita:Medicine (Baltimore) 2024 Mar 29; 103 (13) : e37320.

Autor/es:Hu, Jen-Jan (a)
Wang, Da-Ling (b)

institución:(a) Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan.
(b) Department of Pediatrics, Taiwan Adventist Hospital, Taipei, Taiwan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/MD.0000000000037320

Rapid and long-lasting efficacy of high-dose ambroxol therapy for neuronopathic Gaucher disease

Fuente:Molecular Genetics & Genomic Medicine

Tipo de trabajo:Revisión

Extracto: These results highlight the long-lasting effect of ambroxol-based chaperone therapy for patients with an expanding spectrum of mutations in GBA1.

Claves:Gaucher disease, ambroxol, chaperone, genotype, glucocerebrosidase, therapy

Cita:Mol Genet Genomic Med 2024 Apr; 12 (4) : e2427.

Autor/es:Higashi, Kanako (a)
Sonoda, Yuri (b)

institución:(a) Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
(b) Emergency and Critical Care Center, Kyushu University Hospital, Fukuoka, Japan.

Conflicto:The authors declare that there is no conflict of interest concerning this work.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/mgg3.2427

Prognostic significance of systemic immune-inflammation index in patients with nonfunction pancreatic neuroendocrine tumor undergoing surgical resection.

Fuente:Cancer Medicine

Extracto: In conclusion, our study revealed that a higher SII level was associated with tumor-related features (larger tumor size and advanced grade) and subsequent shorter DFS and OS in patients with nonfunctioning pNETs. These results indicated that the SII could serve as an efficient prognostic biomarker for nonfunctioning pNETs.

Claves:inflammation, nonfunction, pancreatic neuroendocrine tumor, prognosis, systemic immune‐inflammation index

Cita:Cancer Med 2024 Apr; 13 (7) : e7114.

Autor/es:Chen, Guanhua (a)
Liu, Li (b)

institución:(a) Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
(b) Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Conflicto:The authors have no relevant financial or nonfinancial interests to disclose, and informed consent was obtained from all individual participants included in the study.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/cam4.7114

Added value of whole-exome and RNA sequencing in advanced and refractory cancer patients with no molecular-based treatment recommendation based on a 90-gene panel.

Fuente:Cancer Medicine

Extracto: In advanced and refractory cancer patients in whom no MBTR was recommended from TGP/aCGH, WES/RNA-Seq allowed to identify more alterations which may in turn, in a limited fraction of patients, lead to new MBTR.

Claves:RNA‐sequencing, cancer biology, cancer management, gene panel, molecular tumor board, precision oncology, targeted therapy, whole exome sequencing

Cita:Cancer Med 2024 Apr; 13 (7) : e7115.

Autor/es:Dufresne, Armelle (a)
Attignon, Valéry (b)

institución:(a) Department of Medical Oncology, Centre Léon Bérard, Lyon, France.
(b) Platform of Cancer Genomics, Centre Léon Bérard, Lyon, France.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1002/cam4.7115

Feasibility and Impact Assessment of a Food Insecurity Protocol in a Large Urban Pediatric Primary Care Network.

Fuente:Journal of Primary Care & Community Health

Tipo de trabajo:Revisión

Extracto: Out of 42 clinicians invited to complete the survey, 35 completed responses. All respondents reported universal screening for FI (100%) at routine examinations, 80% reported frequently electronically documenting FI in medical records, and 91% of clinicians reported frequently referring families who screened positive for FI to at least one FI resource, with 24% reporting that resources met families' needs. Open-ended responses revealed increased awareness of FI prevalence and of patient experiences in households experiencing FI, increased satisfaction with clinical management of FI, but also concerns around having limited clinical time to do the protocol and the usefulness and accessibility of referred resources. In conclusion, implementing this pilot FI protocol was feasible, but clinicians perceived limited impact of the protocol on alleviating FI and desired more robust intervention options. Further improvements include shifting the burden of performing the protocol away from the clinician, such as by streamlining the protocol or identifying a resource staff member, and establishing more accessible and effective FI interventions such as "Food as Medicine" offerings in partnership with community organizations.

Claves:food as medicine, food insecurity, pediatrics, primary care, social determinants of health

Cita:J Prim Care Community Health 2024 Jan-Dec; 15 : 21501319241236009.

Autor/es:Kim, Noah (a)
Fischer, Laura (b)

institución:(a) Children's National Hospital, Washington, DC, USA.
(b) Children's National Hospital, Washington, DC, USA.

Conflicto:Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1177/21501319241236009

Learning with our peers: peer-led versus instructor-led debriefing for simulated crises, a randomized controlled trial.

Fuente:Korean Journal of Anesthesiology

Tipo de trabajo:Estudio aleatorizado y controlado

Extracto: Peer-led debriefing was as effective as instructor-led debriefing at improving undergraduate medical students' non-technical skill performance in simulated crisis situations. Peer debriefers also improved their simulated clinical skills. The peer debriefing model is a feasible alternative to the traditional, costlier instructor model.

Claves:Critical care, Education, Feedback, Peer group, Professional competence, Simulation training

Cita:Korean J Anesthesiol 2024 Apr; 77 (2) : 265-272.

Autor/es:Jaffrelot, Morgan (a)
Boet, Sylvain (b)

institución:(a) University of Ottawa Skills and Simulation Center and Academy for Innovation in Medical Education, University of Ottawa, Ottawa, ON, Canada.
(b) Simulation Center, University of Western Brittany and University Hospital of Brest, Brest, France.

Conflicto:Conflicts of Interest No potential conflict of interest relevant to this article was reported.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Corea del Sur

Sitio web:http://dx.doi.org/10.4097/kja.23317

IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.

Fuente:The Journal of Clinical Investigation

Extracto: Hence, cytokine inhibition represents a logical strategy to prevent endothelial injury, thereby preserving humoral immunity after immunotherapy.

Claves:Bone marrow transplantation, Cytokines, Immunoglobulins, Transplantation

Cita:J Clin Invest 2024 Apr 1; 134 (7)

Autor/es:Zhang, Ping (a)
Fleming, Peter (b)

institución:(a) Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
(b) QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1172/JCI174184

ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells.

Fuente:Endocrine Regulations

Extracto: The results of the present study demonstrate that hypoxia affected the expression of homeobox genes MEIS1, MEIS2, MEIS3, LHX1, LHX2, LHX6, SPAG4, and NKX3-1 in U87MG glioblastoma cells in gene-specific manner and that the sensitivity of all studied genes to hypoxia condition is mediated by ERN1, the major pathway of the endoplasmic reticulum stress signaling, and possibly contributed to the control of glioblastoma growth. A fundamentally new results of this work is the establishment of the fact regarding the dependence of hypoxic regulation of SPAG4 gene expression on ER stress, in particular ERN1, which is associated with suppression of cell proliferation and tumor growth.

Claves:ERN1 knockdown, U87MG glioblastoma cells, homeobox genes, hypoxia, mRNA expression

Cita:Endocr Regul 2024 Jan 1; 58 (1) : 47-56.

Autor/es:Krasnytska, Daria A (a)
Khita, Olena O (b)

institución:(a) Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
(b) Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Ukraine.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Alemania

Sitio web:http://dx.doi.org/10.2478/enr-2024-0006

Transient 2:1 Atrioventricular Block with Peri-Conduction System Pacing After Leadless Pacemaker Implantation.

Fuente:Texas Heart Institute Journal

Extracto: Further study of techniques, limitations, and complications related to intentional right ventricular leadless conduction system pacing is warranted.

Claves:Electrophysiology, atrioventricular block, heart conduction system, pacemaker, artificial

Cita:Tex Heart Inst J 2024 Jan 1; 51 (1)

Autor/es:Najjar, Salim N (a)
Bruno, Michael A (b)

institución:(a) Department of Medicine, Baylor College of Medicine, Houston, Texas.
(b) Department of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine, Houston, Texas.

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.14503/THIJ-23-8268

Exploring ex vivo biofilm dynamics: consequences of low ampicillin concentrations on the human oral microbiome.

Fuente:Npj Biofilms and Microbiomes

Extracto: Overall, the results highlight the potential of using the model to further our understanding of ecological and evolutionary forces driving antimicrobial resistance in oral microbiomes.

Cita:NPJ Biofilms Microbiomes 2024 Apr 2; 10 (1) : 37.

Autor/es:Brar, N K (a)
Dhariwal, A (b)

institución:(a) Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
(b) Institute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41522-024-00507-7

Conserved methylation signatures associate with the tumor immune microenvironment and immunotherapy response.

Fuente:Genome Medicine

Extracto: Our findings demonstrated that the methylation signatures of distinct biological processes are associated with immune activity in the cancer microenvironment and predict immunotherapy response.

Claves:DNA methylation signature, DNA-binding motifs, Determinant genes, Immunotherapy response

Cita:Genome Med 2024 Apr 2; 16 (1) : 47.

Autor/es:Qin, Qingqing (a)
Zhou, Ying (b)

institución:(a) Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, 361003, China.
(b) School of Medicine, National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361102, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13073-024-01318-3

Longitudinal associations of screen time, physical activity, and sleep duration with body mass index in U.S. youth.

Fuente:The International Journal of Behavioral Nutrition and Physical Activity

Extracto: One-year longitudinal associations between screen time and BMI may depend on form of screen time, what behavior it replaces (physical activity or sleep), and participant sex. The alternative statistical approaches yielded somewhat different results. Experimental manipulation of screen time and investigation of biopsychosocial mechanisms underlying the observed sex differences will allow for causal inference and can inform interventions.

Claves:ABCD study, Movement behaviors, Obesity, Youth

Cita:Int J Behav Nutr Phys Act 2024 Apr 2; 21 (1) : 35.

Autor/es:Zink, Jennifer (a)
Booker, Robert (b)

institución:(a) Division of Cancer Control and Population Sciences, Behavioral Research Program, Health Behaviors Research Branch, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA. jennifer.zink@nih.gov.
(b) Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL, 60611, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12966-024-01587-6

The interaction of inflammasomes and gut microbiota: novel therapeutic insights.

Fuente:Cell Communication and Signaling Ccs

Extracto: Additionally, we introduce novel biologics and antagonists, such as inhibitors of IL-1β and inflammasomes, as therapeutic strategies for treating gastrointestinal disorders when inflammasomes are dysregulated or the composition of gut microbiota changes.

Claves:Canonical, Dysregulation, Gut microbiota, Inflammasome, Non-canonical

Cita:Cell Commun Signal 2024 Apr 2; 22 (1) : 209.

Autor/es:Manshouri, Shirin (a)
Seif, Farhad (b)

institución:(a) Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Valiasr St, Niayesh Intersection, Tehran, 1995614331, Iran.
(b) Department of Photodynamic Therapy, Medical Laser Research Center, Academic Center for Education, Culture, and Research (ACECR), Tehran, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12964-024-01504-1

The management of heart failure cardiogenic shock: an international RAND appropriateness panel.

Fuente:Critical Care (london, England)

Tipo de trabajo:Consenso

Extracto: This study has highlighted several areas of practice where large-scale prospective registries and clinical trials in the HF-CS population are urgently needed to reliably inform clinical practice and the synthesis of future societal HF-CS guidelines.

Claves:Cardiogenic, Decompensated heart failure, Haemodynamic, RAND, Shock

Cita:Crit Care 2024 Apr 2; 28 (1) : 105.

Autor/es:Williams, Stefan (a)
Kalakoutas, Antonis (b)

institución:(a) Perioperative Medicine Department, Barts Heart Centre, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
(b) Perioperative Medicine Department, Barts Heart Centre, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.

Conflicto:S.O. reports speakers fees from Vygon, Medtronic, Sonosite, and GE healthcare. S.C.O. reports receipt of institutional research and study funds from Novartis Pharma GmbH, as well as institutional research, study and educational grants, speaker fees, advisory board fees and travel cost reimbursement from Abiomed. M.F. reports receipt of a travel grant from Abbott, speaking fees and collaborations from Novartis, Boehringer,... Astra-Zeneca, Bayer, Orion Pharma, Vifor. The other authors report no conflicts.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13054-024-04884-5

Association of factors with childhood asthma and allergic diseases using latent class analysis.

Association of factors with childhood asthma and allergic diseases using latent class analysis.

Fuente:Scientific Reports

Extracto: Multifactorial-LCA mother-clusters may characterize associations of children's health outcomes and care, adjusting for interrelationships.

Claves:Allergic disease, Asthma, Child health determinants, Child health outcomes, Latent class analysis

Cita:Sci Rep 2024 Mar 22; 14 (1) : 6874.

Autor/es:To, Teresa (a)
Borkhoff, Cornelia M (b)

institución:(a) Child Health Evaluative Sciences, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay St, Toronto, ON, M5G 0A4, Canada. teresa.to@sickkids.ca.
(b) Division of Paediatric Medicine and the Paediatric Outcomes Research Team (PORT), Hospital for Sick Children, Toronto, ON, Canada.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-56805-9

Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections.

Characterisation of Plasmodium vivax lactate dehydrogenase dynamics in P. vivax infections.

Fuente:Communications Biology

Extracto: vivax biology and will facilitate the improvement of PvLDH-based diagnostic tools.

Cita:Commun Biol 2024 Mar 22; 7 (1) : 355.

Autor/es:Cao, Pengxing (a)
Kho, Steven (b)

institución:(a) School of Mathematics and Statistics, University of Melbourne, Melbourne, VIC, Australia.
(b) Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-05956-6

Association of in utero HIV exposure with child brain structure and language development

Association of in utero HIV exposure with child brain structure and language development

Fuente:Bmc Medicine

Tipo de trabajo:Estudio de cohortes

Extracto: In this cohort study, exposure to HIV during pregnancy was associated with altered cortical structure in early life. Our findings indicate that differences in cortical thickness development in the prefrontal region in children who are HEU may be a pathway leading to language impairment. Longitudinal studies are needed to determine the lasting impact.

Claves:Antiretroviral therapy, Brain structure, HIV, Language, Magnetic resonance imaging, Neurodevelopment

Cita:BMC Med 2024 Mar 22; 22 (1) : 129.

Autor/es:Wedderburn, Catherine J (a)
Yeung, Shunmay (b)

institución:(a) Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. catherine.wedderburn@uct.ac.za.
(b) Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK. catherine.wedderburn@uct.ac.za.

Conflicto:DJS has received research grants and/or consultancy honoraria from Discovery Vitality, Johnson & Johnson, Kanna, L’Oreal, Lundbeck, Orion, Sanofi, Servier, Takeda, and Vistagen. The other authors declare no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12916-024-03282-6

Serum cholesterol level as a predictive biomarker for prognosis of Neuroblastoma.

Serum cholesterol level as a predictive biomarker for prognosis of Neuroblastoma.

Fuente:Bmc Pediatrics

Extracto: We found that serum Tchol level, a clinical biomarker, is a risk factor for recurrence and death among the children with NB. The serum Tchol level could significantly increase the accuracy of the prediction for NB prognosis.

Claves:Neuroblastoma, Predictive biomarker, Prognosis, Serum cholesterol

Cita:BMC Pediatr 2024 Mar 22; 24 (1) : 205.

Autor/es:Min, Jie (a)
Wu, Yi (b)

institución:(a) Children's Hospital of Soochow University, Pediatric Research Institute of Soochow University, Suzhou, 215123, Jiangsu, China.
(b) Children's Hospital of Soochow University, Pediatric Research Institute of Soochow University, Suzhou, 215123, Jiangsu, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04700-7

Association of maternal nutritional status and small for gestational age neonates in peri-urban communities of Karachi, Pakistan: findings from the PRISMA study.

Association of maternal nutritional status and small for gestational age neonates in peri-urban communities of Karachi, Pakistan: findings from the PRISMA study.

Fuente:Bmc Pregnancy and Childbirth

Tipo de trabajo:Revisión

Extracto: Maternal nutritional status as indicated by BMI and MUAC are strongly associated with adverse pregnancy outcomes including SGA, LGA and LBW. Although MUAC and BMI are widely used to determine maternal nutritional status, they have poor predictive ability for newborn size. Further research is needed to identify other tools or a combination of tools to better predict adverse birth outcomes in resource-limited settings and plan interventions.

Claves:Body mass index, Low birth weight, Maternal nutrition, Mid-upper arm circumference, Small-for-gestational age

Cita:BMC Pregnancy Childbirth 2024 Mar 22; 24 (1) : 214.

Autor/es:Ambreen, Sobia (a)
Yazdani, Nida (b)

institución:(a) Aga Khan University, Karachi, Pakistan.
(b) Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12884-024-06420-3

Correlation between dental and skeletal maturity in Korean children based on dental maturity percentile: a retrospective study.

Correlation between dental and skeletal maturity in Korean children based on dental maturity percentile: a retrospective study.

Fuente:Bmc Oral Health

Extracto: A correlation between dental and skeletal maturity, as well as advanced skeletal maturity in the advanced dental maturity group, was observed. Using percentile curves to determine dental maturity may aid in assessing skeletal maturity, with potential applications in orthodontic diagnosis and treatment planning.

Claves:Cervical vertebral maturation method, Demirjian method, Dental maturity, Dental maturity percentile, Skeletal maturity

Cita:BMC Oral Health 2024 Mar 22; 24 (1) : 377.

Autor/es:Ong, Seung-Hwan (a)
Kim, Hyuntae (b)

institución:(a) Department of Pediatric Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
(b) Department of Pediatric Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12903-024-04015-0