Immortalized hepatocyte-like cells: A competent hepatocyte model for studying clinical HCV isolate infection.

Immortalized hepatocyte-like cells: A competent hepatocyte model for studying clinical HCV isolate infection.

Fuente:Plos One

Extracto: The insights from HCV-cell culture model hold promise for understanding disease pathogenesis and novel anti-HCV development.

Cita:PLoS One 2024; 19 (5) : e0303265.

Autor/es:Pewkliang, Yongyut (a)
Thongsri, Piyanoot (b)

institución:(a) Faculty of Medicine Ramathibodi Hospital, Program in Translational Medicine, Mahidol University, Rama VI Road, Rajathevi, Bangkok, Thailand.
(b) Faculty of Medicine Ramathibodi Hospital, Program in Translational Medicine, Mahidol University, Rama VI Road, Rajathevi, Bangkok, Thailand.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303265

Is refractive error a factor affecting scoliosis?

Fuente:Plos One

Extracto: Refractive errors did not correlate with the development of scoliosis. However, BMI, living in rural areas and older age did correlate with the development of scoliosis.

Cita:PLoS One 2024; 19 (5) : e0303324.

Autor/es:Cai, Jianru (a)
Zhou, Yue (b)

institución:(a) Department of Ophthalmology, Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
(b) Department of Ophthalmology, Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303324

Baseline characteristics of SARS-CoV-2 vaccine non-responders in a large population-based sample.

Fuente:Plos One

Extracto: Consistent with smaller targeted studies, a large epidemiologic cohort bears the same conclusion and demonstrates immunocompromised, cancer, kidney disease, and the number of diseases are associated with vaccine non-response. This study suggests that those individuals, with chronic diseases with the potential to affect their immune system response, may need increased doses or repeated doses of COVID-19 vaccines to develop a protective antibody level.

Cita:PLoS One 2024; 19 (5) : e0303420.

Autor/es:Yaseen, Ashraf (a)
DeSantis, Stacia M (b)

institución:(a) The University of Texas Health Science Center at Houston, School of Public Health in Houston, Houston, TX, United States of America.
(b) The University of Texas Health Science Center at Houston, School of Public Health in Houston, Houston, TX, United States of America.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303420

Viral load suppression and its predictor among HIV seropositive people who receive enhanced adherence counseling at public health institutions in Bahir Dar, Northwest Ethiopia. Retrospective follow-up study.

Fuente:Plos One

Extracto: ND RECOMMENDATION: Most importantly, this study found that most people had suppressed viral loads after receiving enhanced adherence counseling. Significant predictors of viral load suppression included recurrent OI, length of stay on EAC, daily ARV dosing regimen, baseline viral load, and religion. Clients with a high baseline viral load and those who experience recurring opportunistic infections should get extra care during EAC sessions.

Cita:PLoS One 2024; 19 (5) : e0303243.

Autor/es:Belete, Minyichil Birhanu (a)
Bitew, Abebayehu (b)

institución:(a) Department of Pediatrics and Child Health Nursing, School of Health Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
(b) Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303243

An evaluation of the impact of social and structural determinants of health on forgone care during the COVID-19 pandemic in Baltimore, Maryland.

Fuente:Plos One

Extracto: Finally, additional research is needed to better understand how healthcare access and utilization practices have changed during versus before the pandemic.

Cita:PLoS One 2024; 19 (5) : e0302064.

Autor/es:Meyer, Diane (a)
Lowensen, Kelly (b)

institución:(a) Center for Infectious Disease and Nursing Innovation, Johns Hopkins University, School of Nursing, Baltimore, MD, United States of America.
(b) Center for Health Security, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, United States of America.

Conflicto:S. Mehta receives material support from Abbott Diagnostics. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The authors do not have any other conflicts of interest to disclose

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0302064

Assessing the impact of obesity interventions in the early years

Assessing the impact of obesity interventions in the early years

Fuente:Bmj Open

Tipo de trabajo:Revisión sistemática

Extracto: UK evidence was limited but some interventions showed promising results in promoting healthy growth. As part of a programme of policies, interventions in the early years may have an important role in reducing the risk of childhood obesity. PROSPERO REGISTRATION NUMBER: CRD42021290676.

Claves:Community child health, NUTRITION & DIETETICS, Obesity

Cita:BMJ Open 2024 May 13; 14 (5) : e076479.

Autor/es:Michalopoulou, Semina (a)
Sifaki, Maria (b)

institución:(a) Great Ormond Street Institute of Child Health, University College London, London, UK.
(b) Institute of Epidemiology and Health Care, University College London, London, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-076479

Obesity and lipid indices as predictors of depressive symptoms in middle-aged and elderly Chinese

Obesity and lipid indices as predictors of depressive symptoms in middle-aged and elderly Chinese

Fuente:Bmc Psychiatry

Tipo de trabajo:Estudio de cohortes

Extracto: The research indicates that in the middle-aged and elderly Chinese, most obesity- and lipid-related indices have statistical significance in predicting depressive symptoms, but the accuracy of these indicators in prediction is relatively low and may not be practical predictors.

Claves:Anthropometric indicators, Cohort study, Depressive symptoms, Lipid-related index, Middle-aged and elderly, Obesity

Cita:BMC Psychiatry 2024 May 10; 24 (1) : 351.

Autor/es:Zhang, Xiaoyun (a)
Wang, Ying (b)

institución:(a) Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China.
(b) Department of Graduate School, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu City, An Hui Province, People's Republic of China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12888-024-05806-z

Paediatric Atopic Dermatitis: The Unexpected Impact on Life with a Specific Look at the Molecular Level.

Paediatric Atopic Dermatitis: The Unexpected Impact on Life with a Specific Look at the Molecular Level.

Fuente:International Journal of Molecular Sciences

Extracto: Drawing on a comprehensive review of the literature in PubMed/MedLine, our review offers an in-depth exploration of both the psychosocial impacts of AD and the molecular processes that contribute to this disorder.

Claves:anxiety, atopic dermatitis, cognitive dysfunction, quality of life, school performance

Cita:Int J Mol Sci 2024 Apr 27; 25 (9)

Autor/es:Artusa, Silvia (a)
Mazzuca, Giorgia (b)

institución:(a) Pediatric Clinic, Department of Surgical Sciences, Dentistry, Pediatrics and Gynecology, University of Verona, 37126 Verona, Italy.
(b) Pediatric Clinic, Department of Surgical Sciences, Dentistry, Pediatrics and Gynecology, University of Verona, 37126 Verona, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094778

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies.

Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies.

Fuente:Scientific Reports

Extracto: We propose that during early pregnancy, complicated by subsequent SPTB, modest elevation of serum AAT associates with SPTB.

Cita:Sci Rep 2024 May 11; 14 (1) : 10819.

Autor/es:Tissarinen, Pinja (a)
Tiensuu, Heli (b)

institución:(a) Research Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
(b) Research Unit of Clinical Medicine and Medical Research Center, Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, University of Oulu, PO Box 5000, 90014, Oulu, Finland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61206-z

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.

Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder.

Fuente:Communications Biology

Extracto: These results revealed previously unknown metabolic phenotypes, identified new developmental states of the metabolic correlation network, and underscored the role of mitochondrial functional changes, purine metabolism, and purinergic signaling in autism spectrum disorder.

Cita:Commun Biol 2024 May 10; 7 (1) : 536.

Autor/es:Lingampelly, Sai Sachin (a)
Naviaux, Jane C (b)

institución:(a) The Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA, 92103-8467, USA.
(b) Department of Medicine, University of California, San Diego School of Medicine, San Diego, CA, 92103-8467, USA.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s42003-024-06102-y

Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.

Herpes simplex encephalitis due to a mutation in an E3 ubiquitin ligase.

Fuente:Nature Communications

Extracto: Moreover, the introduction of p.R841H in wild type cells reduced such immunity, suggesting that this mutation is linked to the observed phenotypes.

Cita:Nat Commun 2024 May 10; 15 (1) : 3969.

Autor/es:Bibert, Stéphanie (a)
Quinodoz, Mathieu (b)

institución:(a) Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne, Switzerland.
(b) Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, Switzerland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48287-0

Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India.

Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India.

Fuente:Human Genomics

Extracto: We developed a flexible and scalable assay to reliably detect genetic causes of 29 common LSDs in India. The assay consolidates the detection of multiple variant types in multiple sample types while having improved diagnostic yield at same or lower cost compared to current clinical paradigm.

Claves:Cost effective, Diagnostic yield, Dried blood spot, Lysosomal storage disorders, smMIP probes

Cita:Hum Genomics 2024 May 10; 18 (1) : 46.

Autor/es:Sheth, Harsh (a)
Nair, Aadhira (b)

institución:(a) FRIGE Institute of Human Genetics, FRIGE House, Jodhpur Village Road, Satellite, Ahmedabad, India, 380015. harsh.sheth@frige.co.in.
(b) FRIGE Institute of Human Genetics, FRIGE House, Jodhpur Village Road, Satellite, Ahmedabad, India, 380015.

Conflicto:Harsh Sheth, Aadhira Nair and Jayesh Sheth are named as inventors on the patent describing the use of smMIP based target capture and associated computational analyses for simultaneous detection of single nucleotide variants and copy number variants in germline DNA. The patent is held by FRIGE’s Institute of Human Genetics (Patent ID: TEMP/E-1/30548/2022-MUM, submitted in May 2022). All other authors... rs declare that they have no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s40246-024-00613-9

D-Bifunctional Protein Deficiency Diagnosis-A Challenge in Low Resource Settings

D-Bifunctional Protein Deficiency Diagnosis-A Challenge in Low Resource Settings

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: We advocate for using molecular diagnosis in critically ill newborns and infants to improve care, reduce healthcare costs, and allow for familial counseling.

Claves:D-bifunctional protein deficiency, neonatal hypotonia, neonatal seizures, peroxisomal disorders, whole-exome sequencing

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Ognean, Maria Livia (a)
Mutică, Ioana Bianca (b)

institución:(a) Faculty of Medicine, Lucian Blaga University, 550025 Sibiu, Romania.
(b) Neonatology Department, Clinical County Emergency Hospital, 550245 Sibiu, Romania.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094924

The Influence of a Genetic Variant in CCDC78 on LMNA-Associated Skeletal Muscle Disease.

Fuente:International Journal of Molecular Sciences

Extracto: Taken together, our findings suggest that a relatively common variant in CCDC78 can impart profound muscle pathology in combination with a LMNA mutation and accounts for variability in skeletal muscle disease phenotypes.

Claves:core myopathy, genetic modifiers, laminopathy, lamins, limb–girdle muscular dystrophy

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Mohar, Nathaniel P (a)
Cox, Efrem M (b)

institución:(a) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.
(b) Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094930

Bridging Genetic Insights with Neuroimaging in Autism Spectrum Disorder-A Systematic Review.

Fuente:International Journal of Molecular Sciences

Extracto: This review shows that specific genetic variants and altered patterns of gene expression in individuals with ASD may have an effect on brain circuits associated with face processing and social cognition, and contribute to excitation-inhibition imbalances and to anomalies in brain volumes.

Claves:autism spectrum disorder, brain imaging, electroencephalography, functional magnetic resonance imaging, magnetic resonance imaging, neurogenetics, neuroimaging, systematic review

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Vilela, Joana (a)
Rasga, Célia (b)

institución:(a) Departamento de Promoção da Saúde e Doenças Não Transmissíveis, Instituto Nacional de Saúde Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal.
(b) BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, C8, 1749-016 Lisboa, Portugal.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094938

Evaluation of the Effect of Parenting Style and Parental Mealtime Actions on the Eating Behavior of Children with Epilepsy.

Evaluation of the Effect of Parenting Style and Parental Mealtime Actions on the Eating Behavior of Children with Epilepsy.

Fuente:Nutrients

Extracto: Owing to the chronic disease, the effects of parent-child interaction on the child's eating behavior in the epilepsy group differed from those of healthy children reported in the literature.

Claves:childhood epilepsy, children, diet quality, eating behavior, growth, parental eating-time actions, parenting practices, parenting style, parents, parents’ mealtime behaviors

Cita:Nutrients 2024 May 2; 16 (9)

Autor/es:Balcı, Tutku (a)
Çakır Biçer, Nihan (b)

institución:(a) Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Atasehir, Istanbul, Turkey.
(b) Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Içerenköy Mahallesi Kayisdagi Caddesi No. 32, 34752 Atasehir, Istanbul, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091384

Antibiotic impregnated catheters and intrathecal antibiotics for CSF shunt infection prevention in children undergoing low-risk CSF shunt surgery.

Antibiotic impregnated catheters and intrathecal antibiotics for CSF shunt infection prevention in children undergoing low-risk CSF shunt surgery.

Fuente:Bmc Pediatrics

Tipo de trabajo:Estudio de cohortes

Extracto: In a large, observational multicenter cohort, IT antibiotics and AICs do not confer a statistically significant risk reduction compared to standard care for pediatric patients undergoing low-risk (i.e., initial or revision) shunt surgeries.

Claves:Antibiotic impregnated catheter, CSF, Hydrocephalus, Infection

Cita:BMC Pediatr 2024 May 11; 24 (1) : 325.

Autor/es:Podkovik, Stacey (a)
Zhou, Chuan (b)

institución:(a) Department of Neurological Surgery, Riverside University Health Sciences Medical Center, Riverside, CA, USA.
(b) Center for Child Health, Seattle Children's Research Institute, Behavior, and Development, Seattle, WA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04798-9

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis.

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis.

Fuente:Journal of Neuroinflammation

Extracto: These findings may lead to new therapeutic approaches targeting HIF1A in the development of TAMG.

Claves:Hypoxia-inducible factor-1, Myasthenia gravis, Thymoma, Thymus

Cita:J Neuroinflammation 2024 May 11; 21 (1) : 126.

Autor/es:Altınönder, İlayda (a)
Kaya, Mustafa (b)

institución:(a) Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, 34093, Turkey.
(b) Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, 34093, Turkey.

Conflicto:None of the authors has any potential financial conflict of interest related to this manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12974-024-03095-7

Adults with cerebral palsy exhibit uncharacteristic cortical oscillations during an adaptive sensorimotor control task.

Adults with cerebral palsy exhibit uncharacteristic cortical oscillations during an adaptive sensorimotor control task.

Fuente:Scientific Reports

Extracto: These results may suggest that alterations in the theta and gamma cortical oscillations play a role in the altered hand dexterity and uncharacteristic adaptive sensorimotor control noted in adults with CP.

Claves:Brain imaging, Dexterity, Hand, Magnetoencephalography, Neuroimaging

Cita:Sci Rep 2024 May 11; 14 (1) : 10788.

Autor/es:Hinton, Erica H (a)
Busboom, Morgan T (b)

institución:(a) Institute for Human Neuroscience, Boys Town National Research Hospital, Omaha, NE, USA.
(b) Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61375-x

Best practices for the management of febrile seizures in children.

Best practices for the management of febrile seizures in children.

Fuente:Italian Journal of Pediatrics

Extracto: Our thorough literature search resulted in a compilation of references, with carefully selected papers thoughtfully integrated into this review.

Claves:Children, Febrile seizure, Management, Prognostic factors, Recommendations for caregivers, Red flags

Cita:Ital J Pediatr 2024 May 12; 50 (1) : 95.

Autor/es:Ferretti, Alessandro (a)
Riva, Antonella (b)

institución:(a) Pediatrics Unit, Neurosciences, Mental Health and Sensory Organ (NESMOS) Department, Faculty of Medicine and Psychology, S. Andrea Hospital, Sapienza University, via di Grottarossa 1035/1039, Rome, 00189, Italy. alessandro.ferretti@uniroma1.it.
(b) IRCCS Giannina Gaslini, Genoa, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13052-024-01666-1