Burden and outcome of respiratory morbidities among children and adolescents with sickle cell disease-A retrospective review of emergency presentations in some Nigerian tertiary institutions.

Burden and outcome of respiratory morbidities among children and adolescents with sickle cell disease-A retrospective review of emergency presentations in some Nigerian tertiary institutions.

Fuente:Plos One

Tipo de trabajo:Revisión

Extracto: Sickle cell disease is a major contributor to hospitalization among Nigerian children and adolescents, with high respiratory morbidity and mortality. Pneumonia and acute chest syndrome were associated with mortality, andthe highest risk of death within the first 72 hours.

Cita:PLoS One 2024; 19 (5) : e0303323.

Autor/es:Ibraheem, Rasheedat Mobolaji (a)
Abdulkadir, Mohammed Baba (b)

institución:(a) Department of Paediatrics & Child Health, University of Ilorin and University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
(b) Department of Paediatrics & Child Health, University of Ilorin and University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303323

Symptoms of depression among outpatients with suspected COVID-19 in metropolitan Local Government Areas of Kaduna State, Nigeria.

Fuente:Plos One

Extracto: Symptoms of depression were commoner among respondents who presented with symptoms of Acute Respiratory Infection (ARI) at the Outpatient Department (OPD). However, further explanatory research is needed to establish causality.

Cita:PLoS One 2024; 19 (5) : e0288567.

Autor/es:Umeh, Gregory C (a)
Cleenwerck de Kiev, Laurent (b)

institución:(a) World Health Organization, Kaduna, Nigeria.
(b) International Faculty Coordinator, Euclid University, Banjul, The Gambia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0288567

Scoping review of exposure questionnaires and surveys in interstitial lung disease.

Scoping review of exposure questionnaires and surveys in interstitial lung disease.

Fuente:Bmj Open Respiratory Research

Tipo de trabajo:Revisión

Extracto: Designing a robust ILD-specific questionnaire should include an evidence-based and relevance-based approach to exposure derivation, with clinicians and patients involved in its development and tested to ensure relevance and feasibility.

Claves:interstitial fibrosis, occupational lung disease

Cita:BMJ Open Respir Res 2024 May 15; 11 (1)

Autor/es:Barnes, Hayley (a)
Elmrayed, Seham (b)

institución:(a) School of Translational Medicine, Monash University, Melbourne, Victoria, Australia Hayley.Barnes@monash.edu.
(b) Monash Centre for Occupational and Environmental Health, Monash University, Melbourne, Victoria, Australia.

Conflicto:Competing interests: HB reports travel support from Boehringer Ingelheim, United Therapeutics, and Janssen, outside the submitted work. CTL reports grant support from the Pulmonary Fibrosis Foundation Scholar Award. CEP reports grant support from CIHR, Worksafe BC and Alberta Health, and consulting fees from Health Canada, and the International Agency for Research on Cancer (WHO). MLS reports grant support from NIH,... consulting fees from Boehringer Ingelheim, Orinove and Roche, and travel support from Boehringer Ingelheim, outside the submitted work. KAJ reports grant support from Three Lakes Foundation, consulting fees from Boehringer Ingelheim, Hoffman-La Roche, Pliant Therapeutics, Thyron SAB and Brainomix, outside the submitted work.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-002155

When to reinvite initially ineligible populations for targeted lung cancer screening?

Fuente:Bmj Open Respiratory Research

Extracto: Those with risk scores closer to the eligibility threshold, particularly people who continue to smoke, will reach eligibility in subsequent rounds while those at the lowest risk may be discharged from the programme from the outset.

Claves:Clinical Epidemiology, Lung Cancer, Mass Screening

Cita:BMJ Open Respir Res 2024 May 15; 11 (1)

Autor/es:Goodley, Patrick (a)
Crosbie, Philip A J (b)

institución:(a) Manchester Thoracic Oncology Centre, Manchester University NHS Foundation Trust, Manchester, UK.
(b) Division of Immunology, Immunity to Infection and Respiratory Medicine, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK.

Conflicto:Competing interests: RB has received honoraria for educational events by Siemens Healthineers and Cobalt Medical Imaging.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjresp-2023-002193

Impacts of human mobility on the citywide transmission dynamics of 18 respiratory viruses in pre- and post-COVID-19 pandemic years.

Impacts of human mobility on the citywide transmission dynamics of 18 respiratory viruses in pre- and post-COVID-19 pandemic years.

Fuente:Nature Communications

Extracto: Overall, mobility is most predictive of respiratory virus transmission during periods of dramatic behavioral change and at the beginning of epidemic waves.

Cita:Nat Commun 2024 May 16; 15 (1) : 4164.

Autor/es:Perofsky, Amanda C (a)
Hansen, Chelsea L (b)

institución:(a) Brotman Baty Institute for Precision Medicine, University of Washington, Seattle, WA, USA. acperof@uw.edu.
(b) Fogarty International Center, National Institutes of Health, Bethesda, MD, USA. acperof@uw.edu.

Conflicto:CLH received personal fees from Sanofi outside the submitted work. MLJ received funding as a contractor to Merck & Co. AW received clinical trial support to their institution from Pfizer, Ansun Biopharma, Allovir, and GlaxoSmithKline/Vir, personal fees from Vir and GlaxoSmithKline, and grants from Amazon outside the submitted work. JAE received grants from Pfizer, AstraZeneca, Merck, and GlaxoSmithKline and personal... fees from Pfizer, AstraZeneca, GlaxoSmithKline, Merck, Meissa Vaccines, Moderna, and Sanofi Pasteur outside the submitted work. HYC received personal fees from Ellume, the Bill and Melinda Gates Foundation, Vindico, Abbvie, Merck, and Pfizer, research funding from Gates Ventures and Sanofi Pasteur, and support and reagents from Ellume and Cepheid outside the submitted work. CV received honoraria from Elsevier outside the submitted work. All other authors declare they have no competing interests.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48528-2

Tobacco control policies and respiratory conditions among children presenting in primary care.

Tobacco control policies and respiratory conditions among children presenting in primary care.

Fuente:Npj Primary Care Respiratory Medicine

Extracto: Our findings need to be interpreted with caution due to substantial uncertainty in the pre-legislation outcome trends.

Cita:NPJ Prim Care Respir Med 2024 May 16; 34 (1) : 11.

Autor/es:Faber, Timor (a)
Coffeng, Luc E (b)

institución:(a) Division of Neonatology, Department of Neonatal and Paediatric Intensive Care, Erasmus MC Sophia Children's Hospital, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
(b) Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41533-024-00369-8

Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping.

Identification of Mycobacterium abscessus using the peaks of ribosomal protein L29, L30 and hemophore-related protein by MALDI-MS proteotyping.

Fuente:Scientific Reports

Extracto: abscessus infections.

Cita:Sci Rep 2024 May 16; 14 (1) : 11187.

Autor/es:Takei, Satomi (a)
Teramoto, Kanae (b)

institución:(a) Department of Clinical Laboratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
(b) Department of MALDI-TOF MS Practical Application Research, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Conflicto:The Department of MALDI-TOF MS at Juntendo University Graduate School of Medicine has been endowed partially by Shimadzu Corp. (Kyoto, Japan) to develop and validate new diagnostic technology and to conduct academic research through collaborations. ST, KTe, HI, SM, TN, TK and YT belong to the Department of MALDI-TOF MS. Shimadzu Corp. provided MALDI-8020 and reagents for MALDI-MS analysis free... of cost to YT. All other authors declare no conflict of interest. The study was performed by scientifically proper methods without any bias.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61549-7

Predictive models-assisted diagnosis of AIDS-associated Pneumocystis jirovecii pneumonia in the emergency room, based on clinical, laboratory, and radiological data.

Fuente:Scientific Reports

Extracto: In conclusion, ER-based PMs using readily available data can significantly aid PCP treatment decisions in AIDS patients.

Cita:Sci Rep 2024 May 16; 14 (1) : 11247.

Autor/es:Chagas, Oscar José (a)
Gonçalves, Fabio Augusto Rodrigues (b)

institución:(a) Laboratório de Micologia Médica (LIM53), Instituto de Medicina Tropical (IMT), Faculdade de Medicina (FMUSP), Universidade de São Paulo, São Paulo, SP, Brazil. oscarchagasf@hotmail.com.
(b) Laboratório de Medicina Laboratorial (LIM03), Hospital das Clínicas da Faculdade de Medicina (HCFMUSP), Universidade de São Paulo, São Paulo, SP, Brazil.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-61174-4

Characteristics of children readmitted with severe pneumonia in Kenyan hospitals.

Characteristics of children readmitted with severe pneumonia in Kenyan hospitals.

Fuente:Bmc Public Health

Tipo de trabajo:Estudio de cohortes

Extracto: Children readmitted with severe pneumonia account for a substantial proportion of pneumonia hospitalisations and deaths. Further research is required to develop evidence-based approaches to screening, case management, and follow-up of children with severe pneumonia, prioritising those with underlying risk factors for readmission and mortality.

Claves:Adolescents, Africa, Low-and-middle-income countries, Lower respiratory tract infections, Paediatrics, Persistent pneumonia, Recurrent pneumonia

Cita:BMC Public Health 2024 May 16; 24 (1) : 1324.

Autor/es:Marangu-Boore, Diana (a)
Mwaniki, Paul (b)

institución:(a) Paediatric Pulmonology Division, Department of Paediatrics and Child Health, University of Nairobi, Nairobi, Kenya. dmarangu@uonbi.ac.ke.
(b) Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18651-2

A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients

A novel MT-ATP6 variant associated with complicated ataxia in two unrelated Italian patients

Fuente:Orphanet Journal of Rare Diseases

Tipo de trabajo:Caso clínico

Extracto: We describe a novel pathogenic mtDNA variant in MT-ATP6 associated with adult-onset ataxia, reinforcing the value of mtDNA screening within the diagnostic workflow of selected patients with late onset ataxias.

Claves:MT-ATP6, ATP synthase, Ataxia, Complex V, Cybrids, Mitochondria, OXPHOS, Oxygen consumption

Cita:Orphanet J Rare Dis 2024 May 16; 19 (1) : 200.

Autor/es:Sala, Daniele (a)
Marchet, Silvia (b)

institución:(a) Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126, Milan, Italy.
(b) Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20126, Milan, Italy.

Conflicto:The authors declare that they have no conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03212-y

Interaction of Neisseria meningitidis carrier and disease isolates of MenB cc32 and MenW cc22 with epithelial cells of the nasopharyngeal barrier.

Interaction of Neisseria meningitidis carrier and disease isolates of MenB cc32 and MenW cc22 with epithelial cells of the nasopharyngeal barrier.

Fuente:Frontiers in Cellular and Infection Microbiology

Extracto: Moreover, we found that the representative meningococcal isolates tested in this study did not damage the epithelial barrier, as shown by TEER measurement, FITC-dextran permeability assays, and expression of cell-junction components.

Claves:Neisseria meningitidis, air-liquid-interface, clonal complexes, epithelial barrier, transmigration

Cita:Front Cell Infect Microbiol 2024; 14 : 1389527.

Autor/es:Peters, Simon (a)
Mohort, Katherina (b)

institución:(a) Institute for Hygiene and Microbiology, Julius-Maximilian University Wuerzburg, Wuerzburg, Germany.
(b) Institute for Hygiene and Microbiology, Julius-Maximilian University Wuerzburg, Wuerzburg, Germany.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fcimb.2024.1389527

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.

The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps.

Fuente:Frontiers in Immunology

Extracto: Oxidative stress plays an important role in the development of CRSwNP by promoting various types of inflammation. The oxidative stress of nasal polyps comes from epithelial cells and macrophages. Antioxidant therapy may be a promising strategy for treating CRSwNP.

Claves:CRSwNP, Nrf2, macrophages, nasal epithelial cells, oxidative stress

Cita:Front Immunol 2024; 15 : 1380846.

Autor/es:Zhou, Jing (a)
Zhou, Jiao (b)

institución:(a) Department of Otolaryngology-Head & Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.
(b) Upper Respiratory Tract Laboratory of Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fimmu.2024.1380846

Investigation of epidemiological and clinical characteristics of people infected with SARS-CoV-2 during the second pandemic of COVID-19 in Chengdu, China.

Investigation of epidemiological and clinical characteristics of people infected with SARS-CoV-2 during the second pandemic of COVID-19 in Chengdu, China.

Fuente:Frontiers in Public Health

Extracto: The SARS-CoV-2 infected individuals in Chengdu, China, during the second pandemic of COVID-19 had mild clinical symptoms and a short course of disease. Furthermore, compared with the first infection, re-infection cases had mild symptoms, low incidences of complications, short fever duration, and course of disease.

Claves:COVID-19, SARS-CoV-2, clinical characteristics, epidemiological characteristics, first infection, re-infection

Cita:Front Public Health 2024; 12 : 1394762.

Autor/es:Li, Cheng (a)
Zhou, Tao (b)

institución:(a) Department of Infectious Diseases, The Third People's Hospital of Chengdu, Chengdu, China.
(b) Department of Infectious Diseases, The Third People's Hospital of Chengdu, Chengdu, China.

Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3389/fpubh.2024.1394762

Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015-2021.

Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015-2021.

Fuente:Influenza and Other Respiratory Viruses

Extracto: In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and S.p. was not associated with increased severity.

Claves:influenza virus, lower respiratory tract infections, respiratory syncytial virus

Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13303.

Autor/es:Do, Lien Anh Ha (a)
Tsedenbal, Naranzul (b)

institución:(a) New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.
(b) Department of Paediatrics, The University of Melbourne, Parkville, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/irv.13303

The Detection of Influenza Virus Before and During the COVID-19 Pandemic in Cameroon.

Fuente:Influenza and Other Respiratory Viruses

Extracto: The COVID-19 pandemic had a significant impact on the seasonal influenza by changing the seasonality of the virus and reducing its detection rates.

Claves:COVID‐19 pandemic, Cameroon, SARS‐CoV‐2, epidemiology, influenza

Cita:Influenza Other Respir Viruses 2024 May; 18 (5) : e13313.

Autor/es:Monamele, Gwladys Chavely (a)
Tsafack, Desmon Toutou (b)

institución:(a) Virology Service, Centre Pasteur of Cameroon, Yaounde, Cameroon.
(b) Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1111/irv.13313

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.

Evaluation of Acute and Convalescent Antibody Concentration Against Pneumococcal Capsular Polysaccharides for the Diagnosis of Pneumococcal Infection in Children with Community-Acquired Pneumonia.

Fuente:The Pediatric Infectious Disease Journal

Extracto: Caution is needed in interpreting antibody responses in pneumococcal infections.

Cita:Pediatr Infect Dis J 2024 Feb 1; 43 (2) : e67-e70.

Autor/es:Carter, Michael J (a)
Shrestha, Sonu (b)

institución:(a) Paediatric Intensive Care, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
(b) Oxford Vaccine Group, Department of Paediatrics, University of Oxford.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1097/INF.0000000000004185

Artificial intelligence augmented home sleep apnea testing device study (AISAP study).

Artificial intelligence augmented home sleep apnea testing device study (AISAP study).

Fuente:Plos One

Extracto: The WVU-device demonstrated good accuracy in predicting REI when compared to an approved HSAT device, even in patients with darker skin tones.

Cita:PLoS One 2024; 19 (5) : e0303076.

Autor/es:Sharma, Sunil (a)
Olgers, Kassandra (b)

institución:(a) Division of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, Morgantown, WV, United States of America.
(b) Division of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, Morgantown, WV, United States of America.

Conflicto:Sunil Sharma, M.D. is on the speaker bureau for Zoll Respicardia Inc No other COI to report

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303076

Controlling COVID-19 outbreaks in the correctional setting: A mathematical modelling study.

Fuente:Plos One

Extracto: These results have informed public health policy for respiratory pathogens in Australian correctional systems.

Cita:PLoS One 2024; 19 (5) : e0303062.

Autor/es:Bretaña, Neil Arvin (a)
Kwon, Jisoo A (b)

institución:(a) Allied Health and Human Performance, University of South Australia, Australia.
(b) Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1371/journal.pone.0303062

Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study.

Strategies to address recruitment to a randomised trial of surgical and non-surgical treatment for cancer: results from a complex recruitment intervention within the Mesothelioma and Radical Surgery 2 (MARS 2) study.

Fuente:Bmj Open

Tipo de trabajo:Estudio aleatorizado

Extracto: With bespoke support to overcome identified issues, recruitment to a challenging RCT of surgery versus no surgery in a thoracic cancer setting with a complex recruitment pathway and multiple health professional involvement is possible. TRIAL REGISTRATION NUMBER: ISRCTN ISRCTN44351742, Clinical Trials.gov NCT02040272.

Claves:Clinical Trial, ONCOLOGY, QUALITATIVE RESEARCH, Randomized Controlled Trial, Thoracic surgery

Cita:BMJ Open 2024 May 16; 14 (5) : e079108.

Autor/es:Mills, Nicola (a)
Farrar, Nicola (b)

institución:(a) Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UK nicola.mills@bristol.ac.uk.
(b) Bristol Medical School, University of Bristol Faculty of Health Sciences, Bristol, UK.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjopen-2023-079108

Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study.

Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study.

Fuente:Bmc Pulmonary Medicine

Extracto: The daily home monitoring of Fe(NO50) in asthmatic patients showed significant circadian rhythm, and the sensitivity of Fe(NO50) in evaluating the response to treatment was higher than mSpirometry. The daily and weekly variation rates of Fe(NO50) change dynamically with time, which may be used to assess the condition of asthma.

Claves:Asthma, Biomarker, FeNO50, Home monitoring, Mobile spirometry

Cita:BMC Pulm Med 2024 May 17; 24 (1) : 244.

Autor/es:Li, Hongwen (a)
Lin, Jiangtao (b)

institución:(a) Department of Geriatric Respiratory Disease, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China.
(b) Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, No 2, East Yinghua Road, Chaoyang District, Beijing, 100029, China. jiangtao_l@263.net.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12890-024-03031-8