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Apnea during moderate to deep sedation using continuous infusion of remimazolam compared to propofol and dexmedetomidine: A retrospective observational study.
Apnea during moderate to deep sedation using continuous infusion of remimazolam compared to propofol and dexmedetomidine: A retrospective observational study.
Fuente:Plos One
Extracto:
Therefore, careful titration and respiratory monitoring is warranted.
Cita:PLoS One 2024; 19 (4) : e0301635.
Autor/es:Oh, Chahyun (a) Lee, Jiyong (b)
institución:(a) Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, Daejeon, Korea. (b) Department of Anesthesiology and Pain Medicine, College of Medicine, Chungnam National University, Daejeon, Korea.
Conflicto:Boohwi Hong has received research (financial) support from Hana Pharmaceutical (Seoul, South Korea). This does not alter our adherence to PLOS ONE policies on sharing data and materials. Other authors declare that they have no competing interests.
Mutual Associations of Exposure to Ambient Air Pollutants in the First 1000 Days of Life With Asthma/Wheezing in Children
Mutual Associations of Exposure to Ambient Air Pollutants in the First 1000 Days of Life With Asthma/Wheezing in Children
Fuente:Jmir Public Health and Surveillance
Tipo de trabajo:Estudio de cohortes
Extracto:
Exposure to
elevated levels of mixed air pollutants during the first 1000 days of life
appears to elevate the risk of childhood asthma/wheezing. Specifically, the
second trimester, especially during the pseudoglandular and canalicular stages,
and the initial 2 years after birth emerge as crucial susceptibility windows.
TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR-ROC-17013496;
https://tinyurl.com/2ctufw8n.
Cita:JMIR Public Health Surveill 2024 Apr 17; 10 : e52456.
Autor/es:Tian, Fenglin (a) Zhong, Xinqi (b)
institución:(a) Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China. (b) China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, China.
Assessing SARS-CoV-2 Testing Adherence in a University Town: Recurrent Event Modeling Analysis.
Assessing SARS-CoV-2 Testing Adherence in a University Town: Recurrent Event Modeling Analysis.
Fuente:Jmir Public Health and Surveillance
Extracto:
The
unique features of a pandemic response program that supported community-wide
access to free asymptomatic testing provide a unique opportunity to evaluate
adherence to testing recommendations and testing trends over time. Identification
of individual and group-level factors associated with testing behaviors can
provide insights for identifying potential areas of improvement in future testing
initiatives.
Claves:COVID-19, COVID-19 surveillance program, HDT: HYT, Healthy Davis Together, Healthy Yolo Together, PCR, RT-qPCR, SARS-CoV-2, USA, United States, adherence, community based, community surveillance, compliance, coronavirus, demographic, demographics, engagement, infection control, infectious, participation, polymerase chain reaction, public health, response program, response programs, reverse transcription quantitative polymerase chain reaction, severe acute respiratory syndrome coronavirus 2, surveillance, testing, trend, trends, viral, virus, viruses
Cita:JMIR Public Health Surveill 2024 Apr 17; 10 : e48784.
Autor/es:García, Yury E (a) Schmidt, Alec J (b)
institución:(a) Department of Public Health Sciences, University of California, Davis, CA, United States. (b) Department of Public Health Sciences, University of California, Davis, CA, United States.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Colchicine for the treatment of patients with COVID-19
Colchicine for the treatment of patients with COVID-19
Fuente:Bmj Open
Tipo de trabajo:Revisión sistemática
Extracto:
The results of this meta-analysis do not support the use of colchicine as a
treatment for reducing the risk of mortality or improving other relevant clinical
outcomes in patients with COVID-19. However, RCTs investigating early treatment
with colchicine (within 5 days of symptom onset or in patients with early-stage
disease) are needed to fully elucidate the potential benefits of colchicine in
this patient population. PROSPERO REGISTRATION NUMBER: CRD42022369850.
Claves:CLINICAL PHARMACOLOGY, COVID-19, VIROLOGY
Cita:BMJ Open 2024 Apr 17; 14 (4) : e074373.
Autor/es:Cheema, Huzaifa Ahmad (a) Jafar, Uzair (b)
institución:(a) Department of Medicine, King Edward Medical University, Lahore, Pakistan. (b) Department of Medicine, King Edward Medical University, Lahore, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cost of SARS-CoV-2 self-test distribution programmes by different modalities: a micro-costing study in five countries (Brazil, Georgia, Malaysia, Ethiopia and the Philippines).
Cost of SARS-CoV-2 self-test distribution programmes by different modalities: a micro-costing study in five countries (Brazil, Georgia, Malaysia, Ethiopia and the Philippines).
Fuente:Bmj Open
Extracto:
Our results indicate that it is likely to cost between
$2.44 and $12.78 per test to distribute COVID-19 self-tests across common
settings in five heterogeneous countries. Cost-effectiveness analyses using these
results will allow policymakers to make informed decisions on optimally scaling
up COVID-19 self-test distribution programmes across diverse settings and
evolving needs.
Claves:COVID-19, health economics, public health, respiratory infections
Cita:BMJ Open 2024 Apr 17; 14 (4) : e078852.
Autor/es:Hansen, Megan A (a) Lekodeba, Nkgomeleng A (b)
institución:(a) Department of Global Health, Amsterdam Institute for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. (b) Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Evaluation of a manualised neurofeedback training in psychosomatic-psychotherapeutic outpatient treatment (Neuro-pp-out): study protocol for a clinical mixed-methods pilot study.
Evaluation of a manualised neurofeedback training in psychosomatic-psychotherapeutic outpatient treatment (Neuro-pp-out): study protocol for a clinical mixed-methods pilot study.
Fuente:Bmj Open
Tipo de trabajo:Revisión
Extracto:
TRIAL
REGISTRATION NUMBER: Prospectively registered on 28 March 2023 in the German
clinical trials register, DRKS00031497.
Autor/es:Schmidt, Kira Leandra (a) Kowalski, Axel (b)
institución:(a) Department for Psychosomatic Medicine and Psychotherapy, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Nordrhein-Westfalen, Germany kira.schmidt@lvr.de. (b) Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University of Duisburg-Essen, Essen, Germany.
Conflicto:Competing interests: Author AK is employed by NeuroFit GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
institución:(a) Médecine Intensive Réanimation, APHP.Nord, Hôpital Bichat Claude Bernard, Paris, France romain.sonneville@aphp.fr. (b) INSERM UMR 1137, IAME, Université Paris Cité, Paris, France.
Conflicto:Competing interests: RS received grants from the French Ministry of Health and from LB.
MmcA is an electron conduit that facilitates both intracellular and extracellular electron transport in Methanosarcina acetivorans.
MmcA is an electron conduit that facilitates both intracellular and extracellular electron transport in Methanosarcina acetivorans.
Fuente:Nature Communications
Extracto:
Taken together, MmcA might act as an electron conduit that can
potentially support a variety of energy conservation strategies that extend
beyond methanogenesis.
Cita:Nat Commun 2024 Apr 17; 15 (1) : 3300.
Autor/es:Gupta, Dinesh (a) Chen, Keying (b)
institución:(a) Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. (b) Department of Chemistry, Boston University, Boston, MA, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Riboflavin based setup as an alternative method for a preliminary screening of face mask filtration efficiency.
Riboflavin based setup as an alternative method for a preliminary screening of face mask filtration efficiency.
Fuente:Scientific Reports
Extracto:
The proposed setup can be easily implemented at low price,
is more rapid and eco-friendly and can be performed in chemical-physical
laboratories without the needing of biosafety laboratory and specialised
operators.
Cita:Sci Rep 2024 Apr 17; 14 (1) : 8830.
Autor/es:Cavallo, Aida (a) Al Kayal, Tamer (b)
institución:(a) Institute of Clinical Physiology, National Research Council, Pisa, Italy. (b) Institute of Clinical Physiology, National Research Council, Pisa, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Theoretical and mathematical codynamics of nonlinear tuberculosis and COVID-19 model pertaining to fractional calculus and probabilistic approach.
Theoretical and mathematical codynamics of nonlinear tuberculosis and COVID-19 model pertaining to fractional calculus and probabilistic approach.
Fuente:Scientific Reports
Extracto:
Random perturbations in TB and COVID-19 co-infection are crucial in
controlling the spread of an epidemic whenever the suggested circulation is
steady and the amount of infection eliminated is closely correlated with the
random perturbation level.
Claves:Co-infection TB and COVID-19 model, Deterministic and probabilistic model, Ergodic stationary distribution, Fractional calculus, Global positive solution, Probability density function, Quasi-equilibrium
Cita:Sci Rep 2024 Apr 17; 14 (1) : 8827.
Autor/es:Rashid, Saima (a) Hamidi, Sher Zaman (b)
institución:(a) Department of Mathematics, Government College University, Faisalabad, 38000, Pakistan. (b) Department of Computer Science and Mathematics, Lebanese American University, Beirut, 11022801, Lebanon.
TIMM17A overexpression in lung adenocarcinoma and its association with prognosis.
TIMM17A overexpression in lung adenocarcinoma and its association with prognosis.
Fuente:Scientific Reports
Extracto:
The potential of TIMM17A as a biomarker and therapeutic
target for LUAD presents a promising pathway for improving patient diagnosis and
treatment strategies.
institución:(a) Department of Respiration, YiZheng People's Hospital, YiZheng, Jiangsu, China. (b) Department of Respiration, YiZheng People's Hospital, YiZheng, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prognostic implication of 1-year decline in diffusing capacity in newly diagnosed idiopathic pulmonary fibrosis.
Prognostic implication of 1-year decline in diffusing capacity in newly diagnosed idiopathic pulmonary fibrosis.
Fuente:Scientific Reports
Extracto:
Therefore,
serial monitoring of DLCO should be recommended because it may offer additional
prognostic information compared with monitoring of FVC alone.
institución:(a) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. (b) Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer.
Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer.
Fuente:Bmc Cancer
Tipo de trabajo:Estudio abierto
Extracto:
Aerosol inhalation of EGCG is well tolerated, and
preliminary investigation in cancer population suggests that EGCG may be
effective in COVID-19-induced pneumonia, which can promote the improvement of
patients with moderate pneumonia or prevent them from developing into severe
pneumonia. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT05758571. Date
of registration: 8 February 2023.
institución:(a) Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, 250117, Jinan, Shandong, China. (b) Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jiyan Road 440, 250117, Jinan, Shandong, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.
Application of propofol-remifentanil intravenous general anesthesia combined with regional block in pediatric ophthalmic surgery.
Fuente:Bmc Anesthesiology
Extracto:
Propofol-remifentanil intravenous anesthesia combined with
long-acting local anesthetic regional block anesthesia, combined with laryngeal
mask ventilation technology without muscle relaxants, can be safely used in
pediatric eye surgery to achieve rapid and smooth recovery from general
anesthesia and better postoperative analgesia. This anesthesia scheme can improve
the comfort and safety of children in perioperative period, and has a certain
clinical popularization value.
institución:(a) Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 5 Jingyuan Street, Beijing, 100043, China. (b) Department of Anesthesiology, Eye Hospital China Academy of Chinese Medical Sciences, Beijing, 100040, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Utility of bronchoscopically obtained frozen cytology pellets for next-generation sequencing.
Utility of bronchoscopically obtained frozen cytology pellets for next-generation sequencing.
Fuente:Bmc Cancer
Extracto:
Our study showed that frozen cytology pellets may have
equivalent diagnostic value to frozen tissue for NGS analyses. Bronchial cytology
specimens are usually used only for cytology, but NGS analysis is possible if
enough cells are collected to create pellet specimens. In particular, the frozen
cytology pellets obtained by endobronchial ultrasound-guided transbronchial
needle aspiration yielded sufficient amounts of DNA. TRIAL REGISTRATION: This was
registered with the University Medical Hospital Information Network in Japan
(UMINCTR registration no. UMIN000052050).
institución:(a) Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe-City, Hyogo, 650-0017, Japan. (b) Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe-City, Hyogo, 650-0017, Japan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Burden of antimicrobial prescribing in primary care attributable to sore throat
Burden of antimicrobial prescribing in primary care attributable to sore throat
Fuente:Bmc Primary Care
Tipo de trabajo:Estudio de cohortes
Extracto:
Frequency of antibiotic
prescribing for sore throat is high and broad, despite Australian Therapeutic
guideline recommendations. Multiple, sustained interventions to reduce
prescribing, including availability of effective S. pyogenes vaccines that could
reduce the incidence of streptococcal pharyngitis, could obviate the need to
prescribe antibiotics and support ongoing efforts to promote antimicrobial
stewardship.
Claves:Streptococcus pyogenes, Antimicrobial prescribing, Primary care, Sore throat, URTI
Cita:BMC Prim Care 2024 Apr 17; 25 (1) : 117.
Autor/es:Carville, Kylie S (a) Meagher, Niamh (b)
institución:(a) Doherty Epidemiology, Victorian Infectious Diseases Reference Laboratory, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. (b) Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia.
Respiratory carriage of hypervirulent Klebsiella pneumoniae by indigenous populations of Malaysia.
Fuente:Bmc Genomics
Extracto:
A proportion were hypervirulent (hvKp)
however antibiotic resistance was low.
Claves:Klebsiella pneumoniae, Antimicrobial resistance, ESBL, Hypervirulent, Malaysia
Cita:BMC Genomics 2024 Apr 17; 25 (1) : 381.
Autor/es:Das, Souradeep (a) Pandey, Anish K (b)
institución:(a) Faculty of Medicine, Institute for Life Sciences, University of Southampton, Southampton, UK. (b) Faculty of Medicine, Institute for Life Sciences, University of Southampton, Southampton, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.
Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency.
Fuente:Bmc Pulmonary Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
Cardiac AD is
associated with impaired pulmonary vascular volume and ventilatory efficiency.
This suggests that lung blood perfusion abnormalities may occur in these
patients. Further confirmation is required in a large population-based cohort.
institución:(a) National Center for Respiratory Diseases, No. 2 East Yinghua Road, Chaoyang District, 100029, Beijing, China. (b) Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, No. 2 East Yinghua Road, Chaoyang District, 100029, Beijing, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Correlation Between HIF1-A Expression and Airway Remodeling in COPD.
Correlation Between HIF1-A Expression and Airway Remodeling in COPD.
Fuente:International Journal of Chronic Obstructive Pulmonary Disease
Extracto:
The
findings suggest a correlation between increased HIF-1α expression and COPD
airway remodelling. This study provides novel evidence that HIF-1α may be a
potential biomarker for airway remodelling in COPD patients.
institución:(a) The Nanhua Affiliated Hospital, Department of Respiratory Physicians, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China. (b) The Nanhua Affiliated Hospital, Department of General Medicine, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients.
Improved diagnostic markers for invasive pulmonary aspergillosis in COPD patients.
Fuente:Frontiers in Cellular and Infection Microbiology
Extracto:
Our study
highlights the diagnostic potential of CRP, ESR, PCT, LDH, and CER for IPA in
COPD patients. CRP and LDH can also initially predict the need for assisted
ventilation, while CRP can initially estimate the length of hospitalization. This
study represents the first report of the potential of CER for diagnosing IPA,
suggesting its significance for further research.
institución:(a) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, Guangzhou, China. (b) State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, Guangzhou, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.