Impact of clinical frailty on surgical and non-surgical complications after major emergency abdominal surgery.

Impact of clinical frailty on surgical and non-surgical complications after major emergency abdominal surgery.

Fuente:Bjs Open

Tipo de trabajo:Estudio de cohortes

Extracto: Patients with frailty have a significantly increased risk of postoperative complications after major emergency abdominal surgery, especially atrial fibrillation, delirium, and pneumonia. Likewise, patients with frailty have an increased risk of mortality within 90 days. Thus, frailty is a significant predictor for adverse events after major emergency abdominal surgery and should be considered in all patients undergoing major emergency abdominal surgery.

Cita:BJS Open 2024 May 8; 8 (3)

Autor/es:Snitkjær, Christian (a)
Rehné Jensen, Lasse (b)

institución:(a) Department of Gastrointestinal and Hepatic Diseases, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
(b) Emergency Surgery Research Group Copenhagen (EMERGE Cph), Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1093/bjsopen/zrae039

Clinical, endoscopic and therapeutic features of bleeding Dieulafoy's lesions

Clinical, endoscopic and therapeutic features of bleeding Dieulafoy's lesions

Fuente:Bmj Open Gastroenterology

Tipo de trabajo:Revisión

Extracto: Although rare, DLs may be responsible for active, recurrent and unexplained GI bleeding. Thanks to the emergence of endoscopic therapies, the recurrence rate has decreased and the prognosis has highly improved. Therefore, the endoscopic approach remains the first choice to manage bleeding DLs.

Claves:ENDOSCOPIC PROCEDURES, ENDOSCOPY, GASTROINTESTINAL BLEEDING, GASTROINTESTINAL HAEMORRHAGE

Cita:BMJ Open Gastroenterol 2024 May 24; 11 (1)

Autor/es:Aabdi, Basma (a)
Kharrasse, Ghizlane (b)

institución:(a) Gastroenterology, Mohammed VI University Hospital Oujda, Morocco, Oujda, Morocco basma.aabdi@ump.ac.ma.
(b) Gastroenterology, Mohammed VI University Hospital Oujda, Morocco, Oujda, Morocco.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1136/bmjgast-2023-001299

Relative dispersion ratios following fecal microbiota transplant elucidate principles governing microbial migration dynamics.

Relative dispersion ratios following fecal microbiota transplant elucidate principles governing microbial migration dynamics.

Fuente:Nature Communications

Extracto: Collectively, our findings provide insights into the principles and determinants of community dynamics following ecological translocation, informing potential opportunities for precise community design.

Cita:Nat Commun 2024 May 24; 15 (1) : 4447.

Autor/es:Algavi, Yadid M (a)
Borenstein, Elhanan (b)

institución:(a) Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel.
(b) Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. elbo@tauex.tau.ac.il.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41467-024-48717-z

A miniaturised semi-dynamic in-vitro model of human digestion.

A miniaturised semi-dynamic in-vitro model of human digestion.

Fuente:Scientific Reports

Extracto: These devices can be easily adapted to dynamic features in an automated, sensorised, and inexpensive platform and will enable reliable, low-cost and efficient assessment of the bioaccessibility of new and expensive drugs, bioactive ingredients or nanoengineered materials aimed for oral consumption, thereby avoiding unnecessary animal testing.

Cita:Sci Rep 2024 May 24; 14 (1) : 11923.

Autor/es:Calero, Victor (a)
Rodrigues, Patrícia M (b)

institución:(a) International Iberian Nanotechnology Laboratory, Avenida Mestre José Veiga, S/N, 4715-330, Braga, Portugal.
(b) International Iberian Nanotechnology Laboratory, Avenida Mestre José Veiga, S/N, 4715-330, Braga, Portugal.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-54612-w

Intravenous versus oral 'L-ornithine-L-aspartate' in overt hepatic encephalopathy: a randomized comparative study.

Fuente:Scientific Reports

Tipo de trabajo:Estudio clínico

Extracto: LOLA, regardless of administration route, has demonstrated efficacy in OHE.

Claves:l-ornithine-l-aspartate (LOLA), Child turcotte pugh (CTP), Overt hepatic encephalopathy (OHE), Randomized controlled trial (RCT)

Cita:Sci Rep 2024 May 24; 14 (1) : 11862.

Autor/es:Jhajharia, Ashok (a)
Singh, Shashank (b)

institución:(a) Department of Gastroenterology, SMS Medical College & Hospital, Jaipur, Rajasthan, 302004, India. drashokjhajharia@gmail.com.
(b) House No. 109, Shiv Vihar, VKI, Infront of road number 5, Sikar Road, Jaipur, 302039, India. drashokjhajharia@gmail.com.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62293-8

Type 1 diabetes human enteroid studies reveal major changes in the intestinal epithelial compartment.

Fuente:Scientific Reports

Extracto: Our data supports the use of pediatric enteroids as an ex-vivo model to advance studies of GI complications and drug discovery in T1D patients.

Cita:Sci Rep 2024 May 24; 14 (1) : 11911.

Autor/es:Bharadiya, Vishwesh (a)
Rong, Yan (b)

institución:(a) Divisions of Gastroenterology and Hepatology, Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
(b) Divisions of Gastroenterology and Hepatology, Department of Medicine, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62282-x

Identification and clinical validation of diverse cell-death patterns-associated prognostic features among low-grade gliomas.

Fuente:Scientific Reports

Extracto: Take together, the four-gene feature constructed based on PCD-related genes provides valuable information for further study of the pathogenesis and clinical treatment of LGG.

Claves:CLU, FHL3, GIMAP2, HVCN1, Diverse programmed cell death, LGG, Prognostic features, Tumor immunology

Cita:Sci Rep 2024 May 24; 14 (1) : 11874.

Autor/es:Yang, Wenyong (a)
Yu, Hui (b)

institución:(a) Medical Research Center, Department of Neurosurgery, Department of Urology, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, 610014, China.
(b) Medical Research Center, Department of Neurosurgery, Department of Urology, Department of General Surgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, 610014, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1038/s41598-024-62869-4

Can the pan-immune-inflammation value predict gram negative bloodstream infection-related 30-day mortality in solid organ transplant patients?

Can the pan-immune-inflammation value predict gram negative bloodstream infection-related 30-day mortality in solid organ transplant patients?

Fuente:Bmc Infectious Diseases

Extracto: PIV is a simple and inexpensive biomarker that can be used to estimate mortality in immunosuppressed patients, but the results need to be interpreted carefully.

Claves:Gram negative bacterial infection, Mortality, Multidrug resistance, Pan-immune-inflammation value, Solid organ transplantation

Cita:BMC Infect Dis 2024 May 24; 24 (1) : 526.

Autor/es:Ayaz, Çağlayan Merve (a)
Turhan, Özge (b)

institución:(a) Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
(b) Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey. ozgeturhan@akdeniz.edu.tr.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12879-024-09413-x

Exploring the foundations of a digital health information service for patients with inflammatory bowel disease: a mixed method study in Gravitate-Health.

Exploring the foundations of a digital health information service for patients with inflammatory bowel disease: a mixed method study in Gravitate-Health.

Fuente:Bmc Gastroenterology

Extracto: The findings delineate key aspects for developing a suitable digital health information service. Patients seek information from healthcare professionals about treatment; however, in a digital solution, they want access to relevant and practical information about the disease, treatment and self-management. Both patients and healthcare professionals saw opportunities for increasing health data availability to patients. However, healthcare professionals expressed concerns about adapting, maintaining and ensuring the relevance of patient health information without increasing their workload and, thus, reducing quality of care.

Claves:Health information, Inflammatory bowel disease, eHealth

Cita:BMC Gastroenterol 2024 May 24; 24 (1) : 184.

Autor/es:Maurud, Sigurd (a)
Lunde, Lene (b)

institución:(a) Department of Public Health Science, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway. sigurd.maurud@medisin.uio.no.
(b) Department of Public Health Science, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12876-024-03272-1

Epidemiological characteristics of neuroendocrine neoplasms in Beijing: a population-based retrospective study.

Epidemiological characteristics of neuroendocrine neoplasms in Beijing: a population-based retrospective study.

Fuente:Bmc Public Health

Tipo de trabajo:Estudio de cohortes

Extracto: This study retrospectively analyzed the epidemiological characteristics of NENs in Beijing from 1998 to 2018. Our findings provide a reference regarding the epidemiological statistics of NENs in Beijing to contribute to the prevention, diagnosis, and treatment of these specific tumors.

Claves:Epidemiological characteristics, Incidence, Neuroendocrine neoplasms (NENs), Overall survival

Cita:BMC Public Health 2024 May 24; 24 (1) : 1396.

Autor/es:Chi, Yujia (a)
Liu, Shuo (b)

institución:(a) Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department I of Thoracic Oncology, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Haidian District, Beijing, 100142, China.
(b) Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing Office for Cancer Prevention and Control, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18845-8

Epidemiologic profile of inflammatory bowel disease in Eastern Mediterranean Region (EMRO) countries

Fuente:Bmc Public Health

Tipo de trabajo:Revisión sistemática

Extracto: As a result, we were able to establish the traits of IBD patients in EMRO nations. UC patients had a higher incidence than CD patients. The most common regions of involvement in CD and UC patients, respectively, were the colon and pancolitis. Compared to UC patients, CD patients had a higher history of appendectomy.

Claves:Crohn’s disease, Inflammatory bowel disease, Meta-analysis, Systematic review, Ulcerative colitis

Cita:BMC Public Health 2024 May 24; 24 (1) : 1395.

Autor/es:Sanat, Zahra Momayez (a)
Vahedi, Homayoon (b)

institución:(a) Assistant Professor of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran.
(b) Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12889-024-18816-z

Diagnostic yield of exome and genome sequencing after non-diagnostic multi-gene panels in patients with single-system diseases.

Diagnostic yield of exome and genome sequencing after non-diagnostic multi-gene panels in patients with single-system diseases.

Fuente:Orphanet Journal of Rare Diseases

Extracto: ES and GS show diagnostic yields comparable to EGBP for single-system diseases. However, EGBP's limitations in detecting new disease-associated genes underscore the necessity for periodic updates.

Claves:Diagnostic yield, Exome, Gene panels, Genetic testing, Genome, Rare diseases

Cita:Orphanet J Rare Dis 2024 May 24; 19 (1) : 216.

Autor/es:Wilke, Matheus V M B (a)
Klee, Eric W (b)

institución:(a) Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
(b) Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13023-024-03213-x

Wandering spleen presenting in the form of right sided pelvic mass and pain in a patient with AD-PCKD

Wandering spleen presenting in the form of right sided pelvic mass and pain in a patient with AD-PCKD

Fuente:Journal of Medical Case Reports

Tipo de trabajo:Revisión

Extracto: Wandering spleen is a rare clinical condition that needs to be included in the list of differential diagnosis in patients presenting with lower abdominal and pelvic masses. As we have learnt from our case, a high index of suspicion is required to detect it early and intervene by doing splenopexy and thereby avoiding splenectomy and its related complications.

Claves:AD-PCKD, Splenectomy, Splenic infarction, Splenic torsion, Splenopexy, Wandering spleen

Cita:J Med Case Rep 2024 May 25; 18 (1) : 259.

Autor/es:Shibiru, Yitagesu Aberra (a)
Wondimu, Sahlu (b)

institución:(a) Addis Ababa University, Addis Ababa, Ethiopia. aberrayitagesu@yahoo.com.
(b) Addis Ababa University, Addis Ababa, Ethiopia.

Conflicto:There is no competing interest in this case presentation.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s13256-024-04580-6

Evaluation of miR-148a-3p and miR-106a-5p as Biomarkers for Prostate Cancer: Pilot Study.

Evaluation of miR-148a-3p and miR-106a-5p as Biomarkers for Prostate Cancer: Pilot Study.

Fuente:Genes

Extracto: Further validation of these miRNAs in larger patient cohorts and across different stages of PCa may strengthen their candidacy as clinically relevant biomarkers for diagnosis and prognosis.

Claves:miR-106a-5p, miR-148a-3p, microRNAs, prostate cancer

Cita:Genes (Basel) 2024 May 4; 15 (5)

Autor/es:Coman, Roxana Andra (a)
Schitcu, Vlad Horia (b)

institución:(a) Department of Urology, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.
(b) Department of Urology, "Prof Dr. Ion Chiricuta" Oncology Institute, 400015 Cluj-Napoca, Romania.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/genes15050584

Vitamin Status in Patients with Phenylketonuria

Vitamin Status in Patients with Phenylketonuria

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión sistemática

Extracto: Our study provides valuable insights into the nutritional status of PKU patients, but further research is required to confirm these findings and explore additional factors influencing vitamin status in PKU.

Claves:PKU, diet therapy, meta-analysis, metabolism, nutrition, phenylketonuria, vitamin status, vitamins

Cita:Int J Mol Sci 2024 May 7; 25 (10)

Autor/es:Bokayeva, Kamila (a)
Jamka, Małgorzata (b)

institución:(a) Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, Poland.
(b) Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105065

Multi-Omics Characterization of Colon Mucosa and Submucosa/Wall from Crohn's Disease Patients.

Fuente:International Journal of Molecular Sciences

Extracto: These findings have the potential to inform the development of novel therapeutic strategies to achieve TH.

Claves:Crohn’s disease, colon, histology, isoform, mucosa, proteomics, submucosa, transcriptomics, transmural healing, wall

Cita:Int J Mol Sci 2024 May 8; 25 (10)

Autor/es:Jin, Liang (a)
Macoritto, Michael (b)

institución:(a) AbbVie Bioresearch Center, Worcester, MA 01605, USA.
(b) Immunology Research, AbbVie, Cambridge, MA 02139, USA.

Conflicto:AbbVie funded the study and participated in study design; research; data collection, analysis and interpretation of data; writing, reviewing, and approving the publication. L.J., M.M., J.W., Y.B., F.W., A.S.-F., H.K., M.M.S., A.S.S., S.W., and Y.T. are employees of AbbVie and may own AbbVie stock. J.P.-C., C.H., and I.M. were employees of AbbVie at the time when this study was conducted... and may own AbbVie stock. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105108

In Vitro Digestion of Polyphenolic Compounds and the Antioxidant Activity of Acorn Flour and Pasta Enriched with Acorn Flour.

Fuente:International Journal of Molecular Sciences

Extracto: In the case of pasta, total polyphenols, phenolic acids and flavonoids, as well as free radical scavenging properties, demonstrated a decreasing trend following each digestion stage.

Claves:Quercus suber L., chromatography, flavonoids, functional food, gastrointestinal digestion, gluten-free food, phenolic acids

Cita:Int J Mol Sci 2024 May 15; 25 (10)

Autor/es:Kasprzak-Drozd, Kamila (a)
Mołdoch, Jarosław (b)

institución:(a) Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
(b) Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation, State Research Institute, Czartoryskich 8, 24-100 Puławy, Poland.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105404

Soluble Neuropilin-1 Is Elevated in Sepsis and Correlates with Organ Dysfunction and Long-Term Mortality in Critical Illness.

Fuente:International Journal of Molecular Sciences

Extracto: Critically ill and septic patients exhibit higher serum concentrations of circulating sNRP-1, which correlates to organ failure, particularly hepatic and kidney dysfunction.

Claves:Neuropilin-1, critical illness, human, immune system, inflammation, intensive care unit, mortality, prognosis, sepsis, survival

Cita:Int J Mol Sci 2024 May 16; 25 (10)

Autor/es:Hohlstein, Philipp (a)
Schumacher, Eileen (b)

institución:(a) Department for Gastroenterology, Metabolic Disorders and Intensive Care Medicine, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
(b) Department for Gastroenterology, Metabolic Disorders and Intensive Care Medicine, RWTH-University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105438

Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.

Fuente:International Journal of Molecular Sciences

Extracto: For the first time, the singularity of the gut microbial composition in IBD and NAFLD patients has been shown, implying a potential microbial signature mainly influenced by gut inflammation.

Claves:IBD, NAFLD, gut microbiota, leaky gut, liver steatosis

Cita:Int J Mol Sci 2024 May 17; 25 (10)

Autor/es:De Caro, Carmen (a)
Spagnuolo, Rocco (b)

institución:(a) Health Sciences Department, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.
(b) Health Sciences Department, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105453

Stage-Specific Alteration and Prognostic Relationship of Serum Fumarate Hydratase Autoantibodies in Gastric Cancer.

Fuente:International Journal of Molecular Sciences

Extracto: Therefore, s-FH-Ab levels may be a useful biomarker for early diagnosis and the prediction of prognosis in patients with gastric cancer.

Claves:autoantibody, fumarate hydratase, gastric cancer, prognosis

Cita:Int J Mol Sci 2024 May 17; 25 (10)

Autor/es:Sasajima, Natsuko (a)
Sumazaki, Makoto (b)

institución:(a) Department of Gastroenterological Surgery, Toho University School of Medicine, Tokyo 143-8541, Japan.
(b) Department of Clinical Oncology, Toho University Graduate School of Medicine, Tokyo 143-8541, Japan.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25105470