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Gut microbiota, blood metabolites, and left ventricular diastolic dysfunction in US Hispanics/Latinos.
Gut microbiota, blood metabolites, and left ventricular diastolic dysfunction in US Hispanics/Latinos.
Fuente:Microbiome
Extracto:
In this
study of US Hispanics/Latinos, we identified multiple gut bacteria and related
metabolites linked to LVDD, suggesting their potential roles in this preclinical
HF entity. Video Abstract.
Claves:Blood metabolome, Gut dysbiosis, Hispanic/Latino individuals, Left ventricular diastolic dysfunction
Cita:Microbiome 2024 May 10; 12 (1) : 85.
Autor/es:Luo, Kai (a) Taryn, Alkis (b)
institución:(a) Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. (b) Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Radiation Therapy and Oncology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. (b) Institute of Veterinary Clinical Science, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis.
Identification of potential mediators of the relationship between body mass index and colorectal cancer: a Mendelian randomization analysis.
Fuente:International Journal of Epidemiology
Extracto:
The effect of BMI on CRC risk is
possibly partly mediated through plasma IGF1, whereas the attenuation of the
BMI-CRC association by smoking and PA may reflect confounding and shared
underlying mechanisms rather than mediation.
Claves:BMI, Body mass index, CRC, Mendelian randomization, colorectal cancer, mediation analysis, obesity
Cita:Int J Epidemiol 2024 Apr 11; 53 (3)
Autor/es:Bouras, Emmanouil (a) Gill, Dipender (b)
institución:(a) Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. (b) Chief Scientific Advisor Office, Research and Early Development, Novo Nordisk, Copenhagen, Denmark.
Conflicto:I have read the Journal’s policy and the authors of this manuscript have the following competing interests: D.G. is employed part-time by Novo Nordisk. The remaining authors have no competing interests to declare.
Extracto:
The importance of
histopathological examination should be emphasized to establish the diagnosis in
the absence of signs in favor of a primary localization.
EEG functional connectivity as a Riemannian mediator: An application to malnutrition and cognition.
EEG functional connectivity as a Riemannian mediator: An application to malnutrition and cognition.
Fuente:Human Brain Mapping
Extracto:
Our methods offer a versatile framework
applicable to mediation studies encompassing matrix and Hermitian 3D tensor
mediators alongside scalar exposures and outcomes, facilitating comprehensive
analyses across diverse research domains.
Autor/es:Lopez Naranjo, Carlos (a) Razzaq, Fuleah Abdul (b)
institución:(a) The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. (b) The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.
A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry.
Fuente:Hepatology Communications
Extracto:
PRSALC incorporates 20
single-nucleotide polymorphisms, predicts increased risk for ALC, and improves
risk stratification for ALC compared with the models that only include clinical
risk factors. This new score has the potential for early detection of heavy
drinking patients who are at high risk for ALC.
Cita:Hepatol Commun 2024 Jun 1; 8 (6)
Autor/es:Schwantes-An, Tae-Hwi (a) Whitfield, John B (b)
institución:(a) Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis IN, USA. (b) Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Queensland 4029, Australia.
Conflicto:Naga P. Chalasani has a number of consulting agreements with and research grants from the pharmaceutical industry, but they are not significantly or directly related to this paper. Munir Pirmohamed receives research funding from various organizations, including the MRC and NIHR. He has also received partnership funding for the following: MRC Clinical Pharmacology Training Scheme (co-funded by MRC and Roche,...
UCB, Eli Lilly and Novartis); a PhD studentship jointly funded by EPSRC and Astra Zeneca; and grant funding from Vistagen Therapeutics. He has also unrestricted educational grant support for the UK Pharmacogenetics and Stratified Medicine Network from Bristol-Myers Squibb and UCB. He has developed an HLA genotyping panel with MC Diagnostics but does not benefit financially from this. He is part of the IMI Consortium ARDAT (www.ardat.org). None of these funding sources were deployed in the undertaking of this study. Timothy R. Morgan has conducted clinical research with AbbVie, Genfit, Gilead, and Merck but none of these are related to this manuscript. Tae-Hwi Schwantes-An is a paid consultant for Target RWE. Guruprasad P. Aithal consults and advises Clinipace, Servier, Pfizer, GSK, AstraZeneca, DNDi, BenevolentAI, Abbott Product Operations AG, Albireo, PureTech and Merck. RB is on the speakers’ bureau for AbbVie. Samer Gawrieh consults for TransMedics and Pfizer and received grants from Zydus, Viking, and SonicIncytes. Paul S. Haber received grants from Woke Pharmaceuticals. S Masson consults and is on the speakers’ bureau for Norgine and is on the speakers’ bureau for Dr. Falk and Sandoz. Christophe Moreno consults and received grants from AbbVie and Gilead. He consults for Surrozen, Intercept, Echosens, Novartis, Bayer, and Astellas. Beat Müllhaupt consults and received grants from Gilead and consults for Ipsen. Pierre Nahon consults and received grants from AstraZeneca, Bristol-Myers Squibb, and Eisai. He consults for Ipsen and Roche. Eric Trépo received grants from Gilead and Julius Clinical.
Patient-focused drug development in primary sclerosing cholangitis: Insights on patient priorities and involvement in clinical trials.
Patient-focused drug development in primary sclerosing cholangitis: Insights on patient priorities and involvement in clinical trials.
Fuente:Hepatology Communications
Tipo de trabajo:Estudio clínico
Extracto:
Most patients with PSC report interest in participating in clinical
trials, but few have been asked to participate. Referral of patients with PSC by
their hepatologist/gastroenterologist to clinical trials and patient education on
trial participation are vital to closing the gap between trial interest and
participation. Pruritus may serve as a key indicator of patient interest in trial
participation.
Cita:Hepatol Commun 2024 Jun 1; 8 (6)
Autor/es:Li, Michael (a) Pai, Ruth-Anne (b)
institución:(a) Department of Medicine, Division of Gastroenterology and Hepatology, University of California, San Francisco, California, USA. (b) PSC Partners Seeking a Cure, Greenwood Village, Colorado, USA.
Conflicto:Christopher L. Bowlus received grants from Gilead, Bristol Myers Squibb, BiomX, Boston Scientific, COUR, CymaBay, GENFIT, GlaxoSmithKline, Mirum, Genkyotex, Intercept, Novartis, Pliant, and Target. Jennifer C. Lai consults for GENFIT. She advises Novo Nordisk. She received grants from Axcella and Pliant. The remaining authors have no conflicts to report.
Cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as conversion regimen in RAS/BRAF wild-type patients with initially unresectable colorectal liver metastases (TRICE trial): A randomized controlled trial.
Cetuximab plus FOLFOXIRI versus cetuximab plus FOLFOX as conversion regimen in RAS/BRAF wild-type patients with initially unresectable colorectal liver metastases (TRICE trial): A randomized controlled trial.
Fuente:Plos Medicine
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
The
combination of cetuximab with FOLFOXIRI did not significantly improve ORR
compared to cetuximab plus FOLFOX. Despite achieving an enhanced DpR, this
improvement did not translate into improved R0 resection rates or PFS. Moreover,
the triplet arm was associated with an increase in treatment-related toxicity.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03493048.
Cita:PLoS Med 2024 May; 21 (5) : e1004389.
Autor/es:Wang, De-Shen (a) Ren, Chao (b)
institución:(a) Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. (b) Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prevalence and factors associated with inappropriate continuation of stress ulcer prophylaxis at discharge.
Prevalence and factors associated with inappropriate continuation of stress ulcer prophylaxis at discharge.
Fuente:Bmj Open Quality
Extracto:
The prevalence of
inappropriate continuation was found to be higher than prior studies. Given the
risk of unnecessary medication intake and the associated healthcare cost, a
web-based quality improvement initiative is being considered.
Claves:Medication reconciliation, Patient safety, Patient-centred care, Safety culture
institución:(a) Internal Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, USA chinnapp@msu.edu. (b) Internal Medicine, Hurley Medical Center, Flint, Michigan, USA.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A chain mediation model reveals the association between family sense of coherence and quality of life in caregivers of advanced cancer patients.
A chain mediation model reveals the association between family sense of coherence and quality of life in caregivers of advanced cancer patients.
Fuente:Scientific Reports
Extracto:
These insights enhance our
understanding of the complex interplay between FSOC and QoL, underscoring the
potential benefits of bolstering FSOC to strengthen caregiver resilience,
alleviate distress, and ultimately elevate their QoL.
Claves:Advanced cancer caregivers, Chain mediation, Family sense of coherence, Psychological distress, Psychological resilience, Quality of life
Cita:Sci Rep 2024 May 10; 14 (1) : 10701.
Autor/es:Cui, Panpan (a) Cheng, Chunyan (b)
institución:(a) Department of Nursing, Henan Provincial Key Medicine Laboratory of Nursing, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, No. 7 Weiwu Road, Zhengzhou, China. (b) School of Nursing, Zhengzhou University, Zhengzhou, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Early nutrition is safe and does not increase complications after upper gastrointestinal bleeding-a systematic review and meta-analysis of randomized controlled trials.
Early nutrition is safe and does not increase complications after upper gastrointestinal bleeding-a systematic review and meta-analysis of randomized controlled trials.
Fuente:Scientific Reports
Extracto:
In conclusion, compared with DN, EN (within 24 h) appears to
be a safe intervention and could reduce the length of hospital stay without
increasing the risk of complications after UGIB.
institución:(a) Centre for Translational Medicine, Semmelweis University, Budapest, 1085, Hungary. (b) Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7623, Hungary.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Associated factors of mortality and morbidity in emergency and elective abdominal surgery
Associated factors of mortality and morbidity in emergency and elective abdominal surgery
Fuente:Bmc Surgery
Tipo de trabajo:Estudio de cohortes
Extracto:
Cholelithiasis and gastroduodenal perforation
were key surgical indications, with factors like postoperative ventilation and
adrenaline infusion linked to mortality. Emergency surgeries had higher
complication rates, particularly surgical site infections, despite similar
hospital stay and mortality rates compared to elective surgeries.
The effect of antiresorptive therapy on the prevalence and severity of oral lichen planus: a retrospective study.
The effect of antiresorptive therapy on the prevalence and severity of oral lichen planus: a retrospective study.
Fuente:Bmc Oral Health
Extracto:
Patients under AR therapy show more clinical symptoms associated to the erosive
type of OLP. Regardless of the AR therapy, the erosive type of OLP is associated
with more severe symptoms.
institución:(a) Department of Oral Surgery and Implantology, Carolinum, Goethe University, Frankfurt am Main, Germany. (b) Department of Oral Surgery and Implantology, Carolinum, Goethe University, Frankfurt am Main, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Co-localization of antibiotic resistance genes is widespread in the infant gut microbiome and associates with an immature gut microbial composition.
Co-localization of antibiotic resistance genes is widespread in the infant gut microbiome and associates with an immature gut microbial composition.
Fuente:Microbiome
Extracto:
We found that the phenomenon of
co-localization between ARGs and other resistance and VGs was prevalent in the
gut at the beginning of life. It reveals the diversity that sustains antibiotic
resistance and therefore indirectly emphasizes the need to apply caution in the
use of antimicrobial agents in clinical practice, animal husbandry, and daily
life to mitigate the escalation of resistance. Video Abstract.
Claves:Antibiotics resistance genes, Co-localization, Gut microbiome, Infants, Metagenomics
Cita:Microbiome 2024 May 10; 12 (1) : 87.
Autor/es:Li, Xuanji (a) Brejnrod, Asker (b)
institución:(a) Section of Microbiology, Department of Biology, University of Copenhagen, 2100, Copenhagen, Denmark. xuanji@bio.ku.dk. (b) Section of Bioinformatics, Department of Health Technology, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Exploring the association between dietary fiber intake and hepatic steatosis: insights from NHANES.
Exploring the association between dietary fiber intake and hepatic steatosis: insights from NHANES.
Fuente:Bmc Gastroenterology
Tipo de trabajo:Orientaciones y guía
Extracto:
Our
research indicates that in the majority of Americans, there is an inverse
relationship between dietary fiber intake and hepatic steatosis. This
relationship exhibits an inverted U-shaped curve in women and other race, with a
threshold effect. The findings of this study hold potential significance for
clinical nutrition interventions, personalized dietary guidance, and advancing
research into the diet-disease mechanism relationship.
institución:(a) Clinical Research Center, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, 311200, P.R. China. (b) Voluntary Blood Donation Service Center of Xiaoshan District, Hangzhou, Zhejiang, 311200, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Machine learning-based prediction models affecting the recovery of postoperative bowel function for patients undergoing colorectal surgeries.
Machine learning-based prediction models affecting the recovery of postoperative bowel function for patients undergoing colorectal surgeries.
Fuente:Bmc Surgery
Extracto:
The study suggests that he use of
probiotics and early recovery of diet may enhance the recovery of bowel function
in patients undergoing colorectal surgeries. Among the various analytical methods
used, logistic regression emerged as the most effective approach for predicting
the timing of the first postoperative flatus and defecation in this patient
population.
Claves:Colorectal surgeries, Machine learning, Prediction models, Time of first postoperative defecation, Time of first postoperative flatus
Cita:BMC Surg 2024 May 10; 24 (1) : 143.
Autor/es:Yang, Shuguang (a) Zhao, Huiying (b)
institución:(a) Department of Critical Care Medicine, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, P.R. China. (b) Department of Critical Care Medicine, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, P.R. China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Spatial Distribution of Macrophage and Lymphocyte Subtypes within Tumor Microenvironment to Predict Recurrence of Non-Muscle-Invasive Papillary Urothelial Carcinoma after BCG Immunotherapy.
Spatial Distribution of Macrophage and Lymphocyte Subtypes within Tumor Microenvironment to Predict Recurrence of Non-Muscle-Invasive Papillary Urothelial Carcinoma after BCG Immunotherapy.
Fuente:International Journal of Molecular Sciences
Extracto:
Our findings highlight the importance of assessment of the
spatial distribution of immune cells in the tumor microenvironment.
Autor/es:Drachneris, Julius (a) Morkunas, Mindaugas (b)
institución:(a) Department of Pathology and Forensic Medicine, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania. (b) National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, 08406 Vilnius, Lithuania.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, Italy. (b) Laboratory of Physiology, Department for Sustainable Development and Ecological Transition, 13100 Vercelli, Italy.
Conflicto:Author Rebecca Galla was employed by Noivita Srls. In addition, Francesca Uberti and Claudio Molinari are co-founders of Noivita Srls. The remaining authors declare that the research was conducted without commercial or financial relationships that could be construed as a potential conflict of interest.
Autor/es:Bozzatello, Paola (a) Novelli, Roberta (b)
institución:(a) Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy. (b) Department of Neuroscience, University of Turin, Via Cherasco 15, 10126 Turin, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
A Two-Faced Gut Microbiome: Butyrogenic and Proinflammatory Bacteria Predominate in the Intestinal Milieu of People Living with HIV from Western Mexico.
A Two-Faced Gut Microbiome: Butyrogenic and Proinflammatory Bacteria Predominate in the Intestinal Milieu of People Living with HIV from Western Mexico.
Fuente:International Journal of Molecular Sciences
Extracto:
This mixed profile is described for the first time in PLWHIV from Mexico.
Claves:HIV infection, SCFA, butyrate, dysbiosis, gut microbiota
Cita:Int J Mol Sci 2024 Apr 29; 25 (9)
Autor/es:Baltazar-Díaz, Tonatiuh Abimael (a) Andrade-Villanueva, Jaime F (b)
institución:(a) Instituto de Investigación en Enfermedades Crónico-Degenerativas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Guadalajara 44340, Mexico. (b) Instituto de Investigación en Inmunodeficiencias y VIH, Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Hospital 278, Guadalajara 44280, Mexico.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación