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institución:(a) Department of Geriatrics and Internal medicine, Sorlandet Hospital Arendal, Kristiansand, Agder, Norway susanne.sorensen.hernes@sshf.no. (b) Department of Clinical Sciences, University of Bergen, Bergen, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.
Fuente:Nature Communications
Extracto:
We also demonstrate that the wider consequence of any protein-altering
intervention on well-being and morbidity is required to interpret any utility of
proteins as potential future targets for therapeutic prevention.
Cita:Nat Commun 2024 Apr 29; 15 (1) : 3621.
Autor/es:Smith-Byrne, Karl (a) Hedman, Åsa (b)
institución:(a) Cancer Epidemiology Unit, Oxford Population Health, University of Oxford, Oxford, UK. karl.smith-byrne@ndph.ox.ac.uk. (b) External Science and Innovation, Pfizer Worldwide Research, Development and Medical, Stockholm, Sweden.
Conflicto:Å.H., M.D., J.B., X.J.M. and A.M. are employees at Pfizer Inc., the remaining authors declare no competing interests.
Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy.
Cognitive profile in multiple sclerosis and post-COVID condition: a comparative study using a unified taxonomy.
Fuente:Scientific Reports
Extracto:
Further comparative studies addressing the mechanisms related
to cognitive dysfunction and fatigue may be of interest to advance the knowledge
of these disorders and develop new therapies.
Claves:COVID-19, Cognition, Fatigue, Long COVID, Multiple sclerosis
Cita:Sci Rep 2024 Apr 29; 14 (1) : 9806.
Autor/es:Delgado-Alonso, Cristina (a) Delgado-Alvarez, Alfonso (b)
institución:(a) Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria "San Carlos" (IdISSC), C/Profesor Martín Lagos, 28040, Madrid, Spain. (b) Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigacion Sanitaria "San Carlos" (IdISSC), C/Profesor Martín Lagos, 28040, Madrid, Spain.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Mortality and re-fracture rates in low trauma hip fracture.
Mortality and re-fracture rates in low trauma hip fracture.
Fuente:Bmc Geriatrics
Tipo de trabajo:Estudio de cohortes
Extracto:
Patients with low-trauma hip fractures have shown a high rate of mortality in the
first year. Considering the increase in the incidence of hip fractures with age,
comprehensive strategies are needed to prevent fractures caused by minor trauma
in the elderly population.
Claves:Death, Hip fracture, Incidence, One-year survival, Osteoporosis, Re-fracture
institución:(a) Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. (b) Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Diabetes and the social, biologic, and behavioral determinants of endometrial cancer in the United States.
Diabetes and the social, biologic, and behavioral determinants of endometrial cancer in the United States.
Fuente:Bmc Cancer
Extracto:
Our results revealed
the importance of adopting a comprehensive approach to the study of the
associated factors of endometrial cancer by including social, biologic, and
behavioral determinants of health. The observed social inequity in endometrial
cancer among women needs to be addressed through effective policies and changes
in social structures to advocate for a standardized healthcare system that
ensures equitable access to preventive measures and quality of care.
Claves:Behavioral risk factor Surveillance System (BRFSS), Diabetes, Endometrial cancer, Obesity, Race, Social determinants of Health, Weighted Chi-square test, Weighted logistic regression
Cita:BMC Cancer 2024 Apr 29; 24 (1) : 540.
Autor/es:Massouh, Nour (a) Jaffa, Ayad A (b)
institución:(a) Epidemiology and Population Health Department, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon. (b) Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.
Liraglutide and not lifestyle intervention reduces soluble CD163 after comparable weight loss in obese participants with prediabetes or type 2 diabetes mellitus.
Fuente:Cardiovascular Diabetology
Extracto:
Weight loss following treatment with liraglutide was
associated with reduced circulating levels of sCD163 when compared to the same
extent of weight loss after lifestyle changes. This might contribute to reduced
cardiometabolic risk in individuals receiving treatment with liraglutide.
Claves:GLP-1 analogue, Immune cells, Obesity, T2DM, Weight loss
institución:(a) Research Institute for Internal Medicine, Oslo University Hospital Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway. (b) Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
institución:(a) Department of Endocrinology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310052, China. (b) Department of Endocrinology, the Children's Hospital of Zhejiang University School of Medicine, Hangzhou, 310052, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Prognosis of Methanol Poisoning in a Developing Setting.
Prognosis of Methanol Poisoning in a Developing Setting.
Fuente:Archives of Iranian Medicine
Tipo de trabajo:Estudio de cohortes
Extracto:
Besides LOC, patients
with any abnormality in their brain CT scan on admission were found to be at
higher risk of death, and patients with supratentorial edema were at risk of
longer LOS. Brain CT-scan on admission should be considered as a part of the
routine procedure during the management of methanol-poisoning.
Autor/es:Sasani, Mohammad Reza (a) Molavi Vardanjani, Hossein (b)
institución:(a) Medical Imaging Research Center, Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (b) Department of MPH, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes.
Accuracy of continuous glucose monitoring during exercise-related hypoglycemia in individuals with type 1 diabetes.
Fuente:Frontiers in Endocrinology
Extracto:
Physical
exercise had clinically relevant impact on the accuracy of the investigated
continuous glucose monitoring systems and their ability to accurately detect
hypoglycemia.
Claves:accuracy, continuous glucose monitoring, exercise, hypoglycemia, mean absolute relative difference, type 1 diabetes
Autor/es:Maytham, Kaisar (a) Hagelqvist, Per G (b)
institución:(a) Clinical Research, Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Copenhagen, Denmark. (b) Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Conflicto:SE is currently employed by Novo Nordisk and holds stock in Novo Nordisk. UP-b has served on advisory boards for and/or received lecture fees from Novo Nordisk and Sanofi. FK has served on advisory panels at, been part of speaker’s bureaus for, served as a consultant to, and/or received research support from AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Gubra, MSD/Merck,...
k, Novo Nordisk, Sanofi, ShouTi, Zealand Pharma and Zucara. TV has served on scientific advisory panels at, been part of speaker’s bureaus for, served as a consultant to, and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Gilead, GSK, Mundipharma, MSD/Merck, Novo Nordisk, Sanofi, and Sun Pharmaceuticals. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Intraoperative radiofrequency ablation for unresectable abdominal paraganglioma
Intraoperative radiofrequency ablation for unresectable abdominal paraganglioma
Fuente:Frontiers in Endocrinology
Tipo de trabajo:Caso clínico
Extracto:
To our
best knowledge, this was the first report on intraoperative RFA that markedly
reduced the size of a large primary unresectable PPGL, along with clinical and
biochemical responses.
Autor/es:Magalhaes, Isabelle P A (a) Boger, Bibiana D (b)
institución:(a) Adrenal Unit, Laboratory of Molecular and Cellular Endocrinology, LIM/25, Division of Endocrinology and Metabolism, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil. (b) Adrenal Unit, Laboratory of Molecular and Cellular Endocrinology, LIM/25, Division of Endocrinology and Metabolism, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study.
Association of high disease activity and serum IL-6 levels with the incidence of inflammatory major organ events in Behçet disease: a prospective registry study.
Fuente:Frontiers in Immunology
Extracto:
This study suggests that treatment strategies targeting overall
disease activity and monitoring residual serum IL-6 may help prevent inflammatory
major organ events in BD.
institución:(a) Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan. (b) Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Conflicto:YK has received support from Amgen speaking fees, support for attending meetings and travel, and advisory board, Novartis speaking fees and advisory board, and Nippon Shinyaku grants. Mitsuhiro Takeno has received consulting and speaking fees from Amgen; research grants and speaking fees from AbbVie, Asahi Kasei, Chugai, Eisai, Tanabe-Mitsubishi, and Taisyo; and speaking fees from Astellas, Asympti, Boehringer-Ingelheim, Eli Lily,...
Jansen Pharma, Nippon Shinyaku, Novartis, Ono Pharmaceuticals, Takeda, UBC Japan, and Viatris. Tatsuya Atsumi has received grants from Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co. Ltd., Nippon Boehringer Ingelheim Co., Ltd., TEIJIN PHARMA LIMITED., Eisai Co., Ltd., and Eli Lilly Japan K.K. Tetsuya Atsumi has also received consulting fees from Sanofi K.K, GlaxoSmithKline plc, AbbVie Inc., AstraZeneca plc, Chugai Pharmaceutical Co., Ltd., Nippon Boehringer Ingelheim Co., Ltd., Janssen Pharmaceutical K.K., Gilead Sciences, Inc., Eli Lilly Japan K.K., and ONO PHARMACEUTICAL CO., LTD. TA has also received payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing, or educational events from Takeda Pharmaceutical Co., Ltd., Astellas Pharma Inc., Mitsubishi Tanabe Pharma Co., Chugai Pharmaceutical Co., Ltd., Daiichi Sankyo Co. Ltd., Pfizer Inc., Alexion Inc., Novartis Pharma K.K., Eli Lilly Japan K.K., Kyowa Kirin Co., Ltd., AbbVie Inc., Nippon Boehringer Ingelheim Co., Ltd., Amgen Inc. UCB Japan Co. Ltd., AstraZeneca plc, and Eisai Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Identification of potential biomarkers of gout through weighted gene correlation network analysis.
Identification of potential biomarkers of gout through weighted gene correlation network analysis.
Fuente:Frontiers in Immunology
Extracto:
In this study, we screened and validated essential genes using a
variety of bioinformatics tools to generate novel ideas for the diagnosis and
treatment of gout.
Claves:CXCL1, CXCL2, CXCL8, WGCNA, gout
Cita:Front Immunol 2024; 15 : 1367019.
Autor/es:Wang, Xinyi (a) Yang, Bing (b)
institución:(a) Department of Endocrinology, First Affiliated Hospital, Guangxi Medical University, Nanning, China. (b) Department of Geriatric Endocrinology and Metabolism, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells.
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells.
Fuente:Journal of Cancer Research and Therapeutics
Extracto:
This study reveals
the potent antitumor activity of BVD-523 against thyroid cancer cells bearing
MAPK-activating mutations, offering promise for treating aggressive forms of
thyroid cancer.
Cita:J Cancer Res Ther 2024 Apr 1; 20 (2) : 570-577.
Autor/es:Chen, Yulu (a) Xiao, Xi (b)
institución:(a) Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. (b) Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Longitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia.
Longitudinal changes in body mass index, height, and weight in children with acute myeloid leukemia.
Fuente:Bmc Pediatrics
Extracto:
Physicians should pay more
attention to the changes in height and weight of children with AML at these
crucial treatment stages and intervene in time.
Claves:Acute myeloid leukemia, Body mass index, Bone age, Children, Height, Weight
Cita:BMC Pediatr 2024 Apr 30; 24 (1) : 293.
Autor/es:Wen, Xiaojia (a) He, Hongbo (b)
institución:(a) Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's, 56 Nanlishi Road, Beijing, 100045, China. (b) Leukemia Department, Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Clinical Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's, 56 Nanlishi Road, Beijing, 100045, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Unlocking the power of synergy: High-intensity functional training and early time-restricted eating for transformative changes in body composition and cardiometabolic health in inactive women with obesity.
Unlocking the power of synergy: High-intensity functional training and early time-restricted eating for transformative changes in body composition and cardiometabolic health in inactive women with obesity.
Fuente:Plos One
Tipo de trabajo:Estudio clínico
Extracto:
In inactive women with obesity,
combining TRE with HIFT can be a good strategy to induce superior effects on body
composition, lipid profile and glucose regulation compared with either diet or
exercise intervention alone. TRIAL REGISTRATION: Clinical Trials Number:
PACTR202301674821174.
Cita:PLoS One 2024; 19 (5) : e0301369.
Autor/es:Ameur, Ranya (a) Maaloul, Rami (b)
institución:(a) High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. (b) Research Laboratory of Evaluation and Management of Musculoskeletal System Pathologies, LR20ES09, University of Sfax, Sfax, Tunisia.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors.
Metabolic Syndrome in people treated with Antipsychotics (RISKMet): A multimethod study protocol investigating genetic, behavioural, and environmental risk factors.
Fuente:Plos One
Extracto:
This project innovates MetS monitoring in psychiatry by using intensive digital
phenotyping, identifying biochemical markers, assessing familial risks, and
including genetically similar healthy controls. STUDY REGISTRATION NUMBER:
ISRCTN18419418 at www.isrctn.com.
Cita:PLoS One 2024; 19 (5) : e0298161.
Autor/es:de Girolamo, Giovanni (a) La Cascia, Caterina (b)
institución:(a) Unit of Epidemiological and Evaluation Psychiatry, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy. (b) Department of Biomedicine, Neuroscience, and Advanced Diagnostics, Section of Psychiatry, University of Palermo, Palermo, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case-control study.
Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case-control study.
Fuente:Bmc Geriatrics
Extracto:
This study
established a positive correlation between the TyG index and the risk of
in-hospital and ICU mortality in patients over 60 years who diagnosed with ICH,
suggesting that the TyG index holds promise as an indicator for risk
stratification in this patient population.
Claves:All-cause mortality, Intensive care unit, Intracerebral hemorrhage, Triglyceride-glucose index
Cita:BMC Geriatr 2024 May 1; 24 (1) : 385.
Autor/es:Yang, Yang (a) Liang, Shengru (b)
institución:(a) Department of Emergency, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China. (b) Department of Endocrinology, Tangdu Hospital, Fourth Military Medical University, Xi'an, 710038, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Development of palliative care clinical practice guidelines and referral care pathways for primary care practitioners in Pakistan.
Development of palliative care clinical practice guidelines and referral care pathways for primary care practitioners in Pakistan.
Fuente:Bmc Palliative Care
Tipo de trabajo:Guía de práctica clínica
Extracto:
The described
clinical practice guidelines and primary care clinical referral pathways will aid
to standardize palliative care provision in Pakistan. These can be used by other
resource constrained settings to develop guidelines within their own local
context.
Claves:Clinical Practice Guideline, Pakistan, Palliative Care, Referral
Cita:BMC Palliat Care 2024 May 1; 23 (1) : 112.
Autor/es:Hashmi, Syeda Amrah (a) Martins, Russell Seth (b)
institución:(a) Center for Clinical Best Practices, Clinical and Translational Research Incubator (CITRIC), Aga Khan University Hospital, Karachi, 74800, Pakistan. (b) Center for Clinical Best Practices, Clinical and Translational Research Incubator (CITRIC), Aga Khan University Hospital, Karachi, 74800, Pakistan.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women.
Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women.
Fuente:Frontiers in Public Health
Extracto:
According to our
study, there were positive correlations between iAs, especially As(3+), MMA and
VDD, but negative correlations between other As species and VDD. Further studies
are needed to determine the mechanisms that exist between different As species
and VDD.
Claves:BKMR, arsenic species, cross-sectional study, pregnancy, vitamin D deficiency
Cita:Front Public Health 2024; 12 : 1371920.
Autor/es:Zhang, Jingran (a) Bai, Yuxuan (b)
institución:(a) Department of Occupational and Environmental Health, School of Public Health, Tianjin Medical University, Tianjin, China. (b) Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Serum klotho associated with thyroid hormone in adults: A population-based cross-sectional research.
Serum klotho associated with thyroid hormone in adults: A population-based cross-sectional research.
Fuente:Plos One
Extracto:
There is an L-shaped
nonlinear relationship between ln(klotho) and fT3, tT3, suggesting that klotho
could be involved in the physiological regulation of thyroid function.
Cita:PLoS One 2024; 19 (5) : e0301484.
Autor/es:Zhang, Xia (a) Liu, Xuekui (b)
institución:(a) The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China. (b) Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Clinical School of Nanjing Medical University, Affiliated Hospital of Medical School of Southeast University, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación