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A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence.
A guide to selecting high-performing antibodies for Rab1A and Rab1B for use in Western Blot, immunoprecipitation and immunofluorescence.
Fuente:F1000research
Extracto:
While uses of antibodies and protocols vary between laboratories, we
encourage readers to use this report as a guide to select the most appropriate
antibodies for their specific needs.
Claves:RAB1A and RAB1B, Rab1A and Rab1B, Uniprot ID P62820 (Rab1A) and Q9H0U4 (Rab1B), Western Blot, antibody characterization, antibody validation, immunofluorescence, immunoprecipitation
Cita:F1000Res 2023; 12 : 1578.
Autor/es:Ruíz Moleón, Vera (a) Fotouhi, Maryam (b)
institución:(a) Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada. (b) Department of Neurology and Neurosurgery, Structural Genomics Consortium, The Montreal Neurological Institute, McGill University, Montreal, Québec, H3A 2B4, Canada.
Conflicto:Competing interests: For this project, the laboratory of Peter McPherson developed partnerships with high-quality antibody manufacturers and knockout cell line providers. The partners provide antibodies and knockout cell lines to the McPherson laboratory at no cost. These partners include: - Abcam-Aviva Systems Biology -Bio Techne -Cell Signalling Technology -Developmental Studies Hybridoma Bank -GeneTex – Horizon Discovery – Proteintech – Synaptic...
naptic Systems –Thermo Fisher Scientific.
Sex-related disparities in vehicle crash injury and hemodynamics.
Sex-related disparities in vehicle crash injury and hemodynamics.
Fuente:Frontiers in Public Health
Extracto:
Female crash injury victims' tendency for higher (AIS)
severity of pelvis and liver injuries may relate to how their bodies interact
with safety equipment. Females are entering shock states (SI > 1.0) with lesser
injury severity (ISS) than male crash injury victims, which may suggest that
female crash patients are somehow more susceptible to compromised hemodynamics
than males. These findings indicate an urgent need to conduct vehicle crash
injury research within a sex-equity framework; evaluating sex-related clinical
data may hold the key to reducing disparities in vehicle crash injury.
Claves:crash safety, equity in research, sex differences, shock index, traumatic injury, vehicle crash
Cita:Front Public Health 2024; 12 : 1331313.
Autor/es:Cronn, Susan (a) Somasundaram, Karthik (b)
institución:(a) Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, WI, United States. (b) Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Genetic associations of protein-coding variants in venous thromboembolism.
Genetic associations of protein-coding variants in venous thromboembolism.
Fuente:Nature Communications
Extracto:
In conclusion, our study
unveils the valuable contribution of protein-coding variants in VTE etiology and
sheds new light on its risk stratification.
Cita:Nat Commun 2024 Apr 1; 15 (1) : 2819.
Autor/es:He, Xiao-Yu (a) Wu, Bang-Sheng (b)
institución:(a) Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China. (b) Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial.
Intrathecal delivery of adipose-derived mesenchymal stem cells in traumatic spinal cord injury: Phase I trial.
Fuente:Nature Communications
Extracto:
In conclusion, the study met the primary
endpoint, demonstrating that AD-MSC harvesting and administration were
well-tolerated in patients with traumatic SCI.
Cita:Nat Commun 2024 Apr 1; 15 (1) : 2201.
Autor/es:Bydon, Mohamad (a) Qu, Wenchun (b)
institución:(a) Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA. bydon.mohamad@mayo.edu. (b) Department of Neurological Surgery, Mayo Clinic, Rochester, MN, USA. bydon.mohamad@mayo.edu.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Reliability and validity of a graphical computerized adaptive test Longshi scale for rapid assessment of activities of daily living in stroke survivors.
Reliability and validity of a graphical computerized adaptive test Longshi scale for rapid assessment of activities of daily living in stroke survivors.
Fuente:Scientific Reports
Extracto:
Further validation of this tool in other populations
and settings is necessary.Study registration number: No.: ChiCTR2000034067;
http://www.chictr.org.cn/showproj.aspx?proj=54770 .
institución:(a) Department of Rehabilitation, First Affiliated Hospital of Shenzhen University/Shenzhen Second People's Hospital, 3002 Sungang West Road, Futian District, Shenzhen, 518035, Guangdong, China. (b) Department of Neurology, Institutes of Brain Science, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute of Biological Science, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Impression management in sex and gender neuroscience research reporting
Impression management in sex and gender neuroscience research reporting
Fuente:Nature Communications
Tipo de trabajo:Guía
Extracto:
Guidelines to identify
and avoid such problems are proposed.
Cita:Nat Commun 2024 Apr 1; 15 (1) : 2826.
Autor/es:Rippon, Gina (a) Losse, Katy (b)
institución:(a) Institute of Health and Neurodevelopment, School of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK. g.rippon@aston.ac.uk. (b) Independent Researcher, St Albans, UK.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.
Mobility-related brain regions linking carotid intima-media thickness to specific gait performances in old age.
Fuente:Bmc Geriatrics
Extracto:
Carotid intima-media thickness is
associated with gait performances, and mobility-related brain volume mediates
these associations. Moreover, the distribution of brain regions regulating
mobility varies in the different gait domains. Our study adds value in exploring
the underlying mechanisms of gait disturbance in the aging population.
institución:(a) School of Public Health, the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China. (b) Fudan University Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Next-generation sequencing based newborn screening and comparative analysis with MS/MS.
Next-generation sequencing based newborn screening and comparative analysis with MS/MS.
Fuente:Bmc Pediatrics
Tipo de trabajo:Guía
Extracto:
NBS using NGS technology broadened the range of diseases screened,
and enhanced the accuracy of diagnoses in comparison to MS/MS for screening IMD.
Combining NGS and biochemical screening would improve the efficiency of current
NBS.
Claves:Gene mutations, Inherited metabolic diseases, Newborn screening, Next-generation sequencing, Tandem mass spectrometry
Cita:BMC Pediatr 2024 Apr 1; 24 (1) : 230.
Autor/es:Shen, Guosong (a) Li, Wenwen (b)
institución:(a) Medical Laboratory Center, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang Province, 313000, China. hzfbysgs@163.com. (b) Medical Laboratory Center, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang Province, 313000, China.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Cost-effectiveness of Transforaminal epidural steroid injections for patients with ACUTE sciatica: a randomized controlled trial.
Cost-effectiveness of Transforaminal epidural steroid injections for patients with ACUTE sciatica: a randomized controlled trial.
Fuente:Bmc Musculoskeletal Disorders
Tipo de trabajo:Estudio aleatorizado y controlado
Extracto:
These results suggest that adding TESI (or TEI)
to usual care is not cost-effective compared to usual care in patients with acute
sciatica (< 8 weeks) from a societal perspective in a Dutch healthcare setting.
TRIAL REGISTRATION: Dutch National trial register: NTR4457 (March, 6th, 2014).
Autor/es:Ter Meulen, Bastiaan C (a) Maas, Esther T (b)
institución:(a) Department of Neurology at OLVG Teaching Hospital, Amsterdam, The Netherlands. b.c.termeulen@olvg.nl. (b) Department of Epidemiology and Data Sciences, Amsterdam UMC, Vrije Universiteit, Amsterdam Movement Sciences Research Institute Musculoskeletal Health, De Boelelaan 1089a, 1081, HV, Amsterdam, The Netherlands. b.c.termeulen@olvg.nl.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
The efficacy of machine learning models in forecasting treatment failure in thoracolumbar burst fractures treated with short-segment posterior spinal fixation.
The efficacy of machine learning models in forecasting treatment failure in thoracolumbar burst fractures treated with short-segment posterior spinal fixation.
Fuente:Journal of Orthopaedic Surgery and Research
Tipo de trabajo:Revisión
Extracto:
This study demonstrated the utility of machine
learning models in predicting treatment failure in thoracolumbar burst fractures
treated with SSPSF. The findings support the potential of MLMs to predict
treatment failure in this patient population, offering valuable prognostic
information for early intervention and cost savings.
Claves:Failure of treatment, Load sharing classification, Machine learning models, Short segment posterior spinal fixation, Thoracolumbar burst fractures
institución:(a) Kermanshah University of Medical Sciences, Kermanshah, Iran. (b) Department of neurosurgery, Kermanshah University of Medical Sciences, Imam Reza hospital, Kermanshah, Iran.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Bilateral juvenile osteochondrosis dissecans in monozygotic twins
Bilateral juvenile osteochondrosis dissecans in monozygotic twins
Fuente:Journal of Orthopaedic Surgery and Research
Tipo de trabajo:Caso clínico
Extracto:
There could be a
genetic component to the development of OCD, although this has not yet been
proven. Based on a two-year MRI follow-up, we were able to show the self-limiting
characteristics of juvenile osteochondrosis dissecans.
institución:(a) Department of Sports Orthopaedics, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany. (b) Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Extracto:
A potential
contribution of senescent cells in cancer dormancy, as a mechanism of therapy
resistance and cancer relapse, will be discussed with the final objective to
unravel the immunotherapeutic implications of senescence modulation in cancer.
institución:(a) Department of Molecular Medicine, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, 00161, Italy. (b) Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, 00185, Italy.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1.
Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1.
Fuente:Orphanet Journal of Rare Diseases
Extracto:
We confirmed 6 patients as LGMDR1 (with CAPN3
variants) from our cohort and calpain-3 protein expression was significantly
reduced by immunoblot analysis as compared to control. Besides the previously
known variants, our study found two novel variants in CAPN3 gene by Sanger
sequencing-based approach indicating that genetic variants in LGMDR1 patients may
help to understand the etiology of the disease and future prognostication.
Claves:Calpain-3, Immunohistochemistry, LGMDR1, Sanger sequencing, Western blotting
Autor/es:Banerjee, Sukanya (a) Radotra, Bishan Dass (b)
institución:(a) Department of Histopathology, Post Graduate Institute of Medical Education and Research, 160012, Chandigarh, India. (b) Department of Histopathology, Post Graduate Institute of Medical Education and Research, 160012, Chandigarh, India. bishanradotra@gmail.com.
Conflicto:The authors have no relevant financial or non-financial interests to disclose.
Does Preoperative Radiation Therapy Performed for Metastatic Spine Cancer at the Cervical Spine Increase Perioperative Complications of Anterior Cervical Surgery?
Does Preoperative Radiation Therapy Performed for Metastatic Spine Cancer at the Cervical Spine Increase Perioperative Complications of Anterior Cervical Surgery?
Fuente:Clinics in Orthopedic Surgery
Tipo de trabajo:Revisión
Extracto:
RT performed before surgery for
MSC does not increase the risk of wound complication, mechanical failure, or
vital structure injury during ACSS. The surgical procedural approach was not
complicated by previous RT history. Therefore, surgeons can safely choose the
anterior approach when the number of levels or location of MSC favors anterior
surgery, and performing a posterior surgery is unnecessary due to a concern that
previous RT may increase complication rates of ACSS.
institución:(a) Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. (b) Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Conflicto:CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.
Mechanism study of ubiquitination in T cell development and autoimmune disease.
Mechanism study of ubiquitination in T cell development and autoimmune disease.
Fuente:Frontiers in Immunology
Extracto:
There are remarkable progresses in
understanding of the regulatory mechanisms regarding ubiquitination in T cell
development and the establishment of self-tolerance in the past few years, which
holds great potential for further therapeutic interventions in immune-related
diseases.
institución:(a) Department of Urology, Medical Research Center, Department of Neurosurgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, China. (b) Department of Urology, Medical Research Center, Department of Neurosurgery, The Third People's Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
institución:(a) Department of Neuroimmunology, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China. (b) BGI College, Zhengzhou University, Zhengzhou, Henan, China.
Conflicto:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Factors that contributed to Ontario adults' mental health during the first 16 months of the COVID-19 pandemic: a decision tree analysis.
Factors that contributed to Ontario adults' mental health during the first 16 months of the COVID-19 pandemic: a decision tree analysis.
Fuente:Peerj
Extracto:
Given that
wellbeing was the biggest contributor to mental health, researchers should focus
on targeting adults' wellbeing to improve their mental health during future
health crises.
Autor/es:Shillington, Katie J (a) Vanderloo, Leigh M (b)
institución:(a) Health and Rehabilitation Sciences, Faculty of Health Sciences, University of Western Ontario, London, Ontario, Canada. (b) Department of Neurobiology, University of California San Diego, San Diego, California, United States.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Characterization of patients requiring inpatient hospital ethics consults- A single center study.
Characterization of patients requiring inpatient hospital ethics consults- A single center study.
Fuente:Plos One
Tipo de trabajo:Estudio de cohortes
Extracto:
This study demonstrates the need to consider clinical
and demographic features when planning and prioritizing ethics consultations at
large institutions to enhance consult efficiency, resource utilization, and
patient experience and autonomy.
Cita:PLoS One 2024; 19 (4) : e0296763.
Autor/es:Mahadevan, Aditya (a) Azizi, Armon (b)
institución:(a) University of California Irvine School of Medicine, Irvine, Irvine, CA, United States of America. (b) University of California Irvine School of Medicine, Irvine, Irvine, CA, United States of America.
Conflicto:Los autores declaran no tener conflictos de interés con la investigación
Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort.
Determinants of health as predictors for differential antibody responses following SARS-CoV-2 primary and booster vaccination in an at-risk, longitudinal cohort.
Fuente:Plos One
Extracto:
The absence of
predictive factors for second booster immunogenicity suggests a more robust and
consistent immune response after the second booster vaccine administration.
Cita:PLoS One 2024; 19 (4) : e0292566.
Autor/es:Echeverri Tribin, Felipe (a) Williams, Erin (b)
institución:(a) Department of Biomedical Engineering, University of Miami, Miami, Florida, United States of America. (b) University of Miami Miller School of Medicine, Miami, Florida, United States of America.
Conflicto:Florian Krammer has been consulting for Curevac, Seqirus and Merck and is currently consulting for Pfizer, Third Rock Ventures, Avimex and GSK. He is named on several patent regarding influenza virus and SARS-CoV-2 virus vaccines, influenza virus therapeutics and SARS-CoV-2 serological tests. Some of these technologies have been licensed to commercial entities and Dr. Krammer is receiving royalties from these...
entities. Dr. Krammer is also an advisory board member of Castlevax, a spin-off company formed by the Icahn School of Medicine at Mount Sinai to develop SARS-CoV-2 vaccines. The Krammer laboratory has received funding for research projects from Pfizer, GSK and Dynavax and three of Dr. Krammer’s mentees have recently joined Moderna. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. This does not alter our adherence to PLOS ONE policies on sharing data and/or materials.