The Role of Structural Variants in the Genetic Architecture of Parkinson's Disease.

The Role of Structural Variants in the Genetic Architecture of Parkinson's Disease.

Fuente:International Journal of Molecular Sciences

Extracto: This review aims to provide a comprehensive overview of our current understanding of the involvement of coding and noncoding SVs in the genetic architecture of PD.

Claves:Parkinson’s disease, genetics, long-read sequencing, structural variants

Cita:Int J Mol Sci 2024 Apr 27; 25 (9)

Autor/es:Miano-Burkhardt, Abigail (a)
Alvarez Jerez, Pilar (b)

institución:(a) Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
(b) Center for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD 20892, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094801

Evaluating the Diagnostic Potential of Combined Salivary and Skin Biomarkers in Parkinson's Disease.

Fuente:International Journal of Molecular Sciences

Extracto: This study's results highlight the potential of utilizing a multimodal biomarker approach to enhance diagnostic accuracy in PD.

Claves:Parkinson’s disease, alpha-synuclein, biomarkers, synucleinopathies

Cita:Int J Mol Sci 2024 Apr 28; 25 (9)

Autor/es:Costanzo, Matteo (a)
Galosi, Eleonora (b)

institución:(a) Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università 30, 00185 Rome, Italy.
(b) Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094823

Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.

Fuente:International Journal of Molecular Sciences

Extracto: In summary, the obtained results demonstrate that exposure to environmental phthalates could be related to altered expression profiles of specific ELV-miRs in adult men, thereby demonstrating the potential of miRs carried by exosomes to act as early effect biomarkers.

Claves:biomarkers, endocrine disruptors, exosome-like vesicles, miRNA, pathway analysis, urine

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Cocci, Paolo (a)
Bondi, Danilo (b)

institución:(a) School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy.
(b) Dipartimento di Neuroscienze, Imaging e Scienze Cliniche, University "G. d'Annunzio" of Chieti, 66100 Chieti, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094876

Tobacco Smoke Condensate Induces Morphologic Changes in Human Papillomavirus-Positive Cervical Epithelial Cells Consistent with Epithelial to Mesenchymal Transition (EMT) with Activation of Receptor Tyrosine Kinases and Regulation of TGFB.

Fuente:International Journal of Molecular Sciences

Extracto: Understanding the molecular pathways and environmental factors that initiate EMT in ectocervical cells will help delineate molecular targets for intervention and define the role of EMT in the initiation and progression of cervical intraepithelial neoplasia and CC.

Claves:cervical cancer (CC), cigarette smoke condensate (CSC), epithelial to mesenchymal transition (EMT), high-risk human papillomavirus (HR-HPV), receptor tyrosine kinase (RTK), transforming growth factor-beta (TGFB)

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Mark, Zaniya A (a)
Yu, Linda (b)

institución:(a) Department of Biochemistry, Cancer Biology, Neuroscience, and Pharmacology, Meharry Medical College, Nashville, TN 37208, USA.
(b) Molecular Pathogenesis Group, Mechanistic Toxicology Branch, National Institute of Environmental Health Sciences, NIH, Research Trriangle Park, Durham, NC 27709, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094902

D-Bifunctional Protein Deficiency Diagnosis-A Challenge in Low Resource Settings

Fuente:International Journal of Molecular Sciences

Tipo de trabajo:Revisión

Extracto: We advocate for using molecular diagnosis in critically ill newborns and infants to improve care, reduce healthcare costs, and allow for familial counseling.

Claves:D-bifunctional protein deficiency, neonatal hypotonia, neonatal seizures, peroxisomal disorders, whole-exome sequencing

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Ognean, Maria Livia (a)
Mutică, Ioana Bianca (b)

institución:(a) Faculty of Medicine, Lucian Blaga University, 550025 Sibiu, Romania.
(b) Neonatology Department, Clinical County Emergency Hospital, 550245 Sibiu, Romania.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094924

A Nonlinear Relation between Body Mass Index and Long-Term Poststroke Functional Outcome-The Importance of Insulin Resistance, Inflammation, and Insulin-like Growth Factor-Binding Protein-1.

Fuente:International Journal of Molecular Sciences

Extracto: Thus, a nonlinear relation between BMI and poor 7-year functional outcome was differently attenuated in the normal-weight and the obese.

Claves:body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), insulin-like growth factor-binding protein-1 (IGFBP-1), modified Rankin Score (mRS), obesity paradox

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Gadd, Gustaf (a)
Åberg, Daniel (b)

institución:(a) Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
(b) Region Västra Götaland, Department of Acute Medicine and Geriatrics, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.

Conflicto:H.Z. has served at scientific advisory boards and/or as a consultant for Abbvie, Acumen, Alector, Alzinova, ALZPath, Amylyx, Annexon, Apellis, Artery Therapeutics, AZTherapies, Cognito Therapeutics, CogRx, Denali, Eisai, Merry Life, Nervgen, Novo Nordisk, Optoceutics, Passage Bio, Pinteon Therapeutics, Prothena, Red Abbey Labs, reMYND, Roche, Samumed, Siemens Healthineers, Triplet Therapeutics, and Wave, has given lectures in symposia sponsored by Alzecure, Biogen,... Cellectricon, Fujirebio, Lilly, Novo Nordisk, and Roche, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work).

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094931

The Influence of a Genetic Variant in CCDC78 on LMNA-Associated Skeletal Muscle Disease.

Fuente:International Journal of Molecular Sciences

Extracto: Taken together, our findings suggest that a relatively common variant in CCDC78 can impart profound muscle pathology in combination with a LMNA mutation and accounts for variability in skeletal muscle disease phenotypes.

Claves:core myopathy, genetic modifiers, laminopathy, lamins, limb–girdle muscular dystrophy

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Mohar, Nathaniel P (a)
Cox, Efrem M (b)

institución:(a) Interdisciplinary Graduate Program in Genetics, University of Iowa, Iowa City, IA 52242, USA.
(b) Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094930

Bridging Genetic Insights with Neuroimaging in Autism Spectrum Disorder-A Systematic Review.

Fuente:International Journal of Molecular Sciences

Extracto: This review shows that specific genetic variants and altered patterns of gene expression in individuals with ASD may have an effect on brain circuits associated with face processing and social cognition, and contribute to excitation-inhibition imbalances and to anomalies in brain volumes.

Claves:autism spectrum disorder, brain imaging, electroencephalography, functional magnetic resonance imaging, magnetic resonance imaging, neurogenetics, neuroimaging, systematic review

Cita:Int J Mol Sci 2024 Apr 30; 25 (9)

Autor/es:Vilela, Joana (a)
Rasga, Célia (b)

institución:(a) Departamento de Promoção da Saúde e Doenças Não Transmissíveis, Instituto Nacional de Saúde Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisboa, Portugal.
(b) BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Campo Grande, C8, 1749-016 Lisboa, Portugal.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094938

Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.

Fuente:International Journal of Molecular Sciences

Extracto: Our findings reveal distinct correlations in gene expression patterns, particularly involving PTK2, PTK2B, NGFR, PDGFRB, and EGFR among Puerto Rican Hispanic patients when compared to non-Hispanic counterparts.

Claves:ethnicity, gene expression, glioblastoma

Cita:Int J Mol Sci 2024 May 1; 25 (9)

Autor/es:Porter, Tyrel (a)
Del Valle, Miguel Mayol (b)

institución:(a) Department of Biochemistry, Universidad Central del Caribe, Bayamón, PR 00956, USA.
(b) Department of Surgery, Neurosurgery Section, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00921, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094947

Age Prediction Using DNA Methylation Heterogeneity Metrics.

Fuente:International Journal of Molecular Sciences

Extracto: Although this region-based model was relatively more efficient than the WSH-based model, the latter required the analysis of just a few short genomic regions and, therefore, could be a useful tool to design a reduced epigenetic clock that is analyzed by targeted next-generation sequencing.

Claves:DNA methylation heterogeneity, bisulfite sequencing, eAge clocks, epigenetic age

Cita:Int J Mol Sci 2024 May 2; 25 (9)

Autor/es:Karetnikov, Dmitry I (a)
Romanov, Stanislav E (b)

institución:(a) Federal Research Center Institute of Cytology and Genetics SB RAS, 630090 Novosibirsk, Russia.
(b) Epigenetics Laboratory, Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25094967

SPAST Intragenic CNVs Lead to Hereditary Spastic Paraplegia via a Haploinsufficiency Mechanism.

Fuente:International Journal of Molecular Sciences

Extracto: The obtained data indicate that nonsense-mediated decay degradation is not the only mechanism of hereditary spastic paraplegia in patients with SPAST microrearrangements.

Claves:SPAST deletions, hereditary spastic paraplegia, microrearrangements

Cita:Int J Mol Sci 2024 May 3; 25 (9)

Autor/es:Elert-Dobkowska, Ewelina (a)
Stepniak, Iwona (b)

institución:(a) Department of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.
(b) Department of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland.

Conflicto:Author Christian Beetz was employed by the company Centogene. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest..

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/ijms25095008

Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.

Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.

Fuente:Nutrients

Extracto: Higher neonatal 25(OH)D3 levels, a reflection of maternal vitamin D levels in pregnancy, may reduce the risk of early-onset persistent eczema.

Claves:25-hydroxyvitamin D, dried whole blood spots, eczema phenotype, risk factors, sensitization

Cita:Nutrients 2024 Apr 26; 16 (9)

Autor/es:Zeng, Rong (a)
Lodge, Caroline J (b)

institución:(a) Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.
(b) Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.

Conflicto:A.J.L., C.J.L. and S.C.D. have received an investigator-initiated grant from GlaxoSmithKline (GSK) for unrelated research, and S.C.D. holds a similar grant from AstraZeneca. A.J.L. has received an investigational product (EpiCeram™) free of charge from Primus Pharmaceuticals for use in unrelated research. A.J.L., S.C.D. and J.J.K. have received grant funding from Sanofi Regeneron for unrelated research. M.J.A. holds investigator-initiated grants from... om Boehringer-Ingelheim, Pfizer, GSK, and Sanofi Regeneron for unrelated research. He also undertook an unrelated consultancy for Sanofi and received a lecture fee from GSK. Other authors have nothing to disclose.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091303

Comparison between Physical Activity and Stress-Related Lifestyle between Orthorexic and Non-Orthorexic University Students: A Case-Control Study.

Fuente:Nutrients

Extracto: Further studies are necessary to highlight the causality between ON, stress, and physical activity but it may be possible to hypothesize that "obsessive" physical exercise may not generate the benefits generally known by the literature.

Claves:eating disorders, lifestyle, mental health, obsessive–compulsive disorders, orthorexia, physical activity, physical exercise, somatizations, stress, university students

Cita:Nutrients 2024 Apr 29; 16 (9)

Autor/es:Guidotti, Sara (a)
Fiduccia, Alice (b)

institución:(a) Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Laboratory, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
(b) Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology Laboratory, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091340

Evaluation of the Effect of Parenting Style and Parental Mealtime Actions on the Eating Behavior of Children with Epilepsy.

Fuente:Nutrients

Extracto: Owing to the chronic disease, the effects of parent-child interaction on the child's eating behavior in the epilepsy group differed from those of healthy children reported in the literature.

Claves:childhood epilepsy, children, diet quality, eating behavior, growth, parental eating-time actions, parenting practices, parenting style, parents, parents’ mealtime behaviors

Cita:Nutrients 2024 May 2; 16 (9)

Autor/es:Balcı, Tutku (a)
Çakır Biçer, Nihan (b)

institución:(a) Department of Nutrition and Dietetics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Atasehir, Istanbul, Turkey.
(b) Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Içerenköy Mahallesi Kayisdagi Caddesi No. 32, 34752 Atasehir, Istanbul, Turkey.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Suiza

Sitio web:http://dx.doi.org/10.3390/nu16091384

Loss, gain and choice difficulty in gambling patients: Neural and behavioural processes.

Loss, gain and choice difficulty in gambling patients: Neural and behavioural processes.

Fuente:Addiction Biology

Extracto: In addition, our findings on choice difficulty give new insights on the psychopathology of GD and on neural processes related to impaired decision-making in GD.

Claves:choice difficulty, decision‐making, fMRI, gambling, loss aversion

Cita:Addict Biol 2024 May; 29 (5) : e13396.

Autor/es:Freinhofer, Daniel (a)
Schwartenbeck, Philipp (b)

institución:(a) Centre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria.
(b) Centre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe impreso

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1111/adb.13396

Comparison of the genotoxicity of propofol and desflurane using the comet assay in the lymphocytes of patients who underwent lumbar discectomy: A randomized trial.

Comparison of the genotoxicity of propofol and desflurane using the comet assay in the lymphocytes of patients who underwent lumbar discectomy: A randomized trial.

Fuente:Saudi Medical Journal

Extracto: Propofol and desflurane do not appear to induce DNA damage in lymphocytes. However, when the quantitative data were compared, it was determined that propofol had relatively lower genotoxic potential than desflurane.ClinicalTrials.gov Reg. No.: NCT05185167.

Claves:comet assay, desflurane, genotoxicity, lymphocyte, propofol

Cita:Saudi Med J 2024 May; 45 (5) : 468-475.

Autor/es:Toker, Melike Korkmaz (a)
Altiparmak, Basak (b)

institución:(a) From the Department of Anesthesiology and Reanimation (Korkmaz Toker, Altiparmak, Ugur); from the Department of Neurosurgery (Gursoy,), Mugla Sıtkı Kocman; from the Department of Anesthesiology and Reanimation (Uysal, Dede), Mugla Sıtkı Kocman University, Training and Research Hospital, Mugla; from the Department of Physiology (Gundogdu); and from the Department of Medical Biology (Dodurga), Medical Faculty, Pamukkale University, Denizli, Turkey.
(b) From the Department of Anesthesiology and Reanimation (Korkmaz Toker, Altiparmak, Ugur); from the Department of Neurosurgery (Gursoy,), Mugla Sıtkı Kocman; from the Department of Anesthesiology and Reanimation (Uysal, Dede), Mugla Sıtkı Kocman University, Training and Research Hospital, Mugla; from the Department of Physiology (Gundogdu); and from the Department of Medical Biology (Dodurga), Medical Faculty, Pamukkale University, Denizli, Turkey.

Formato:Informe impreso

Idioma:Inglés

País de fuente:Arabia Saudí

Sitio web:http://dx.doi.org/10.15537/smj.2024.45.5.20240077

Antibiotic impregnated catheters and intrathecal antibiotics for CSF shunt infection prevention in children undergoing low-risk CSF shunt surgery.

Antibiotic impregnated catheters and intrathecal antibiotics for CSF shunt infection prevention in children undergoing low-risk CSF shunt surgery.

Fuente:Bmc Pediatrics

Tipo de trabajo:Estudio de cohortes

Extracto: In a large, observational multicenter cohort, IT antibiotics and AICs do not confer a statistically significant risk reduction compared to standard care for pediatric patients undergoing low-risk (i.e., initial or revision) shunt surgeries.

Claves:Antibiotic impregnated catheter, CSF, Hydrocephalus, Infection

Cita:BMC Pediatr 2024 May 11; 24 (1) : 325.

Autor/es:Podkovik, Stacey (a)
Zhou, Chuan (b)

institución:(a) Department of Neurological Surgery, Riverside University Health Sciences Medical Center, Riverside, CA, USA.
(b) Center for Child Health, Seattle Children's Research Institute, Behavior, and Development, Seattle, WA, USA.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12887-024-04798-9

Carbon monoxide poisoning with hippocampi lesions on MRI

Carbon monoxide poisoning with hippocampi lesions on MRI

Fuente:Bmc Neurology

Tipo de trabajo:Revisión

Extracto: Hippocampi, as a relatively rare lesion on MRI of CO poisoning, is of important significance both in the early and delayed stages of acute CO poisoning. In this article, we summarize the case reports of hippocampal lesions on MRI in patients with CO poisoning in recent years, in order to provide reference for the diagnosis and prognosis of CO poisoning.

Claves:Carbon monoxide, Case report, Hippocampi, Magnetic resonance imaging, Poisoning

Cita:BMC Neurol 2024 May 11; 24 (1) : 159.

Autor/es:Li, Wenxia (a)
Meng, Jun (b)

institución:(a) Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, 300070, China.
(b) Tianjin Huanhu Hospital, Tianjin, 300350, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12883-024-03668-2

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis.

Thymic gene expression analysis reveals a potential link between HIF-1A and Th17/Treg imbalance in thymoma associated myasthenia gravis.

Fuente:Journal of Neuroinflammation

Extracto: These findings may lead to new therapeutic approaches targeting HIF1A in the development of TAMG.

Claves:Hypoxia-inducible factor-1, Myasthenia gravis, Thymoma, Thymus

Cita:J Neuroinflammation 2024 May 11; 21 (1) : 126.

Autor/es:Altınönder, İlayda (a)
Kaya, Mustafa (b)

institución:(a) Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, 34093, Turkey.
(b) Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, 34093, Turkey.

Conflicto:None of the authors has any potential financial conflict of interest related to this manuscript.

Formato:Informe virtual

Idioma:Inglés

País de fuente:Reino Unido

Sitio web:http://dx.doi.org/10.1186/s12974-024-03095-7

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder.

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder.

Fuente:Translational Psychiatry

Extracto: Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.

Cita:Transl Psychiatry 2024 May 11; 14 (1) : 202.

Autor/es:Xu, Ke (a)
Zhao, Shuang (b)

institución:(a) Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
(b) National Health Commission Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Conflicto:Los autores declaran no tener conflictos de interés con la investigación

Formato:Informe virtual

Idioma:Inglés

País de fuente:EE.UU.

Sitio web:http://dx.doi.org/10.1038/s41398-024-02916-w