INHIBIDORES DE LA BOMBA DE PROTONES. ACTUALIZACION

La eficacia de los inhibidores de la bomba de protones es claramente superior a la de otras opciones terapéuticas.

Autor:
Rodolfo Corti
Columnista Experto de SIIC

Institución:
Unidad de Esófago y Estómago, Hospital de Gastroenterología B. Udaondo

Artículos publicados por Rodolfo Corti

Coautores
Rafael Améndola* Judith Doweck** Liliana Schenone** Amado Escobar* José Luis Ayoroa* Muhannad Sarem***
Médico Especialista en Gastroenterología, Unidad de Esófago y Estómago, Hospital de Gastroenterología B. Udaondo, Buenos Aires, Argentina*
Médica Especialista en Gastroenterología, Unidad de Esófago y Estómago, Hospital de Gastroenterología B. Udaondo, Buenos Aires, Argentina**
Investigador, Instituto Universitario de Ciencias de la Salud, Fundación H. Barceló, Buenos Aires, Argentina***

Recepción del artículo
23 de Marzo, 2006

Aprobación
22 de Mayo, 2006

Primera edición
13 de Julio, 2006

Segunda edición, ampliada y corregida
7 de Junio, 2021

INHIBIDORES DE LA BOMBA DE PROTONES. ACTUALIZACION

Resumen
Puesta al día sobre las drogas de mayor efectividad en la terapéutica de las enfermedades relacionadas con el ácido, se hace referencia a sus características farmacológicas y efectividad en el tratamiento de la úlcera gástrica, duodenal y enfermedad por reflujo gastroesofágico. Se hace referencia además a las nuevas estructuras químicas en investigación, como el tenatoprazol, los inhibidores de la bomba buffereados (omeprazol + bicarbonato de sodio) y los antagonistas de la bomba de ácido (soraprazan, revaprazan, AZD0865 y CS-526), hasta la actualidad sin uso clínico por su hepatotoxicidad.

Palabras clave
inhibidores de la bomba de protones, farmacología, aplicaciones clínicas

Artículo completo
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Proton Pump Inhibitors: An Update

Abstract
We reviewed the most effective drugs used in acid-related disorders with emphasis on their pharmacological characteristics and usefulness in the treatment of gastric ulcers, duodenal ulcers and gastro-oesophageal reflux disease. Also, novel molecules and chemical structures that have not yet been used in clinic applications, like tenatoprazole, new immediate-release omeprazole (IR-OME) and acid pump antagonists (soraprazan, revaprazan, AZD0865 y el CS-526) are discussed in this review.

Key words
proton-pump inhibitors, pharmacology, clinical applications

Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Gastroenterología
Relacionadas: Atención Primaria, Farmacología, Medicina Farmacéutica, Medicina Interna

Enviar correspondencia a:
Muhannad Sarem

Bibliografía del artículo
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