Suscriptores   Asóciese  
Textos Completos Autorizados
METILACION DEL GEN ER EN EL CARCINOMA ENDOMETRIAL

v-estudie-lo-mejor.gif
Expertos Invitados





METILACION DEL GEN ER EN EL CARCINOMA ENDOMETRIAL

(especial para SIIC © Derechos reservados)
La metilación del gen del receptor estrogénico (ER) cumpliría un papel en la regulación de la trascripción ER en el carcinoma endometrial.
shiozawa9.jpg Autor:
t Shiozawa
Columnista Experto de SIIC
Artículos publicados por t Shiozawa
Coautor
Ikuo Konishi.* 
M.D., Ph. D Department of Obstetrics and Gynecology, Shinshu University School of Medicine*
Recepción del artículo
26 de Enero, 2004 		Primera edición
7 de Mayo, 2004 		Segunda edición, ampliada y corregida
7 de Junio, 2021

METILACION DEL GEN ER EN EL CARCINOMA ENDOMETRIAL

Resumen
Recientes investigaciones revelaron que la metilación CpGs de varios genes se encuentra profundamente involucrada en la regulación de la trascripción. La regulación de la expresión del receptor estrogénico (ER) es un ejemplo representativo del silenciamiento génico mediado por la metilación. Este artículo revisa los patrones de expresión y el papel del ER en los tejidos endometriales y la posible responsabilidad de la metilación del gen ER en la regulación de la trascripción del ER en el carcinoma endometrial.

Palabras clave
Endometrio, carcinoma endometrial, receptor estrogénico, isla CpG, metilación, cambios epigenéticos


Artículo completo
(castellano)
Extensión:  +/-9.72 páginas impresas en papel A4
Exclusivo para suscriptores/assinantes

ESTROGEN RECEPTOR EXPRESSION AND GENE METHYLATION IN ENDOMETRIAL CARCINOMA

Abstract
Recent researches have revealed that the methylation CpGs of various genes is deeply involved in the transcription regulation. The regulation of estrogen receptor (ER) expression is a representative example of methylation-mediated gene silencing. This article reviews the expression pattern and its roles of ER in endometrial tissues, and possible involvement of ER gene methylation in ER transcription regulation in endometrial carcinoma.

Key words
Endometrium, endometrial carcinoma, estrogen receptor, CpG island, methylation, epigenetic change


Full text
(english)
 para suscriptores/ assinantes
Clasificación en siicsalud
Artículos originales > Expertos del Mundo >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Oncología
Relacionadas: Bioquímica, Obstetricia y Ginecología



Comprar este artículo
Extensión: 9.72 páginas impresas en papel A4

file05.gif (1491 bytes) Artículos seleccionados para su compra



Bibliografía del artículo
  1. Lurain JR. Uterine cancer. In: Novak's gynecology. 13th ed. Berek JS ed. Lippincott Williams & Wilkins, Philadelphia, 2002 pp1143-97.
  2. Ronnett BM, Zaino RJ, Ellenson LH, Kurman RJ. Endometrial carcinoma. In: Blausteins pathology of the female genital tract. 5th ed. Kurmann RJ ed. Springer-Verlag, New York, 2001 pp501-59.
  3. Speroff L, Glass RH, Kase NG. Anovulation and the polycystic ovary. In: Clinical endocrinology and infertility. 6th ed. Lippincott Williams & Wilkins, Baltimore, 1999 pp506-11.
  4. Creasman WT. Prognostic significance of hormone receptors in endometrial cancer. Cancer 1993; 71: 1467-70.
  5. Gehrig PA, Le LV, Olatidoye B et al. Estrogen receptor status, determined by immunohistochemistry, as a predictor of the reccurence of stage I endometrial carcinoma. Cancer 1999; 86: 2083-9.
  6. Ingram SS, Rosenman J, Heath H,et al. The predictive value of progesterone receptor levels in endometrial cancer. Int J Radiat Oncol Biol Phys 1989; 17: 21-7.
  7. Fukuda K, Mori M, Uchiyama M et al. Prognostic significance of progesterone receptor immunohistochemistry in endometrial carcinoma. Gynecol Oncol 1998; 69: 220-5.
  8. Li S-F, Shiozawa T, Nakayama K, et al. Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. Cancer 1996; 77: 321-9.
  9. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986 ; 321: 209-13.
  10. Antequera F, Bird A.CpG islands. EXS. 1993; 64: 169-85.
  11. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003; 349: 2042-54.
  12. Strauss III J, Coutifaris C. The endometrium and myometrium: Regulation and dysfunction. In: Reproductive endocrinology. 4th ed. Yen SSC, Jaffe RB, Barbieri R, eds. WB Saunders Co., Philadelphia 1999 pp218-256.
  13. Lessey BA, Killam AP, Metzger DA et al. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstrual cycle. J Clin Endocrinol Metab 1988; 67: 334-40.
  14. Gronroos M, Maenpaa J, Kangas L et al. Steroid rceptors and response of endometrial cancer to hormones. Ann. Chir. Gynecol 1987; 76: 76-9.
  15. Tseng L, Mazzella J. Cyclic changes of estradiol metabolic enzymes in human endometrium during the menstrual cycle. In: The endometrium. Kimball FA ed. SP Medial and Scientific Books, New York, 1980 pp211-26.
  16. Giudice LC. Growth factors and growth modulators in human uterine endometrium: their potential relevance to reproductive medicine. Fertil Steril 1994: 61; 1-17.
  17. Sherr CJ. G1 phase progression: Cyclin on Cue. Cell 1994; 79: 551-5.
  18. Nurse P. Ordering S phase and M phase in the cell cycle. Cell 1994; 79: 547-50.
  19. Shiozawa T, Nikaido T, Nakayama K et al. Involvement of the cyclin-dependent kinase inhibitor p27Kip1 in the growth inhibition of endometrium in the secretory phase and in hyperplastic endometrium treated with progesterone. Mol Hum Reprod 1988; 4: 899-905.
  20. Shiozawa T, Horiuchi A, Kato K et al. Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells. Endocrinology 2001; 142: 4182-8.
  21. Walter P, Green S, Greene G et al. Cloning of the human estrogen receptor cDNA. Proc Natl Acad Sci USA 1985; 82: 7889-93.
  22. Gosden JR, Middleton PG, Rout D. Localization of the human oestrogen receptor gene to chromosome 6q24----q27 by in situ hybridization. Cytogenet Cell Genet 1986; 43: 218-20.
  23. Enmark E, Pelto-Huikko M, Grandien K et al. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.J Clin Endocrinol Metab 1997; 82: 4258-65.
  24. Matsuzaki S, Fukaya T, Suzuki T et al. Oestrogen receptor alpha and beta mRNA expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod 1999; 5: 559-64.
  25. Matsuzaki S, Uehara S, Murakami T et al. Quantitative analysis of estrogen receptor alpha and beta messenger ribonucleic acid levels in normal endometrium and ovarian endometriotic cysts using a real-time reverse transcription-polymerase chain reaction assay. Fertil Steril 2000; 74: 753-9.
  26. Lecce G, Meduri G, Ancelin M et al. Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab 2001; 86: 1379-86.
  27. Shiozawa T, Li S-F, Nakayama K et al. Relationship between the expression of cyclins / cyclin-dependentkinases and sex-steroid receptors / Ki-67 in normal human endometrial glands and stroma during the menstrual cycle. Mol Hum Reprod 1996; 2: 745-52.
  28. Conneely OM, Maxwell BL, Toft DO et al. The A and B forms of the chicken progesterone receptor arise by alternate initiation of translation of a unique mRNA. Biochem Biophys Res Commun 1987; 149: 493-501.
  29. Conneely OM, Kettelberger DM, Tsai MJ et al. The chicken progesterone receptor A and B isoforms are products of an alternate translation initiation event. J Biol Chem 1989; 264: 14062-4.
  30. Mote PA, Balleine RL, McGowan EM et al. Colocalization of progesterone receptors A and B by dual immunofluorescent histochemistry in human endometrium during the menstrual cycle. J Clin Endocrinol Metab 1999; 84: 2963-71.
  31. Arnett-Mansfield RL, deFazio A, Wain GV et al. Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium. Cancer Res 2001; 61: 4576-82.
  32. Utsunomiya H, Suzuki T, Harada N et al. Analysis of estrogen receptor alpha and beta in endometrial carcinomas: correlation with ER beta and clinicopathologic findings in 45 cases. Int J Gynecol Pathol 2000; 19: 335-41.
  33. Takama F, Kanuma T, Wang D et al. Oestrogen receptor beta expression and depth of myometrial invasion in human endometrial cancer. Br J Cancer 2001; 84: 545-9.
  34. Holliday R. DNA methylation and epigenetic mechanisms. Cell Biophys 1989; 15: 15-20.
  35. Wolffe AP, Matzke MA. Epigenetics: regulation through repression. Science 1999; 286: 481-6.
  36. Yan L, Yang X, Davidson NE. Role of DNA methylation and histone acetylation in steroid receptor expression in breast cancer. J Mammary Gland Biol Neoplasia 2001; 6: 183-92.
  37. Berger J, Daxenbichler G. DNA methylation of nuclear receptor genes--possible role in malignancy.J Steroid Biochem Mol Biol 2002; 80: 1-11.
  38. Ohtani-Fujita N, Fujita T, Aoike A et al. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene 1993; 8: 1063-7.
  39. Wong YF, Chung TK, Cheung TH et al. Methylation of p16INK4A in primary gynecologic malignancy. Cancer Lett 1999; 136: 231-5.
  40. Kitazawa S, Kitazawa R, Maeda S. Transcriptional regulation of rat cyclin D1 gene by CpG methylation status in promoter region. J Biol Chem 1999; 274: 28787-93.
  41. Esteller M, Levine R, Baylin SB et al. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998; 17: 2413-7.
  42. Simpkins SB, Bocker T, Swisher EM et al. MLH1 promoter methylation and gene silencing is the primary cause of microsatellite instability in sporadic endometrial cancers. Hum Mol Genet 1999; 8: 661-6.
  43. Yen RW, Vertino PM, Nelkin BD et al. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res 1992; 20: 2287-91.
  44. Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 1998; 19: 219-20.
  45. Okano M, Xie S, Li E. Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells. Nucleic Acids Res 1998; 26: 2536-40.
  46. Aapola U, Lyle R, Krohn K et al. Isolation and initial characterization of the mouse Dnmt3l gene. Cytogenet Cell Genet 2001; 92: 122-6.
  47. Meehan RR, Lewis JD, Mckay S et al. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 1989; 58: 499-507.
  48. Lewis JD, Meehan RR, Henzel WJ et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 1992; 69: 905-14.
  49. Nan X, Campoy FJ, Bird A. MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell 1997; 88: 471-81.
  50. Green S, Walter P, Kumar V et al. Human estrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 1986; 320: 134-9.
  51. Donaghue C, Westley BR, May FE. Selective promoter usage of the human estrogen receptor-alpha gene and its regulation by estrogen. Mol Endocrinol 1999; 13: 1934-50.
  52. Kos M, Reid G, Denger S et al. Minireview: genomic organization of the human ERalpha gene promoter region. Mol Endocrinol 2001; 15: 2057-63.
  53. Hori M, Iwasaki M, Shimazaki J et al. Assessment of hypermethylated DNA in two promoter regions of the estrogen receptor alpha gene in human endometrial diseases. Gynecol Oncol 2000; 76: 89-96.
  54. Sasaki M, Kotcherguina L, Dharia A et al. Cytosine-phosphoguanine methylation of estrogen receptors in endometrial cancer. Cancer Res 2001; 61: 3262-6.
  55. Piva R, Rimondi AP, Hanau S et al. Different methylation of estrogen receptor DNA in human breast carcinomas with and without estrogen receptor. Br J Cancer 1990; 61: 270-5.
  56. Ottaviano YL, Issa JJ, Parl FF et al. Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res 1994; 54: 2552-5.
  57. Lapidus RG, Ferguson AT, Ottaviano YL et al. Methylation of estrogen and progesterone receptor gene 5 CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors. Clin Cancer Res 1996; 2: 805-10.
  58. Shiozawa T, Itoh K, Horiuchi A et al. Down-regulation of estrogen receptor by the methylation of the estrogen receptor gene in endometrial carcinoma. Anticancer Res 2002; 22: 139-43.
  59. Herman JG, Graff JR, Myohanen S et al. Methylation specific PCR: A novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821-6.
  60. Archey WB, McEachern KA, Robson M et al. Increased CpG methylation of the estrogen receptor gene in BRCA1-linked estrogen receptor-negative breast cancers. Oncogene 2002; 21: 7034-41.
  61. Navari JR, Roland PY, Keh P et al. Loss of estrogen receptor (ER) expression in endometrial tumors is not associated with de novo methylation of the 5' end of the ER gene. Clin Cancer Res 2000; 6: 4026-32.
Título español
Resumen
 Palabras clave
 Bibliografía
 Artículo completo
(exclusivo a suscriptores)
 Autoevaluación
  Tema principal en SIIC Data Bases
 Especialidades

 English title
 Abstract
 Key words
Full text
(exclusivo a suscriptores)

Autor 
Artículos
Correspondencia

Patrocinio y reconocimiento
Imprimir esta página
 
 
 
 
 
 
 
 
 
 
 
 
Está expresamente prohibida la redistribución y la redifusión de todo o parte de los contenidos de la Sociedad Iberoamericana de Información Científica (SIIC) S.A. sin previo y expreso consentimiento de SIIC.
ua31618
Acerca de SIIC   Estructura de SIIC   Fuentes informativas  

Sociedad Iberoamericana de Información Científica

Copyright siicsalud© 1997-2024 ISSN siicsalud: 1667-9008
ua31517