O PRURIGO ESTROFULO EM CRIANÇAS COM INFECÇAO PELO VIRUS DA IMUNODEFICIENCIA HUMANA E A ASSOCIAÇAO INVERSA COM GRAU DE IMUNOCOMPROMETIMENTO





O PRURIGO ESTROFULO EM CRIANÇAS COM INFECÇAO PELO VIRUS DA IMUNODEFICIENCIA HUMANA E A ASSOCIAÇAO INVERSA COM GRAU DE IMUNOCOMPROMETIMENTO

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As modificações imunológicas presentes em crianças infectadas pelo HIV nas fases de ausência de imunossupressão favorecem o desenvolvimento de hipersensibilidade à picada dos insetos.
oliveiradecarvalho.jpg Autor:
Vânia Oliveira De Carvalho
Columnista Experto de SIIC

Institución:
Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná


Artículos publicados por Vânia Oliveira De Carvalho
Coautores
Crisitna Rodrigues da Cruz* Hermênio Cavalcante Lima** 
Dra em Saúde da Criança e do Adolescente, Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brasil*
Doutor em Imunologia Harvard University, Disciplina de Imunologia Clínica e Alergia do Departamento de Patologia Médica do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brasil**
Recepción del artículo
7 de Julio, 2006
Aprobación
25 de Julio, 2006
Primera edición
27 de Octubre, 2007
Segunda edición, ampliada y corregida
7 de Junio, 2021

Resumen
Objetivo: Avaliar a prevalência do prurigo estrófulo em crianças infectadas pelo HIV e sua distribuição conforme as categorias imunológicas e a carga viral. Métodos: Estudo prospectivo, observacional de pacientes menores de 14 anos infectados pelo HIV que consultaram o Serviço de Infectologia Pediátrica do HC da UFPR. Uma avaliação foi realizada por Dermatopediatra e considerado caso de prurigo estrófulo o paciente com alergia a picadas de insetos e lesões clínicas compatíveis. A determinação dos valores de linfócitos T CD4+ e da carga viral foi feita no momento da consulta. Os pacientes foram estratificados nas categorias imunológicas. O estudo estatístico foi realizado com nível de significância de 5%. Resultados: Foram examinadas 127 crianças. Prurigo estrófulo foi observado em 33 pacientes, com média de 3 anos de idade e predominou nos meses quentes. Prurigo estrófulo foi mais prevalente nos pacientes com ausência de imunodeficiência. Porém, não houve diferença da média do número de cópias virais em pacientes com ou sem a dermatose. Conclusões: O prurigo estrófulo é observado em crianças infectadas pelo HIV na classificação imunológica "sem imunossupressão". Estes achados sugerem que modificações imunológicas, promovidas pelo HIV em algumas fases da doença, podem favorecer o desenvolvimento de hipersensibilidade à picada dos insetos.

Palabras clave
Prurigo, AIDS, HIV, imunossupressão, hipersensibilidade


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Abstract
Objective: To evaluate the prevalence of prurigo strophulus in HIV infected children and whether its distribution conforms to immunological categories and viral load. Methods: Prospective observational study in HIV infected children under 14 year olds who were seen at the Pediatric Infectology Service, UFPR University Hospital. An evaluation was performed by pediatric dermatology specialists who considered prurigo strophulus as an allergy to insect bites and compatible clinical lesions. CD4+ T lymphocyte count and viral load were determined at consultation time. Patients were stratified by immunological category. Statistical analysis was performed with a 5% significance level. Results: Prurigo strophulus was seen in 33 of 127 children, at a mean age of 3 years, with predominance in warmer months and in patients without immunodeficiency. There was no difference in mean number of viral copies between patients with or without the dermatosis. Conclusions: Prurigo strophulus is seen in HIV infected children immunoclassified as without immunosuppression. These findings suggest that immunological changes promoted by HIV in some phases of the disease could help hypersensitivity to insect bites develop.

Key words
Prurigo, AIDS, HIV, imunossupression, hipersensibility


Clasificación en siicsalud
Artículos originales > Expertos de Iberoamérica >
página   www.siicsalud.com/des/expertocompleto.php/

Especialidades
Principal: Infectología
Relacionadas: Bioquímica, Dermatología, Diagnóstico por Laboratorio, Medicina Interna, Pediatría



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Enviar correspondencia a:
Vânia Oliveira de Carvalho, Serviço de Dermatopediatria do Hospital de Clínicas da Universidade Federal do Paraná, 80 820-110, Rua Richard Strauss 62 Vista Alegre, Curitiba, Brasil
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